Bone Destruction Gene Set

Dataset DisGeNET Gene-Disease Associations
Category disease or phenotype associations
Type disease
External Link https://www.disgenet.org/browser/0/1/0/C0238790
Similar Terms
Downloads & Tools

Genes

218 genes associated with the disease Bone Destruction in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.

Symbol Name
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
ADAM17 ADAM metallopeptidase domain 17
ADAM8 ADAM metallopeptidase domain 8
ADK adenosine kinase
AHR aryl hydrocarbon receptor
AHSA1 AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast)
AIMP2 aminoacyl tRNA synthetase complex-interacting multifunctional protein 2
ANGPTL4 angiopoietin-like 4
ASCC2 activating signal cointegrator 1 complex subunit 2
ASF1A anti-silencing function 1A histone chaperone
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila)
ATL3 atlastin GTPase 3
B2M beta-2-microglobulin
BACH1 BTB and CNC homology 1, basic leucine zipper transcription factor 1
BDNF brain-derived neurotrophic factor
BMP6 bone morphogenetic protein 6
BMPR1A bone morphogenetic protein receptor, type IA
BSG basigin (Ok blood group)
BTK Bruton agammaglobulinemia tyrosine kinase
CALCA calcitonin-related polypeptide alpha
CALD1 caldesmon 1
CCL19 chemokine (C-C motif) ligand 19
CCL2 chemokine (C-C motif) ligand 2
CCL21 chemokine (C-C motif) ligand 21
CCL3 chemokine (C-C motif) ligand 3
CCN1 cellular communication network factor 1
CCR7 chemokine (C-C motif) receptor 7
CD46 CD46 molecule, complement regulatory protein
CD80 CD80 molecule
CD9 CD9 molecule
CDKN2A cyclin-dependent kinase inhibitor 2A
CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHP1 calcineurin-like EF-hand protein 1
CLEC7A C-type lectin domain family 7, member A
CNR2 cannabinoid receptor 2 (macrophage)
COMMD1 copper metabolism (Murr1) domain containing 1
COX2
CREBRF CREB3 regulatory factor
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CRMP1 collapsin response mediator protein 1
CRP C-reactive protein, pentraxin-related
CSF1 colony stimulating factor 1 (macrophage)
CSF1R colony stimulating factor 1 receptor
CSK c-src tyrosine kinase
CTLA4 cytotoxic T-lymphocyte-associated protein 4
CTSK cathepsin K
CUX1 cut-like homeobox 1
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR1 chemokine (C-X-C motif) receptor 1
CXCR4 chemokine (C-X-C motif) receptor 4
DAPK2 death-associated protein kinase 2
DCXR dicarbonyl/L-xylulose reductase
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial
DEF6 differentially expressed in FDCP 6 homolog (mouse)
DENR density-regulated protein
DGKZ diacylglycerol kinase, zeta
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB7 DnaJ (Hsp40) homolog, subfamily B, member 7
DNM1L dynamin 1-like
EDA ectodysplasin A
EPHB2 EPH receptor B2
ESR1 estrogen receptor 1
F9 coagulation factor IX
FAM102A family with sequence similarity 102, member A
FAT1 FAT atypical cadherin 1
FCGR3A Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
FN1 fibronectin 1
FOXP3 forkhead box P3
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GABPA GA binding protein transcription factor, alpha subunit 60kDa
GDE1 glycerophosphodiester phosphodiesterase 1
GFI1 growth factor independent 1 transcription repressor
GLI2 GLI family zinc finger 2
GPI glucose-6-phosphate isomerase
GRAP2 GRB2-related adaptor protein 2
GSK3B glycogen synthase kinase 3 beta
HBZ hemoglobin, zeta
HCK HCK proto-oncogene, Src family tyrosine kinase
HDAC1 histone deacetylase 1
HDAC9 histone deacetylase 9
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HMGB1 high mobility group box 1
HMOX1 heme oxygenase 1
HPSE heparanase
ICOS inducible T-cell co-stimulator
ICOSLG inducible T-cell co-stimulator ligand
IFNG interferon, gamma
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
IL10 interleukin 10
IL11 interleukin 11
IL17A interleukin 17A
IL17B interleukin 17B
IL17D interleukin 17D
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL1F10 interleukin 1 family, member 10 (theta)
IL20 interleukin 20
IL21 interleukin 21
IL22 interleukin 22
IL23A interleukin 23, alpha subunit p19
IL27 interleukin 27
IL3 interleukin 3
IL33 interleukin 33
IL37 interleukin 37
IL4 interleukin 4
IL6 interleukin 6
IL7 interleukin 7
IPP intracisternal A particle-promoted polypeptide
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
KDM4B lysine (K)-specific demethylase 4B
KIF22 kinesin family member 22
LGMN legumain
LOC102723996 ICOS ligand
LOX lysyl oxidase
LRP5 low density lipoprotein receptor-related protein 5
LRP6 low density lipoprotein receptor-related protein 6
MAP3K7 mitogen-activated protein kinase kinase kinase 7
MAPK1 mitogen-activated protein kinase 1
MAPK11 mitogen-activated protein kinase 11
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MAPK8 mitogen-activated protein kinase 8
MET MET proto-oncogene, receptor tyrosine kinase
MIP major intrinsic protein of lens fiber
MMP13 matrix metallopeptidase 13
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MMP3 matrix metallopeptidase 3
MMP7 matrix metallopeptidase 7
MMP9 matrix metallopeptidase 9
MST1R macrophage stimulating 1 receptor
MYDGF myeloid-derived growth factor
MYOM2 myomesin 2
NAMPT nicotinamide phosphoribosyltransferase
NCOA5 nuclear receptor coactivator 5
NDRG2 NDRG family member 2
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NFE2L2 nuclear factor, erythroid 2-like 2
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NLRP12 NLR family, pyrin domain containing 12
NOD1 nucleotide-binding oligomerization domain containing 1
NR2C2 nuclear receptor subfamily 2, group C, member 2
NRP1 neuropilin 1
NRSN1 neurensin 1
NTN1 netrin 1
NTRK1 neurotrophic tyrosine kinase, receptor, type 1
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa
OBP2A odorant binding protein 2A
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7
PECAM1 platelet/endothelial cell adhesion molecule 1
PLD1 phospholipase D1, phosphatidylcholine-specific
PLG plasminogen
PLK1 polo-like kinase 1
PMEL premelanosome protein
PMEPA1 prostate transmembrane protein, androgen induced 1
POLDIP2 polymerase (DNA-directed), delta interacting protein 2
PPARGC1B peroxisome proliferator-activated receptor gamma, coactivator 1 beta
PPIA peptidylprolyl isomerase A (cyclophilin A)
PRDX2 peroxiredoxin 2
PRL prolactin
PTEN phosphatase and tensin homolog
PTH parathyroid hormone
PTHLH parathyroid hormone-like hormone
PTN pleiotrophin
PTPA protein phosphatase 2 phosphatase activator
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
REG1A regenerating islet-derived 1 alpha
RET ret proto-oncogene
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase
RORA RAR-related orphan receptor A
RPS19 ribosomal protein S19
RUNX2 runt-related transcription factor 2
RUNX3 runt-related transcription factor 3
S100A4 S100 calcium binding protein A4
SART3 squamous cell carcinoma antigen recognized by T cells 3
SCO2 SCO2 cytochrome c oxidase assembly protein
SDC1 syndecan 1
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
SH3BP2 SH3-domain binding protein 2
SIRT6 sirtuin 6
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1
SND1 staphylococcal nuclease and tudor domain containing 1
SOCS3 suppressor of cytokine signaling 3
SOST sclerostin
SPP1 secreted phosphoprotein 1
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
SYK spleen tyrosine kinase
TGFB1 transforming growth factor, beta 1
TGFBR1 transforming growth factor, beta receptor 1
TIMP1 TIMP metallopeptidase inhibitor 1
TLR2 toll-like receptor 2
TLR3 toll-like receptor 3
TLR4 toll-like receptor 4
TLR7 toll-like receptor 7
TMED2 transmembrane emp24 domain trafficking protein 2
TNF tumor necrosis factor
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14
TPPP tubulin polymerization promoting protein
TPX2 TPX2, microtubule-associated
TRAF3 TNF receptor-associated factor 3
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TREM2 triggering receptor expressed on myeloid cells 2
TRIM44 tripartite motif containing 44
TWIST1 twist family bHLH transcription factor 1
TYMP thymidine phosphorylase
UTRN utrophin
VEGFA vascular endothelial growth factor A
WIF1 WNT inhibitory factor 1
ZBTB7A zinc finger and BTB domain containing 7A