Bisoprolol (hemifumarate)_hTERT-HPNE Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Bisoprolol (hemifumarate) perturbation in hTERT-HPNE cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Bisoprolol (hemifumarate)_hTERT-HPNE drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MYH9 myosin, heavy chain 9, non-muscle 0.0551877
COL6A3 collagen, type VI, alpha 3 0.0547299
ATP13A3 ATPase type 13A3 0.0536609
SMAD3 SMAD family member 3 0.0525648
ELL2 elongation factor, RNA polymerase II, 2 0.045812
FNDC3B fibronectin type III domain containing 3B 0.0427002
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0386527
LOXL2 lysyl oxidase-like 2 0.0379997
RUNX1 runt-related transcription factor 1 0.03624
PDE4D phosphodiesterase 4D, cAMP-specific 0.0323522
COL4A2 collagen, type IV, alpha 2 0.0320662
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0285821
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0261851
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0259186
NAMPT nicotinamide phosphoribosyltransferase 0.0255543
FAM13A family with sequence similarity 13, member A 0.0249133
CDK17 cyclin-dependent kinase 17 0.0237342
WNT5A wingless-type MMTV integration site family, member 5A 0.0233192
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.0219373
USP3 ubiquitin specific peptidase 3 0.0214557
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0213411
ANO6 anoctamin 6 0.0212692
FRMD6 FERM domain containing 6 0.0209623
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0207763
EPAS1 endothelial PAS domain protein 1 0.0203199
HSPA8 heat shock 70kDa protein 8 0.0201453
FLNA filamin A, alpha 0.0200067
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0194133
COL4A1 collagen, type IV, alpha 1 0.0188851
ANXA5 annexin A5 0.0183689
ZNF292 zinc finger protein 292 0.0183054
ANKRD28 ankyrin repeat domain 28 0.0182535
SOD2 superoxide dismutase 2, mitochondrial 0.0181706
SNAI2 snail family zinc finger 2 0.0180729
ADAMTS16 ADAM metallopeptidase with thrombospondin type 1 motif, 16 0.0180483
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.0174421
SPAG9 sperm associated antigen 9 0.017366
CPEB2 cytoplasmic polyadenylation element binding protein 2 0.0171648
PALM2AKAP2 PALM2 and AKAP2 fusion 0.017011
ACSL3 acyl-CoA synthetase long-chain family member 3 0.016738
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0162906
SEPTIN9 septin 9 0.0162607
SYAP1 synapse associated protein 1 0.0160139
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.01599
TRPC4 transient receptor potential cation channel, subfamily C, member 4 0.0158236
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0157662
UBA6 ubiquitin-like modifier activating enzyme 6 0.0153557
RARS1 arginyl-tRNA synthetase 1 0.0149963
APAF1 apoptotic peptidase activating factor 1 0.0149883
PSME4 proteasome (prosome, macropain) activator subunit 4 0.014876
MSN moesin 0.0148262
PLPP3 phospholipid phosphatase 3 0.0147873
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0146944
ARHGAP21 Rho GTPase activating protein 21 0.014669
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0142448
PTP4A1 protein tyrosine phosphatase type IVA, member 1 0.0141099
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0140986
SMOX spermine oxidase 0.013807
CAMTA1 calmodulin binding transcription activator 1 0.0137829
ELP2 elongator acetyltransferase complex subunit 2 0.0136903
MIER1 mesoderm induction early response 1, transcriptional regulator 0.0135914
ARF6 ADP-ribosylation factor 6 0.0134631
DCUN1D3 DCN1, defective in cullin neddylation 1, domain containing 3 0.0133745
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0132256
DUSP10 dual specificity phosphatase 10 0.0131656
CHD1 chromodomain helicase DNA binding protein 1 0.0130763
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0129095
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3 0.0129
TNIP1 TNFAIP3 interacting protein 1 0.0128753
WDR43 WD repeat domain 43 0.0128112
NCKAP1 NCK-associated protein 1 0.0127838
PER1 period circadian clock 1 0.0127685
PSMD12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 0.0127605
THBS2 thrombospondin 2 0.0127559
ANKRD17 ankyrin repeat domain 17 0.0127486
MALT1 MALT1 paracaspase 0.0126887
HOMER2 homer scaffolding protein 2 0.0126116
SHB Src homology 2 domain containing adaptor protein B 0.0125738
SOCS5 suppressor of cytokine signaling 5 0.0125491
RNF145 ring finger protein 145 0.012549
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0125275
PTBP3 polypyrimidine tract binding protein 3 0.0125213
ZFC3H1 zinc finger, C3H1-type containing 0.0122265
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.012221
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0122001
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0121527
NDRG1 N-myc downstream regulated 1 0.0121504
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.012135
SPRED2 sprouty-related, EVH1 domain containing 2 0.0121127
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0120813
AHR aryl hydrocarbon receptor 0.01201
ADGRB3 adhesion G protein-coupled receptor B3 0.0118504
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.011847
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0118169
TAPBP TAP binding protein (tapasin) 0.0116458
TOP2B topoisomerase (DNA) II beta 180kDa 0.0114949
LCORL ligand dependent nuclear receptor corepressor-like 0.0114881
TENT4A terminal nucleotidyltransferase 4A 0.0114333
BHLHE40 basic helix-loop-helix family, member e40 0.0114316
TPX2 TPX2, microtubule-associated 0.01143

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.263967
TMSB10 thymosin beta 10 -0.154572
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.149649
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.148779
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.14846
HLA-B major histocompatibility complex, class I, B -0.143791
HMGA2 high mobility group AT-hook 2 -0.139356
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.122102
PRKG1 protein kinase, cGMP-dependent, type I -0.120949
NALF1 NALCN channel auxiliary factor 1 -0.114959
FTL ferritin, light polypeptide -0.103924
B2M beta-2-microglobulin -0.0999152
AKAP12 A kinase (PRKA) anchor protein 12 -0.0966911
MMP1 matrix metallopeptidase 1 -0.0936886
MT2A metallothionein 2A -0.0926917
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.0890134
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0782785
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0744219
RPS6 ribosomal protein S6 -0.0730261
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0729197
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0655257
TPT1 tumor protein, translationally-controlled 1 -0.0638519
RPS8 ribosomal protein S8 -0.0630751
RPLP1 ribosomal protein, large, P1 -0.0620712
ACTG1 actin gamma 1 -0.0603358
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0585666
RPS19 ribosomal protein S19 -0.057118
EIF1 eukaryotic translation initiation factor 1 -0.0566895
RPL34 ribosomal protein L34 -0.0565615
HLA-A major histocompatibility complex, class I, A -0.0552553
PTMA prothymosin, alpha -0.0549261
RPL37A ribosomal protein L37a -0.0539385
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0534928
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0507513
TPM4 tropomyosin 4 -0.0497163
ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12 -0.0470103
ASPH aspartate beta-hydroxylase -0.0459947
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.045986
TGFBI transforming growth factor, beta-induced, 68kDa -0.0459514
RPL19 ribosomal protein L19 -0.0447057
RPL23 ribosomal protein L23 -0.0442211
RPS12 ribosomal protein S12 -0.0440287
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0438715
OXR1 oxidation resistance 1 -0.043351
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0419222
CDH13 cadherin 13 -0.0418676
FMNL2 formin-like 2 -0.0404387
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0404278
RPL9 ribosomal protein L9 -0.0400245
TM4SF1 transmembrane 4 L six family member 1 -0.0399804
RPL31 ribosomal protein L31 -0.0397989
COL6A1 collagen, type VI, alpha 1 -0.0390347
MMP12 matrix metallopeptidase 12 -0.0382279
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0379915
RPL26 ribosomal protein L26 -0.0376426
NCKAP5 NCK-associated protein 5 -0.0369879
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0369189
GLIS3 GLIS family zinc finger 3 -0.0368373
VCL vinculin -0.0367579
ENO1 enolase 1, (alpha) -0.0367418
RPL5 ribosomal protein L5 -0.0366768
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -0.0360739
RPL35A ribosomal protein L35a -0.0357447
CANX calnexin -0.0355532
RPS17 ribosomal protein S17 -0.0355058
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0353363
TFPI2 tissue factor pathway inhibitor 2 -0.0352698
ENO2 enolase 2 (gamma, neuronal) -0.0352323
SAMD3 sterile alpha motif domain containing 3 -0.0341554
RACK1 receptor for activated C kinase 1 -0.0341147
INTS6 integrator complex subunit 6 -0.033994
NPTX1 neuronal pentraxin I -0.0328898
JARID2 jumonji, AT rich interactive domain 2 -0.0326329
INHBA inhibin, beta A -0.0323088
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0321684
RPS3 ribosomal protein S3 -0.0318551
RPL11 ribosomal protein L11 -0.0316283
RPL37 ribosomal protein L37 -0.0315476
ADM adrenomedullin -0.0312047
ARHGAP22 Rho GTPase activating protein 22 -0.0308679
CAVIN1 caveolae associated protein 1 -0.030813
EMP1 epithelial membrane protein 1 -0.0307814
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0302978
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 -0.0299261
FN1 fibronectin 1 -0.0298345
FBN1 fibrillin 1 -0.0296926
RPL12 ribosomal protein L12 -0.0296182
CEMIP cell migration inducing protein, hyaluronan binding -0.0294299
CALR calreticulin -0.0288529
PDIA3 protein disulfide isomerase family A, member 3 -0.028422
KTN1 kinectin 1 (kinesin receptor) -0.0282652
DST dystonin -0.0280995
MAML3 mastermind-like 3 (Drosophila) -0.0279379
WSB1 WD repeat and SOCS box containing 1 -0.0274887
GNAS GNAS complex locus -0.0274154
MED13L mediator complex subunit 13-like -0.0272225
FRMD4A FERM domain containing 4A -0.0271108
HDAC9 histone deacetylase 9 -0.0262773
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0260773
RPL36 ribosomal protein L36 -0.0260132