Bisoprolol (hemifumarate)_SW1417 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Bisoprolol (hemifumarate) perturbation in SW1417 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Bisoprolol (hemifumarate)_SW1417 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.172893
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.119161
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0689985
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0654059
RPLP2 ribosomal protein, large, P2 0.0546381
PKM pyruvate kinase, muscle 0.0518315
S100A10 S100 calcium binding protein A10 0.0478849
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0477722
POTEF POTE ankyrin domain family, member F 0.0431109
XPO1 exportin 1 0.0426892
RPS23 ribosomal protein S23 0.0419151
RPL28 ribosomal protein L28 0.0417814
RPS25 ribosomal protein S25 0.039747
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0392234
RPL35A ribosomal protein L35a 0.0389995
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.0389062
RPL7A ribosomal protein L7a 0.0384911
HSPA8 heat shock 70kDa protein 8 0.0384545
RPS13 ribosomal protein S13 0.0376918
FLNA filamin A, alpha 0.0375466
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.03532
CST3 cystatin C 0.0347837
RPS11 ribosomal protein S11 0.0345507
CD46 CD46 molecule, complement regulatory protein 0.0339696
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0320481
CD47 CD47 molecule 0.0319574
PFN1 profilin 1 0.0295923
CCNL1 cyclin L1 0.0292766
KRT8 keratin 8, type II 0.0291089
TXNIP thioredoxin interacting protein 0.0286245
PNISR PNN-interacting serine/arginine-rich protein 0.0284713
RPL15 ribosomal protein L15 0.027832
FOSL1 FOS-like antigen 1 0.027344
RIOK3 RIO kinase 3 0.027174
S100A9 S100 calcium binding protein A9 0.0267577
ATP5MG ATP synthase membrane subunit g 0.0266339
CALR calreticulin 0.0264351
MT2A metallothionein 2A 0.0252283
LENG8 leukocyte receptor cluster (LRC) member 8 0.0251671
RPL36A ribosomal protein L36a 0.0251042
RPL8 ribosomal protein L8 0.0250709
ATP5F1B ATP synthase F1 subunit beta 0.0249764
MNAT1 MNAT CDK-activating kinase assembly factor 1 0.0249416
RPS15 ribosomal protein S15 0.024297
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0231174
PDIA3 protein disulfide isomerase family A, member 3 0.0231089
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0230572
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0230339
CCND1 cyclin D1 0.022987
EEF2 eukaryotic translation elongation factor 2 0.0229322
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.0228608
RTN4 reticulon 4 0.0226483
CDK2AP2 cyclin-dependent kinase 2 associated protein 2 0.0223754
PHIP pleckstrin homology domain interacting protein 0.0223292
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0218821
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.0218365
HIPK3 homeodomain interacting protein kinase 3 0.0217337
PERP PERP, TP53 apoptosis effector 0.0214483
CTSA cathepsin A 0.0213313
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa 0.0213044
VGF VGF nerve growth factor inducible 0.0213001
UBE2B ubiquitin-conjugating enzyme E2B 0.0212684
ZFP36 ZFP36 ring finger protein 0.0208997
RPS24 ribosomal protein S24 0.0206386
NONO non-POU domain containing, octamer-binding 0.0206356
HOXB9 homeobox B9 0.0205827
ESYT2 extended synaptotagmin-like protein 2 0.0203265
CLDN4 claudin 4 0.0201914
HMGA1 high mobility group AT-hook 1 0.0201695
SUCO SUN domain containing ossification factor 0.0200397
WWOX WW domain containing oxidoreductase 0.0198248
SCARB2 scavenger receptor class B, member 2 0.0197291
BCL9L B-cell CLL/lymphoma 9-like 0.0195072
RHOA ras homolog family member A 0.0191561
SLK STE20-like kinase 0.0191251
MBNL1 muscleblind-like splicing regulator 1 0.0190431
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 0.0190247
TPM3 tropomyosin 3 0.0189102
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0186515
RBP1 retinol binding protein 1, cellular 0.0185505
PTBP3 polypyrimidine tract binding protein 3 0.0185364
CEMIP cell migration inducing protein, hyaluronan binding 0.0185159
PCBP2 poly(rC) binding protein 2 0.0184225
IFI27 interferon, alpha-inducible protein 27 0.0183962
RPS16 ribosomal protein S16 0.0182341
TMEM259 transmembrane protein 259 0.0180274
PCDH1 protocadherin 1 0.0179993
TFG TRK-fused gene 0.0179334
KRT19 keratin 19, type I 0.0178057
UGCG UDP-glucose ceramide glucosyltransferase 0.0175639
RPLP0 ribosomal protein, large, P0 0.0175207
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B 0.0173945
UBXN2A UBX domain protein 2A 0.0173199
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0171799
VIM vimentin 0.0171741
HOXB3 homeobox B3 0.017166
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 0.0170797
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0170286
HACD3 3-hydroxyacyl-CoA dehydratase 3 0.0168438
SF3B2 splicing factor 3b, subunit 2, 145kDa 0.0168349

decreased expression

Symbol Name Standardized Value
FTH1 ferritin, heavy polypeptide 1 -0.235804
FTL ferritin, light polypeptide -0.187468
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.129172
NCEH1 neutral cholesterol ester hydrolase 1 -0.111766
PTMA prothymosin, alpha -0.0956546
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 -0.0841001
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0779785
SLC38A1 solute carrier family 38, member 1 -0.0757373
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0631133
RBM39 RNA binding motif protein 39 -0.0588984
RAB7A RAB7A, member RAS oncogene family -0.0579227
GNAS GNAS complex locus -0.0577776
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0576056
LOC112694756 uncharaterized LOC112694756 -0.0568961
MAML2 mastermind-like 2 (Drosophila) -0.0550568
IFRD1 interferon-related developmental regulator 1 -0.0538373
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0534284
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 -0.0519068
EHBP1 EH domain binding protein 1 -0.0509498
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.0501517
CDK13 cyclin-dependent kinase 13 -0.0483566
CUX1 cut-like homeobox 1 -0.0478735
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0477209
NEBL nebulette -0.0465414
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0462579
MYO1E myosin IE -0.0462518
IARS1 isoleucyl-tRNA synthetase 1 -0.0461292
GOLGA4 golgin A4 -0.0460067
ZBTB38 zinc finger and BTB domain containing 38 -0.0450838
EGR1 early growth response 1 -0.044282
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0441712
CSNK1A1 casein kinase 1, alpha 1 -0.0438841
CTBP2 C-terminal binding protein 2 -0.043153
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0429704
TGFA transforming growth factor, alpha -0.0428557
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0427938
OXSR1 oxidative stress responsive 1 -0.042573
PTPRK protein tyrosine phosphatase, receptor type, K -0.0424498
PLSCR1 phospholipid scramblase 1 -0.0421899
RPL34 ribosomal protein L34 -0.0421427
RAD21 RAD21 homolog (S. pombe) -0.0421225
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0415462
ARHGAP5 Rho GTPase activating protein 5 -0.0413091
ADAM19 ADAM metallopeptidase domain 19 -0.041092
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.0401697
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) -0.0395016
TTC3 tetratricopeptide repeat domain 3 -0.0394478
SPAG9 sperm associated antigen 9 -0.0390765
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide -0.0385979
SMAD2 SMAD family member 2 -0.0385516
EIF3H eukaryotic translation initiation factor 3, subunit H -0.0383516
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0375614
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 -0.0374734
DLG1 discs, large homolog 1 (Drosophila) -0.0374314
EXOC4 exocyst complex component 4 -0.037394
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.0373754
NFIA nuclear factor I/A -0.0373673
AFDN afadin, adherens junction formation factor -0.0373129
CD2AP CD2-associated protein -0.0372527
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0361019
LAMA4 laminin, alpha 4 -0.0359402
PMEPA1 prostate transmembrane protein, androgen induced 1 -0.0357076
VTI1A vesicle transport through interaction with t-SNAREs 1A -0.0356649
CANX calnexin -0.0354852
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0354656
FNBP4 formin binding protein 4 -0.0353319
BIRC6 baculoviral IAP repeat containing 6 -0.0346427
KCNH8 potassium channel, voltage gated eag related subfamily H, member 8 -0.0345908
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0345634
GCC2 GRIP and coiled-coil domain containing 2 -0.0343692
EXT1 exostosin glycosyltransferase 1 -0.0338782
BCL2L1 BCL2-like 1 -0.033583
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0334373
NCOA3 nuclear receptor coactivator 3 -0.0332798
COPB1 coatomer protein complex, subunit beta 1 -0.0327763
SND1 staphylococcal nuclease and tudor domain containing 1 -0.032557
H1-0 H1.0 linker histone -0.0323983
ETV6 ets variant 6 -0.0323835
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0323224
EIF4A2 eukaryotic translation initiation factor 4A2 -0.0321289
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase -0.0317327
GPHN gephyrin -0.0312353
NIPBL Nipped-B homolog (Drosophila) -0.0311404
TRPS1 trichorhinophalangeal syndrome I -0.030876
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0306457
CALU calumenin -0.0305044
PPARD peroxisome proliferator-activated receptor delta -0.0303926
CARS1 cysteinyl-tRNA synthetase 1 -0.0300785
TRIO trio Rho guanine nucleotide exchange factor -0.0299813
ERBIN erbb2 interacting protein -0.0299721
KIAA0232 KIAA0232 -0.0299567
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 -0.0295931
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0295628
GOLGB1 golgin B1 -0.0291677
GMDS GDP-mannose 4,6-dehydratase -0.0288235
TJP1 tight junction protein 1 -0.0288085
PPP6R3 protein phosphatase 6, regulatory subunit 3 -0.0286643
SAMD4A sterile alpha motif domain containing 4A -0.0286011
NABP1 nucleic acid binding protein 1 -0.0284039
GARS1 glycyl-tRNA synthetase 1 -0.0281726