Bone Resorption Gene Set

Dataset CTD Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description The process in which specialized cells known as osteoclasts degrade the organic and inorganic portions of bone, and endocytose and transport the degradation products. (Gene Ontology, GO_0045453)
External Link http://ctdbase.org/detail.go?type=disease&acc=MESH:D001862
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Genes

237 genes/proteins associated with the disease Bone Resorption from the curated CTD Gene-Disease Associations dataset.

Symbol Name Standardized Value
PTHLH parathyroid hormone-like hormone 2.88009
CXCL2 chemokine (C-X-C motif) ligand 2 2.88009
AHR aryl hydrocarbon receptor 2.88009
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1 2.88009
BMP7 bone morphogenetic protein 7 2.88009
PTH parathyroid hormone 2.88009
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b 2.88009
ICAM1 intercellular adhesion molecule 1 1.80472
IL1B interleukin 1, beta 1.79579
TGFB1 transforming growth factor, beta 1 1.76501
TNF tumor necrosis factor 1.76072
VEGFA vascular endothelial growth factor A 1.73858
CASP3 caspase 3, apoptosis-related cysteine peptidase 1.72467
FAS Fas cell surface death receptor 1.71973
MAPK1 mitogen-activated protein kinase 1 1.68953
IL10 interleukin 10 1.63205
NOS2 nitric oxide synthase 2, inducible 1.61248
CASP9 caspase 9, apoptosis-related cysteine peptidase 1.60291
CCL2 chemokine (C-C motif) ligand 2 1.58654
SPP1 secreted phosphoprotein 1 1.57329
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11 1.56509
TH tyrosine hydroxylase 1.53184
MAPK3 mitogen-activated protein kinase 3 1.52515
SELE selectin E 1.52413
IFNG interferon, gamma 1.51759
AKT1 v-akt murine thymoma viral oncogene homolog 1 1.51305
IL6 interleukin 6 1.51305
FOS FBJ murine osteosarcoma viral oncogene homolog 1.49686
EGFR epidermal growth factor receptor 1.47838
BCL2 B-cell CLL/lymphoma 2 1.47296
BGLAP bone gamma-carboxyglutamate (gla) protein 1.46648
MAPK8 mitogen-activated protein kinase 8 1.46277
CCND1 cyclin D1 1.44817
VCAM1 vascular cell adhesion molecule 1 1.42859
RHOA ras homolog family member A 1.42616
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 1.42266
ACP5 acid phosphatase 5, tartrate resistant 1.41008
BID BH3 interacting domain death agonist 1.39702
MMP9 matrix metallopeptidase 9 1.39086
MAPK14 mitogen-activated protein kinase 14 1.37676
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) 1.37504
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 1.37418
BAG3 BCL2-associated athanogene 3 1.37047
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 1.36476
MMP2 matrix metallopeptidase 2 1.36304
IL4 interleukin 4 1.36304
AIFM1 apoptosis-inducing factor, mitochondrion-associated, 1 1.36133
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide 1.35502
ENC1 ectodermal-neural cortex 1 (with BTB domain) 1.35271
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 1.34459
TIMP1 TIMP metallopeptidase inhibitor 1 1.3382
MCM2 minichromosome maintenance complex component 2 1.33612
FDPS farnesyl diphosphate synthase 1.33405
CAT catalase 1.32935
FSHB follicle stimulating hormone, beta polypeptide 1.32458
NGF nerve growth factor (beta polypeptide) 1.32339
BAX BCL2-associated X protein 1.31985
BCL2L1 BCL2-like 1 1.31897
SOD1 superoxide dismutase 1, soluble 1.31716
CD36 CD36 molecule (thrombospondin receptor) 1.31476
COL1A1 collagen, type I, alpha 1 1.30911
HRAS Harvey rat sarcoma viral oncogene homolog 1.29936
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 1.29348
NFE2L2 nuclear factor, erythroid 2-like 2 1.29041
STAR steroidogenic acute regulatory protein 1.28796
RARA retinoic acid receptor, alpha 1.28364
CYBB cytochrome b-245, beta polypeptide 1.28027
IL1A interleukin 1, alpha 1.27782
CXCL8 chemokine (C-X-C motif) ligand 8 1.27502
CASP8 caspase 8, apoptosis-related cysteine peptidase 1.2707
EDN1 endothelin 1 1.26947
PPARG peroxisome proliferator-activated receptor gamma 1.26483
MAPK9 mitogen-activated protein kinase 9 1.26421
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A 1.25929
CSF2 colony stimulating factor 2 (granulocyte-macrophage) 1.24718
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 1.24687
CXCL3 chemokine (C-X-C motif) ligand 3 1.24528
XBP1 X-box binding protein 1 1.24401
NOS3 nitric oxide synthase 3 (endothelial cell) 1.24307
JUN jun proto-oncogene 1.23042
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 1.22821
TP53 tumor protein p53 1.22599
HMOX1 heme oxygenase 1 1.22501
CTSD cathepsin D 1.22371
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) 1.21855
PARP1 poly (ADP-ribose) polymerase 1 1.21695
GSK3B glycogen synthase kinase 3 beta 1.21567
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit 1.21402
CCDC174 coiled-coil domain containing 174 1.21206
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 1.21076
FST follistatin 1.20946
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha 1.20361
SLC26A2 solute carrier family 26 (anion exchanger), member 2 1.20328
LDLR low density lipoprotein receptor 1.19312
HNF4A hepatocyte nuclear factor 4, alpha 1.19246
CD80 CD80 molecule 1.19246
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 1.18915
SRC SRC proto-oncogene, non-receptor tyrosine kinase 1.18816
CRP C-reactive protein, pentraxin-related 1.18326
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 1.17596
TFIP11 tuftelin interacting protein 11 1.17101
HMGB1 high mobility group box 1 1.16833
CYCS cytochrome c, somatic 1.166
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 1.16467
NPPA natriuretic peptide A 1.16302
BMP2 bone morphogenetic protein 2 1.16104
TFRC transferrin receptor 1.15831
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 1.15729
TP53INP1 tumor protein p53 inducible nuclear protein 1 1.15729
SREBF1 sterol regulatory element binding transcription factor 1 1.15627
LOX lysyl oxidase 1.15357
EGR1 early growth response 1 1.15256
OXTR oxytocin receptor 1.15022
JUND jun D proto-oncogene 1.14781
DUSP1 dual specificity phosphatase 1 1.14713
IL2 interleukin 2 1.14507
CASP2 caspase 2, apoptosis-related cysteine peptidase 1.14438
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 1.13929
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 1.13862
RGS2 regulator of G-protein signaling 2 1.13758
CASP6 caspase 6, apoptosis-related cysteine peptidase 1.13586
MPO myeloperoxidase 1.13484
IGF1 insulin-like growth factor 1 (somatomedin C) 1.13347
NOX1 NADPH oxidase 1 1.13143
SMAD1 SMAD family member 1 1.13143
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 1.13109
CLK1 CDC-like kinase 1 1.13075
PTK2 protein tyrosine kinase 2 1.12906
DDIT3 DNA-damage-inducible transcript 3 1.12703
CHUK conserved helix-loop-helix ubiquitous kinase 1.12426
CCL3 chemokine (C-C motif) ligand 3 1.12185
GADD45B growth arrest and DNA-damage-inducible, beta 1.12082
GCLM glutamate-cysteine ligase, modifier subunit 1.11501
ANGPTL4 angiopoietin-like 4 1.11466
IGF2 insulin-like growth factor 2 1.1129
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 1.1129
SH3BP4 SH3-domain binding protein 4 1.10907
MBTPS1 membrane-bound transcription factor peptidase, site 1 1.10872
IL12B interleukin 12B 1.10803
PSMB5 proteasome (prosome, macropain) subunit, beta type, 5 1.10734
COL3A1 collagen, type III, alpha 1 1.10699
FN1 fibronectin 1 1.10699
ATF3 activating transcription factor 3 1.10699
PPP1R15A protein phosphatase 1, regulatory subunit 15A 1.10665
TICAM1 toll-like receptor adaptor molecule 1 1.10246
NMNAT1 nicotinamide nucleotide adenylyltransferase 1 1.10175
SOD2 superoxide dismutase 2, mitochondrial 1.10104
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor 1.10069
GSR glutathione reductase 1.10033
REL v-rel avian reticuloendotheliosis viral oncogene homolog 1.09927
BDNF brain-derived neurotrophic factor 1.09646
MMP13 matrix metallopeptidase 13 1.09332
INS insulin 1.0919
CXCR4 chemokine (C-X-C motif) receptor 4 1.0919
GPX1 glutathione peroxidase 1 1.09011
ACYP1 acylphosphatase 1, erythrocyte (common) type 1.08975
TRIB3 tribbles pseudokinase 3 1.08762
CTSB cathepsin B 1.08619
SP1 Sp1 transcription factor 1.08442
SOX13 SRY (sex determining region Y)-box 13 1.08372
PRDX3 peroxiredoxin 3 1.08337
ATF4 activating transcription factor 4 1.08301
SNAI1 snail family zinc finger 1 1.08055
FKBP4 FK506 binding protein 4, 59kDa 1.08055
MTA1 metastasis associated 1 1.07768
CD14 CD14 molecule 1.07768
TF transferrin 1.07732
CD44 CD44 molecule (Indian blood group) 1.07625
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 1.07553
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) 1.07553
DDIT4 DNA-damage-inducible transcript 4 1.07482
LEP leptin 1.07376
UCP2 uncoupling protein 2 (mitochondrial, proton carrier) 1.0734
FABP4 fatty acid binding protein 4, adipocyte 1.0734
EFNA1 ephrin-A1 1.07305
GPAM glycerol-3-phosphate acyltransferase, mitochondrial 1.07305
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 1.07093
BCL6 B-cell CLL/lymphoma 6 1.06844
TFAM transcription factor A, mitochondrial 1.06844
FAM214A family with sequence similarity 214, member A 1.06698
PECAM1 platelet/endothelial cell adhesion molecule 1 1.06588
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta 1.06406
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) 1.0637
HK2 hexokinase 2 1.06333
CASP7 caspase 7, apoptosis-related cysteine peptidase 1.06333
RHBDF1 rhomboid 5 homolog 1 (Drosophila) 1.06152
CASP1 caspase 1, apoptosis-related cysteine peptidase 1.06116
MANEA mannosidase, endo-alpha 1.06116
PLAU plasminogen activator, urokinase 1.05864
TSC22D2 TSC22 domain family, member 2 1.05648
EZR ezrin 1.05423
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 1.05312
NMU neuromedin U 1.05126
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 1.05052
SESN2 sestrin 2 1.04941
RAF1 Raf-1 proto-oncogene, serine/threonine kinase 1.04831
PER2 period circadian clock 2 1.04721
SLC30A1 solute carrier family 30 (zinc transporter), member 1 1.04721
GSTO1 glutathione S-transferase omega 1 1.04684
HSPD1 heat shock 60kDa protein 1 (chaperonin) 1.04574
EIF2B4 eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa 1.04574
CSF1 colony stimulating factor 1 (macrophage) 1.04501
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 1.04314
COX1 1.04276
PSAT1 phosphoserine aminotransferase 1 1.04276
THPO thrombopoietin 1.04163
TBK1 TANK-binding kinase 1 1.04163
CCNB1 cyclin B1 1.04163
PPID peptidylprolyl isomerase D 1.04126
SMTN smoothelin 1.04126
JAK1 Janus kinase 1 1.04051
ENO2 enolase 2 (gamma, neuronal) 1.03864
MFN1 mitofusin 1 1.03641
FADD Fas (TNFRSF6)-associated via death domain 1.03419
UBE3B ubiquitin protein ligase E3B 1.03382
KDM5B lysine (K)-specific demethylase 5B 1.03159
ANXA3 annexin A3 1.02971
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 1.02821
CAP2 CAP, adenylate cyclase-associated protein, 2 (yeast) 1.02708
MMP1 matrix metallopeptidase 1 1.02485
CTGF connective tissue growth factor 1.02485
ALB albumin 1.02447
CYP11A1 cytochrome P450, family 11, subfamily A, polypeptide 1 1.0204
ADORA2A adenosine A2a receptor 1.01966
BTG1 B-cell translocation gene 1, anti-proliferative 1.01966
IL18 interleukin 18 1.01928
IL5 interleukin 5 1.01928
MYOF myoferlin 1.0189
SLK STE20-like kinase 1.01852
ATP5G3 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C3 (subunit 9) 1.01814
BAD BCL2-associated agonist of cell death 1.01776
ATF2 activating transcription factor 2 1.01587
TLR4 toll-like receptor 4 1.01587
IRF3 interferon regulatory factor 3 1.01512
STAT1 signal transducer and activator of transcription 1, 91kDa 1.01324
CLU clusterin 1.01099
COX17 COX17 cytochrome c oxidase copper chaperone 1.01025