Bisoprolol (hemifumarate)_HT-29 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Bisoprolol (hemifumarate) perturbation in HT-29 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Bisoprolol (hemifumarate)_HT-29 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0648432
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0588795
SAMD12 sterile alpha motif domain containing 12 0.0586768
AHNAK AHNAK nucleoprotein 0.0471016
FRY furry homolog (Drosophila) 0.0470154
TMEM123 transmembrane protein 123 0.0453091
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 0.0442294
FNDC3B fibronectin type III domain containing 3B 0.0387783
ASPH aspartate beta-hydroxylase 0.0361657
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0344306
PTK2 protein tyrosine kinase 2 0.0341015
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 0.0309971
KRT20 keratin 20, type I 0.0308436
SLC45A4 solute carrier family 45, member 4 0.0281891
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0269553
GMDS GDP-mannose 4,6-dehydratase 0.0267108
NECTIN2 nectin cell adhesion molecule 2 0.0264846
ITPKC inositol-trisphosphate 3-kinase C 0.0259821
NDRG1 N-myc downstream regulated 1 0.0242357
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0241478
KRT18 keratin 18, type I 0.0237304
ARHGAP32 Rho GTPase activating protein 32 0.0233196
PRELID2 PRELI domain containing 2 0.0231886
MYH14 myosin, heavy chain 14, non-muscle 0.0227327
EZR ezrin 0.0227194
MMP7 matrix metallopeptidase 7 0.021896
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 0.0218516
CCNY cyclin Y 0.0217959
CCSER1 coiled-coil serine-rich protein 1 0.0216591
USP54 ubiquitin specific peptidase 54 0.0215319
ACACA acetyl-CoA carboxylase alpha 0.0214033
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0212264
NIBAN2 niban apoptosis regulator 2 0.0208313
DIAPH2 diaphanous-related formin 2 0.0204627
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B 0.0200786
ZMYND8 zinc finger, MYND-type containing 8 0.0196001
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0192714
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0190623
ACTN4 actinin, alpha 4 0.0188178
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2 0.0187447
PCED1B PC-esterase domain containing 1B 0.0185795
MYH9 myosin, heavy chain 9, non-muscle 0.0181479
GNGT1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 0.0177903
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0177391
TRAPPC9 trafficking protein particle complex 9 0.0176414
DNM2 dynamin 2 0.0175135
STK24 serine/threonine kinase 24 0.0174711
TRPS1 trichorhinophalangeal syndrome I 0.0171799
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0171205
TMEM45B transmembrane protein 45B 0.0169995
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0168494
FAT1 FAT atypical cadherin 1 0.0165207
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0160846
MAML3 mastermind-like 3 (Drosophila) 0.0160677
MECOM MDS1 and EVI1 complex locus 0.0160591
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 0.015943
CAMK2D calcium/calmodulin-dependent protein kinase II delta 0.0158473
KLF3 Kruppel-like factor 3 (basic) 0.0157487
RHPN2 rhophilin, Rho GTPase binding protein 2 0.0157235
PLEC plectin 0.0156557
ITGB4 integrin, beta 4 0.0156494
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0155361
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 0.0152519
TM9SF3 transmembrane 9 superfamily member 3 0.0151159
PICALM phosphatidylinositol binding clathrin assembly protein 0.0150628
CD2AP CD2-associated protein 0.0150282
PARP4 poly (ADP-ribose) polymerase family, member 4 0.0147378
PDS5B PDS5 cohesin associated factor B 0.0144037
ITGA1 integrin, alpha 1 0.0143361
MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene) 0.0142439
BCAS1 breast carcinoma amplified sequence 1 0.0142243
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0138989
ARHGAP26 Rho GTPase activating protein 26 0.0138499
CA12 carbonic anhydrase XII 0.0137178
TM4SF4 transmembrane 4 L six family member 4 0.0135058
ZNF292 zinc finger protein 292 0.0134987
APOL1 apolipoprotein L, 1 0.0134534
SORL1 sortilin-related receptor, L(DLR class) A repeats containing 0.0131292
RPN1 ribophorin I 0.0131231
TPM3 tropomyosin 3 0.0129878
HDLBP high density lipoprotein binding protein 0.0128853
PGK1 phosphoglycerate kinase 1 0.0127122
ITGA6 integrin, alpha 6 0.0126227
USP12 ubiquitin specific peptidase 12 0.0125103
GSE1 Gse1 coiled-coil protein 0.0123376
MEIS2 Meis homeobox 2 0.0122025
MUC13 mucin 13, cell surface associated 0.0121821
ARFGEF3 ARFGEF family member 3 0.012158
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1 0.0121574
ZBTB20 zinc finger and BTB domain containing 20 0.0121517
ETV6 ets variant 6 0.0121469
NCOA2 nuclear receptor coactivator 2 0.012044
ZFAND3 zinc finger, AN1-type domain 3 0.0118753
DGKH diacylglycerol kinase, eta 0.0117794
CTTNBP2NL CTTNBP2 N-terminal like 0.0115672
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) 0.0115198
CREB3L1 cAMP responsive element binding protein 3-like 1 0.0114683
TNS1 tensin 1 0.0114253
PRKCA protein kinase C, alpha 0.0114167
USP3 ubiquitin specific peptidase 3 0.0113659

decreased expression

Symbol Name Standardized Value
FTL ferritin, light polypeptide -0.256405
RPLP1 ribosomal protein, large, P1 -0.137071
TMSB10 thymosin beta 10 -0.13692
RPL23 ribosomal protein L23 -0.130119
RPS6 ribosomal protein S6 -0.126163
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.115667
RPS19 ribosomal protein S19 -0.115137
RPS3 ribosomal protein S3 -0.0893694
RPS8 ribosomal protein S8 -0.0821704
FTH1 ferritin, heavy polypeptide 1 -0.07075
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0696761
RPL34 ribosomal protein L34 -0.068875
RPL9 ribosomal protein L9 -0.0678996
PTMA prothymosin, alpha -0.0656044
RPL37A ribosomal protein L37a -0.064228
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0627724
RPL11 ribosomal protein L11 -0.0615183
RPL12 ribosomal protein L12 -0.0565932
RPL35A ribosomal protein L35a -0.0562477
RPS12 ribosomal protein S12 -0.0558301
RPL5 ribosomal protein L5 -0.0555311
RPL31 ribosomal protein L31 -0.0549148
EIF1 eukaryotic translation initiation factor 1 -0.0545698
RPS17 ribosomal protein S17 -0.0529121
RPL26 ribosomal protein L26 -0.0494616
RPL37 ribosomal protein L37 -0.0492751
RPL19 ribosomal protein L19 -0.0490367
RPL18 ribosomal protein L18 -0.04863
B2M beta-2-microglobulin -0.0464964
RPS27 ribosomal protein S27 -0.046331
RPL13A ribosomal protein L13a -0.0451941
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0435193
S100P S100 calcium binding protein P -0.0429652
RPLP2 ribosomal protein, large, P2 -0.0427011
TXNRD1 thioredoxin reductase 1 -0.0423989
RPL30 ribosomal protein L30 -0.0413286
RPL36 ribosomal protein L36 -0.0394863
RPL7 ribosomal protein L7 -0.039076
RPS14 ribosomal protein S14 -0.0390674
RPS11 ribosomal protein S11 -0.0388172
RPS13 ribosomal protein S13 -0.0375973
RACK1 receptor for activated C kinase 1 -0.0375686
GCLC glutamate-cysteine ligase, catalytic subunit -0.0366186
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0362402
RPS5 ribosomal protein S5 -0.0359235
EGR1 early growth response 1 -0.0347941
RPS21 ribosomal protein S21 -0.0346854
RPS27A ribosomal protein S27a -0.0338379
ACTG1 actin gamma 1 -0.0330084
FOSB FBJ murine osteosarcoma viral oncogene homolog B -0.0329336
TJP1 tight junction protein 1 -0.0329061
RPS16 ribosomal protein S16 -0.0322184
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.0317883
AREG amphiregulin -0.0316578
CLDN4 claudin 4 -0.031547
RPL28 ribosomal protein L28 -0.0314371
EEF1G eukaryotic translation elongation factor 1 gamma -0.0311466
RPL27 ribosomal protein L27 -0.0305565
HMGA1 high mobility group AT-hook 1 -0.0302433
RPL35 ribosomal protein L35 -0.0299332
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 -0.0298914
GARS1 glycyl-tRNA synthetase 1 -0.0298842
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0296874
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0293393
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0292766
YBX3 Y box binding protein 3 -0.0284217
PRRC2C proline-rich coiled-coil 2C -0.0284108
TPI1 triosephosphate isomerase 1 -0.0278809
S100A6 S100 calcium binding protein A6 -0.0273661
ATP5F1E ATP synthase F1 subunit epsilon -0.0269454
ANKRD12 ankyrin repeat domain 12 -0.0267065
POMP proteasome maturation protein -0.026696
KLF6 Kruppel-like factor 6 -0.0266727
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0265893
RPL32 ribosomal protein L32 -0.0264689
RBM39 RNA binding motif protein 39 -0.0263136
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0262603
UBE2B ubiquitin-conjugating enzyme E2B -0.02622
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0261918
NAP1L1 nucleosome assembly protein 1-like 1 -0.0260712
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0259201
NACA nascent polypeptide-associated complex alpha subunit -0.0258661
CNRIP1 cannabinoid receptor interacting protein 1 -0.0257476
MYL12B myosin, light chain 12B, regulatory -0.0255637
YBX1 Y box binding protein 1 -0.0254026
RPS4X ribosomal protein S4, X-linked -0.0253304
MYO1E myosin IE -0.0251094
LOC112694756 uncharaterized LOC112694756 -0.0248747
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0248198
RPS29 ribosomal protein S29 -0.0233417
HLA-A major histocompatibility complex, class I, A -0.023107
ATF4 activating transcription factor 4 -0.0228005
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0227039
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.022428
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0224115
RPL21 ribosomal protein L21 -0.0223947
RPS2 ribosomal protein S2 -0.0218289
RPS23 ribosomal protein S23 -0.021784
RPLP0 ribosomal protein, large, P0 -0.0217371
EIF5B eukaryotic translation initiation factor 5B -0.0212308