Bisoprolol (hemifumarate)_MIA PaCa-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Bisoprolol (hemifumarate) perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Bisoprolol (hemifumarate)_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.159162
TXNRD1 thioredoxin reductase 1 0.103922
ERRFI1 ERBB receptor feedback inhibitor 1 0.103663
EEF2 eukaryotic translation elongation factor 2 0.094357
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0897415
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0680821
PABPC1 poly(A) binding protein, cytoplasmic 1 0.055603
POTEF POTE ankyrin domain family, member F 0.0545528
EREG epiregulin 0.0517834
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0512485
SLC38A2 solute carrier family 38, member 2 0.0498843
CANX calnexin 0.0491662
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0484825
EZR ezrin 0.0481643
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.046127
PGK1 phosphoglycerate kinase 1 0.0444175
TM4SF1 transmembrane 4 L six family member 1 0.044201
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0425549
LOC112694756 uncharaterized LOC112694756 0.041951
RAI1 retinoic acid induced 1 0.0414347
AHNAK AHNAK nucleoprotein 0.0413394
TMEM123 transmembrane protein 123 0.0404352
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0404003
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0397927
CENPF centromere protein F, 350/400kDa 0.0387725
GPAT3 glycerol-3-phosphate acyltransferase 3 0.0387478
RTN4 reticulon 4 0.0386374
APP amyloid beta (A4) precursor protein 0.0381637
VIM vimentin 0.0378574
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0378455
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0376921
XPO1 exportin 1 0.0364007
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 0.036172
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0361022
KMT2E lysine (K)-specific methyltransferase 2E 0.0358014
NUP58 nucleoporin 58 0.0353949
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0353314
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0350617
PODXL podocalyxin-like 0.0346649
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0346056
ADAM17 ADAM metallopeptidase domain 17 0.0344888
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0333963
KMT2C lysine (K)-specific methyltransferase 2C 0.0329565
NAMPT nicotinamide phosphoribosyltransferase 0.0328959
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.03288
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0325776
AFF4 AF4/FMR2 family, member 4 0.031622
LDHA lactate dehydrogenase A 0.0315493
HSPA8 heat shock 70kDa protein 8 0.0315076
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.031431
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0309534
TMEM41B transmembrane protein 41B 0.0309361
WDR43 WD repeat domain 43 0.0303866
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0299964
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0298563
DENND5A DENN/MADD domain containing 5A 0.0297914
MKI67 marker of proliferation Ki-67 0.0280834
CKAP5 cytoskeleton associated protein 5 0.0276327
PRRC2B proline-rich coiled-coil 2B 0.0272848
TNPO1 transportin 1 0.0272615
PRPF8 pre-mRNA processing factor 8 0.0265927
FLNB filamin B, beta 0.0265332
ADGRG6 adhesion G protein-coupled receptor G6 0.0265276
TRIP12 thyroid hormone receptor interactor 12 0.0264733
PYGB phosphorylase, glycogen; brain 0.0264481
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.026299
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 0.0262137
WAC WW domain containing adaptor with coiled-coil 0.0262125
ARHGAP5 Rho GTPase activating protein 5 0.0261786
KDM3A lysine (K)-specific demethylase 3A 0.0261223
ADAR adenosine deaminase, RNA-specific 0.0261032
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.026092
MAP1LC3B microtubule-associated protein 1 light chain 3 beta 0.026052
PUM2 pumilio RNA-binding family member 2 0.0259958
BCAR3 breast cancer anti-estrogen resistance 3 0.0253452
SPAG9 sperm associated antigen 9 0.0252569
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0251966
NUP153 nucleoporin 153kDa 0.0251349
TPX2 TPX2, microtubule-associated 0.0249105
PDIA6 protein disulfide isomerase family A, member 6 0.0248838
PLK2 polo-like kinase 2 0.0246505
SINHCAF SIN3-HDAC complex associated factor 0.0245272
AP2B1 adaptor-related protein complex 2, beta 1 subunit 0.024526
KIF5B kinesin family member 5B 0.0243494
PRRC2A proline-rich coiled-coil 2A 0.0242614
ANLN anillin, actin binding protein 0.0242432
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 0.0242157
SET SET nuclear proto-oncogene 0.0240205
WWTR1 WW domain containing transcription regulator 1 0.0240134
MYH9 myosin, heavy chain 9, non-muscle 0.0239956
IPO7 importin 7 0.0239943
JMJD1C jumonji domain containing 1C 0.0239192
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0238728
RLF rearranged L-myc fusion 0.0238542
UBE2G1 ubiquitin-conjugating enzyme E2G 1 0.0237741
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.023729
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.023709
HOOK2 hook microtubule-tethering protein 2 0.0235481
NCAPD2 non-SMC condensin I complex, subunit D2 0.0234586
ACTR2 ARP2 actin-related protein 2 homolog (yeast) 0.0232662

decreased expression

Symbol Name Standardized Value
MT2A metallothionein 2A -0.218297
TMSB10 thymosin beta 10 -0.179866
TP63 tumor protein p63 -0.135773
PTMA prothymosin, alpha -0.122528
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.103718
FTL ferritin, light polypeptide -0.102148
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0993098
DST dystonin -0.0879219
CADM2 cell adhesion molecule 2 -0.0837568
RPS8 ribosomal protein S8 -0.0791949
RPS19 ribosomal protein S19 -0.0789042
ZDHHC14 zinc finger, DHHC-type containing 14 -0.0672915
CSMD3 CUB and Sushi multiple domains 3 -0.0660243
PSD3 pleckstrin and Sec7 domain containing 3 -0.064243
TNS3 tensin 3 -0.0625527
RPL37A ribosomal protein L37a -0.0613171
PRELID2 PRELI domain containing 2 -0.0591176
RPL23 ribosomal protein L23 -0.0565523
RPL36 ribosomal protein L36 -0.0554512
EFNA5 ephrin-A5 -0.0539654
RPL35A ribosomal protein L35a -0.0527057
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0516678
HDAC9 histone deacetylase 9 -0.050791
RPL31 ribosomal protein L31 -0.0501758
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0496913
RPS6 ribosomal protein S6 -0.0482595
RPL26 ribosomal protein L26 -0.0458581
RPS3 ribosomal protein S3 -0.0451981
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0436819
SDK1 sidekick cell adhesion molecule 1 -0.0421196
RPLP1 ribosomal protein, large, P1 -0.0413075
RPL12 ribosomal protein L12 -0.0408022
EPHA4 EPH receptor A4 -0.040557
RPS12 ribosomal protein S12 -0.0382599
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0376913
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0376118
INTS6 integrator complex subunit 6 -0.0363289
SP100 SP100 nuclear antigen -0.0361974
HLA-B major histocompatibility complex, class I, B -0.0353412
MT1E metallothionein 1E -0.0348292
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0339386
RPL9 ribosomal protein L9 -0.0338806
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0337672
CFAP299 cilia and flagella associated protein 299 -0.0331939
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0331494
RPL34 ribosomal protein L34 -0.0322545
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.032163
EXOC4 exocyst complex component 4 -0.0320477
ENO2 enolase 2 (gamma, neuronal) -0.0313141
EHBP1 EH domain binding protein 1 -0.0307864
PDE10A phosphodiesterase 10A -0.0305845
TSC22D1 TSC22 domain family, member 1 -0.0305647
DPYD dihydropyrimidine dehydrogenase -0.0300838
LPP LIM domain containing preferred translocation partner in lipoma -0.0299398
KDM4C lysine (K)-specific demethylase 4C -0.0291776
IFITM1 interferon induced transmembrane protein 1 -0.0287739
RPS27 ribosomal protein S27 -0.0275825
AEBP2 AE binding protein 2 -0.0273521
TTC3 tetratricopeptide repeat domain 3 -0.0269189
RPL19 ribosomal protein L19 -0.0268238
EGFR epidermal growth factor receptor -0.0267007
RPS29 ribosomal protein S29 -0.0266674
B2M beta-2-microglobulin -0.026618
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.0265751
RPL11 ribosomal protein L11 -0.0264029
RPL35 ribosomal protein L35 -0.0263899
FNIP1 folliculin interacting protein 1 -0.026049
RPL37 ribosomal protein L37 -0.0256581
RPL27 ribosomal protein L27 -0.025318
SLC39A10 solute carrier family 39 (zinc transporter), member 10 -0.0249465
MCTP1 multiple C2 domains, transmembrane 1 -0.0242015
TBCA tubulin folding cofactor A -0.0241715
MBD5 methyl-CpG binding domain protein 5 -0.0235493
PLSCR1 phospholipid scramblase 1 -0.0233596
RPL28 ribosomal protein L28 -0.0229117
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough -0.022846
RPS21 ribosomal protein S21 -0.0226932
RPS14 ribosomal protein S14 -0.0224563
GNGT1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 -0.0224341
RIGI RNA sensor RIG-I -0.0224255
RPL18 ribosomal protein L18 -0.0216051
NPAS2 neuronal PAS domain protein 2 -0.021412
ZBTB20 zinc finger and BTB domain containing 20 -0.021385
RPS17 ribosomal protein S17 -0.0213499
NEK10 NIMA-related kinase 10 -0.0212411
PRKCE protein kinase C, epsilon -0.0204781
KDM4B lysine (K)-specific demethylase 4B -0.0204742
SMYD3 SET and MYND domain containing 3 -0.0204291
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) -0.0201876
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0200931
BICD1 bicaudal D homolog 1 (Drosophila) -0.0200621
RAD51B RAD51 paralog B -0.0200463
WDR27 WD repeat domain 27 -0.0199501
DENND1A DENN/MADD domain containing 1A -0.0195533
PIAS2 protein inhibitor of activated STAT, 2 -0.0195319
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0192191
RPL5 ribosomal protein L5 -0.0191823
RNF213 ring finger protein 213 -0.0191438
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0191281
DNER delta/notch-like EGF repeat containing -0.0189769