Bisoprolol (hemifumarate)_RKO Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Bisoprolol (hemifumarate) perturbation in RKO cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Bisoprolol (hemifumarate)_RKO drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ARHGAP22 Rho GTPase activating protein 22 0.0637159
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0627605
ZNF438 zinc finger protein 438 0.0539983
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0481616
FRMD4A FERM domain containing 4A 0.0458725
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0411365
STC1 stanniocalcin 1 0.0408388
FRMD6 FERM domain containing 6 0.0398506
C2CD2 C2 calcium-dependent domain containing 2 0.0398119
DLC1 DLC1 Rho GTPase activating protein 0.0383273
ZEB1 zinc finger E-box binding homeobox 1 0.0376393
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0362985
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.035736
FLNB filamin B, beta 0.0354421
AHNAK AHNAK nucleoprotein 0.0329253
NAV2 neuron navigator 2 0.0328956
PHC2 polyhomeotic homolog 2 (Drosophila) 0.0321579
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0320259
LAMB3 laminin, beta 3 0.0316034
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0311498
EFNB2 ephrin-B2 0.0290188
AGO2 argonaute RISC catalytic component 2 0.0288487
EXT1 exostosin glycosyltransferase 1 0.0279134
SMYD3 SET and MYND domain containing 3 0.0263325
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0262381
HSPA8 heat shock 70kDa protein 8 0.0261475
TTR transthyretin 0.0261281
SLC38A2 solute carrier family 38, member 2 0.0259743
IFI16 interferon, gamma-inducible protein 16 0.0258566
SP100 SP100 nuclear antigen 0.0254861
MTAP methylthioadenosine phosphorylase 0.0252353
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0245499
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0241375
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0234023
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0232761
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough 0.0230141
ALCAM activated leukocyte cell adhesion molecule 0.0229655
NABP1 nucleic acid binding protein 1 0.0229259
PRRC2B proline-rich coiled-coil 2B 0.0221313
CORO1C coronin, actin binding protein, 1C 0.022046
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0219205
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) 0.0217539
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0214285
FLNA filamin A, alpha 0.0214263
RPL4 ribosomal protein L4 0.0210862
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 0.0208673
BNC2 basonuclin 2 0.0205135
PGK1 phosphoglycerate kinase 1 0.0205081
ACSL4 acyl-CoA synthetase long-chain family member 4 0.0204565
LOC112694756 uncharaterized LOC112694756 0.0202263
ANTXR2 anthrax toxin receptor 2 0.0200509
GFPT2 glutamine-fructose-6-phosphate transaminase 2 0.0199358
MACF1 microtubule-actin crosslinking factor 1 0.0197694
ADAR adenosine deaminase, RNA-specific 0.019359
SPIDR scaffolding protein involved in DNA repair 0.0187542
ACTN1 actinin, alpha 1 0.0186707
RIGI RNA sensor RIG-I 0.0186185
BZW1 basic leucine zipper and W2 domains 1 0.0185499
TEX10 testis expressed 10 0.0185491
FHL2 four and a half LIM domains 2 0.018235
PARP4 poly (ADP-ribose) polymerase family, member 4 0.0175023
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked 0.0173345
TASOR2 transcription activation suppressor family member 2 0.0172619
CUX1 cut-like homeobox 1 0.0170413
CMSS1 cms1 ribosomal small subunit homolog (yeast) 0.0169512
CCND2 cyclin D2 0.0168955
TRIM44 tripartite motif containing 44 0.0168253
ZBTB20 zinc finger and BTB domain containing 20 0.0168099
ADTRP androgen-dependent TFPI-regulating protein 0.0165857
ELL2 elongation factor, RNA polymerase II, 2 0.0161929
CAMKMT calmodulin-lysine N-methyltransferase 0.0159518
RGS4 regulator of G-protein signaling 4 0.0158788
CLTC clathrin, heavy chain (Hc) 0.0157227
NAV3 neuron navigator 3 0.015505
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0154625
LARP1 La ribonucleoprotein domain family, member 1 0.0153225
LARP4B La ribonucleoprotein domain family, member 4B 0.0145716
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 0.0145635
CAST calpastatin 0.0145515
MAST4 microtubule associated serine/threonine kinase family member 4 0.0144484
EEF2 eukaryotic translation elongation factor 2 0.0142563
ERCC6L2 excision repair cross-complementation group 6-like 2 0.0141861
STK4 serine/threonine kinase 4 0.01416
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0141257
CYFIP1 cytoplasmic FMR1 interacting protein 1 0.014098
ANKRD17 ankyrin repeat domain 17 0.0140956
CDK12 cyclin-dependent kinase 12 0.0140827
SGMS2 sphingomyelin synthase 2 0.013977
CAPN2 calpain 2, (m/II) large subunit 0.0139557
ACACA acetyl-CoA carboxylase alpha 0.0138248
COL27A1 collagen, type XXVII, alpha 1 0.0138128
STAU1 staufen double-stranded RNA binding protein 1 0.0138059
WDR1 WD repeat domain 1 0.0137713
CUL1 cullin 1 0.0137047
KANK1 KN motif and ankyrin repeat domains 1 0.0136045
FHIT fragile histidine triad 0.013521
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.0134739
SAMD12 sterile alpha motif domain containing 12 0.0133842
CD274 CD274 molecule 0.0131354
SAMD4A sterile alpha motif domain containing 4A 0.0131102

decreased expression

Symbol Name Standardized Value
MT2A metallothionein 2A -0.116721
RPS6 ribosomal protein S6 -0.0873184
RPL37A ribosomal protein L37a -0.0580154
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0544833
RPS19 ribosomal protein S19 -0.0517414
RPS8 ribosomal protein S8 -0.0469695
RPL23 ribosomal protein L23 -0.0468932
RPS3 ribosomal protein S3 -0.0457706
RPLP1 ribosomal protein, large, P1 -0.0453719
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0423265
HMGA1 high mobility group AT-hook 1 -0.0402155
RPS12 ribosomal protein S12 -0.0375203
RPL9 ribosomal protein L9 -0.0373497
NDRG1 N-myc downstream regulated 1 -0.0363765
ZNF292 zinc finger protein 292 -0.0362326
TMSB10 thymosin beta 10 -0.0360183
ENO2 enolase 2 (gamma, neuronal) -0.0332806
RPL7 ribosomal protein L7 -0.0325393
RPL19 ribosomal protein L19 -0.0317265
RPL30 ribosomal protein L30 -0.031442
RPL12 ribosomal protein L12 -0.0295649
PTMA prothymosin, alpha -0.0293774
KTN1 kinectin 1 (kinesin receptor) -0.0292725
RPL13A ribosomal protein L13a -0.0288328
RPL11 ribosomal protein L11 -0.028731
FTL ferritin, light polypeptide -0.0285933
RPL36 ribosomal protein L36 -0.0285227
GOLGA4 golgin A4 -0.0281699
KMT2E lysine (K)-specific methyltransferase 2E -0.0278118
EIF1 eukaryotic translation initiation factor 1 -0.0275037
RB1CC1 RB1-inducible coiled-coil 1 -0.0273641
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0271009
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0259908
RPL34 ribosomal protein L34 -0.025872
RPL26 ribosomal protein L26 -0.0257316
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0251212
TMBIM6 transmembrane BAX inhibitor motif containing 6 -0.0249117
RPS17 ribosomal protein S17 -0.0243694
CCNL1 cyclin L1 -0.0239492
RPS27 ribosomal protein S27 -0.0235769
RPS2 ribosomal protein S2 -0.0235651
RPL35A ribosomal protein L35a -0.02348
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 -0.0230942
RPL35 ribosomal protein L35 -0.0230328
RPL5 ribosomal protein L5 -0.0228303
KMT2C lysine (K)-specific methyltransferase 2C -0.0221941
B2M beta-2-microglobulin -0.0217934
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0214542
POTEF POTE ankyrin domain family, member F -0.0213188
ADAM9 ADAM metallopeptidase domain 9 -0.0209893
SREK1 splicing regulatory glutamine/lysine-rich protein 1 -0.020953
TSC22D2 TSC22 domain family, member 2 -0.0209437
FOSL1 FOS-like antigen 1 -0.0209061
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0206283
KDM2A lysine (K)-specific demethylase 2A -0.0204966
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0202671
MTDH metadherin -0.020232
S100A2 S100 calcium binding protein A2 -0.0200656
LDHB lactate dehydrogenase B -0.0199506
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0197139
GARS1 glycyl-tRNA synthetase 1 -0.0196509
NUP58 nucleoporin 58 -0.0195969
BAZ2A bromodomain adjacent to zinc finger domain, 2A -0.0195455
PRRC2C proline-rich coiled-coil 2C -0.0194615
RBM25 RNA binding motif protein 25 -0.0191442
SEC31A SEC31 homolog A (S. cerevisiae) -0.0188517
RSF1 remodeling and spacing factor 1 -0.0187034
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0186889
WDFY2 WD repeat and FYVE domain containing 2 -0.0185405
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0184875
SEC62 SEC62 homolog (S. cerevisiae) -0.0184391
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0184001
RYBP RING1 and YY1 binding protein -0.0183837
NF1 neurofibromin 1 -0.018137
ACBD3 acyl-CoA binding domain containing 3 -0.0180447
BRD2 bromodomain containing 2 -0.0180161
JMJD1C jumonji domain containing 1C -0.0178098
RBM39 RNA binding motif protein 39 -0.0177295
UBA6 ubiquitin-like modifier activating enzyme 6 -0.017692
SCAF11 SR-related CTD-associated factor 11 -0.0176165
TCERG1 transcription elongation regulator 1 -0.0175742
RLF rearranged L-myc fusion -0.0175003
SEPTIN7 septin 7 -0.0173832
RPL18 ribosomal protein L18 -0.0172749
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0172085
TPD52 tumor protein D52 -0.0169608
ACTG1 actin gamma 1 -0.0166639
SESN2 sestrin 2 -0.0165882
EGR1 early growth response 1 -0.0165278
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.016523
RPL37 ribosomal protein L37 -0.0164766
AKAP9 A kinase (PRKA) anchor protein 9 -0.0164307
RPS29 ribosomal protein S29 -0.016332
SRSF11 serine/arginine-rich splicing factor 11 -0.0160068
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0159991
PDIA3 protein disulfide isomerase family A, member 3 -0.0159438
BHLHE40 basic helix-loop-helix family, member e40 -0.0157218
RPS10 ribosomal protein S10 -0.0156613
NKTR natural killer cell triggering receptor -0.0156293
WSB1 WD repeat and SOCS box containing 1 -0.0155857