Bortezomib_A-427 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Bortezomib perturbation in A-427 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Bortezomib_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.069668
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0608286
HSPA1A heat shock 70kDa protein 1A 0.0587418
UBC ubiquitin C 0.0384829
HSPB1 heat shock 27kDa protein 1 0.0321135
HSPH1 heat shock 105kDa/110kDa protein 1 0.0295418
RAB7A RAB7A, member RAS oncogene family 0.0277104
HSPA1B heat shock 70kDa protein 1B 0.0254914
HSPA8 heat shock 70kDa protein 8 0.0225687
JMJD1C jumonji domain containing 1C 0.0186548
ATP2C1 ATPase, Ca++ transporting, type 2C, member 1 0.0186
HSPA4 heat shock 70kDa protein 4 0.0164237
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0154558
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0148537
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) 0.0136781
HMGA2 high mobility group AT-hook 2 0.0134402
ARID1B AT rich interactive domain 1B (SWI1-like) 0.013084
FGFR1 fibroblast growth factor receptor 1 0.012809
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0125476
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 0.0119281
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) 0.0119018
EHBP1 EH domain binding protein 1 0.0118206
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0117158
DST dystonin 0.0115089
NEBL nebulette 0.0111373
SLMAP sarcolemma associated protein 0.011019
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0108907
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 0.0107521
JUN jun proto-oncogene 0.010723
STIP1 stress-induced phosphoprotein 1 0.0106939
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0105463
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0104222
MACF1 microtubule-actin crosslinking factor 1 0.010394
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0103841
LPP LIM domain containing preferred translocation partner in lipoma 0.0103509
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 0.0102685
RAB10 RAB10, member RAS oncogene family 0.0100372
AFF4 AF4/FMR2 family, member 4 0.00987544
CSNK1A1 casein kinase 1, alpha 1 0.00984856
ZSWIM6 zinc finger, SWIM-type containing 6 0.00982334
ABHD3 abhydrolase domain containing 3 0.00976203
KCMF1 potassium channel modulatory factor 1 0.00940134
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 0.00914607
ZFAND3 zinc finger, AN1-type domain 3 0.00911031
SPATS2 spermatogenesis associated, serine-rich 2 0.00906464
RASAL2 RAS protein activator like 2 0.00906008
USP14 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) 0.00903946
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.00902629
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.00900643
PSMD1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 0.00898948
TPM3 tropomyosin 3 0.00896756
DENND5A DENN/MADD domain containing 5A 0.00882574
CACYBP calcyclin binding protein 0.0087764
TBCA tubulin folding cofactor A 0.00875689
NPC1 Niemann-Pick disease, type C1 0.0087232
NBAS neuroblastoma amplified sequence 0.00870762
RPTOR regulatory associated protein of MTOR, complex 1 0.00865301
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.00852843
HIBCH 3-hydroxyisobutyryl-CoA hydrolase 0.00851263
LARP4 La ribonucleoprotein domain family, member 4 0.00849226
BAG3 BCL2-associated athanogene 3 0.00844866
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.00842178
INTS6 integrator complex subunit 6 0.00836329
APP amyloid beta (A4) precursor protein 0.00810195
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.00808135
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.00804064
UBR3 ubiquitin protein ligase E3 component n-recognin 3 (putative) 0.00793849
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 0.00792447
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.00789817
NCKAP1 NCK-associated protein 1 0.007864
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.00782742
CANX calnexin 0.00780299
AHSA1 AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast) 0.00773894
ZNF407 zinc finger protein 407 0.00769847
SPAG9 sperm associated antigen 9 0.00756222
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.00742733
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) 0.00736607
ADIPOR2 adiponectin receptor 2 0.00724437
SOD1 superoxide dismutase 1, soluble 0.00721723
RBM19 RNA binding motif protein 19 0.00714414
SLC38A1 solute carrier family 38, member 1 0.00714053
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0071147
TRIO trio Rho guanine nucleotide exchange factor 0.00706172
PHC3 polyhomeotic homolog 3 (Drosophila) 0.00705743
NPLOC4 nuclear protein localization 4 homolog (S. cerevisiae) 0.00702532
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 0.00687196
FXR1 fragile X mental retardation, autosomal homolog 1 0.00681203
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.00679307
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.00674405
SNX13 sorting nexin 13 0.006673
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.00666423
EEF2 eukaryotic translation elongation factor 2 0.00657295
UBE4B ubiquitination factor E4B 0.00653298
SIK3 SIK family kinase 3 0.00643425
COPA coatomer protein complex, subunit alpha 0.00641477
AEBP2 AE binding protein 2 0.00634173
SAMD4A sterile alpha motif domain containing 4A 0.006297
OSBPL1A oxysterol binding protein-like 1A 0.00629199
RPL3 ribosomal protein L3 0.00625777
UBQLN1 ubiquilin 1 0.00623704

decreased expression

Symbol Name Standardized Value
AREG amphiregulin -0.167673
VIM vimentin -0.158902
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.151027
TMSB10 thymosin beta 10 -0.123441
PTMA prothymosin, alpha -0.0391615
MYL12B myosin, light chain 12B, regulatory -0.0387842
SMC4 structural maintenance of chromosomes 4 -0.0385289
RPS6 ribosomal protein S6 -0.032894
PDE4D phosphodiesterase 4D, cAMP-specific -0.0328512
RPLP1 ribosomal protein, large, P1 -0.0314056
CNRIP1 cannabinoid receptor interacting protein 1 -0.0309175
RPS19 ribosomal protein S19 -0.0300755
ACTG1 actin gamma 1 -0.030036
ATP5F1B ATP synthase F1 subunit beta -0.0296801
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0280291
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -0.0277258
PFN1 profilin 1 -0.0273284
ANKRD12 ankyrin repeat domain 12 -0.0264305
RPL35A ribosomal protein L35a -0.0264057
BIRC3 baculoviral IAP repeat containing 3 -0.0263277
RPLP2 ribosomal protein, large, P2 -0.0262908
NLGN1 neuroligin 1 -0.0260329
RPL23 ribosomal protein L23 -0.0246256
RPL19 ribosomal protein L19 -0.0239975
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0234139
RPLP0 ribosomal protein, large, P0 -0.0231971
RPL12 ribosomal protein L12 -0.0227975
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0215302
RPS23 ribosomal protein S23 -0.0213917
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0210958
RPS27A ribosomal protein S27a -0.0210077
EIF1 eukaryotic translation initiation factor 1 -0.0208141
RPS8 ribosomal protein S8 -0.020741
PCDH7 protocadherin 7 -0.0205632
RPS21 ribosomal protein S21 -0.0201883
TUBA1B tubulin, alpha 1b -0.0200898
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0200605
RPL36 ribosomal protein L36 -0.0199206
ZBTB20 zinc finger and BTB domain containing 20 -0.0195346
POTEF POTE ankyrin domain family, member F -0.0194071
RPS29 ribosomal protein S29 -0.019375
RPS16 ribosomal protein S16 -0.0191217
RPL28 ribosomal protein L28 -0.0189244
CUBN cubilin (intrinsic factor-cobalamin receptor) -0.0183785
HMGA1 high mobility group AT-hook 1 -0.0180818
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0180539
LDHB lactate dehydrogenase B -0.0177185
MKI67 marker of proliferation Ki-67 -0.0176951
YBX3 Y box binding protein 3 -0.0175876
DKK1 dickkopf WNT signaling pathway inhibitor 1 -0.0171715
RRM2 ribonucleotide reductase M2 -0.0169596
RPL34 ribosomal protein L34 -0.0166854
RPS14 ribosomal protein S14 -0.0166196
RPL32 ribosomal protein L32 -0.0165705
SLC38A2 solute carrier family 38, member 2 -0.0165124
RPS3 ribosomal protein S3 -0.0164835
RPS15 ribosomal protein S15 -0.0164625
RPL31 ribosomal protein L31 -0.0164161
RPL9 ribosomal protein L9 -0.0161732
RPS13 ribosomal protein S13 -0.0161502
RPS5 ribosomal protein S5 -0.0158902
RPS27 ribosomal protein S27 -0.0158361
CCND1 cyclin D1 -0.0158126
RPS24 ribosomal protein S24 -0.0157662
LDHA lactate dehydrogenase A -0.0155738
RPL8 ribosomal protein L8 -0.0155547
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0151477
RPL11 ribosomal protein L11 -0.0151301
FTL ferritin, light polypeptide -0.0150225
PTMS parathymosin -0.0147016
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0145542
RPL38 ribosomal protein L38 -0.0144338
RPL37A ribosomal protein L37a -0.0143582
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0142428
IFIH1 interferon induced with helicase C domain 1 -0.0140451
DEK DEK proto-oncogene -0.0136933
PGK1 phosphoglycerate kinase 1 -0.0136171
EDN1 endothelin 1 -0.0135631
TMEM41B transmembrane protein 41B -0.0135256
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0133873
NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa -0.0131322
CENPF centromere protein F, 350/400kDa -0.0129443
RPS12 ribosomal protein S12 -0.0127264
CXADR coxsackie virus and adenovirus receptor -0.0126814
S100A9 S100 calcium binding protein A9 -0.0125546
ECT2 epithelial cell transforming 2 -0.0124571
ATP5F1E ATP synthase F1 subunit epsilon -0.0122058
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0121417
CBX3 chromobox homolog 3 -0.0121017
RPL27A ribosomal protein L27a -0.0120391
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0120316
TMEM123 transmembrane protein 123 -0.0118076
CPOX coproporphyrinogen oxidase -0.0117543
RPS20 ribosomal protein S20 -0.0117488
KIF5B kinesin family member 5B -0.011735
HMGB1 high mobility group box 1 -0.0117153
CCDC88A coiled-coil domain containing 88A -0.0116682
RPS25 ribosomal protein S25 -0.0115146
PCBP2 poly(rC) binding protein 2 -0.0114497
GNAS GNAS complex locus -0.0112884