| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Bisoprolol (hemifumarate) perturbation in HS-578T cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Bisoprolol (hemifumarate)_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| VEGFA | vascular endothelial growth factor A | 0.0497886 |
| CD44 | CD44 molecule (Indian blood group) | 0.0486949 |
| SMAD3 | SMAD family member 3 | 0.0474819 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0353282 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.035045 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0343655 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0337433 |
| MYO10 | myosin X | 0.0293284 |
| HAS2 | hyaluronan synthase 2 | 0.0264485 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0261174 |
| ST3GAL1 | ST3 beta-galactoside alpha-2,3-sialyltransferase 1 | 0.0259299 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0255627 |
| CSF1 | colony stimulating factor 1 (macrophage) | 0.0244333 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | 0.0241255 |
| FLNA | filamin A, alpha | 0.0238587 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0234902 |
| TAPBP | TAP binding protein (tapasin) | 0.0229878 |
| NAV2 | neuron navigator 2 | 0.0222462 |
| MTSS1 | metastasis suppressor 1 | 0.0217826 |
| FAT1 | FAT atypical cadherin 1 | 0.0212064 |
| LAMA5 | laminin, alpha 5 | 0.0209446 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0208103 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0202178 |
| ECE1 | endothelin converting enzyme 1 | 0.0194966 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0185758 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0184635 |
| MSN | moesin | 0.0179671 |
| SLC39A14 | solute carrier family 39 (zinc transporter), member 14 | 0.0178902 |
| ARRDC3 | arrestin domain containing 3 | 0.0176558 |
| RUNX1 | runt-related transcription factor 1 | 0.0172197 |
| NOTCH2 | notch 2 | 0.0170672 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0168515 |
| AXL | AXL receptor tyrosine kinase | 0.0168117 |
| SEPTIN9 | septin 9 | 0.0166761 |
| MT1X | metallothionein 1X | 0.0166285 |
| YWHAQ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta | 0.0161885 |
| LENG8 | leukocyte receptor cluster (LRC) member 8 | 0.0161221 |
| EGFR | epidermal growth factor receptor | 0.0158887 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0158721 |
| JAG1 | jagged 1 | 0.0157595 |
| NAV1 | neuron navigator 1 | 0.0153794 |
| CYB5R3 | cytochrome b5 reductase 3 | 0.0151376 |
| ADAM12 | ADAM metallopeptidase domain 12 | 0.0150561 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0144883 |
| BRD2 | bromodomain containing 2 | 0.0144479 |
| AGFG1 | ArfGAP with FG repeats 1 | 0.0139634 |
| IRAK2 | interleukin-1 receptor-associated kinase 2 | 0.0136849 |
| PLEC | plectin | 0.0134954 |
| COL7A1 | collagen, type VII, alpha 1 | 0.0134719 |
| AGRN | agrin | 0.013399 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0131716 |
| ICAM1 | intercellular adhesion molecule 1 | 0.0130138 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | 0.0129224 |
| KIAA1217 | KIAA1217 | 0.0128477 |
| SLC20A1 | solute carrier family 20 (phosphate transporter), member 1 | 0.0127945 |
| BMP1 | bone morphogenetic protein 1 | 0.0127046 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0124754 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0123681 |
| BCL9L | B-cell CLL/lymphoma 9-like | 0.0119287 |
| PRRC2A | proline-rich coiled-coil 2A | 0.0118815 |
| TNS1 | tensin 1 | 0.0118685 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0118355 |
| HSPG2 | heparan sulfate proteoglycan 2 | 0.0116442 |
| SPSB1 | splA/ryanodine receptor domain and SOCS box containing 1 | 0.0116013 |
| PIK3R3 | phosphoinositide-3-kinase, regulatory subunit 3 (gamma) | 0.0115804 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.0113548 |
| ADAM19 | ADAM metallopeptidase domain 19 | 0.0113103 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.0112718 |
| LGALS3BP | lectin, galactoside-binding, soluble, 3 binding protein | 0.0109987 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0109556 |
| DPYSL3 | dihydropyrimidinase-like 3 | 0.0102198 |
| TTYH3 | tweety family member 3 | 0.0101675 |
| WWOX | WW domain containing oxidoreductase | 0.00990468 |
| FOSL2 | FOS-like antigen 2 | 0.0097376 |
| GNA12 | guanine nucleotide binding protein (G protein) alpha 12 | 0.00959757 |
| PLXNA1 | plexin A1 | 0.00949286 |
| PRPF8 | pre-mRNA processing factor 8 | 0.00947588 |
| EPAS1 | endothelial PAS domain protein 1 | 0.00940866 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.00936047 |
| LOC112694756 | uncharaterized LOC112694756 | 0.00932863 |
| DAB2 | Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) | 0.00928899 |
| ZFP36 | ZFP36 ring finger protein | 0.00918454 |
| HEG1 | heart development protein with EGF-like domains 1 | 0.00913121 |
| PHC2 | polyhomeotic homolog 2 (Drosophila) | 0.00912376 |
| TMEM259 | transmembrane protein 259 | 0.00903564 |
| ARID1A | AT rich interactive domain 1A (SWI-like) | 0.0089672 |
| ANGPTL4 | angiopoietin-like 4 | 0.00894244 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.00890609 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.00880102 |
| GFPT2 | glutamine-fructose-6-phosphate transaminase 2 | 0.0087639 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.00875637 |
| COL5A3 | collagen, type V, alpha 3 | 0.00873868 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | 0.00867398 |
| PPP1R18 | protein phosphatase 1, regulatory subunit 18 | 0.00866 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.00858311 |
| MAN2A1 | mannosidase, alpha, class 2A, member 1 | 0.00853122 |
| ITGAV | integrin, alpha V | 0.00850621 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | 0.00848672 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | 0.00847334 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.00845607 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.421089 |
| VIM | vimentin | -0.195014 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.179151 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.172626 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.144531 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.120752 |
| FBN1 | fibrillin 1 | -0.10858 |
| COL1A1 | collagen, type I, alpha 1 | -0.106876 |
| FN1 | fibronectin 1 | -0.106435 |
| TMSB10 | thymosin beta 10 | -0.0995447 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0894364 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0878303 |
| CANX | calnexin | -0.0867795 |
| COL1A2 | collagen, type I, alpha 2 | -0.0849902 |
| COL6A3 | collagen, type VI, alpha 3 | -0.0824443 |
| TPM4 | tropomyosin 4 | -0.0815612 |
| CDH13 | cadherin 13 | -0.0802476 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0773074 |
| NDRG1 | N-myc downstream regulated 1 | -0.0644119 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0638261 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0633479 |
| NKAIN3 | Na+/K+ transporting ATPase interacting 3 | -0.0624493 |
| ASPH | aspartate beta-hydroxylase | -0.0621313 |
| HMGA2 | high mobility group AT-hook 2 | -0.0608185 |
| PTMA | prothymosin, alpha | -0.060289 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0560862 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0553572 |
| FTL | ferritin, light polypeptide | -0.0538754 |
| TRPS1 | trichorhinophalangeal syndrome I | -0.0531025 |
| ENO1 | enolase 1, (alpha) | -0.0527253 |
| AHNAK | AHNAK nucleoprotein | -0.0526743 |
| VCAN | versican | -0.0519848 |
| DST | dystonin | -0.0503688 |
| LOX | lysyl oxidase | -0.0490456 |
| GOLGA4 | golgin A4 | -0.0488155 |
| RPS8 | ribosomal protein S8 | -0.0477211 |
| RRBP1 | ribosome binding protein 1 | -0.0471037 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0470356 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.0450239 |
| TMSB4X | thymosin beta 4, X-linked | -0.0444669 |
| CAVIN1 | caveolae associated protein 1 | -0.0444189 |
| CALD1 | caldesmon 1 | -0.0433718 |
| CALR | calreticulin | -0.0424965 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0423792 |
| RAB2A | RAB2A, member RAS oncogene family | -0.0420878 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | -0.0419268 |
| MAP4 | microtubule-associated protein 4 | -0.0415646 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0415084 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0411032 |
| GOLGB1 | golgin B1 | -0.0407043 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.0395721 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0395005 |
| PGK1 | phosphoglycerate kinase 1 | -0.0388758 |
| CALU | calumenin | -0.0387885 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | -0.0386416 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0384424 |
| S100A6 | S100 calcium binding protein A6 | -0.0378435 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0363861 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | -0.0363547 |
| SBF2 | SET binding factor 2 | -0.0361446 |
| HYCC1 | hyccin PI4KA lipid kinase complex subunit 1 | -0.0353759 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0350316 |
| ACTG1 | actin gamma 1 | -0.0350013 |
| B2M | beta-2-microglobulin | -0.0345198 |
| PRELID2 | PRELI domain containing 2 | -0.0342291 |
| RPS6 | ribosomal protein S6 | -0.0341711 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.03308 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0328618 |
| HMCN1 | hemicentin 1 | -0.0328613 |
| ARFGAP3 | ADP-ribosylation factor GTPase activating protein 3 | -0.0316718 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | -0.0311384 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | -0.0311066 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.03079 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.0289709 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0289531 |
| MTDH | metadherin | -0.0289485 |
| TMEM263 | transmembrane protein 263 | -0.0288403 |
| CAMTA1 | calmodulin binding transcription activator 1 | -0.0287511 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.0284992 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0279083 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0277256 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0276605 |
| RPL11 | ribosomal protein L11 | -0.0271524 |
| RPL23 | ribosomal protein L23 | -0.0270469 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0269675 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0268947 |
| COPB2 | coatomer protein complex, subunit beta 2 (beta prime) | -0.0268927 |
| KCTD9 | potassium channel tetramerization domain containing 9 | -0.0267654 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0267495 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0266976 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0266679 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0265828 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0265436 |
| COPB1 | coatomer protein complex, subunit beta 1 | -0.0264566 |
| SPAG9 | sperm associated antigen 9 | -0.0258877 |
| RPS3 | ribosomal protein S3 | -0.0258074 |
| OXR1 | oxidation resistance 1 | -0.0257612 |
| ANXA2 | annexin A2 | -0.025275 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0251511 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0248796 |
