Bisoprolol (hemifumarate)_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Bisoprolol (hemifumarate) perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Bisoprolol (hemifumarate)_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NDRG1 N-myc downstream regulated 1 0.0754645
HMGA1 high mobility group AT-hook 1 0.071852
FN1 fibronectin 1 0.0618908
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0568862
TSC22D2 TSC22 domain family, member 2 0.0443712
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0423277
ADAM9 ADAM metallopeptidase domain 9 0.0421457
NAMPT nicotinamide phosphoribosyltransferase 0.0403796
MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene) 0.0382141
UBA6 ubiquitin-like modifier activating enzyme 6 0.0368118
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0343184
RNF145 ring finger protein 145 0.0321165
BHLHE40 basic helix-loop-helix family, member e40 0.0321027
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0305894
CCNL1 cyclin L1 0.0303665
TFG TRK-fused gene 0.0301858
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0297196
FTH1 ferritin, heavy polypeptide 1 0.0295024
MSN moesin 0.0288551
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0284433
MT2A metallothionein 2A 0.0266537
USP3 ubiquitin specific peptidase 3 0.0255215
POTEF POTE ankyrin domain family, member F 0.0254763
FXR1 fragile X mental retardation, autosomal homolog 1 0.0249752
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.0234847
ANXA5 annexin A5 0.0225152
FOSL1 FOS-like antigen 1 0.022447
PCBP2 poly(rC) binding protein 2 0.0222142
MSMO1 methylsterol monooxygenase 1 0.0219912
NUP58 nucleoporin 58 0.0217741
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0215396
ELL2 elongation factor, RNA polymerase II, 2 0.0215349
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0210251
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0207168
UGCG UDP-glucose ceramide glucosyltransferase 0.0204052
TACSTD2 tumor-associated calcium signal transducer 2 0.0200058
FAM13A family with sequence similarity 13, member A 0.0198934
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 0.0196079
ZNF292 zinc finger protein 292 0.0194684
EEF2 eukaryotic translation elongation factor 2 0.0194586
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 0.0192987
NCKAP1 NCK-associated protein 1 0.0191235
GARS1 glycyl-tRNA synthetase 1 0.0186209
ARRDC3 arrestin domain containing 3 0.0185372
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0183559
TMBIM6 transmembrane BAX inhibitor motif containing 6 0.0183299
RYBP RING1 and YY1 binding protein 0.0178925
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0178065
TXNRD1 thioredoxin reductase 1 0.0176764
CD46 CD46 molecule, complement regulatory protein 0.0175138
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0167144
LOC112694756 uncharaterized LOC112694756 0.0166496
ECT2 epithelial cell transforming 2 0.0164281
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0162924
SNX9 sorting nexin 9 0.0162882
MIER1 mesoderm induction early response 1, transcriptional regulator 0.0160667
AZIN1 antizyme inhibitor 1 0.0160553
ARL5B ADP-ribosylation factor-like 5B 0.0158177
ATP13A3 ATPase type 13A3 0.0157901
TNIP1 TNFAIP3 interacting protein 1 0.0153407
B3GNT5 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5 0.0153261
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0153101
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0151664
RAD23B RAD23 homolog B (S. cerevisiae) 0.0151375
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0151246
MATR3 matrin 3 0.0148013
G2E3 G2/M-phase specific E3 ubiquitin protein ligase 0.0144986
DDIT4 DNA-damage-inducible transcript 4 0.0144464
CD83 CD83 molecule 0.0143759
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.014127
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.0139568
MEF2A myocyte enhancer factor 2A 0.0136659
MTMR3 myotubularin related protein 3 0.0135425
CPNE8 copine VIII 0.0134786
RTN4 reticulon 4 0.0134052
HSPA8 heat shock 70kDa protein 8 0.0133804
SF1 splicing factor 1 0.0132478
TRA2B transformer 2 beta homolog (Drosophila) 0.0132463
RBM33 RNA binding motif protein 33 0.0131861
PELI1 pellino E3 ubiquitin protein ligase 1 0.0130208
SPOPL speckle-type POZ protein-like 0.0127992
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0126815
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.012589
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase 0.0123348
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3 0.0122987
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0122733
YBX3 Y box binding protein 3 0.0122046
CDK17 cyclin-dependent kinase 17 0.0121329
PEG10 paternally expressed 10 0.0121299
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0119274
PPP1R2 protein phosphatase 1, regulatory (inhibitor) subunit 2 0.0118263
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 0.0117188
QKI QKI, KH domain containing, RNA binding 0.0115716
KDM1A lysine (K)-specific demethylase 1A 0.0115519
CAV1 caveolin 1, caveolae protein, 22kDa 0.0115401
CLDN4 claudin 4 0.0114896
TAGLN2 transgelin 2 0.0114854
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.0113327
FAM3C family with sequence similarity 3, member C 0.0113004
PDIA6 protein disulfide isomerase family A, member 6 0.0112001

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.259932
ACTG1 actin gamma 1 -0.170353
FTL ferritin, light polypeptide -0.113475
TPT1 tumor protein, translationally-controlled 1 -0.112077
RPL35A ribosomal protein L35a -0.106795
EXT1 exostosin glycosyltransferase 1 -0.100764
SAMD4A sterile alpha motif domain containing 4A -0.096209
TMSB10 thymosin beta 10 -0.0953372
LPP LIM domain containing preferred translocation partner in lipoma -0.0916246
FBXO32 F-box protein 32 -0.0816343
LIMCH1 LIM and calponin homology domains 1 -0.078927
ZSWIM6 zinc finger, SWIM-type containing 6 -0.077817
EIF1 eukaryotic translation initiation factor 1 -0.074809
HLA-B major histocompatibility complex, class I, B -0.0639099
RPS29 ribosomal protein S29 -0.0595133
ISG15 ISG15 ubiquitin-like modifier -0.0589141
WSB1 WD repeat and SOCS box containing 1 -0.058468
IFI6 interferon, alpha-inducible protein 6 -0.0546581
LMO7 LIM domain 7 -0.053888
RPS8 ribosomal protein S8 -0.0530044
RPLP1 ribosomal protein, large, P1 -0.0514385
RPS13 ribosomal protein S13 -0.0502789
VCL vinculin -0.0495518
GOLGB1 golgin B1 -0.0489496
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0482481
RPL34 ribosomal protein L34 -0.0479839
IFI16 interferon, gamma-inducible protein 16 -0.0470096
LAMB3 laminin, beta 3 -0.0453506
IFI27 interferon, alpha-inducible protein 27 -0.0451059
CAVIN1 caveolae associated protein 1 -0.0440425
MYO1E myosin IE -0.0438805
SQSTM1 sequestosome 1 -0.0436841
HLA-A major histocompatibility complex, class I, A -0.0435496
TPM4 tropomyosin 4 -0.0432043
EFNA5 ephrin-A5 -0.0431249
RPS27A ribosomal protein S27a -0.0430096
RPS23 ribosomal protein S23 -0.0425242
RPL37A ribosomal protein L37a -0.0424653
TMSB4X thymosin beta 4, X-linked -0.0422503
RPL31 ribosomal protein L31 -0.042198
MAP3K13 mitogen-activated protein kinase kinase kinase 13 -0.0420563
CSTB cystatin B (stefin B) -0.0416311
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0413171
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0409636
SH3KBP1 SH3-domain kinase binding protein 1 -0.0404234
TTC3 tetratricopeptide repeat domain 3 -0.0402383
VIM vimentin -0.0400642
SEC31A SEC31 homolog A (S. cerevisiae) -0.0395881
SOX4 SRY (sex determining region Y)-box 4 -0.0394051
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0394
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0388982
RPS25 ribosomal protein S25 -0.0386848
RNF213 ring finger protein 213 -0.0386196
RPL23 ribosomal protein L23 -0.0385013
RPS24 ribosomal protein S24 -0.0382606
IFIH1 interferon induced with helicase C domain 1 -0.0381877
TM4SF1 transmembrane 4 L six family member 1 -0.0381141
RPLP2 ribosomal protein, large, P2 -0.038089
CD2AP CD2-associated protein -0.0375162
RPS3 ribosomal protein S3 -0.0370579
RPL38 ribosomal protein L38 -0.0367998
RBM47 RNA binding motif protein 47 -0.0367949
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0367009
RPL9 ribosomal protein L9 -0.0364453
IFITM3 interferon induced transmembrane protein 3 -0.0360987
ERBIN erbb2 interacting protein -0.0357258
MCU mitochondrial calcium uniporter -0.035396
FNIP1 folliculin interacting protein 1 -0.0353452
S100A10 S100 calcium binding protein A10 -0.0348108
UBE2H ubiquitin-conjugating enzyme E2H -0.034538
ARHGAP5 Rho GTPase activating protein 5 -0.0341932
CCND1 cyclin D1 -0.0337921
ALCAM activated leukocyte cell adhesion molecule -0.0334731
CEP350 centrosomal protein 350kDa -0.0332688
SP100 SP100 nuclear antigen -0.0332467
PDLIM5 PDZ and LIM domain 5 -0.0328628
HLA-E major histocompatibility complex, class I, E -0.0323319
CD63 CD63 molecule -0.0320239
RAI14 retinoic acid induced 14 -0.031754
SCFD1 sec1 family domain containing 1 -0.0314154
FBXO11 F-box protein 11 -0.0313376
MX2 MX dynamin-like GTPase 2 -0.0313253
CTBP2 C-terminal binding protein 2 -0.0312621
NUMB numb homolog (Drosophila) -0.0312003
LMNA lamin A/C -0.0311333
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) -0.0310286
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0307063
KPNB1 karyopherin (importin) beta 1 -0.030554
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0304711
FBXO34 F-box protein 34 -0.0304007
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0302072
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.030164
RRBP1 ribosome binding protein 1 -0.0297459
ENO2 enolase 2 (gamma, neuronal) -0.0294822
CDK13 cyclin-dependent kinase 13 -0.029367
EPCAM epithelial cell adhesion molecule -0.0293512
RPS10 ribosomal protein S10 -0.0292533
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0291984
RAB7A RAB7A, member RAS oncogene family -0.0291922
C15ORF48 chromosome 15 open reading frame 48 -0.029114