Bisoprolol (hemifumarate)_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Bisoprolol (hemifumarate) perturbation in NCI-H460 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Bisoprolol (hemifumarate)_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.15473
ASPH aspartate beta-hydroxylase 0.108863
TXNRD1 thioredoxin reductase 1 0.0769765
EFNA5 ephrin-A5 0.0668648
GDA guanine deaminase 0.0634541
NAMPT nicotinamide phosphoribosyltransferase 0.0569182
GRAMD1B GRAM domain containing 1B 0.0568409
TRIO trio Rho guanine nucleotide exchange factor 0.0519487
COL8A1 collagen, type VIII, alpha 1 0.04881
PSD3 pleckstrin and Sec7 domain containing 3 0.0487135
NEK7 NIMA-related kinase 7 0.0471261
NRCAM neuronal cell adhesion molecule 0.0442084
COL5A2 collagen, type V, alpha 2 0.0428069
PDE10A phosphodiesterase 10A 0.0422942
EPB41L3 erythrocyte membrane protein band 4.1-like 3 0.0413269
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0387274
CXCL8 chemokine (C-X-C motif) ligand 8 0.0379623
KYNU kynureninase 0.037142
FNDC3B fibronectin type III domain containing 3B 0.036062
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0350924
TNPO1 transportin 1 0.0336636
MYOF myoferlin 0.033565
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0320336
DST dystonin 0.0304773
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.027673
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0275389
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.0269121
CTSC cathepsin C 0.0269032
TGFBR1 transforming growth factor, beta receptor 1 0.0263729
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0257684
AGFG1 ArfGAP with FG repeats 1 0.0254315
HSPA8 heat shock 70kDa protein 8 0.0251053
PDLIM5 PDZ and LIM domain 5 0.0244619
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0244439
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0238765
ENAH enabled homolog (Drosophila) 0.0237837
TM4SF1 transmembrane 4 L six family member 1 0.0227233
DOCK4 dedicator of cytokinesis 4 0.0223109
UBC ubiquitin C 0.0222655
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 0.0221146
CARD16 caspase recruitment domain family, member 16 0.0220028
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0218555
SLC39A8 solute carrier family 39 (zinc transporter), member 8 0.0217115
PCBP3 poly(rC) binding protein 3 0.0214216
SAMD4A sterile alpha motif domain containing 4A 0.0208722
AHNAK AHNAK nucleoprotein 0.0204451
USP9X ubiquitin specific peptidase 9, X-linked 0.0201946
RTN4 reticulon 4 0.0201398
ARHGAP29 Rho GTPase activating protein 29 0.020099
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0199638
PM20D1 peptidase M20 domain containing 1 0.0199286
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.019919
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.019756
EEF2 eukaryotic translation elongation factor 2 0.019747
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0194663
SFPQ splicing factor proline/glutamine-rich 0.0193535
BCAR3 breast cancer anti-estrogen resistance 3 0.0190461
PALLD palladin, cytoskeletal associated protein 0.0190364
ZEB2 zinc finger E-box binding homeobox 2 0.0188813
LIMCH1 LIM and calponin homology domains 1 0.0187411
FLNB filamin B, beta 0.0185464
FLNA filamin A, alpha 0.0184836
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0180469
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 0.0179863
RAB3B RAB3B, member RAS oncogene family 0.0177917
NCKAP1 NCK-associated protein 1 0.0171586
APP amyloid beta (A4) precursor protein 0.0170996
ANKRD28 ankyrin repeat domain 28 0.0170849
COL4A6 collagen, type IV, alpha 6 0.0167313
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0166298
CFLAR CASP8 and FADD-like apoptosis regulator 0.0163188
LAMA1 laminin, alpha 1 0.0161737
NPAS2 neuronal PAS domain protein 2 0.0161624
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0159053
ANTXR1 anthrax toxin receptor 1 0.0153962
LPGAT1 lysophosphatidylglycerol acyltransferase 1 0.0153549
ATP13A3 ATPase type 13A3 0.0153133
NCAM1 neural cell adhesion molecule 1 0.0153063
ECT2 epithelial cell transforming 2 0.0148361
ANLN anillin, actin binding protein 0.0146224
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0145861
GPAT3 glycerol-3-phosphate acyltransferase 3 0.0145702
TGFB2 transforming growth factor, beta 2 0.0143115
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0142177
PTEN phosphatase and tensin homolog 0.0141364
ANKRD17 ankyrin repeat domain 17 0.0141167
COL4A5 collagen, type IV, alpha 5 0.0138728
GPRIN3 GPRIN family member 3 0.0136496
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0136427
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0135482
ELL2 elongation factor, RNA polymerase II, 2 0.0134898
RBMS2 RNA binding motif, single stranded interacting protein 2 0.0134264
APLP2 amyloid beta (A4) precursor-like protein 2 0.0134075
TMX4 thioredoxin-related transmembrane protein 4 0.013393
PRKACB protein kinase, cAMP-dependent, catalytic, beta 0.0133401
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0133125
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.013105
MAN2A1 mannosidase, alpha, class 2A, member 1 0.0130377
TRIP12 thyroid hormone receptor interactor 12 0.0129996
FAT1 FAT atypical cadherin 1 0.0129946

decreased expression

Symbol Name Standardized Value
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.145075
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.130572
TMSB10 thymosin beta 10 -0.1295
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.126864
RPS6 ribosomal protein S6 -0.113968
VIM vimentin -0.101857
RPLP1 ribosomal protein, large, P1 -0.101289
FTL ferritin, light polypeptide -0.098924
RPL37A ribosomal protein L37a -0.0779008
PTMA prothymosin, alpha -0.0767451
RPS19 ribosomal protein S19 -0.0760917
RPS8 ribosomal protein S8 -0.0699325
TPT1 tumor protein, translationally-controlled 1 -0.0660931
RPL31 ribosomal protein L31 -0.0643267
RPL26 ribosomal protein L26 -0.0622414
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0614132
RPS12 ribosomal protein S12 -0.0605682
RPL35A ribosomal protein L35a -0.059438
RPL9 ribosomal protein L9 -0.0571104
RPS3 ribosomal protein S3 -0.0565058
RPL12 ribosomal protein L12 -0.0555718
MT2A metallothionein 2A -0.052792
RPS27 ribosomal protein S27 -0.051363
RPL19 ribosomal protein L19 -0.0506627
RPL36 ribosomal protein L36 -0.0503183
RPL23 ribosomal protein L23 -0.049564
B2M beta-2-microglobulin -0.0488902
RPL34 ribosomal protein L34 -0.0468796
S100A6 S100 calcium binding protein A6 -0.0466145
RPL37 ribosomal protein L37 -0.0465145
RPS14 ribosomal protein S14 -0.0423152
RPL11 ribosomal protein L11 -0.0408783
RPL13A ribosomal protein L13a -0.0400578
RPS29 ribosomal protein S29 -0.0388831
NDRG1 N-myc downstream regulated 1 -0.0383267
RACK1 receptor for activated C kinase 1 -0.0376835
RPLP0 ribosomal protein, large, P0 -0.0362876
FTH1 ferritin, heavy polypeptide 1 -0.0346832
HLA-A major histocompatibility complex, class I, A -0.0345447
RPS4X ribosomal protein S4, X-linked -0.0344565
EIF1 eukaryotic translation initiation factor 1 -0.0341103
RPS17 ribosomal protein S17 -0.0340197
RPS23 ribosomal protein S23 -0.0334182
HLA-B major histocompatibility complex, class I, B -0.0334047
GNAS GNAS complex locus -0.0324831
ISG15 ISG15 ubiquitin-like modifier -0.0314518
SOX4 SRY (sex determining region Y)-box 4 -0.030782
RPL35 ribosomal protein L35 -0.0303856
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0303371
WSB1 WD repeat and SOCS box containing 1 -0.0299383
EGR1 early growth response 1 -0.0298972
IL6 interleukin 6 -0.0298432
LMNA lamin A/C -0.0295679
OASL 2'-5'-oligoadenylate synthetase-like -0.0289681
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0289518
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0284607
IGFBP3 insulin-like growth factor binding protein 3 -0.0279711
RPL5 ribosomal protein L5 -0.0277174
RPL27 ribosomal protein L27 -0.0276377
RPS21 ribosomal protein S21 -0.02727
RPS16 ribosomal protein S16 -0.0271412
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0265075
YBX3 Y box binding protein 3 -0.0262208
DDIT4 DNA-damage-inducible transcript 4 -0.0261376
RPLP2 ribosomal protein, large, P2 -0.0260289
IFIH1 interferon induced with helicase C domain 1 -0.0257099
RPL18 ribosomal protein L18 -0.0247427
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0246824
RPS13 ribosomal protein S13 -0.0246252
RPL7 ribosomal protein L7 -0.024415
RPL32 ribosomal protein L32 -0.024394
RPL30 ribosomal protein L30 -0.0242294
RPL38 ribosomal protein L38 -0.0238467
RPS24 ribosomal protein S24 -0.023811
WARS1 tryptophanyl-tRNA synthetase 1 -0.0236742
TPI1 triosephosphate isomerase 1 -0.0235042
S100A10 S100 calcium binding protein A10 -0.0232425
RPS25 ribosomal protein S25 -0.0229389
STC1 stanniocalcin 1 -0.0220844
RPS5 ribosomal protein S5 -0.0218551
ENO2 enolase 2 (gamma, neuronal) -0.0216759
BASP1 brain abundant, membrane attached signal protein 1 -0.0214862
RPS28 ribosomal protein S28 -0.0210228
RPL7A ribosomal protein L7a -0.0209891
RPL36A ribosomal protein L36a -0.0209761
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0207778
LOC102724023 ES1 protein homolog, mitochondrial -0.020769
CTSL cathepsin L -0.0206908
NAP1L1 nucleosome assembly protein 1-like 1 -0.0206774
DHRSX dehydrogenase/reductase (SDR family) X-linked -0.0204894
S100A11 S100 calcium binding protein A11 -0.0200664
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0200594
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0199573
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0196812
DPP10 dipeptidyl-peptidase 10 (non-functional) -0.0195999
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0193736
NBEAL1 neurobeachin-like 1 -0.0192386
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0191822
HILPDA hypoxia inducible lipid droplet-associated -0.0189564
BTG1 B-cell translocation gene 1, anti-proliferative -0.0189442