| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Bisoprolol (hemifumarate) perturbation in SK-MEL-2 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Bisoprolol (hemifumarate)_SK-MEL-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.135786 |
| UBC | ubiquitin C | 0.0982505 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0786391 |
| FLNA | filamin A, alpha | 0.0765189 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.074783 |
| FMN1 | formin 1 | 0.069512 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0660556 |
| ANKRD1 | ankyrin repeat domain 1 (cardiac muscle) | 0.0639202 |
| ICAM1 | intercellular adhesion molecule 1 | 0.0618813 |
| TXNRD1 | thioredoxin reductase 1 | 0.0603151 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0602139 |
| SLC39A11 | solute carrier family 39, member 11 | 0.0572037 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0521119 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0482202 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0440493 |
| RPS27A | ribosomal protein S27a | 0.0432616 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0429936 |
| NAV2 | neuron navigator 2 | 0.0428091 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0392113 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0386973 |
| AHNAK | AHNAK nucleoprotein | 0.0373966 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0365846 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0364438 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0363004 |
| XRCC6 | X-ray repair complementing defective repair in Chinese hamster cells 6 | 0.0351862 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.035122 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | 0.0345174 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0343613 |
| ENO1 | enolase 1, (alpha) | 0.0341894 |
| RASAL2 | RAS protein activator like 2 | 0.0337594 |
| CD44 | CD44 molecule (Indian blood group) | 0.0329446 |
| CANX | calnexin | 0.0326225 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.03119 |
| RUNX1 | runt-related transcription factor 1 | 0.0310056 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | 0.0309658 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0299781 |
| MCL1 | myeloid cell leukemia 1 | 0.0293294 |
| RPL4 | ribosomal protein L4 | 0.029242 |
| KAZN | kazrin, periplakin interacting protein | 0.0276851 |
| CALU | calumenin | 0.0274336 |
| SQSTM1 | sequestosome 1 | 0.0268981 |
| ACTN1 | actinin, alpha 1 | 0.0266688 |
| CLIC4 | chloride intracellular channel 4 | 0.0261635 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0260624 |
| EMP1 | epithelial membrane protein 1 | 0.0260516 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0255162 |
| ZNF697 | zinc finger protein 697 | 0.0247533 |
| PRELID2 | PRELI domain containing 2 | 0.0246731 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0242383 |
| ACTN4 | actinin, alpha 4 | 0.0235715 |
| PGK1 | phosphoglycerate kinase 1 | 0.0232682 |
| CTTN | cortactin | 0.0232296 |
| PCBP2 | poly(rC) binding protein 2 | 0.0231022 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0227332 |
| TPM3 | tropomyosin 3 | 0.0226514 |
| EZR | ezrin | 0.0218168 |
| IGFN1 | immunoglobulin-like and fibronectin type III domain containing 1 | 0.0217356 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.0213872 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0213746 |
| KLHL29 | kelch-like family member 29 | 0.0213631 |
| MELTF | melanotransferrin | 0.02117 |
| RANGAP1 | Ran GTPase activating protein 1 | 0.0207897 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0205786 |
| HMG20B | high mobility group 20B | 0.0205539 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0205389 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | 0.0204579 |
| PKM | pyruvate kinase, muscle | 0.0204427 |
| SEPTIN9 | septin 9 | 0.0203884 |
| NPC1 | Niemann-Pick disease, type C1 | 0.0203375 |
| WDR1 | WD repeat domain 1 | 0.0202595 |
| IL6ST | interleukin 6 signal transducer | 0.0200516 |
| VGLL4 | vestigial-like family member 4 | 0.0200466 |
| GNAI3 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 | 0.0200119 |
| RHOA | ras homolog family member A | 0.0199275 |
| FLNB | filamin B, beta | 0.0199223 |
| LAMP2 | lysosomal-associated membrane protein 2 | 0.0196247 |
| SENP5 | SUMO1/sentrin specific peptidase 5 | 0.0195246 |
| ANXA5 | annexin A5 | 0.0192983 |
| IGF1R | insulin-like growth factor 1 receptor | 0.0191308 |
| SET | SET nuclear proto-oncogene | 0.0191053 |
| NBAS | neuroblastoma amplified sequence | 0.0190117 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0189651 |
| STK10 | serine/threonine kinase 10 | 0.0188837 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0187095 |
| ST13 | suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) | 0.0187015 |
| CEP250 | centrosomal protein 250kDa | 0.0185694 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | 0.0184633 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0183015 |
| NOTCH2 | notch 2 | 0.0180642 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0180052 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0178988 |
| NONO | non-POU domain containing, octamer-binding | 0.0176503 |
| RPN1 | ribophorin I | 0.0176057 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0171064 |
| CDK2 | cyclin-dependent kinase 2 | 0.0169658 |
| VMP1 | vacuole membrane protein 1 | 0.0169263 |
| PDCD6IP | programmed cell death 6 interacting protein | 0.0168688 |
| MAFF | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F | 0.0167432 |
| EP300 | E1A binding protein p300 | 0.0166019 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0164338 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | -0.138937 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.100122 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0610228 |
| RPL35A | ribosomal protein L35a | -0.0554834 |
| FTL | ferritin, light polypeptide | -0.0519454 |
| MT2A | metallothionein 2A | -0.0479932 |
| GOLGA4 | golgin A4 | -0.0439676 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0419394 |
| RPS6 | ribosomal protein S6 | -0.0406326 |
| JMJD1C | jumonji domain containing 1C | -0.0396143 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0365523 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0356344 |
| RNF145 | ring finger protein 145 | -0.0356306 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0353455 |
| CADM1 | cell adhesion molecule 1 | -0.0340044 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0335429 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.0317149 |
| CCNL1 | cyclin L1 | -0.0302079 |
| PTMA | prothymosin, alpha | -0.0292517 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0287879 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0287381 |
| HELZ | helicase with zinc finger | -0.0286777 |
| RPS19 | ribosomal protein S19 | -0.0282394 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0281924 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.027679 |
| NLGN1 | neuroligin 1 | -0.0271856 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | -0.0271336 |
| SEPTIN7 | septin 7 | -0.0271148 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0269503 |
| VIM | vimentin | -0.0265384 |
| NOP58 | NOP58 ribonucleoprotein | -0.0256765 |
| SPAG9 | sperm associated antigen 9 | -0.0252302 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | -0.0251164 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | -0.0250289 |
| TOB2 | transducer of ERBB2, 2 | -0.0236752 |
| S100A9 | S100 calcium binding protein A9 | -0.0232539 |
| S100A6 | S100 calcium binding protein A6 | -0.0225909 |
| NDRG1 | N-myc downstream regulated 1 | -0.0222941 |
| CHD1 | chromodomain helicase DNA binding protein 1 | -0.0222711 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | -0.0221764 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.021962 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0217946 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.0216995 |
| B2M | beta-2-microglobulin | -0.0216011 |
| PRAME | preferentially expressed antigen in melanoma | -0.0213673 |
| BZW2 | basic leucine zipper and W2 domains 2 | -0.0213393 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0212497 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | -0.0211298 |
| EYA1 | EYA transcriptional coactivator and phosphatase 1 | -0.0209137 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0209088 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.0208978 |
| PDCD10 | programmed cell death 10 | -0.0208161 |
| QKI | QKI, KH domain containing, RNA binding | -0.0208125 |
| HMGA1 | high mobility group AT-hook 1 | -0.0207226 |
| ITGB3 | integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) | -0.0206429 |
| RPS14 | ribosomal protein S14 | -0.0200745 |
| PIK3R3 | phosphoinositide-3-kinase, regulatory subunit 3 (gamma) | -0.0199351 |
| RPL11 | ribosomal protein L11 | -0.0199225 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.0198833 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.019769 |
| RIOK3 | RIO kinase 3 | -0.0197142 |
| CYB5R3 | cytochrome b5 reductase 3 | -0.0196365 |
| RPLP1 | ribosomal protein, large, P1 | -0.0195756 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | -0.0194213 |
| TRA2B | transformer 2 beta homolog (Drosophila) | -0.0191815 |
| USP3 | ubiquitin specific peptidase 3 | -0.0189375 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0186887 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0186264 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0184791 |
| UBE2B | ubiquitin-conjugating enzyme E2B | -0.0184029 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0183952 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0183458 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0182814 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | -0.0181594 |
| UGCG | UDP-glucose ceramide glucosyltransferase | -0.0181523 |
| RLF | rearranged L-myc fusion | -0.0178795 |
| SKIC3 | SKI3 subunit of superkiller complex | -0.0178501 |
| DSTN | destrin (actin depolymerizing factor) | -0.0177778 |
| CBX3 | chromobox homolog 3 | -0.0176662 |
| FMNL2 | formin-like 2 | -0.017612 |
| CHST11 | carbohydrate (chondroitin 4) sulfotransferase 11 | -0.0175034 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.017385 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.017317 |
| VEGFA | vascular endothelial growth factor A | -0.0172679 |
| SEC24A | SEC24 family member A | -0.0168074 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | -0.0167572 |
| MATR3 | matrin 3 | -0.0165672 |
| GOLGB1 | golgin B1 | -0.0165221 |
| ATF4 | activating transcription factor 4 | -0.016319 |
| RPL36 | ribosomal protein L36 | -0.0162877 |
| RAB2A | RAB2A, member RAS oncogene family | -0.0162255 |
| DPM1 | dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit | -0.0161467 |
| FAM162A | family with sequence similarity 162, member A | -0.0158949 |
| EIF3E | eukaryotic translation initiation factor 3, subunit E | -0.015811 |
| PSMA7 | proteasome (prosome, macropain) subunit, alpha type, 7 | -0.015706 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0156191 |
| COPA | coatomer protein complex, subunit alpha | -0.0154553 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0154235 |
| PFN1 | profilin 1 | -0.0153763 |
| RPL38 | ribosomal protein L38 | -0.0153189 |
