Bisoprolol (hemifumarate)_HEC-1-A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Bisoprolol (hemifumarate) perturbation in HEC-1-A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Bisoprolol (hemifumarate)_HEC-1-A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MYH9 myosin, heavy chain 9, non-muscle 0.143862
EEF2 eukaryotic translation elongation factor 2 0.0928334
UBC ubiquitin C 0.0879385
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0777718
APP amyloid beta (A4) precursor protein 0.0776908
FLNA filamin A, alpha 0.0741715
ASPH aspartate beta-hydroxylase 0.072155
AHNAK AHNAK nucleoprotein 0.0626639
PCBP2 poly(rC) binding protein 2 0.0578806
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0573466
SET SET nuclear proto-oncogene 0.0536099
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0527762
SFPQ splicing factor proline/glutamine-rich 0.0463022
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0457494
SMAD3 SMAD family member 3 0.0454561
VCL vinculin 0.0454152
FLNB filamin B, beta 0.0449221
RPS27A ribosomal protein S27a 0.044807
FNDC3B fibronectin type III domain containing 3B 0.0430495
ENO1 enolase 1, (alpha) 0.0427834
DIAPH1 diaphanous-related formin 1 0.0410373
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0395463
TPM3 tropomyosin 3 0.0388825
MYEOV myeloma overexpressed 0.0380504
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0363189
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0361367
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0353238
WWOX WW domain containing oxidoreductase 0.0349443
ANKRD36 ankyrin repeat domain 36 0.0348917
ACTN4 actinin, alpha 4 0.0344609
RTN4 reticulon 4 0.0328357
APLP2 amyloid beta (A4) precursor-like protein 2 0.0327975
ATAD2 ATPase family, AAA domain containing 2 0.0320549
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0315019
KDM6A lysine (K)-specific demethylase 6A 0.031395
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0312658
USP9X ubiquitin specific peptidase 9, X-linked 0.0309526
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0307167
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.03033
AFDN afadin, adherens junction formation factor 0.0299881
OSBPL10 oxysterol binding protein-like 10 0.0297185
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0295362
TNIP1 TNFAIP3 interacting protein 1 0.0294937
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0294353
CSNK1A1 casein kinase 1, alpha 1 0.0293853
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0283892
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B 0.0283015
PLEC plectin 0.0282833
PRELID2 PRELI domain containing 2 0.0282408
NCKAP1 NCK-associated protein 1 0.0278608
PTK2 protein tyrosine kinase 2 0.0277988
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0275017
POTEF POTE ankyrin domain family, member F 0.0270784
SEPTIN9 septin 9 0.026782
HSPA8 heat shock 70kDa protein 8 0.026694
LPP LIM domain containing preferred translocation partner in lipoma 0.0263966
RAD51B RAD51 paralog B 0.026323
FAT1 FAT atypical cadherin 1 0.0261127
OGA O-GlcNAcase 0.0256348
EEF1G eukaryotic translation elongation factor 1 gamma 0.0254432
RPL3 ribosomal protein L3 0.025382
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.025305
PSD3 pleckstrin and Sec7 domain containing 3 0.0250983
GSK3B glycogen synthase kinase 3 beta 0.0249515
SMYD3 SET and MYND domain containing 3 0.0249052
FHIT fragile histidine triad 0.0247029
MACROD2 MACRO domain containing 2 0.0245946
ECPAS Ecm29 proteasome adaptor and scaffold 0.0243824
WAC WW domain containing adaptor with coiled-coil 0.0242197
ZFAND3 zinc finger, AN1-type domain 3 0.0239662
TRIO trio Rho guanine nucleotide exchange factor 0.023932
NRIP1 nuclear receptor interacting protein 1 0.0239304
SRSF1 serine/arginine-rich splicing factor 1 0.0237886
ZNF148 zinc finger protein 148 0.0235979
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0235184
DIAPH3 diaphanous-related formin 3 0.0234417
SMC1A structural maintenance of chromosomes 1A 0.0234322
AXL AXL receptor tyrosine kinase 0.0233848
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0233386
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0233097
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0231712
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0230536
ADAM9 ADAM metallopeptidase domain 9 0.0230413
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0230175
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0229598
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0228105
ZNF207 zinc finger protein 207 0.0226093
MIDEAS mitotic deacetylase associated SANT domain protein 0.0225534
EIF4A2 eukaryotic translation initiation factor 4A2 0.0224811
RANBP2 RAN binding protein 2 0.0224746
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0224146
VMP1 vacuole membrane protein 1 0.0223852
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0220602
ANLN anillin, actin binding protein 0.0219878
HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9) 0.0218321
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0218018
SCAF8 SR-related CTD-associated factor 8 0.0216772
ATXN7 ataxin 7 0.0215398
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0215204
PLS3 plastin 3 0.0214887

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.17178
MT2A metallothionein 2A -0.162212
FTL ferritin, light polypeptide -0.125218
RPL35A ribosomal protein L35a -0.122376
TPT1 tumor protein, translationally-controlled 1 -0.10493
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0882908
ACTG1 actin gamma 1 -0.0813667
RPS6 ribosomal protein S6 -0.0766317
TMSB10 thymosin beta 10 -0.0640018
RPL34 ribosomal protein L34 -0.0634267
RPL12 ribosomal protein L12 -0.0628509
RPLP1 ribosomal protein, large, P1 -0.0585216
NDRG1 N-myc downstream regulated 1 -0.0571755
RPS19 ribosomal protein S19 -0.056368
RPL31 ribosomal protein L31 -0.0532879
IGFBP3 insulin-like growth factor binding protein 3 -0.0529844
RPL19 ribosomal protein L19 -0.0517159
ANXA2 annexin A2 -0.0489993
RPLP0 ribosomal protein, large, P0 -0.0483757
S100A10 S100 calcium binding protein A10 -0.0474229
RPL32 ribosomal protein L32 -0.0474057
EIF1 eukaryotic translation initiation factor 1 -0.0458795
CCND1 cyclin D1 -0.0455707
RPS14 ribosomal protein S14 -0.0447608
RPS8 ribosomal protein S8 -0.0416956
S100A9 S100 calcium binding protein A9 -0.0410868
RPL8 ribosomal protein L8 -0.0344149
RPL28 ribosomal protein L28 -0.0341939
TMSB4X thymosin beta 4, X-linked -0.034082
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0340638
B2M beta-2-microglobulin -0.0339814
RPL11 ribosomal protein L11 -0.0317424
RPL36 ribosomal protein L36 -0.0311759
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0309293
RPS16 ribosomal protein S16 -0.0308078
RSL1D1 ribosomal L1 domain containing 1 -0.0307058
VDAC1 voltage-dependent anion channel 1 -0.0305955
RACK1 receptor for activated C kinase 1 -0.0294783
LMAN1 lectin, mannose-binding, 1 -0.0292555
RPL38 ribosomal protein L38 -0.0292383
RPS4X ribosomal protein S4, X-linked -0.0285838
RPLP2 ribosomal protein, large, P2 -0.0285332
HMGA1 high mobility group AT-hook 1 -0.026878
IARS1 isoleucyl-tRNA synthetase 1 -0.0267857
RPS5 ribosomal protein S5 -0.0267836
RPL35 ribosomal protein L35 -0.0265983
TPI1 triosephosphate isomerase 1 -0.02652
ANXA1 annexin A1 -0.0263146
GNAS GNAS complex locus -0.0258326
KRT19 keratin 19, type I -0.0253313
PTMA prothymosin, alpha -0.0250153
RPS27 ribosomal protein S27 -0.0249967
RPS24 ribosomal protein S24 -0.0244302
FAM162A family with sequence similarity 162, member A -0.0243737
LMNA lamin A/C -0.0234186
RPS20 ribosomal protein S20 -0.0233144
SPINT2 serine peptidase inhibitor, Kunitz type, 2 -0.0228438
RPS11 ribosomal protein S11 -0.022645
HMGB1 high mobility group box 1 -0.0225315
RPL26 ribosomal protein L26 -0.0224484
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.021989
DLC1 DLC1 Rho GTPase activating protein -0.0219881
RPS25 ribosomal protein S25 -0.0217462
NME2 NME/NM23 nucleoside diphosphate kinase 2 -0.0216492
KRT7 keratin 7, type II -0.0216102
GARS1 glycyl-tRNA synthetase 1 -0.0211599
PFN1 profilin 1 -0.0211374
RPS29 ribosomal protein S29 -0.0206503
S100A6 S100 calcium binding protein A6 -0.0202261
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0200913
RAB7A RAB7A, member RAS oncogene family -0.0192002
MT1X metallothionein 1X -0.019029
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0183878
RPL7A ribosomal protein L7a -0.0183576
RPL13A ribosomal protein L13a -0.018212
RPL7 ribosomal protein L7 -0.0179282
FBXL2 F-box and leucine-rich repeat protein 2 -0.0178659
GSTP1 glutathione S-transferase pi 1 -0.0178614
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain -0.0176435
RPL27A ribosomal protein L27a -0.0175524
LCORL ligand dependent nuclear receptor corepressor-like -0.0174673
RPS23 ribosomal protein S23 -0.0174262
WDR45B WD repeat domain 45B -0.0170418
RPS21 ribosomal protein S21 -0.0168812
RPL23 ribosomal protein L23 -0.0168146
RPS2 ribosomal protein S2 -0.0166665
LRRC23 leucine rich repeat containing 23 -0.0165171
EGR1 early growth response 1 -0.0164521
RPL18 ribosomal protein L18 -0.0163305
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0161472
HELZ helicase with zinc finger -0.0159491
RPL27 ribosomal protein L27 -0.0159109
IER3 immediate early response 3 -0.0158669
FOSB FBJ murine osteosarcoma viral oncogene homolog B -0.0158566
EMP1 epithelial membrane protein 1 -0.0157748
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.015741
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10 -0.0156357
HILPDA hypoxia inducible lipid droplet-associated -0.0155311
ADGRE5 adhesion G protein-coupled receptor E5 -0.0153718
H1-0 H1.0 linker histone -0.0152105