| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Bisoprolol (hemifumarate) perturbation in NCI-H1573 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Bisoprolol (hemifumarate)_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| UBC | ubiquitin C | 0.152627 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0773469 |
| PCBP2 | poly(rC) binding protein 2 | 0.0573905 |
| CES1 | carboxylesterase 1 | 0.0566231 |
| TOP1 | topoisomerase (DNA) I | 0.0522526 |
| TXNRD1 | thioredoxin reductase 1 | 0.0518483 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0501913 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.048849 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0435078 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0433673 |
| RUNX1 | runt-related transcription factor 1 | 0.0427276 |
| ARRDC3 | arrestin domain containing 3 | 0.0406105 |
| ZFC3H1 | zinc finger, C3H1-type containing | 0.0369417 |
| UVRAG | UV radiation resistance associated | 0.0354475 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0351197 |
| RPS27A | ribosomal protein S27a | 0.0346121 |
| MCL1 | myeloid cell leukemia 1 | 0.0331128 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0323811 |
| JMJD1C | jumonji domain containing 1C | 0.0315242 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.030587 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0305197 |
| DTNA | dystrobrevin, alpha | 0.029451 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | 0.0291815 |
| OGA | O-GlcNAcase | 0.0287864 |
| AGO2 | argonaute RISC catalytic component 2 | 0.0286768 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0286676 |
| GPAT3 | glycerol-3-phosphate acyltransferase 3 | 0.028565 |
| SPAG9 | sperm associated antigen 9 | 0.0283233 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0281134 |
| HYOU1 | hypoxia up-regulated 1 | 0.0280464 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0277897 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0276963 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0274375 |
| HELZ | helicase with zinc finger | 0.0273575 |
| CANX | calnexin | 0.026644 |
| NPTN | neuroplastin | 0.0263748 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | 0.0262146 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0261153 |
| RTN4 | reticulon 4 | 0.0259564 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0259127 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.0258824 |
| RAP1B | RAP1B, member of RAS oncogene family | 0.025703 |
| GSK3B | glycogen synthase kinase 3 beta | 0.02531 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.025247 |
| USP34 | ubiquitin specific peptidase 34 | 0.0250601 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0248886 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0248639 |
| NGLY1 | N-glycanase 1 | 0.0247507 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0246592 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0242961 |
| RNMT | RNA (guanine-7-) methyltransferase | 0.0241555 |
| KANSL1 | KAT8 regulatory NSL complex subunit 1 | 0.0237401 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | 0.0234719 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0233539 |
| ZC3H11A | zinc finger CCCH-type containing 11A | 0.0231684 |
| BTAF1 | BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa | 0.0230976 |
| MKI67 | marker of proliferation Ki-67 | 0.0230262 |
| YTHDC1 | YTH domain containing 1 | 0.0229992 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | 0.0228244 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0224819 |
| ANKRD11 | ankyrin repeat domain 11 | 0.022427 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0223817 |
| GIGYF2 | GRB10 interacting GYF protein 2 | 0.0222894 |
| NCKAP1 | NCK-associated protein 1 | 0.0222178 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.0220435 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0219797 |
| ARGLU1 | arginine and glutamate rich 1 | 0.0219398 |
| NUP58 | nucleoporin 58 | 0.0219369 |
| ANKRD10 | ankyrin repeat domain 10 | 0.0217717 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0214974 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0214634 |
| MARK3 | MAP/microtubule affinity-regulating kinase 3 | 0.0212822 |
| KCMF1 | potassium channel modulatory factor 1 | 0.0212556 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0205827 |
| RNF145 | ring finger protein 145 | 0.0204046 |
| ARL8B | ADP-ribosylation factor-like 8B | 0.0203815 |
| TENT2 | terminal nucleotidyltransferase 2 | 0.0201705 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0198784 |
| VMP1 | vacuole membrane protein 1 | 0.0196182 |
| OGT | O-linked N-acetylglucosamine (GlcNAc) transferase | 0.0195808 |
| ATP13A3 | ATPase type 13A3 | 0.0195377 |
| CNNM2 | cyclin and CBS domain divalent metal cation transport mediator 2 | 0.0194708 |
| DDX6 | DEAD (Asp-Glu-Ala-Asp) box helicase 6 | 0.0192933 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0191112 |
| SRSF5 | serine/arginine-rich splicing factor 5 | 0.0191021 |
| ANKRD17 | ankyrin repeat domain 17 | 0.0190668 |
| MPZL3 | myelin protein zero-like 3 | 0.0189882 |
| HAPSTR1 | HUWE1 associated protein modifying stress responses | 0.0189182 |
| PPTC7 | PTC7 protein phosphatase homolog (S. cerevisiae) | 0.0188772 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.0188211 |
| MYO5B | myosin VB | 0.0186118 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.018572 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0185545 |
| MAP2K1 | mitogen-activated protein kinase kinase 1 | 0.0183422 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0181013 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.018052 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | 0.0180372 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.01796 |
| EP300 | E1A binding protein p300 | 0.0177582 |
| PER1 | period circadian clock 1 | 0.0176691 |
| Symbol | Name | Standardized Value |
|---|---|---|
| EGFR | epidermal growth factor receptor | -0.361026 |
| TMSB10 | thymosin beta 10 | -0.158169 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.131083 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.11327 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.112663 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.107263 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0991575 |
| EGR1 | early growth response 1 | -0.0902833 |
| ASPH | aspartate beta-hydroxylase | -0.0875488 |
| ACTG1 | actin gamma 1 | -0.0832631 |
| MT2A | metallothionein 2A | -0.0794389 |
| LMO7 | LIM domain 7 | -0.0785189 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.0732993 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.0729163 |
| S100A10 | S100 calcium binding protein A10 | -0.0610932 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0608625 |
| EFNA5 | ephrin-A5 | -0.0601156 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0592204 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0570684 |
| CST3 | cystatin C | -0.0545418 |
| ANXA2 | annexin A2 | -0.0523291 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0516338 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.0490816 |
| LDHA | lactate dehydrogenase A | -0.0479708 |
| FTL | ferritin, light polypeptide | -0.0471306 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0461645 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0456209 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0451374 |
| KRT18 | keratin 18, type I | -0.044983 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0448163 |
| RNF213 | ring finger protein 213 | -0.0447885 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0445866 |
| OSMR | oncostatin M receptor | -0.0443306 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0432679 |
| RPL35A | ribosomal protein L35a | -0.0431435 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0430766 |
| KRT7 | keratin 7, type II | -0.0424757 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0411723 |
| RPS6 | ribosomal protein S6 | -0.0406075 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0405098 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0402807 |
| SCEL | sciellin | -0.0400717 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0390141 |
| DSPP | dentin sialophosphoprotein | -0.0390133 |
| PTMA | prothymosin, alpha | -0.0386955 |
| RPLP1 | ribosomal protein, large, P1 | -0.038617 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.038507 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0382177 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0375794 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0365604 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0355914 |
| S100A11 | S100 calcium binding protein A11 | -0.0353778 |
| AKR1C1 | aldo-keto reductase family 1, member C1 | -0.0351789 |
| CAV2 | caveolin 2 | -0.0342721 |
| S100P | S100 calcium binding protein P | -0.0340467 |
| MYO1E | myosin IE | -0.033624 |
| CCND1 | cyclin D1 | -0.033624 |
| SLTM | SAFB-like, transcription modulator | -0.0333351 |
| INTS6 | integrator complex subunit 6 | -0.0329516 |
| RPL37A | ribosomal protein L37a | -0.0327448 |
| CUX1 | cut-like homeobox 1 | -0.032342 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0322896 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.032051 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.0317074 |
| RPL34 | ribosomal protein L34 | -0.0315979 |
| NDRG1 | N-myc downstream regulated 1 | -0.0315373 |
| LGALS12 | lectin, galactoside-binding, soluble, 12 | -0.0306649 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0293491 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0290826 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0288088 |
| EHBP1 | EH domain binding protein 1 | -0.0275215 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0274153 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0266107 |
| TPM4 | tropomyosin 4 | -0.0265509 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0263641 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | -0.0258916 |
| STC1 | stanniocalcin 1 | -0.0258167 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | -0.0255651 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | -0.0255639 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | -0.0255331 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0254277 |
| RPS19 | ribosomal protein S19 | -0.0251463 |
| HLA-B | major histocompatibility complex, class I, B | -0.0251092 |
| RPL31 | ribosomal protein L31 | -0.0249521 |
| S100A6 | S100 calcium binding protein A6 | -0.0248217 |
| SEC61G | Sec61 gamma subunit | -0.0247828 |
| RPS8 | ribosomal protein S8 | -0.0247042 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0245292 |
| PRKCA | protein kinase C, alpha | -0.0242923 |
| PKM | pyruvate kinase, muscle | -0.0240639 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0238421 |
| AGR2 | anterior gradient 2 | -0.0234408 |
| RPL11 | ribosomal protein L11 | -0.0233069 |
| GNAS | GNAS complex locus | -0.023075 |
| RPS14 | ribosomal protein S14 | -0.0229636 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0228674 |
| LAMA4 | laminin, alpha 4 | -0.0227787 |
| SUMF1 | sulfatase modifying factor 1 | -0.0220401 |
| SLC38A1 | solute carrier family 38, member 1 | -0.022004 |
| GM2A | GM2 ganglioside activator | -0.0219678 |
