| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Bisoprolol (hemifumarate) perturbation in HepG2/C3A cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Bisoprolol (hemifumarate)_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ENO1 | enolase 1, (alpha) | 0.127765 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.114062 |
| UBC | ubiquitin C | 0.108479 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.095752 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0882108 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0860515 |
| RPS27A | ribosomal protein S27a | 0.0649925 |
| ASPH | aspartate beta-hydroxylase | 0.0636921 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0602143 |
| FLNB | filamin B, beta | 0.059582 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | 0.058364 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0542717 |
| SVIL | supervillin | 0.0499351 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.049309 |
| C3 | complement component 3 | 0.0464907 |
| JUN | jun proto-oncogene | 0.0447196 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0441536 |
| FN1 | fibronectin 1 | 0.0433557 |
| TF | transferrin | 0.0429986 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0418368 |
| TNS1 | tensin 1 | 0.0415632 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.040895 |
| LDHA | lactate dehydrogenase A | 0.039999 |
| FAM107B | family with sequence similarity 107, member B | 0.0397854 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0397643 |
| PCBP2 | poly(rC) binding protein 2 | 0.0395025 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | 0.0387556 |
| VMP1 | vacuole membrane protein 1 | 0.0384145 |
| ANO6 | anoctamin 6 | 0.0383518 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0373878 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0370612 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0357971 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0356166 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0355049 |
| MCL1 | myeloid cell leukemia 1 | 0.032866 |
| AHNAK | AHNAK nucleoprotein | 0.0322809 |
| SDC4 | syndecan 4 | 0.0306038 |
| SMAD3 | SMAD family member 3 | 0.0299431 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.02941 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0279482 |
| DSPP | dentin sialophosphoprotein | 0.0277447 |
| RPL3 | ribosomal protein L3 | 0.0275399 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0268377 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0266419 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0265132 |
| DST | dystonin | 0.0264307 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0261459 |
| PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | 0.0259582 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.025929 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0255885 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.025329 |
| INTS6 | integrator complex subunit 6 | 0.0252101 |
| VCL | vinculin | 0.0250424 |
| FAT1 | FAT atypical cadherin 1 | 0.0250316 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0243531 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0238379 |
| POTEF | POTE ankyrin domain family, member F | 0.0237782 |
| SEPTIN9 | septin 9 | 0.0236692 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0234521 |
| PKM | pyruvate kinase, muscle | 0.0231628 |
| DIAPH1 | diaphanous-related formin 1 | 0.0231621 |
| GSE1 | Gse1 coiled-coil protein | 0.0231197 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0228409 |
| PLIN2 | perilipin 2 | 0.0227589 |
| CEMIP2 | cell migration inducing hyaluronidase 2 | 0.0223836 |
| RAB3B | RAB3B, member RAS oncogene family | 0.0223585 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0223294 |
| KRT8 | keratin 8, type II | 0.0221372 |
| CALR | calreticulin | 0.0220943 |
| CMIP | c-Maf inducing protein | 0.0218915 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0216074 |
| USP34 | ubiquitin specific peptidase 34 | 0.0212393 |
| CPEB4 | cytoplasmic polyadenylation element binding protein 4 | 0.0211038 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.020623 |
| BRD4 | bromodomain containing 4 | 0.0201466 |
| AFF1 | AF4/FMR2 family, member 1 | 0.0200654 |
| COL7A1 | collagen, type VII, alpha 1 | 0.0199435 |
| APP | amyloid beta (A4) precursor protein | 0.0197035 |
| ANKRD11 | ankyrin repeat domain 11 | 0.019683 |
| ATXN1 | ataxin 1 | 0.0196241 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0192712 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | 0.0190699 |
| HPCAL1 | hippocalcin-like 1 | 0.0189105 |
| PRKCA | protein kinase C, alpha | 0.0188755 |
| RNASET2 | ribonuclease T2 | 0.0187695 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0187421 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | 0.0187164 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0186782 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0186451 |
| CABIN1 | calcineurin binding protein 1 | 0.0185555 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.018502 |
| ANKRD1 | ankyrin repeat domain 1 (cardiac muscle) | 0.0184747 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.018416 |
| ADARB1 | adenosine deaminase, RNA-specific, B1 | 0.0183969 |
| BCL2L1 | BCL2-like 1 | 0.0183906 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0183591 |
| WWC2 | WW and C2 domain containing 2 | 0.0181956 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0181723 |
| SLC41A2 | solute carrier family 41 (magnesium transporter), member 2 | 0.0180921 |
| RPS18 | ribosomal protein S18 | 0.0179738 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TPT1 | tumor protein, translationally-controlled 1 | -0.134099 |
| IGF2 | insulin-like growth factor 2 | -0.126238 |
| APOB | apolipoprotein B | -0.109081 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | -0.0995278 |
| RPS6 | ribosomal protein S6 | -0.0930422 |
| MT2A | metallothionein 2A | -0.0913941 |
| FBF1 | Fas (TNFRSF6) binding factor 1 | -0.0715941 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0708238 |
| GPC3 | glypican 3 | -0.0674882 |
| RPL11 | ribosomal protein L11 | -0.0668665 |
| PEG3 | paternally expressed 3 | -0.0651843 |
| APOA2 | apolipoprotein A-II | -0.0644001 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.0643634 |
| RPL35A | ribosomal protein L35a | -0.0632415 |
| VPS54 | vacuolar protein sorting 54 homolog (S. cerevisiae) | -0.0626362 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0585404 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0583095 |
| RPS8 | ribosomal protein S8 | -0.0571071 |
| EML4 | echinoderm microtubule associated protein like 4 | -0.0555523 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.0551637 |
| A2M | alpha-2-macroglobulin | -0.0528172 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0521046 |
| JMJD1C | jumonji domain containing 1C | -0.0499626 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0488569 |
| AHSG | alpha-2-HS-glycoprotein | -0.04833 |
| FTL | ferritin, light polypeptide | -0.0470363 |
| RPLP0 | ribosomal protein, large, P0 | -0.0464257 |
| RBM39 | RNA binding motif protein 39 | -0.0448999 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0448783 |
| RPL34 | ribosomal protein L34 | -0.0421282 |
| RPS19 | ribosomal protein S19 | -0.0419984 |
| SOX5 | SRY (sex determining region Y)-box 5 | -0.0412708 |
| RPL31 | ribosomal protein L31 | -0.040106 |
| EHBP1 | EH domain binding protein 1 | -0.039228 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0384764 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0381361 |
| UBE2D2 | ubiquitin-conjugating enzyme E2D 2 | -0.0370553 |
| RPLP1 | ribosomal protein, large, P1 | -0.0361155 |
| RPL26 | ribosomal protein L26 | -0.0357678 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0356478 |
| SLC6A14 | solute carrier family 6 (amino acid transporter), member 14 | -0.0354412 |
| RPL37 | ribosomal protein L37 | -0.0354287 |
| RPL32 | ribosomal protein L32 | -0.034797 |
| GNAS | GNAS complex locus | -0.0345056 |
| RPL12 | ribosomal protein L12 | -0.0344315 |
| MBNL3 | muscleblind-like splicing regulator 3 | -0.0331779 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | -0.0329666 |
| RPL37A | ribosomal protein L37a | -0.0327386 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0321046 |
| RPS24 | ribosomal protein S24 | -0.0317873 |
| RRBP1 | ribosome binding protein 1 | -0.0307187 |
| PTCHD4 | patched domain containing 4 | -0.0305355 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0300612 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | -0.0291492 |
| TRIM26 | tripartite motif containing 26 | -0.0288858 |
| LPGAT1 | lysophosphatidylglycerol acyltransferase 1 | -0.0288431 |
| RPS21 | ribosomal protein S21 | -0.0287416 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0286458 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | -0.0281837 |
| WDR45B | WD repeat domain 45B | -0.028009 |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | -0.0279938 |
| KIF5B | kinesin family member 5B | -0.027889 |
| TPST1 | tyrosylprotein sulfotransferase 1 | -0.0278469 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0276968 |
| AFDN | afadin, adherens junction formation factor | -0.0276915 |
| NPR2 | natriuretic peptide receptor 2 | -0.0275759 |
| ANKRD10 | ankyrin repeat domain 10 | -0.0275722 |
| RPL19 | ribosomal protein L19 | -0.0272717 |
| ARL5A | ADP-ribosylation factor-like 5A | -0.0272539 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0272466 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0265948 |
| IER3 | immediate early response 3 | -0.0262595 |
| MTUS1 | microtubule associated tumor suppressor 1 | -0.0260532 |
| HP1BP3 | heterochromatin protein 1, binding protein 3 | -0.0257183 |
| ACSS3 | acyl-CoA synthetase short-chain family member 3 | -0.025648 |
| LYZ | lysozyme | -0.0250134 |
| ITIH2 | inter-alpha-trypsin inhibitor heavy chain 2 | -0.0245931 |
| RPL27A | ribosomal protein L27a | -0.0245661 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0242798 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0241429 |
| METTL9 | methyltransferase like 9 | -0.0240183 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0238748 |
| PTK2 | protein tyrosine kinase 2 | -0.0237625 |
| RASGRF2 | Ras protein-specific guanine nucleotide-releasing factor 2 | -0.0237355 |
| ST6GAL1 | ST6 beta-galactosamide alpha-2,6-sialyltranferase 1 | -0.0237193 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.0236746 |
| RPL30 | ribosomal protein L30 | -0.0236388 |
| MAN1A1 | mannosidase, alpha, class 1A, member 1 | -0.0232845 |
| AMBP | alpha-1-microglobulin/bikunin precursor | -0.0232474 |
| RPS6KA3 | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | -0.0231885 |
| DENND4A | DENN/MADD domain containing 4A | -0.0231836 |
| APOA1 | apolipoprotein A-I | -0.0230718 |
| CCDC146 | coiled-coil domain containing 146 | -0.0229526 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | -0.0229065 |
| KIAA1217 | KIAA1217 | -0.0228484 |
| KDM7A | lysine (K)-specific demethylase 7A | -0.0228124 |
| RPS13 | ribosomal protein S13 | -0.0225144 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | -0.0223028 |
| KIF21A | kinesin family member 21A | -0.0222665 |
| DOK6 | docking protein 6 | -0.0222052 |
