Blepharitis Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores 2025
Category disease or phenotype associations
Type disease
Description An eyelid disease that is characterized by often chronic inflammation of the eyelid, generally the part where eyelashes grow. (Human Disease Ontology, DOID_9423)
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Genes

204 genes co-occuring with the disease Blepharitis in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.

Symbol Name Standardized Value
LACRT lacritin 2.599
LTF lactotransferrin 2.178
IL4 interleukin 4 2.148
LCN1 lipocalin 1 2.139
MMP9 matrix metallopeptidase 9 2.127
CD4 CD4 molecule 2.1
IL13 interleukin 13 2.095
IL1B interleukin 1, beta 2.004
TNF tumor necrosis factor 1.987
IL6 interleukin 6 1.982
IFNG interferon, gamma 1.969
IL17A interleukin 17A 1.963
MUC5AC mucin 5AC, oligomeric mucus/gel-forming 1.959
CXCL8 chemokine (C-X-C motif) ligand 8 1.849
CD8A CD8a molecule 1.84
IL1A interleukin 1, alpha 1.836
IL2 interleukin 2 1.782
NGF nerve growth factor (beta polypeptide) 1.756
IL5 interleukin 5 1.753
PIP prolactin-induced protein 1.711
IL10 interleukin 10 1.699
MUC4 mucin 4, cell surface associated 1.699
CST4 cystatin S 1.683
TAC1 tachykinin, precursor 1 1.627
ICAM1 intercellular adhesion molecule 1 1.606
TLR2 toll-like receptor 2 1.57
ALB albumin 1.557
MUC7 mucin 7, secreted 1.55
TGM1 transglutaminase 1 1.549
IL4R interleukin 4 receptor 1.544
MUC16 mucin 16, cell surface associated 1.543
TGFB1 transforming growth factor, beta 1 1.542
FLG filaggrin 1.527
FLG2 filaggrin family member 2 1.52
PTPRC protein tyrosine phosphatase, receptor type, C 1.485
PLIN2 perilipin 2 1.478
PRR4 proline rich 4 (lacrimal) 1.47
MUC1 mucin 1, cell surface associated 1.459
STIM2 stromal interaction molecule 2 1.456
KRT3 keratin 3, type II 1.455
CAMP cathelicidin antimicrobial peptide 1.454
CCL17 chemokine (C-C motif) ligand 17 1.445
CST1 cystatin SN 1.439
IFNA1 interferon, alpha 1 1.436
IL22 interleukin 22 1.426
AIRE autoimmune regulator 1.406
FN1 fibronectin 1 1.394
ACKR1 atypical chemokine receptor 1 (Duffy blood group) 1.388
FOXP3 forkhead box P3 1.372
SHE Src homology 2 domain containing E 1.371
EGFR epidermal growth factor receptor 1.364
PRR27 proline rich 27 1.357
EGF epidermal growth factor 1.357
KRT20 keratin 20, type I 1.353
MMP1 matrix metallopeptidase 1 1.342
KLK5 kallikrein-related peptidase 5 1.342
LYZL1 lysozyme-like 1 1.34
KRT14 keratin 14, type I 1.34
UROS uroporphyrinogen III synthase 1.339
CRP C-reactive protein, pentraxin-related 1.338
ITGAX integrin, alpha X (complement component 3 receptor 4 subunit) 1.335
TINF2 TERF1 (TRF1)-interacting nuclear factor 2 1.333
CSF2 colony stimulating factor 2 (granulocyte-macrophage) 1.333
MMP3 matrix metallopeptidase 3 1.332
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4 1.331
GYPC glycophorin C (Gerbich blood group) 1.325
MBTPS2 membrane-bound transcription factor peptidase, site 2 1.324
TMSB4X thymosin beta 4, X-linked 1.323
FGF7 fibroblast growth factor 7 1.317
CCL5 chemokine (C-C motif) ligand 5 1.311
ELOVL1 ELOVL fatty acid elongase 1 1.31
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced 1.309
AWAT2 acyl-CoA wax alcohol acyltransferase 2 1.307
NIPBL Nipped-B homolog (Drosophila) 1.304
IL17F interleukin 17F 1.293
SCGB2A1 secretoglobin, family 2A, member 1 1.288
CCL2 chemokine (C-C motif) ligand 2 1.288
GJB6 gap junction protein, beta 6, 30kDa 1.284
IL31 interleukin 31 1.284
MPO myeloperoxidase 1.28
TSLP thymic stromal lymphopoietin 1.279
EDARADD EDAR-associated death domain 1.273
CCL11 chemokine (C-C motif) ligand 11 1.27
KRT7 keratin 7, type II 1.265
IFNA2 interferon, alpha 2 1.264
MMP2 matrix metallopeptidase 2 1.264
TLR4 toll-like receptor 4 1.257
ELOVL3 ELOVL fatty acid elongase 3 1.244
ARPC4 actin related protein 2/3 complex, subunit 4, 20kDa 1.236
STIM1 stromal interaction molecule 1 1.234
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) 1.232
KRT5 keratin 5, type II 1.228
IL33 interleukin 33 1.228
DOCK8 dedicator of cytokinesis 8 1.226
DKC1 dyskeratosis congenita 1, dyskerin 1.219
CXCL10 chemokine (C-X-C motif) ligand 10 1.217
KRT12 keratin 12, type I 1.214
CST5 cystatin D 1.206
MUC15 mucin 15, cell surface associated 1.203
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 1.195
EPPK1 epiplakin 1 1.19
SPINK5 serine peptidase inhibitor, Kazal type 5 1.189
PAX6 paired box 6 1.185
MMP8 matrix metallopeptidase 8 1.183
NOP10 NOP10 ribonucleoprotein 1.18
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 1.18
TLR3 toll-like receptor 3 1.179
IL7 interleukin 7 1.178
INS insulin 1.176
FGF10 fibroblast growth factor 10 1.174
CD274 CD274 molecule 1.173
STAT1 signal transducer and activator of transcription 1, 91kDa 1.17
CTLA4 cytotoxic T-lymphocyte-associated protein 4 1.168
FGF20 fibroblast growth factor 20 1.168
DR1 down-regulator of transcription 1, TBP-binding (negative cofactor 2) 1.163
FGF4 fibroblast growth factor 4 1.163
CST2 cystatin SA 1.162
NHP2 NHP2 ribonucleoprotein 1.161
CCL4 chemokine (C-C motif) ligand 4 1.157
FGF22 fibroblast growth factor 22 1.157
FGF16 fibroblast growth factor 16 1.155
FGF6 fibroblast growth factor 6 1.155
CCL3 chemokine (C-C motif) ligand 3 1.153
IL17RE interleukin 17 receptor E 1.152
FGF17 fibroblast growth factor 17 1.15
FGF8 fibroblast growth factor 8 (androgen-induced) 1.148
MYOC myocilin, trabecular meshwork inducible glucocorticoid response 1.147
FGF5 fibroblast growth factor 5 1.147
FGF18 fibroblast growth factor 18 1.147
PPL periplakin 1.144
IL17RA interleukin 17 receptor A 1.142
FGF3 fibroblast growth factor 3 1.141
AZGP1 alpha-2-glycoprotein 1, zinc-binding 1.138
FGF9 fibroblast growth factor 9 1.137
RBP3 retinol binding protein 3, interstitial 1.135
MUC20 mucin 20, cell surface associated 1.135
AQP5 aquaporin 5 1.133
IL17RC interleukin 17 receptor C 1.133
KRT1 keratin 1, type II 1.132
CYP4F22 cytochrome P450, family 4, subfamily F, polypeptide 22 1.132
PRTN3 proteinase 3 1.123
TRAF3IP2 TRAF3 interacting protein 2 1.123
ALS2CL ALS2 C-terminal like 1.122
OPRPN opiorphin prepropeptide 1.12
CXCL9 chemokine (C-X-C motif) ligand 9 1.118
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 1.112
MUC13 mucin 13, cell surface associated 1.109
MYD88 myeloid differentiation primary response 88 1.101
LYZ lysozyme 1.097
NECTIN1 nectin cell adhesion molecule 1 1.095
ORAI2 ORAI calcium release-activated calcium modulator 2 1.095
GAPDH glyceraldehyde-3-phosphate dehydrogenase 1.094
KRT79 keratin 79, type II 1.092
CA6 carbonic anhydrase VI 1.091
IL18 interleukin 18 1.09
CYP27C1 cytochrome P450, family 27, subfamily C, polypeptide 1 1.09
IL9 interleukin 9 1.086
TLR9 toll-like receptor 9 1.085
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 1.084
EDAR ectodysplasin A receptor 1.082
ACE angiotensin I converting enzyme 1.074
VMO1 vitelline membrane outer layer 1 homolog (chicken) 1.073
VIP vasoactive intestinal peptide 1.072
PPIA peptidylprolyl isomerase A (cyclophilin A) 1.07
SDC1 syndecan 1 1.066
KRT6A keratin 6A, type II 1.061
EDA ectodysplasin A 1.059
WRAP53 WD repeat containing, antisense to TP53 1.059
CCR7 chemokine (C-C motif) receptor 7 1.058
PTGER4 prostaglandin E receptor 4 (subtype EP4) 1.057
IFNB1 interferon, beta 1, fibroblast 1.056
TACR1 tachykinin receptor 1 1.054
KRT6B keratin 6B, type II 1.054
CSF3 colony stimulating factor 3 (granulocyte) 1.054
GPT glutamic-pyruvate transaminase (alanine aminotransferase) 1.053
PRG4 proteoglycan 4 1.05
CCL24 chemokine (C-C motif) ligand 24 1.047
CD40 CD40 molecule, TNF receptor superfamily member 5 1.041
NIPAL4 NIPA-like domain containing 4 1.04
ZG16B zymogen granule protein 16B 1.036
MUC2 mucin 2, oligomeric mucus/gel-forming 1.03
LTA lymphotoxin alpha 1.028
PXDN peroxidasin 1.028
MUC5B mucin 5B, oligomeric mucus/gel-forming 1.028
CD86 CD86 molecule 1.028
ST14 suppression of tumorigenicity 14 (colon carcinoma) 1.027
KRT16 keratin 16, type I 1.027
ZMIZ2 zinc finger, MIZ-type containing 2 1.024
HEYL hes-related family bHLH transcription factor with YRPW motif-like 1.024
RTEL1 regulator of telomere elongation helicase 1 1.023
ARHGEF19 Rho guanine nucleotide exchange factor (GEF) 19 1.022
CD34 CD34 molecule 1.02
PXDNL peroxidasin-like 1.018
GJB2 gap junction protein, beta 2, 26kDa 1.015
SPDEF SAM pointed domain containing ETS transcription factor 1.014
TNFRSF14 tumor necrosis factor receptor superfamily, member 14 1.013
HMGB1 high mobility group box 1 1.013
IL3 interleukin 3 1.012
ELANE elastase, neutrophil expressed 1.012
S100A9 S100 calcium binding protein A9 1.011
BPIFA2 BPI fold containing family A, member 2 1.011
CD80 CD80 molecule 1.01
CD44 CD44 molecule (Indian blood group) 1.004
MUC19 mucin 19, oligomeric 1.0