| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Bisoprolol (hemifumarate) perturbation in NCI-H23 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Bisoprolol (hemifumarate)_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.195954 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.0893534 |
| MCL1 | myeloid cell leukemia 1 | 0.0862704 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.0657821 |
| EGR1 | early growth response 1 | 0.0624044 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | 0.0453471 |
| HLA-B | major histocompatibility complex, class I, B | 0.0440813 |
| POTEF | POTE ankyrin domain family, member F | 0.0439468 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.041868 |
| AFF3 | AF4/FMR2 family, member 3 | 0.0372752 |
| RAD51B | RAD51 paralog B | 0.0367922 |
| DOCK5 | dedicator of cytokinesis 5 | 0.036056 |
| HMGA2 | high mobility group AT-hook 2 | 0.0353597 |
| SHC1 | SHC (Src homology 2 domain containing) transforming protein 1 | 0.0338831 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0318976 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | 0.0301775 |
| ACTN1 | actinin, alpha 1 | 0.0297363 |
| INTS6 | integrator complex subunit 6 | 0.0293174 |
| VCL | vinculin | 0.028989 |
| YAP1 | Yes-associated protein 1 | 0.0264967 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0258396 |
| BRD4 | bromodomain containing 4 | 0.0256482 |
| BRD2 | bromodomain containing 2 | 0.0254811 |
| CMIP | c-Maf inducing protein | 0.0252878 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0250694 |
| TAPBP | TAP binding protein (tapasin) | 0.0246885 |
| PRKCE | protein kinase C, epsilon | 0.024645 |
| TRIP12 | thyroid hormone receptor interactor 12 | 0.0245481 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0244052 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | 0.0242361 |
| OSMR | oncostatin M receptor | 0.0236536 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0230331 |
| TPM3 | tropomyosin 3 | 0.0227802 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0224748 |
| TPM4 | tropomyosin 4 | 0.0223895 |
| ATP2A2 | ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 | 0.0219955 |
| SDK1 | sidekick cell adhesion molecule 1 | 0.0219308 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | 0.0219284 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | 0.0219025 |
| KMT2D | lysine (K)-specific methyltransferase 2D | 0.0215427 |
| BPTF | bromodomain PHD finger transcription factor | 0.021343 |
| HDGF | hepatoma-derived growth factor | 0.0212844 |
| AEBP2 | AE binding protein 2 | 0.021129 |
| RYR3 | ryanodine receptor 3 | 0.0210276 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | 0.0208501 |
| HLA-A | major histocompatibility complex, class I, A | 0.0207366 |
| PDE10A | phosphodiesterase 10A | 0.0206219 |
| ATXN1 | ataxin 1 | 0.0206016 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | 0.0205862 |
| CUX1 | cut-like homeobox 1 | 0.0204757 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.020297 |
| EXOC4 | exocyst complex component 4 | 0.0202221 |
| STC1 | stanniocalcin 1 | 0.0199696 |
| RABGAP1L | RAB GTPase activating protein 1-like | 0.0198455 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.019778 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0197571 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0194293 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0193706 |
| PRH1 | proline-rich protein HaeIII subfamily 1 | 0.0193357 |
| TIAM1 | T-cell lymphoma invasion and metastasis 1 | 0.0192124 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0187793 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0186208 |
| BRAF | B-Raf proto-oncogene, serine/threonine kinase | 0.0184312 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0182452 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0179546 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0177211 |
| ATP11A | ATPase, class VI, type 11A | 0.0176838 |
| FLNA | filamin A, alpha | 0.0176751 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | 0.0176511 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0176396 |
| GRAMD1B | GRAM domain containing 1B | 0.0176265 |
| MEF2D | myocyte enhancer factor 2D | 0.0175351 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | 0.0173631 |
| LOXL2 | lysyl oxidase-like 2 | 0.0172832 |
| RRM2 | ribonucleotide reductase M2 | 0.0172766 |
| INTS1 | integrator complex subunit 1 | 0.0172247 |
| IGF2 | insulin-like growth factor 2 | 0.0171846 |
| NDRG1 | N-myc downstream regulated 1 | 0.017166 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0171471 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | 0.0169025 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0168321 |
| CDK17 | cyclin-dependent kinase 17 | 0.01672 |
| NABP1 | nucleic acid binding protein 1 | 0.0166139 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0165765 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0165568 |
| PKM | pyruvate kinase, muscle | 0.016361 |
| NTSR1 | neurotensin receptor 1 (high affinity) | 0.0161864 |
| EXOC6B | exocyst complex component 6B | 0.0161692 |
| SETX | senataxin | 0.0161555 |
| AGRN | agrin | 0.0161512 |
| R3HDM2 | R3H domain containing 2 | 0.0160904 |
| SVIL | supervillin | 0.0158804 |
| ICAM1 | intercellular adhesion molecule 1 | 0.0158511 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0158345 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0157638 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0157028 |
| ALMS1 | Alstrom syndrome protein 1 | 0.0153918 |
| EGFR | epidermal growth factor receptor | 0.0152936 |
| ZNF407 | zinc finger protein 407 | 0.0149617 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.0147151 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.134503 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0891034 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0646029 |
| PTMA | prothymosin, alpha | -0.06434 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0640434 |
| TXNRD1 | thioredoxin reductase 1 | -0.0546462 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0529007 |
| OGA | O-GlcNAcase | -0.0494721 |
| RPL12 | ribosomal protein L12 | -0.0483346 |
| CSDE1 | cold shock domain containing E1, RNA-binding | -0.046202 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0460066 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0422572 |
| MYL12B | myosin, light chain 12B, regulatory | -0.03945 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0388277 |
| TMSB10 | thymosin beta 10 | -0.0368988 |
| XPO1 | exportin 1 | -0.036791 |
| ZFR | zinc finger RNA binding protein | -0.0365864 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0363698 |
| SMCHD1 | structural maintenance of chromosomes flexible hinge domain containing 1 | -0.0349234 |
| RPLP1 | ribosomal protein, large, P1 | -0.0333423 |
| CCND2 | cyclin D2 | -0.0328244 |
| RPLP0 | ribosomal protein, large, P0 | -0.0317873 |
| SPAG9 | sperm associated antigen 9 | -0.0307491 |
| CANX | calnexin | -0.0299627 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | -0.0298246 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0297898 |
| VIM | vimentin | -0.0296254 |
| AHNAK | AHNAK nucleoprotein | -0.0295263 |
| YBX1 | Y box binding protein 1 | -0.0291202 |
| SRP72 | signal recognition particle 72kDa | -0.0290275 |
| RBM39 | RNA binding motif protein 39 | -0.0286175 |
| PHIP | pleckstrin homology domain interacting protein | -0.0283987 |
| RPL23 | ribosomal protein L23 | -0.0283283 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0280772 |
| PGK1 | phosphoglycerate kinase 1 | -0.0279054 |
| MATR3 | matrin 3 | -0.0275733 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0273639 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0265263 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0265243 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0255531 |
| BBX | bobby sox homolog (Drosophila) | -0.0254555 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | -0.0254241 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | -0.0251497 |
| LDHB | lactate dehydrogenase B | -0.0250166 |
| RPS21 | ribosomal protein S21 | -0.0249189 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | -0.0245454 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0242206 |
| H1-0 | H1.0 linker histone | -0.0242097 |
| RLF | rearranged L-myc fusion | -0.0238869 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | -0.0236945 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0231296 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | -0.0231182 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0228799 |
| ZNF292 | zinc finger protein 292 | -0.022595 |
| SINHCAF | SIN3-HDAC complex associated factor | -0.0224594 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0223251 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.022162 |
| TRPC4AP | transient receptor potential cation channel, subfamily C, member 4 associated protein | -0.022142 |
| PREPL | prolyl endopeptidase-like | -0.0221215 |
| PPP2R5E | protein phosphatase 2, regulatory subunit B', epsilon isoform | -0.0221178 |
| SCAF11 | SR-related CTD-associated factor 11 | -0.0220011 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0219701 |
| RPL34 | ribosomal protein L34 | -0.0218583 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0218274 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0217789 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | -0.0215458 |
| TNPO1 | transportin 1 | -0.0215101 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0214855 |
| GPHN | gephyrin | -0.0214585 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0213923 |
| ANXA2 | annexin A2 | -0.0211991 |
| STAG2 | stromal antigen 2 | -0.0209834 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0209649 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0208824 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0208129 |
| EPRS1 | glutamyl-prolyl-tRNA synthetase 1 | -0.0207139 |
| GNAS | GNAS complex locus | -0.0203826 |
| RPS8 | ribosomal protein S8 | -0.0202059 |
| GSTP1 | glutathione S-transferase pi 1 | -0.0201843 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | -0.0199469 |
| SEPTIN2 | septin 2 | -0.0196495 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0195432 |
| GOLGA4 | golgin A4 | -0.0194442 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0194081 |
| OLA1 | Obg-like ATPase 1 | -0.0193291 |
| RPL5 | ribosomal protein L5 | -0.0192962 |
| PCNP | PEST proteolytic signal containing nuclear protein | -0.0192802 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | -0.0192429 |
| CDYL | chromodomain protein, Y-like | -0.019178 |
| WDR45B | WD repeat domain 45B | -0.0191321 |
| RSL1D1 | ribosomal L1 domain containing 1 | -0.019103 |
| COPB1 | coatomer protein complex, subunit beta 1 | -0.0190267 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.0190235 |
| RPL18 | ribosomal protein L18 | -0.0190064 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0187926 |
| NF1 | neurofibromin 1 | -0.0187779 |
| RAP1A | RAP1A, member of RAS oncogene family | -0.0186001 |
| RPS4X | ribosomal protein S4, X-linked | -0.0185616 |
| MORF4L2 | mortality factor 4 like 2 | -0.0185035 |
| HIBADH | 3-hydroxyisobutyrate dehydrogenase | -0.0184561 |
