| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Bortezomib perturbation in A-172 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Bortezomib_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.441302 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.12303 |
| DNAJB1 | DnaJ (Hsp40) homolog, subfamily B, member 1 | 0.0784751 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0670909 |
| HSPA1B | heat shock 70kDa protein 1B | 0.0626266 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0581429 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0575375 |
| BAG3 | BCL2-associated athanogene 3 | 0.0547117 |
| POTEF | POTE ankyrin domain family, member F | 0.0516328 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.050504 |
| CALR | calreticulin | 0.0486983 |
| NDRG1 | N-myc downstream regulated 1 | 0.0483293 |
| HDAC9 | histone deacetylase 9 | 0.0478879 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0469895 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0454721 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0454507 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0351812 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0334391 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0329343 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0328206 |
| MSI2 | musashi RNA-binding protein 2 | 0.0322717 |
| IGFN1 | immunoglobulin-like and fibronectin type III domain containing 1 | 0.031874 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | 0.031451 |
| PSMD14 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | 0.0313397 |
| COPA | coatomer protein complex, subunit alpha | 0.0312123 |
| JUN | jun proto-oncogene | 0.0298852 |
| DLGAP3 | discs, large (Drosophila) homolog-associated protein 3 | 0.0291304 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0290381 |
| MSN | moesin | 0.0288518 |
| EGFR | epidermal growth factor receptor | 0.027825 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0273525 |
| SQSTM1 | sequestosome 1 | 0.0264906 |
| UBC | ubiquitin C | 0.0259224 |
| TPM3 | tropomyosin 3 | 0.0257907 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0256994 |
| ABHD3 | abhydrolase domain containing 3 | 0.0250494 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0249739 |
| UBR3 | ubiquitin protein ligase E3 component n-recognin 3 (putative) | 0.0245446 |
| CDH13 | cadherin 13 | 0.0242506 |
| FLNA | filamin A, alpha | 0.0239179 |
| ERBIN | erbb2 interacting protein | 0.0238974 |
| SEPTIN9 | septin 9 | 0.0238833 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0236118 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0232933 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0229927 |
| VMP1 | vacuole membrane protein 1 | 0.0227693 |
| RAB11FIP3 | RAB11 family interacting protein 3 (class II) | 0.0226723 |
| MCL1 | myeloid cell leukemia 1 | 0.0213446 |
| ZNF207 | zinc finger protein 207 | 0.0212741 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0211594 |
| KIF21A | kinesin family member 21A | 0.0207115 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0204673 |
| PSMD11 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 | 0.0198439 |
| TUSC3 | tumor suppressor candidate 3 | 0.0198308 |
| PEA15 | phosphoprotein enriched in astrocytes 15 | 0.0198234 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0197874 |
| MNT | MAX network transcriptional repressor | 0.0197117 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0195977 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | 0.0194226 |
| SUPT6H | suppressor of Ty 6 homolog (S. cerevisiae) | 0.0194022 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0192596 |
| PCBP2 | poly(rC) binding protein 2 | 0.0191025 |
| RAI1 | retinoic acid induced 1 | 0.0188327 |
| RASAL2 | RAS protein activator like 2 | 0.0186644 |
| RACK1 | receptor for activated C kinase 1 | 0.0185571 |
| PSMD1 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 | 0.018257 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.018226 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0180865 |
| TBCA | tubulin folding cofactor A | 0.0177931 |
| EPS15L1 | epidermal growth factor receptor pathway substrate 15-like 1 | 0.0176166 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0175627 |
| PPARD | peroxisome proliferator-activated receptor delta | 0.0174787 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0172557 |
| FAM219A | family with sequence similarity 219, member A | 0.0172553 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.0169425 |
| NFASC | neurofascin | 0.0168858 |
| FOSL1 | FOS-like antigen 1 | 0.0168808 |
| CACYBP | calcyclin binding protein | 0.0168624 |
| VEGFA | vascular endothelial growth factor A | 0.0166395 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | 0.0163375 |
| UBXN4 | UBX domain protein 4 | 0.0163336 |
| L1CAM | L1 cell adhesion molecule | 0.01628 |
| IARS1 | isoleucyl-tRNA synthetase 1 | 0.016275 |
| FOSL2 | FOS-like antigen 2 | 0.0162627 |
| PFN1 | profilin 1 | 0.0161827 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0160506 |
| GPBP1 | GC-rich promoter binding protein 1 | 0.0155601 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0155344 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.0151376 |
| TGFB1 | transforming growth factor, beta 1 | 0.0151255 |
| LARP4 | La ribonucleoprotein domain family, member 4 | 0.0150421 |
| HIBCH | 3-hydroxyisobutyryl-CoA hydrolase | 0.0149986 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | 0.0148428 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | 0.0148258 |
| RHOBTB3 | Rho-related BTB domain containing 3 | 0.014726 |
| VCP | valosin containing protein | 0.0145392 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0144658 |
| CLIP2 | CAP-GLY domain containing linker protein 2 | 0.0144421 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0144221 |
| WDR43 | WD repeat domain 43 | 0.0143765 |
| Symbol | Name | Standardized Value |
|---|---|---|
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.191369 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.118519 |
| FBN1 | fibrillin 1 | -0.114651 |
| COL3A1 | collagen, type III, alpha 1 | -0.10487 |
| AHNAK | AHNAK nucleoprotein | -0.102264 |
| COL1A2 | collagen, type I, alpha 2 | -0.0972775 |
| FTL | ferritin, light polypeptide | -0.0966458 |
| LOX | lysyl oxidase | -0.090952 |
| THBS2 | thrombospondin 2 | -0.0904118 |
| LOXL2 | lysyl oxidase-like 2 | -0.089626 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0788627 |
| VIM | vimentin | -0.0705396 |
| CD44 | CD44 molecule (Indian blood group) | -0.0678116 |
| COL5A2 | collagen, type V, alpha 2 | -0.0668517 |
| TMSB4X | thymosin beta 4, X-linked | -0.0582816 |
| TMSB10 | thymosin beta 10 | -0.0579922 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0578267 |
| GPC6 | glypican 6 | -0.0576839 |
| PLAT | plasminogen activator, tissue | -0.0567291 |
| ANXA2 | annexin A2 | -0.0514863 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0503102 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0482232 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0479722 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0478602 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0469932 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0450245 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0448598 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0445581 |
| STC1 | stanniocalcin 1 | -0.0442954 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0434499 |
| MX2 | MX dynamin-like GTPase 2 | -0.0432127 |
| PRELID2 | PRELI domain containing 2 | -0.0428506 |
| AUTS2 | autism susceptibility candidate 2 | -0.0427821 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0415346 |
| HLA-B | major histocompatibility complex, class I, B | -0.0410029 |
| NAV1 | neuron navigator 1 | -0.0409022 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.0405139 |
| HSPA6 | heat shock 70kDa protein 6 (HSP70B') | -0.0400098 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0395671 |
| UBB | ubiquitin B | -0.0394023 |
| CTSB | cathepsin B | -0.0391816 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | -0.0390393 |
| KRT16 | keratin 16, type I | -0.0388731 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | -0.0388491 |
| ID1 | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein | -0.0384288 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0376951 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0374647 |
| RIGI | RNA sensor RIG-I | -0.0372535 |
| FLNB | filamin B, beta | -0.0371221 |
| SERPINH1 | serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) | -0.0370489 |
| MEIS2 | Meis homeobox 2 | -0.0367522 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0357741 |
| DPYSL3 | dihydropyrimidinase-like 3 | -0.0350199 |
| SP3 | Sp3 transcription factor | -0.0349818 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | -0.0346076 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0344898 |
| OGA | O-GlcNAcase | -0.0343635 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0342137 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0341731 |
| SAMD9 | sterile alpha motif domain containing 9 | -0.0340935 |
| SMYD3 | SET and MYND domain containing 3 | -0.0339687 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0327156 |
| COL8A1 | collagen, type VIII, alpha 1 | -0.0323619 |
| PRSS23 | protease, serine, 23 | -0.031883 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.0316191 |
| HLA-C | major histocompatibility complex, class I, C | -0.0307032 |
| HLA-E | major histocompatibility complex, class I, E | -0.0305467 |
| APP | amyloid beta (A4) precursor protein | -0.0303167 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0295432 |
| RNF213 | ring finger protein 213 | -0.0293307 |
| SBF2 | SET binding factor 2 | -0.0292832 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0291906 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0291425 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | -0.0290792 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0282481 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0281005 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0274954 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0274897 |
| ARF1 | ADP-ribosylation factor 1 | -0.0273758 |
| DKK3 | dickkopf WNT signaling pathway inhibitor 3 | -0.0272176 |
| ARL4C | ADP-ribosylation factor-like 4C | -0.0270399 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0269448 |
| ATP13A3 | ATPase type 13A3 | -0.0269323 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0269218 |
| TDRD7 | tudor domain containing 7 | -0.0268557 |
| ARHGEF10 | Rho guanine nucleotide exchange factor (GEF) 10 | -0.0267598 |
| NAV2 | neuron navigator 2 | -0.0265529 |
| CAVIN1 | caveolae associated protein 1 | -0.0264715 |
| ZNF217 | zinc finger protein 217 | -0.0262569 |
| CCND1 | cyclin D1 | -0.0259005 |
| MYOF | myoferlin | -0.0258859 |
| COL4A2 | collagen, type IV, alpha 2 | -0.0257881 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0250225 |
| RAI14 | retinoic acid induced 14 | -0.0248563 |
| CACNA2D3 | calcium channel, voltage-dependent, alpha 2/delta subunit 3 | -0.0247561 |
| RRBP1 | ribosome binding protein 1 | -0.0245072 |
| PGK1 | phosphoglycerate kinase 1 | -0.0243919 |
| PXDN | peroxidasin | -0.0243763 |
| GNAS | GNAS complex locus | -0.0241075 |
| FRMD4A | FERM domain containing 4A | -0.0240335 |
