Bleomycin Gene Set

Dataset CTD Gene-Chemical Interactions
Category physical interactions
Type chemical
Description A glycopeptide antibiotic produced by the bacterium Streptomyces verticillus. The term, 'bleomycin' refers to a family of structurally related compounds. When used as an anti-cancer agent, the chemotherapeutical forms are primarily bleomycin A2 and B2. (Chemical Entities of Biological Interest Ontology, CHEBI_22907)
External Link http://ctdbase.org/detail.go?type=chem&acc=D001761
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Genes

72 genes/proteins interacting with the chemical Bleomycin from the curated CTD Gene-Chemical Interactions dataset.

Symbol Name
ACTA2 actin, alpha 2, smooth muscle, aorta
ADAM17 ADAM metallopeptidase domain 17
AKT1 v-akt murine thymoma viral oncogene homolog 1
ATM ATM serine/threonine kinase
BAX BCL2-associated X protein
BCL2 B-cell CLL/lymphoma 2
BIRC2 baculoviral IAP repeat containing 2
BLMH bleomycin hydrolase
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP9 caspase 9, apoptosis-related cysteine peptidase
CAT catalase
CCL11 chemokine (C-C motif) ligand 11
CCL2 chemokine (C-C motif) ligand 2
CCR2 chemokine (C-C motif) receptor 2
CCR3 chemokine (C-C motif) receptor 3
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CHEK2 checkpoint kinase 2
COL1A1 collagen, type I, alpha 1
CP ceruloplasmin (ferroxidase)
CSF2 colony stimulating factor 2 (granulocyte-macrophage)
CTGF connective tissue growth factor
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL8 chemokine (C-X-C motif) ligand 8
CYCS cytochrome c, somatic
DNMT1 DNA (cytosine-5-)-methyltransferase 1
F2RL1 coagulation factor II (thrombin) receptor-like 1
FOS FBJ murine osteosarcoma viral oncogene homolog
GCLC glutamate-cysteine ligase, catalytic subunit
GSK3B glycogen synthase kinase 3 beta
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HMOX1 heme oxygenase 1
IL12B interleukin 12B
IL13 interleukin 13
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL4 interleukin 4
IL6 interleukin 6
JUN jun proto-oncogene
KRAS Kirsten rat sarcoma viral oncogene homolog
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
MECP2 methyl CpG binding protein 2
MERTK MER proto-oncogene, tyrosine kinase
MMP1 matrix metallopeptidase 1
MMP2 matrix metallopeptidase 2
MMP9 matrix metallopeptidase 9
MPO myeloperoxidase
MYC v-myc avian myelocytomatosis viral oncogene homolog
NFE2L2 nuclear factor, erythroid 2-like 2
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NOS2 nitric oxide synthase 2, inducible
PARP1 poly (ADP-ribose) polymerase 1
PPARA peroxisome proliferator-activated receptor alpha
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SFTPA1 surfactant protein A1
SFTPA2 surfactant protein A2
SFTPD surfactant protein D
SMC1A structural maintenance of chromosomes 1A
SOD1 superoxide dismutase 1, soluble
SOD2 superoxide dismutase 2, mitochondrial
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
TERT telomerase reverse transcriptase
TGFB1 transforming growth factor, beta 1
TNF tumor necrosis factor
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B
TP53 tumor protein p53
TRAF2 TNF receptor-associated factor 2
TRIM28 tripartite motif containing 28
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)