| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Bisoprolol (hemifumarate) perturbation in NCI-H2122 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Bisoprolol (hemifumarate)_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ATP2C2 | ATPase, Ca++ transporting, type 2C, member 2 | 0.161329 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.123206 |
| GRB10 | growth factor receptor-bound protein 10 | 0.121073 |
| KYNU | kynureninase | 0.116779 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.10882 |
| DSPP | dentin sialophosphoprotein | 0.10615 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.10494 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0915209 |
| RUNX1 | runt-related transcription factor 1 | 0.0855831 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | 0.0832026 |
| STC1 | stanniocalcin 1 | 0.0764396 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0752652 |
| PLAUR | plasminogen activator, urokinase receptor | 0.0745223 |
| EGR1 | early growth response 1 | 0.0665298 |
| SBF2 | SET binding factor 2 | 0.0658755 |
| KRT17 | keratin 17, type I | 0.0652574 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0651243 |
| GPC6 | glypican 6 | 0.0635691 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0633745 |
| PTEN | phosphatase and tensin homolog | 0.0626069 |
| MAST4 | microtubule associated serine/threonine kinase family member 4 | 0.0604245 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0599237 |
| OSMR | oncostatin M receptor | 0.0592513 |
| ETS2 | v-ets avian erythroblastosis virus E26 oncogene homolog 2 | 0.0591181 |
| ZMYND8 | zinc finger, MYND-type containing 8 | 0.0586789 |
| ISG20 | interferon stimulated exonuclease gene 20kDa | 0.0562264 |
| SACK1A | scaffolding CK1 anchoring protein A | 0.0559958 |
| MCL1 | myeloid cell leukemia 1 | 0.0556527 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.0554958 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0552506 |
| ARL5B | ADP-ribosylation factor-like 5B | 0.0548355 |
| NDRG1 | N-myc downstream regulated 1 | 0.0527347 |
| CEMIP2 | cell migration inducing hyaluronidase 2 | 0.0524504 |
| ADNP | activity-dependent neuroprotector homeobox | 0.0522438 |
| VGF | VGF nerve growth factor inducible | 0.052236 |
| ERN1 | endoplasmic reticulum to nucleus signaling 1 | 0.0521693 |
| RAB11FIP1 | RAB11 family interacting protein 1 (class I) | 0.0512449 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | 0.0512098 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0511397 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0508354 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0505801 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0502261 |
| TAS2R14 | taste receptor, type 2, member 14 | 0.0498382 |
| ATXN1 | ataxin 1 | 0.0496466 |
| TXNRD1 | thioredoxin reductase 1 | 0.048649 |
| ITGB4 | integrin, beta 4 | 0.0484857 |
| EGLN3 | egl-9 family hypoxia-inducible factor 3 | 0.0484482 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0483367 |
| PIBF1 | progesterone immunomodulatory binding factor 1 | 0.0475395 |
| MYO1E | myosin IE | 0.0461129 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0447903 |
| MAP3K20 | mitogen-activated protein kinase kinase kinase 20 | 0.0447353 |
| RAB2A | RAB2A, member RAS oncogene family | 0.0445246 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | 0.0439965 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0430633 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0427344 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0424597 |
| REL | v-rel avian reticuloendotheliosis viral oncogene homolog | 0.0421781 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | 0.0419588 |
| SMOC1 | SPARC related modular calcium binding 1 | 0.0418716 |
| FRY | furry homolog (Drosophila) | 0.0418232 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | 0.0417526 |
| FNIP1 | folliculin interacting protein 1 | 0.0392485 |
| TNPO3 | transportin 3 | 0.0382923 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | 0.0382352 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0375494 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0374804 |
| MEF2A | myocyte enhancer factor 2A | 0.0373017 |
| PPP4R1 | protein phosphatase 4, regulatory subunit 1 | 0.0371074 |
| NAV2 | neuron navigator 2 | 0.0365779 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0361861 |
| CXXC1 | CXXC finger protein 1 | 0.0359221 |
| RAD51B | RAD51 paralog B | 0.035761 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0354167 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.0354039 |
| FBXO11 | F-box protein 11 | 0.0347941 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0346315 |
| OSBPL8 | oxysterol binding protein-like 8 | 0.0341747 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0340443 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0335908 |
| RNF24 | ring finger protein 24 | 0.0332847 |
| ANO6 | anoctamin 6 | 0.0331119 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | 0.0330961 |
| BMAL2 | basic helix-loop-helix ARNT like 2 | 0.0328885 |
| CDK6 | cyclin-dependent kinase 6 | 0.032792 |
| NPC1 | Niemann-Pick disease, type C1 | 0.0327159 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0324965 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0322892 |
| LAMB3 | laminin, beta 3 | 0.0322827 |
| PPP1R12A | protein phosphatase 1, regulatory subunit 12A | 0.0321073 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | 0.031951 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 0.0319181 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | 0.0318551 |
| ITPRID2 | ITPR interacting domain containing 2 | 0.0316144 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | 0.0310539 |
| JAK1 | Janus kinase 1 | 0.0309138 |
| ANTXR2 | anthrax toxin receptor 2 | 0.0306792 |
| RNF213 | ring finger protein 213 | 0.0306189 |
| CTBP2 | C-terminal binding protein 2 | 0.0303462 |
| CUX1 | cut-like homeobox 1 | 0.0303018 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.151619 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.11678 |
| TMSB10 | thymosin beta 10 | -0.115664 |
| PTMA | prothymosin, alpha | -0.114124 |
| FTL | ferritin, light polypeptide | -0.113855 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | -0.0986618 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0874917 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0870272 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | -0.0831826 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | -0.0813184 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | -0.0777872 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.0743882 |
| AHNAK | AHNAK nucleoprotein | -0.07224 |
| PRELID2 | PRELI domain containing 2 | -0.0719259 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.0715097 |
| CANX | calnexin | -0.0668505 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0657333 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0635344 |
| ITCH | itchy E3 ubiquitin protein ligase | -0.0634377 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0633775 |
| VIM | vimentin | -0.0626109 |
| KANSL1 | KAT8 regulatory NSL complex subunit 1 | -0.0625324 |
| GOLGA4 | golgin A4 | -0.0583081 |
| MYOF | myoferlin | -0.0575779 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0574342 |
| B2M | beta-2-microglobulin | -0.0571843 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0531305 |
| PHF21A | PHD finger protein 21A | -0.0527102 |
| SEC24D | SEC24 family member D | -0.0520541 |
| UBE2H | ubiquitin-conjugating enzyme E2H | -0.05121 |
| ANXA2 | annexin A2 | -0.0507702 |
| MAPK6 | mitogen-activated protein kinase 6 | -0.05048 |
| RBM39 | RNA binding motif protein 39 | -0.0502561 |
| NEBL | nebulette | -0.0502087 |
| FN1 | fibronectin 1 | -0.0499077 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0494286 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | -0.0492045 |
| ZMYM2 | zinc finger, MYM-type 2 | -0.0489179 |
| PDE10A | phosphodiesterase 10A | -0.0489148 |
| RIGI | RNA sensor RIG-I | -0.0485903 |
| RACK1 | receptor for activated C kinase 1 | -0.0473381 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0465176 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0463352 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.0458137 |
| AUTS2 | autism susceptibility candidate 2 | -0.0457722 |
| RORA | RAR-related orphan receptor A | -0.0453838 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0444918 |
| XRN1 | 5'-3' exoribonuclease 1 | -0.0442848 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0440141 |
| HOOK3 | hook microtubule-tethering protein 3 | -0.0435747 |
| KIAA1671 | KIAA1671 | -0.0430694 |
| SAR1A | secretion associated, Ras related GTPase 1A | -0.0429516 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0426206 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | -0.0424178 |
| RPS19 | ribosomal protein S19 | -0.0422264 |
| DOCK9 | dedicator of cytokinesis 9 | -0.0422241 |
| S100A10 | S100 calcium binding protein A10 | -0.0421035 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0416438 |
| FBXL20 | F-box and leucine-rich repeat protein 20 | -0.0414341 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | -0.0407578 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | -0.0406837 |
| CSDE1 | cold shock domain containing E1, RNA-binding | -0.0406493 |
| MAP1B | microtubule-associated protein 1B | -0.0401802 |
| NUMB | numb homolog (Drosophila) | -0.0399276 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0398268 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.0397469 |
| TMSB4X | thymosin beta 4, X-linked | -0.0396083 |
| FOXO3 | forkhead box O3 | -0.0395976 |
| ASPH | aspartate beta-hydroxylase | -0.039339 |
| LNPEP | leucyl/cystinyl aminopeptidase | -0.0392089 |
| RUFY1 | RUN and FYVE domain containing 1 | -0.039028 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0386335 |
| TMEM41B | transmembrane protein 41B | -0.0381849 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0381598 |
| SAMD9 | sterile alpha motif domain containing 9 | -0.0380512 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0379212 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0377336 |
| PERP | PERP, TP53 apoptosis effector | -0.0375636 |
| CDC42 | cell division cycle 42 | -0.0374706 |
| TANK | TRAF family member-associated NFKB activator | -0.0373228 |
| LAMB1 | laminin, beta 1 | -0.0370844 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.03675 |
| CARD16 | caspase recruitment domain family, member 16 | -0.0358581 |
| DSG2 | desmoglein 2 | -0.0358216 |
| RASAL2 | RAS protein activator like 2 | -0.0352925 |
| KIAA1217 | KIAA1217 | -0.0352658 |
| ANKRD17 | ankyrin repeat domain 17 | -0.034609 |
| STK24 | serine/threonine kinase 24 | -0.0345863 |
| ADAM10 | ADAM metallopeptidase domain 10 | -0.0342556 |
| DENND4C | DENN/MADD domain containing 4C | -0.034158 |
| CCNI | cyclin I | -0.0336276 |
| RPL31 | ribosomal protein L31 | -0.0335955 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0329222 |
| TMEM87A | transmembrane protein 87A | -0.0327079 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | -0.0326791 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0322283 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.032178 |
| PTGES2 | prostaglandin E synthase 2 | -0.0320818 |
| WDR45B | WD repeat domain 45B | -0.0319841 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.031903 |
