Bisoprolol (hemifumarate)_SW480 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Bisoprolol (hemifumarate) perturbation in SW480 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Bisoprolol (hemifumarate)_SW480 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NKD1 naked cuticle homolog 1 (Drosophila) 0.0949435
TPT1 tumor protein, translationally-controlled 1 0.0720518
NAV2 neuron navigator 2 0.0565799
HDAC4 histone deacetylase 4 0.0466517
INTS6 integrator complex subunit 6 0.0459144
VCL vinculin 0.0401411
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0357381
RPS24 ribosomal protein S24 0.0327854
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0322813
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0316547
RUNX1 runt-related transcription factor 1 0.0306416
CDH13 cadherin 13 0.0304463
GMDS GDP-mannose 4,6-dehydratase 0.0285816
WWOX WW domain containing oxidoreductase 0.0279704
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 0.0273642
SDK1 sidekick cell adhesion molecule 1 0.0268633
MYH9 myosin, heavy chain 9, non-muscle 0.0262562
SYT1 synaptotagmin I 0.0259288
RAD51B RAD51 paralog B 0.0258056
CCND1 cyclin D1 0.0252889
SMYD3 SET and MYND domain containing 3 0.0252542
EXOC4 exocyst complex component 4 0.0249285
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0247358
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0244258
ATXN1 ataxin 1 0.0237184
AHNAK AHNAK nucleoprotein 0.0232091
DIAPH2 diaphanous-related formin 2 0.0231839
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0231638
CUX1 cut-like homeobox 1 0.0229434
TNS3 tensin 3 0.02224
TCF12 transcription factor 12 0.0219
SEPTIN9 septin 9 0.0211973
MED13 mediator complex subunit 13 0.0211122
LPP LIM domain containing preferred translocation partner in lipoma 0.020436
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 0.0197371
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0192495
FRMD5 FERM domain containing 5 0.0190077
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 0.0189536
PRRC2B proline-rich coiled-coil 2B 0.018472
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0183633
PROX1 prospero homeobox 1 0.0183376
FLNA filamin A, alpha 0.0181374
EIF4B eukaryotic translation initiation factor 4B 0.0180654
BRAF B-Raf proto-oncogene, serine/threonine kinase 0.0180004
KDM6A lysine (K)-specific demethylase 6A 0.0179388
ABHD2 abhydrolase domain containing 2 0.0179069
WAC WW domain containing adaptor with coiled-coil 0.0178999
UMAD1 UBAP1-MVB12-associated (UMA) domain containing 1 0.0178413
ZFAND3 zinc finger, AN1-type domain 3 0.0178388
VGLL4 vestigial-like family member 4 0.0177231
CDK12 cyclin-dependent kinase 12 0.0177102
ANKRD17 ankyrin repeat domain 17 0.0176042
TAS2R14 taste receptor, type 2, member 14 0.0174648
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.0174127
FAF1 Fas (TNFRSF6) associated factor 1 0.0171987
ZNRF3 zinc and ring finger 3 0.0171003
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.0170906
MAML2 mastermind-like 2 (Drosophila) 0.0170386
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0170188
GPATCH8 G patch domain containing 8 0.0167222
RBP1 retinol binding protein 1, cellular 0.0165982
JMJD1C jumonji domain containing 1C 0.0165455
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0164288
NOP56 NOP56 ribonucleoprotein 0.0164244
RPL36A ribosomal protein L36a 0.0161902
RPL7A ribosomal protein L7a 0.0160563
NR6A1 nuclear receptor subfamily 6, group A, member 1 0.0159844
SP3 Sp3 transcription factor 0.0159427
AOPEP aminopeptidase O (putative) 0.0159149
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 0.0154238
PDE4D phosphodiesterase 4D, cAMP-specific 0.0153279
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0152698
HSPA8 heat shock 70kDa protein 8 0.0152543
BCL2L1 BCL2-like 1 0.0150423
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0147969
RPL4 ribosomal protein L4 0.0147883
RPS25 ribosomal protein S25 0.014689
RCOR1 REST corepressor 1 0.0145603
RCC1 regulator of chromosome condensation 1 0.0145352
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0144369
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0143342
OSBPL10 oxysterol binding protein-like 10 0.0142216
RBM33 RNA binding motif protein 33 0.0141153
MSI2 musashi RNA-binding protein 2 0.0140187
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 0.0139996
SFPQ splicing factor proline/glutamine-rich 0.0139378
TNRC18 trinucleotide repeat containing 18 0.0138944
KLF12 Kruppel-like factor 12 0.0138653
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5 0.013848
KMT2C lysine (K)-specific methyltransferase 2C 0.0137923
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0136592
CDK6 cyclin-dependent kinase 6 0.0135876
CAPRIN1 cell cycle associated protein 1 0.0134994
CDK13 cyclin-dependent kinase 13 0.0133397
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0131796
AGO3 argonaute RISC catalytic component 3 0.0131505
WNK1 WNK lysine deficient protein kinase 1 0.0130056
TBC1D5 TBC1 domain family, member 5 0.0129577
STK38L serine/threonine kinase 38 like 0.012931
NPAS2 neuronal PAS domain protein 2 0.0128965

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.162628
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.13533
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.129841
RPS6 ribosomal protein S6 -0.127379
RPS19 ribosomal protein S19 -0.106566
RPL23 ribosomal protein L23 -0.0946237
RPS3 ribosomal protein S3 -0.0941159
MT2A metallothionein 2A -0.0925931
EZR ezrin -0.0806725
RPLP1 ribosomal protein, large, P1 -0.0795823
RPL12 ribosomal protein L12 -0.0740899
ANXA2 annexin A2 -0.0716583
RPL36 ribosomal protein L36 -0.0697896
RPL18 ribosomal protein L18 -0.0693775
EGR1 early growth response 1 -0.0666692
RPL26 ribosomal protein L26 -0.0659738
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0642751
RPS12 ribosomal protein S12 -0.0636978
HMGA1 high mobility group AT-hook 1 -0.0635329
VIM vimentin -0.063346
FTH1 ferritin, heavy polypeptide 1 -0.062407
RPL37A ribosomal protein L37a -0.0621178
FTL ferritin, light polypeptide -0.0601337
RPL19 ribosomal protein L19 -0.0565681
RACK1 receptor for activated C kinase 1 -0.0551008
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.054777
RBM25 RNA binding motif protein 25 -0.0535223
RPL9 ribosomal protein L9 -0.0529564
RPS8 ribosomal protein S8 -0.052791
RPL11 ribosomal protein L11 -0.0523151
AKAP12 A kinase (PRKA) anchor protein 12 -0.0511005
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0500413
TPI1 triosephosphate isomerase 1 -0.0500193
EEF1G eukaryotic translation elongation factor 1 gamma -0.0490904
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0486299
NDRG1 N-myc downstream regulated 1 -0.0484456
EIF1 eukaryotic translation initiation factor 1 -0.047007
RPL5 ribosomal protein L5 -0.0466329
PGK1 phosphoglycerate kinase 1 -0.0449397
RPL13A ribosomal protein L13a -0.0449074
YBX3 Y box binding protein 3 -0.0448919
RPS4X ribosomal protein S4, X-linked -0.0447422
LOC102724023 ES1 protein homolog, mitochondrial -0.0436618
RPL35 ribosomal protein L35 -0.04337
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0432333
SLC38A1 solute carrier family 38, member 1 -0.0427442
RPL34 ribosomal protein L34 -0.0426115
SMC4 structural maintenance of chromosomes 4 -0.0410739
EMP1 epithelial membrane protein 1 -0.0402471
LOC112694756 uncharaterized LOC112694756 -0.0398483
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0396376
GOLGA4 golgin A4 -0.0393918
RPL37 ribosomal protein L37 -0.0391105
RPL32 ribosomal protein L32 -0.0390004
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.038513
RPL30 ribosomal protein L30 -0.0384853
NACA nascent polypeptide-associated complex alpha subunit -0.0382973
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0376671
YBX1 Y box binding protein 1 -0.0374537
CBX3 chromobox homolog 3 -0.037409
PCBP2 poly(rC) binding protein 2 -0.0373746
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.036649
AKAP9 A kinase (PRKA) anchor protein 9 -0.0361196
FOSL1 FOS-like antigen 1 -0.0352916
ENO1 enolase 1, (alpha) -0.0348032
DDIT4 DNA-damage-inducible transcript 4 -0.0346451
S100A6 S100 calcium binding protein A6 -0.0341161
PFN1 profilin 1 -0.0337856
GNAS GNAS complex locus -0.033461
MORF4L2 mortality factor 4 like 2 -0.0329506
RPS14 ribosomal protein S14 -0.0326735
CENPF centromere protein F, 350/400kDa -0.0323702
RPL7 ribosomal protein L7 -0.032325
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0322923
GARS1 glycyl-tRNA synthetase 1 -0.0314918
EIF5B eukaryotic translation initiation factor 5B -0.0313041
NSMF NMDA receptor synaptonuclear signaling and neuronal migration factor -0.0311188
S100A11 S100 calcium binding protein A11 -0.0310921
RPS2 ribosomal protein S2 -0.0306577
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0305401
ITGA6 integrin, alpha 6 -0.0305071
KRT19 keratin 19, type I -0.0301987
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0291993
ARF4 ADP-ribosylation factor 4 -0.028786
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0285842
LMNA lamin A/C -0.0280891
TNS4 tensin 4 -0.0279422
RPL10A ribosomal protein L10a -0.0274684
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0271841
SOX4 SRY (sex determining region Y)-box 4 -0.0271561
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0270157
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0268062
SOX9 SRY (sex determining region Y)-box 9 -0.0266892
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.0265984
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.026589
ATF4 activating transcription factor 4 -0.0262908
KTN1 kinectin 1 (kinesin receptor) -0.0262472
ESYT2 extended synaptotagmin-like protein 2 -0.0262217
SEC61G Sec61 gamma subunit -0.0261392
PKM pyruvate kinase, muscle -0.0260367