Bisoprolol (hemifumarate)_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Bisoprolol (hemifumarate) perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Bisoprolol (hemifumarate)_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TIMP3 TIMP metallopeptidase inhibitor 3 0.23904
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.215178
FLNB filamin B, beta 0.186737
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 0.160508
MTSS1 metastasis suppressor 1 0.147531
LMO7 LIM domain 7 0.106107
PDE4D phosphodiesterase 4D, cAMP-specific 0.103038
DPYD dihydropyrimidine dehydrogenase 0.0956993
FOXO1 forkhead box O1 0.0817059
SULF1 sulfatase 1 0.0802018
ALCAM activated leukocyte cell adhesion molecule 0.0801571
HSPG2 heparan sulfate proteoglycan 2 0.077872
PDLIM5 PDZ and LIM domain 5 0.0767495
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0760293
RASAL2 RAS protein activator like 2 0.0728045
SULF2 sulfatase 2 0.072698
SLC35F3 solute carrier family 35, member F3 0.0660809
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0650667
PODXL podocalyxin-like 0.0633671
ANO1 anoctamin 1, calcium activated chloride channel 0.0626336
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 0.0611301
TRIO trio Rho guanine nucleotide exchange factor 0.0603239
AHNAK AHNAK nucleoprotein 0.0563238
PSD3 pleckstrin and Sec7 domain containing 3 0.0559435
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.0557818
RABGAP1L RAB GTPase activating protein 1-like 0.055777
PALLD palladin, cytoskeletal associated protein 0.0547648
LAMA5 laminin, alpha 5 0.054605
BCAR3 breast cancer anti-estrogen resistance 3 0.0543935
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like 0.0536452
BCL2L1 BCL2-like 1 0.0517955
MECOM MDS1 and EVI1 complex locus 0.0516013
EPB41L1 erythrocyte membrane protein band 4.1-like 1 0.0512458
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0500618
DOCK5 dedicator of cytokinesis 5 0.0500454
MSN moesin 0.0494949
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0491114
HMGA2 high mobility group AT-hook 2 0.0490291
CDK6 cyclin-dependent kinase 6 0.0476988
KCNK1 potassium channel, two pore domain subfamily K, member 1 0.047504
CMIP c-Maf inducing protein 0.0458217
EXT1 exostosin glycosyltransferase 1 0.0452977
MPRIP myosin phosphatase Rho interacting protein 0.0451446
RAI14 retinoic acid induced 14 0.0450416
TSC22D1 TSC22 domain family, member 1 0.0448452
OSMR oncostatin M receptor 0.0431871
EFNA5 ephrin-A5 0.0427086
SMYD3 SET and MYND domain containing 3 0.0426498
FOXP1 forkhead box P1 0.0419237
NCOR2 nuclear receptor corepressor 2 0.0414239
MACF1 microtubule-actin crosslinking factor 1 0.0413462
AOPEP aminopeptidase O (putative) 0.0404548
ACTN4 actinin, alpha 4 0.0399026
PTK2 protein tyrosine kinase 2 0.0397248
AKAP13 A kinase (PRKA) anchor protein 13 0.039709
ZEB1 zinc finger E-box binding homeobox 1 0.0396967
FTH1 ferritin, heavy polypeptide 1 0.0382535
KIAA1671 KIAA1671 0.0371716
ZMIZ1 zinc finger, MIZ-type containing 1 0.0367961
RNF217 ring finger protein 217 0.0365754
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0359037
UTRN utrophin 0.0354516
THSD4 thrombospondin, type I, domain containing 4 0.035308
ANKRD11 ankyrin repeat domain 11 0.0349002
AMOTL1 angiomotin like 1 0.0338603
DOK5 docking protein 5 0.0335092
LAMC2 laminin, gamma 2 0.0332536
TGM2 transglutaminase 2 0.0323736
PLXNA2 plexin A2 0.0320394
MYO10 myosin X 0.0314145
KLF5 Kruppel-like factor 5 (intestinal) 0.0310685
PRSS23 protease, serine, 23 0.0308357
TNS3 tensin 3 0.0304854
BLCAP bladder cancer associated protein 0.0303009
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0301409
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2 0.0297492
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) 0.0297424
EXOC4 exocyst complex component 4 0.0295227
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0293031
CNTNAP3 contactin associated protein-like 3 0.0288447
NEK7 NIMA-related kinase 7 0.028727
PLEC plectin 0.0281929
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0278212
CSMD2 CUB and Sushi multiple domains 2 0.0277943
ZMYND8 zinc finger, MYND-type containing 8 0.0274197
EGFR epidermal growth factor receptor 0.0272323
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0269324
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0268069
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0266804
SLCO4A1 solute carrier organic anion transporter family, member 4A1 0.0264503
MBNL1 muscleblind-like splicing regulator 1 0.026418
ABI3BP ABI family, member 3 (NESH) binding protein 0.0260672
HDAC9 histone deacetylase 9 0.0259805
DUSP4 dual specificity phosphatase 4 0.0254939
DDAH1 dimethylarginine dimethylaminohydrolase 1 0.0253304
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0252625
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0251235
EXOC6B exocyst complex component 6B 0.0248829
GRAMD1B GRAM domain containing 1B 0.0247269
DOCK4 dedicator of cytokinesis 4 0.0245194

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0937046
CLU clusterin -0.08041
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0712503
PTMA prothymosin, alpha -0.0503921
ANXA1 annexin A1 -0.0472942
GOLGA4 golgin A4 -0.0401461
DSTN destrin (actin depolymerizing factor) -0.0382297
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0346499
SPAG9 sperm associated antigen 9 -0.0334512
KTN1 kinectin 1 (kinesin receptor) -0.0332354
NDRG1 N-myc downstream regulated 1 -0.0332248
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0330016
S100A10 S100 calcium binding protein A10 -0.031462
TRA2A transformer 2 alpha homolog (Drosophila) -0.0312046
PDIA3 protein disulfide isomerase family A, member 3 -0.0308028
ANLN anillin, actin binding protein -0.0300164
KRT17 keratin 17, type I -0.0299985
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0299529
TPT1 tumor protein, translationally-controlled 1 -0.0291964
NAMPT nicotinamide phosphoribosyltransferase -0.0289937
VDAC1 voltage-dependent anion channel 1 -0.0285173
CANX calnexin -0.0278009
COPB1 coatomer protein complex, subunit beta 1 -0.027707
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0275699
KDM3A lysine (K)-specific demethylase 3A -0.0271266
ESYT2 extended synaptotagmin-like protein 2 -0.0267607
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0265959
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 -0.0261757
RLF rearranged L-myc fusion -0.0261652
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0260201
ANXA2 annexin A2 -0.0256656
SUCO SUN domain containing ossification factor -0.0253201
FNDC3A fibronectin type III domain containing 3A -0.0250106
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0248035
PDK3 pyruvate dehydrogenase kinase, isozyme 3 -0.0245052
ACBD3 acyl-CoA binding domain containing 3 -0.0240815
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0239481
EMP1 epithelial membrane protein 1 -0.023865
TPX2 TPX2, microtubule-associated -0.0234102
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.0231074
MARCHF6 membrane associated ring-CH-type finger 6 -0.0227568
OGA O-GlcNAcase -0.0221271
NPEPPS aminopeptidase puromycin sensitive -0.0219575
ARRDC3 arrestin domain containing 3 -0.021741
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0216614
CUL4B cullin 4B -0.0210093
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0209325
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0198546
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3 -0.0197624
IER3 immediate early response 3 -0.0195529
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0195527
BZW2 basic leucine zipper and W2 domains 2 -0.0194643
CALR calreticulin -0.0194515
OPTN optineurin -0.0193812
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -0.0192709
MORF4L2 mortality factor 4 like 2 -0.01924
DENND4C DENN/MADD domain containing 4C -0.0189425
SRP54 signal recognition particle 54kDa -0.0188954
UFM1 ubiquitin-fold modifier 1 -0.0188182
LMAN1 lectin, mannose-binding, 1 -0.0187835
ADM adrenomedullin -0.0185526
RIOK3 RIO kinase 3 -0.0185145
GLYAT glycine-N-acyltransferase -0.0183611
SEPTIN7 septin 7 -0.0183043
SEC31A SEC31 homolog A (S. cerevisiae) -0.0181544
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0180637
ARF4 ADP-ribosylation factor 4 -0.0180223
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0177445
AP3S1 adaptor-related protein complex 3, sigma 1 subunit -0.0175717
DPM1 dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit -0.0175097
SDCBP syndecan binding protein (syntenin) -0.0173375
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0170911
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0170907
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain -0.0168272
TFG TRK-fused gene -0.0166589
MXI1 MAX interactor 1, dimerization protein -0.0166064
S100A6 S100 calcium binding protein A6 -0.0165879
CKAP2 cytoskeleton associated protein 2 -0.0165529
PDIA6 protein disulfide isomerase family A, member 6 -0.0162592
RBM3 RNA binding motif (RNP1, RRM) protein 3 -0.0162499
COLEC11 collectin sub-family member 11 -0.0160605
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0159253
PHF21A PHD finger protein 21A -0.0158875
YBX1 Y box binding protein 1 -0.0153817
CENPF centromere protein F, 350/400kDa -0.0153206
INSIG2 insulin induced gene 2 -0.0153007
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0152762
VCL vinculin -0.0151931
TXNIP thioredoxin interacting protein -0.0151113
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -0.0150428
FHIP1A FHF complex subunit HOOK interacting protein 1A -0.0149796
PNISR PNN-interacting serine/arginine-rich protein -0.0148807
RNMT RNA (guanine-7-) methyltransferase -0.0148263
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0147445
RNF145 ring finger protein 145 -0.0146608
MEF2A myocyte enhancer factor 2A -0.0145944
TMEM263 transmembrane protein 263 -0.0145918
MBNL2 muscleblind-like splicing regulator 2 -0.0145896
TMEM165 transmembrane protein 165 -0.014449
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 -0.0144034