| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| Description | A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups. (Chemical Entities of Biological Interest Ontology, CHEBI_33216) |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/6623 |
| Similar Terms | |
| Downloads & Tools |
200 proteins with high or low expression in Bisphenol A relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PIP | prolactin-induced protein | 0.87 |
| NPHP3 | nephronophthisis 3 (adolescent) | 0.86 |
| SCAPER | S-phase cyclin A-associated protein in the ER | 0.67 |
| YPEL5 | yippee-like 5 (Drosophila) | 0.56 |
| CD9 | CD9 molecule | 0.54 |
| HAPLN3 | hyaluronan and proteoglycan link protein 3 | 0.52 |
| WDR20 | WD repeat domain 20 | 0.52 |
| SYNGAP1 | synaptic Ras GTPase activating protein 1 | 0.5 |
| SIAE | sialic acid acetylesterase | 0.5 |
| MT-ND1 | NADH dehydrogenase, subunit 1 (complex I) | 0.48 |
| HPSE | heparanase | 0.45 |
| MAP3K20 | mitogen-activated protein kinase kinase kinase 20 | 0.43 |
| MIB2 | mindbomb E3 ubiquitin protein ligase 2 | 0.43 |
| ZNF101 | zinc finger protein 101 | 0.42 |
| CLK1 | CDC-like kinase 1 | 0.42 |
| PIGU | phosphatidylinositol glycan anchor biosynthesis, class U | 0.42 |
| ITPRIPL2 | inositol 1,4,5-trisphosphate receptor interacting protein-like 2 | 0.41 |
| COQ10B | coenzyme Q10 homolog B (S. cerevisiae) | 0.41 |
| PKM | pyruvate kinase, muscle | 0.41 |
| PLEKHN1 | pleckstrin homology domain containing, family N member 1 | 0.41 |
| PPP1R15B | protein phosphatase 1, regulatory subunit 15B | 0.41 |
| PTP4A2 | protein tyrosine phosphatase type IVA, member 2 | 0.4 |
| DNAH14 | dynein, axonemal, heavy chain 14 | 0.4 |
| TRPM4 | transient receptor potential cation channel, subfamily M, member 4 | 0.39 |
| REPIN1 | replication initiator 1 | 0.39 |
| DTD1 | D-tyrosyl-tRNA deacylase 1 | 0.39 |
| RBM23 | RNA binding motif protein 23 | 0.38 |
| ANTKMT | adenine nucleotide translocase lysine methyltransferase | 0.38 |
| CTNND2 | catenin (cadherin-associated protein), delta 2 | 0.38 |
| H1-4 | H1.4 linker histone, cluster member | 0.38 |
| LSM5 | LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) | 0.37 |
| NEDD4 | neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase | 0.37 |
| NOL11 | nucleolar protein 11 | 0.37 |
| APBA3 | amyloid beta (A4) precursor protein-binding, family A, member 3 | 0.37 |
| CTDNEP1 | CTD nuclear envelope phosphatase 1 | 0.36 |
| H1-2 | H1.2 linker histone, cluster member | 0.36 |
| DSTN | destrin (actin depolymerizing factor) | 0.36 |
| CRY1 | cryptochrome circadian clock 1 | 0.36 |
| PLEC | plectin | 0.36 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.36 |
| LASP1 | LIM and SH3 protein 1 | 0.36 |
| TMEM263 | transmembrane protein 263 | 0.36 |
| CDCP1 | CUB domain containing protein 1 | 0.36 |
| GLB1L2 | galactosidase, beta 1-like 2 | 0.36 |
| MICOS10 | mitochondrial contact site and cristae organizing system subunit 10 | 0.35 |
| PLCD1 | phospholipase C, delta 1 | 0.35 |
| ZBTB3 | zinc finger and BTB domain containing 3 | 0.35 |
| SEPSECS | Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase | 0.35 |
| MYNN | myoneurin | 0.35 |
| SLC6A8 | solute carrier family 6 (neurotransmitter transporter), member 8 | 0.34 |
| SLC35A4 | solute carrier family 35, member A4 | 0.34 |
| PDCD6 | programmed cell death 6 | 0.34 |
| GAPDHS | glyceraldehyde-3-phosphate dehydrogenase, spermatogenic | 0.34 |
| SLC6A17 | solute carrier family 6 (neutral amino acid transporter), member 17 | 0.34 |
| ZNF669 | zinc finger protein 669 | 0.34 |
| CD47 | CD47 molecule | 0.34 |
| TUBA1C | tubulin, alpha 1c | 0.34 |
| WDR11 | WD repeat domain 11 | 0.34 |
| RXYLT1 | ribitol xylosyltransferase 1 | 0.34 |
| NAA40 | N(alpha)-acetyltransferase 40, NatD catalytic subunit | 0.34 |
| CLP1 | cleavage and polyadenylation factor I subunit 1 | 0.34 |
| LAMA5 | laminin, alpha 5 | 0.33 |
| TIFA | TRAF-interacting protein with forkhead-associated domain | 0.33 |
| PLEKHG3 | pleckstrin homology domain containing, family G (with RhoGef domain) member 3 | 0.33 |
| CYB5D2 | cytochrome b5 domain containing 2 | 0.33 |
| HMGXB3 | HMG box domain containing 3 | 0.33 |
| TENT2 | terminal nucleotidyltransferase 2 | 0.33 |
| MYO15A | myosin XVA | 0.33 |
| NBEA | neurobeachin | 0.33 |
| WDR26 | WD repeat domain 26 | 0.33 |
| ALG5 | ALG5, dolichyl-phosphate beta-glucosyltransferase | 0.32 |
| MYH15 | myosin, heavy chain 15 | 0.32 |
| SIGIRR | single immunoglobulin and toll-interleukin 1 receptor (TIR) domain | 0.32 |
| RUSC2 | RUN and SH3 domain containing 2 | 0.32 |
| DIRAS1 | DIRAS family, GTP-binding RAS-like 1 | 0.32 |
| SEC11C | SEC11 homolog C (S. cerevisiae) | 0.32 |
| PRMT8 | protein arginine methyltransferase 8 | 0.32 |
| UBQLN2 | ubiquilin 2 | 0.32 |
| MPDU1 | mannose-P-dolichol utilization defect 1 | 0.31 |
| NEMP1 | nuclear envelope integral membrane protein 1 | 0.31 |
| DDX4 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 | 0.31 |
| TMEM135 | transmembrane protein 135 | 0.31 |
| TNFRSF1A | tumor necrosis factor receptor superfamily, member 1A | 0.31 |
| PARP2 | poly (ADP-ribose) polymerase 2 | 0.31 |
| MGA | MGA, MAX dimerization protein | 0.31 |
| METAP2 | methionyl aminopeptidase 2 | 0.31 |
| ATP1A4 | ATPase, Na+/K+ transporting, alpha 4 polypeptide | 0.31 |
| KLHL11 | kelch-like family member 11 | 0.3 |
| CARNMT1 | carnosine N-methyltransferase 1 | 0.3 |
| COQ9 | coenzyme Q9 | 0.3 |
| CD320 | CD320 molecule | 0.3 |
| GON4L | gon-4-like (C. elegans) | 0.3 |
| CLPTM1L | CLPTM1-like | 0.3 |
| HIST1H1T | histone cluster 1, H1t | 0.3 |
| DHRS7B | dehydrogenase/reductase (SDR family) member 7B | 0.3 |
| ARL3 | ADP-ribosylation factor-like 3 | 0.3 |
| NUDT2 | nudix (nucleoside diphosphate linked moiety X)-type motif 2 | 0.3 |
| RRP7A | ribosomal RNA processing 7 homolog A (S. cerevisiae) | 0.3 |
| PPP2R5C | protein phosphatase 2, regulatory subunit B', gamma | 0.3 |
| COMMD3 | COMM domain containing 3 | 0.3 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ANKRD24 | ankyrin repeat domain 24 | -2.53 |
| SRGAP3 | SLIT-ROBO Rho GTPase activating protein 3 | -2.36 |
| SOS2 | son of sevenless homolog 2 (Drosophila) | -2.03 |
| CDC42SE2 | CDC42 small effector 2 | -1.4 |
| EPHA4 | EPH receptor A4 | -1.28 |
| TTLL4 | tubulin tyrosine ligase-like family member 4 | -1.25 |
| TMA7 | translation machinery associated 7 homolog (S. cerevisiae) | -1.01 |
| CNBP | CCHC-type zinc finger, nucleic acid binding protein | -0.98 |
| ZBTB43 | zinc finger and BTB domain containing 43 | -0.95 |
| ZC3H12A | zinc finger CCCH-type containing 12A | -0.89 |
| HIST2H2AA3 | histone cluster 2, H2aa3 | -0.88 |
| TMSB10 | thymosin beta 10 | -0.87 |
| ZNF503 | zinc finger protein 503 | -0.85 |
| JAG2 | jagged 2 | -0.8 |
| ATP6V1F | ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F | -0.8 |
| NSUN3 | NOP2/Sun domain family, member 3 | -0.8 |
| ZNF518B | zinc finger protein 518B | -0.79 |
| MED8 | mediator complex subunit 8 | -0.77 |
| ACTB | actin, beta | -0.73 |
| ATP5PF | ATP synthase peripheral stalk subunit F6 | -0.72 |
| COX16 | COX16 cytochrome c oxidase assembly homolog (S. cerevisiae) | -0.7 |
| CDC26 | cell division cycle 26 | -0.7 |
| TICAM1 | toll-like receptor adaptor molecule 1 | -0.68 |
| MCRIP1 | MAPK regulated corepressor interacting protein 1 | -0.67 |
| MISP3 | MISP family member 3 | -0.66 |
| NR1D2 | nuclear receptor subfamily 1, group D, member 2 | -0.66 |
| TGFB1I1 | transforming growth factor beta 1 induced transcript 1 | -0.63 |
| KLHDC2 | kelch domain containing 2 | -0.62 |
| VGLL4 | vestigial-like family member 4 | -0.59 |
| FARP2 | FERM, RhoGEF and pleckstrin domain protein 2 | -0.58 |
| PXN | paxillin | -0.57 |
| HSBP1 | heat shock factor binding protein 1 | -0.57 |
| EIF2B4 | eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa | -0.56 |
| PPP1R2B | PPP1R2 family member B | -0.56 |
| ADIRF | adipogenesis regulatory factor | -0.56 |
| IGFBP2 | insulin-like growth factor binding protein 2, 36kDa | -0.56 |
| ZNF624 | zinc finger protein 624 | -0.56 |
| STMN2 | stathmin 2 | -0.55 |
| TRPM7 | transient receptor potential cation channel, subfamily M, member 7 | -0.55 |
| RNF126 | ring finger protein 126 | -0.54 |
| ZNF460 | zinc finger protein 460 | -0.54 |
| CRTC1 | CREB regulated transcription coactivator 1 | -0.53 |
| RBM48 | RNA binding motif protein 48 | -0.53 |
| ZNF564 | zinc finger protein 564 | -0.53 |
| ANTXR1 | anthrax toxin receptor 1 | -0.51 |
| MBP | myelin basic protein | -0.51 |
| GID8 | GID complex subunit 8 | -0.51 |
| NEK4 | NIMA-related kinase 4 | -0.51 |
| STMN1 | stathmin 1 | -0.51 |
| IKBKG | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma | -0.5 |
| FAM107B | family with sequence similarity 107, member B | -0.5 |
| AKT1S1 | AKT1 substrate 1 (proline-rich) | -0.5 |
| SSR3 | signal sequence receptor, gamma (translocon-associated protein gamma) | -0.5 |
| AP4B1 | adaptor-related protein complex 4, beta 1 subunit | -0.5 |
| SC5D | sterol-C5-desaturase | -0.5 |
| TSSC4 | tumor suppressing subtransferable candidate 4 | -0.5 |
| GSE1 | Gse1 coiled-coil protein | -0.5 |
| PPP1R14C | protein phosphatase 1, regulatory (inhibitor) subunit 14C | -0.49 |
| ERICH5 | glutamate-rich 5 | -0.48 |
| SLC49A4 | solute carrier family 49 member 4 | -0.48 |
| PLPP6 | phospholipid phosphatase 6 | -0.47 |
| PI4KA | phosphatidylinositol 4-kinase, catalytic, alpha | -0.47 |
| GLCCI1 | glucocorticoid induced 1 | -0.47 |
| RNF7 | ring finger protein 7 | -0.47 |
| NFXL1 | nuclear transcription factor, X-box binding-like 1 | -0.47 |
| AGPAT1 | 1-acylglycerol-3-phosphate O-acyltransferase 1 | -0.47 |
| SS18 | synovial sarcoma translocation, chromosome 18 | -0.47 |
| OMA1 | OMA1 zinc metallopeptidase | -0.46 |
| ASXL2 | additional sex combs like transcriptional regulator 2 | -0.46 |
| PSAP | prosaposin | -0.46 |
| MYL9 | myosin, light chain 9, regulatory | -0.45 |
| LRRC7 | leucine rich repeat containing 7 | -0.45 |
| RUNDC1 | RUN domain containing 1 | -0.45 |
| ZYX | zyxin | -0.45 |
| PLA2G6 | phospholipase A2, group VI (cytosolic, calcium-independent) | -0.45 |
| FSIP2 | fibrous sheath interacting protein 2 | -0.44 |
| SRSF7 | serine/arginine-rich splicing factor 7 | -0.44 |
| NF1 | neurofibromin 1 | -0.44 |
| INAVA | innate immunity activator | -0.44 |
| GATC | glutamyl-tRNA(Gln) amidotransferase, subunit C | -0.44 |
| GTF2H2 | general transcription factor IIH, polypeptide 2, 44kDa | -0.43 |
| FAM219B | family with sequence similarity 219, member B | -0.43 |
| FAM53C | family with sequence similarity 53, member C | -0.43 |
| FBRSL1 | fibrosin-like 1 | -0.43 |
| MYCBP | MYC binding protein | -0.43 |
| NET1 | neuroepithelial cell transforming 1 | -0.43 |
| SSNA1 | Sjogren syndrome nuclear autoantigen 1 | -0.43 |
| LYSMD2 | LysM, putative peptidoglycan-binding, domain containing 2 | -0.42 |
| LSM1 | LSM1, U6 small nuclear RNA associated | -0.42 |
| EPB41L1 | erythrocyte membrane protein band 4.1-like 1 | -0.42 |
| ANKRD26 | ankyrin repeat domain 26 | -0.41 |
| SLC10A4 | solute carrier family 10, member 4 | -0.41 |
| TANK | TRAF family member-associated NFKB activator | -0.41 |
| CIAO2B | cytosolic iron-sulfur assembly component 2B | -0.4 |
| PTMS | parathymosin | -0.4 |
| CRCP | CGRP receptor component | -0.4 |
| GLA | galactosidase, alpha | -0.4 |
| PPHLN1 | periphilin 1 | -0.4 |
| ZNF771 | zinc finger protein 771 | -0.4 |
| NEURL4 | neuralized E3 ubiquitin protein ligase 4 | -0.4 |
