Bortezomib_COLO 205 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Bortezomib perturbation in COLO 205 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Bortezomib_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.154141
HSPH1 heat shock 105kDa/110kDa protein 1 0.0876566
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0571312
GCLC glutamate-cysteine ligase, catalytic subunit 0.0568871
INTS6 integrator complex subunit 6 0.052916
ASPH aspartate beta-hydroxylase 0.0498086
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0495244
DST dystonin 0.0403799
PCDHB16 protocadherin beta 16 0.040156
TXNRD1 thioredoxin reductase 1 0.0392551
ANXA1 annexin A1 0.0337675
UBC ubiquitin C 0.0331175
BTBD9 BTB (POZ) domain containing 9 0.0319289
FAM219A family with sequence similarity 219, member A 0.0314398
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 0.0306472
PSMD1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 0.0299461
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0297202
KIF1B kinesin family member 1B 0.0296644
HSPA8 heat shock 70kDa protein 8 0.0283901
CLIP1 CAP-GLY domain containing linker protein 1 0.0275
SNX29 sorting nexin 29 0.0272463
DLGAP3 discs, large (Drosophila) homolog-associated protein 3 0.0269546
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0267541
UBR3 ubiquitin protein ligase E3 component n-recognin 3 (putative) 0.0267119
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0264798
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 0.0264302
SQSTM1 sequestosome 1 0.0264191
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0259989
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0257469
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.025151
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0250224
ECPAS Ecm29 proteasome adaptor and scaffold 0.0242327
NPLOC4 nuclear protein localization 4 homolog (S. cerevisiae) 0.0241486
LMO7 LIM domain 7 0.023123
ZSWIM6 zinc finger, SWIM-type containing 6 0.0218083
VWA8 von Willebrand factor A domain containing 8 0.0207726
KIF21A kinesin family member 21A 0.0205343
FAF1 Fas (TNFRSF6) associated factor 1 0.0204886
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0201456
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0198554
PCYT1A phosphate cytidylyltransferase 1, choline, alpha 0.0196376
HSPA1B heat shock 70kDa protein 1B 0.0195475
HKDC1 hexokinase domain containing 1 0.0186345
IARS1 isoleucyl-tRNA synthetase 1 0.0177862
PTGES3 prostaglandin E synthase 3 (cytosolic) 0.0173163
VCP valosin containing protein 0.0172806
MAP7 microtubule-associated protein 7 0.0171112
ABHD3 abhydrolase domain containing 3 0.0170602
PSMB7 proteasome (prosome, macropain) subunit, beta type, 7 0.0169544
UBQLN1 ubiquilin 1 0.0167157
LAMA4 laminin, alpha 4 0.016435
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 0.0158655
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0157645
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0155574
SUPT6H suppressor of Ty 6 homolog (S. cerevisiae) 0.0154182
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0151647
RPTOR regulatory associated protein of MTOR, complex 1 0.0149226
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0149193
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 0.014782
CD44 CD44 molecule (Indian blood group) 0.0145205
SLMAP sarcolemma associated protein 0.0145164
GPATCH2L G patch domain containing 2-like 0.0144367
RAD23B RAD23 homolog B (S. cerevisiae) 0.0143147
PHKB phosphorylase kinase, beta 0.0141658
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) 0.0140429
KIAA1671 KIAA1671 0.0139578
TBC1D22A TBC1 domain family, member 22A 0.0139241
PSMD12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 0.0138959
UBL3 ubiquitin-like 3 0.0138864
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4 0.0137975
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 0.0137715
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0135706
ANXA2 annexin A2 0.0133762
SPAG9 sperm associated antigen 9 0.013304
POU2F2 POU class 2 homeobox 2 0.0132766
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 0.0132161
GOLGA3 golgin A3 0.0131866
TAS2R14 taste receptor, type 2, member 14 0.013032
MAST4 microtubule associated serine/threonine kinase family member 4 0.012779
CLTC clathrin, heavy chain (Hc) 0.0126415
NPSR1 neuropeptide S receptor 1 0.0126123
DGKG diacylglycerol kinase, gamma 90kDa 0.0125801
RAB10 RAB10, member RAS oncogene family 0.0125069
GLS2 glutaminase 2 (liver, mitochondrial) 0.012465
RNF6 ring finger protein (C3H2C3 type) 6 0.012432
NFE2L1 nuclear factor, erythroid 2-like 1 0.012204
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 0.0121011
PTGR1 prostaglandin reductase 1 0.0120534
PCCA propionyl CoA carboxylase, alpha polypeptide 0.0120275
BAG3 BCL2-associated athanogene 3 0.0119125
NAA25 N(alpha)-acetyltransferase 25, NatB auxiliary subunit 0.0118865
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.0118428
MED13 mediator complex subunit 13 0.0117202
TUT7 terminal uridylyl transferase 7 0.0116623
RFFL ring finger and FYVE-like domain containing E3 ubiquitin protein ligase 0.0114758
MACF1 microtubule-actin crosslinking factor 1 0.0113936
INO80 INO80 complex subunit 0.0113587
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) 0.0113155
VPS53 vacuolar protein sorting 53 homolog (S. cerevisiae) 0.0113039
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0112794

decreased expression

Symbol Name Standardized Value
B2M beta-2-microglobulin -0.139488
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0590006
EPSTI1 epithelial stromal interaction 1 (breast) -0.0551051
LCN2 lipocalin 2 -0.0517213
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 -0.0481171
C6ORF132 chromosome 6 open reading frame 132 -0.0426695
IFI6 interferon, alpha-inducible protein 6 -0.0421097
RPS6 ribosomal protein S6 -0.0412762
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0373499
RHOBTB3 Rho-related BTB domain containing 3 -0.0371667
HLA-B major histocompatibility complex, class I, B -0.0366503
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.0364522
PTBP3 polypyrimidine tract binding protein 3 -0.0362585
TXNIP thioredoxin interacting protein -0.0355118
IFI27 interferon, alpha-inducible protein 27 -0.035434
ZMYND8 zinc finger, MYND-type containing 8 -0.0353236
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0342552
NCKAP5 NCK-associated protein 5 -0.0332191
CCNL1 cyclin L1 -0.0331353
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0324024
MEIS2 Meis homeobox 2 -0.0317847
PTMA prothymosin, alpha -0.0316751
EGR1 early growth response 1 -0.0307623
RPL35A ribosomal protein L35a -0.0304356
RNF213 ring finger protein 213 -0.0293255
PKM pyruvate kinase, muscle -0.0288631
PDIA3 protein disulfide isomerase family A, member 3 -0.028065
RPLP1 ribosomal protein, large, P1 -0.0278564
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0277976
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0271799
LOC102724023 ES1 protein homolog, mitochondrial -0.0266815
RPL23 ribosomal protein L23 -0.0256531
TMSB10 thymosin beta 10 -0.0253082
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0240664
MACC1 metastasis associated in colon cancer 1 -0.023885
MYO1E myosin IE -0.0236377
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0235439
TSC22D1 TSC22 domain family, member 1 -0.0227495
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0224519
ERBIN erbb2 interacting protein -0.0221211
PERP PERP, TP53 apoptosis effector -0.0220289
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0219907
RUNX1 runt-related transcription factor 1 -0.0219338
TRERF1 transcriptional regulating factor 1 -0.0218318
MX1 MX dynamin-like GTPase 1 -0.0216768
DSTN destrin (actin depolymerizing factor) -0.0215867
MT2A metallothionein 2A -0.0215693
STK24 serine/threonine kinase 24 -0.0214245
EIF1 eukaryotic translation initiation factor 1 -0.0211589
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 -0.0205389
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0202475
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0202446
CST3 cystatin C -0.0195874
RPS8 ribosomal protein S8 -0.0194148
MX2 MX dynamin-like GTPase 2 -0.0192868
NDRG1 N-myc downstream regulated 1 -0.0190557
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.01868
GCC2 GRIP and coiled-coil domain containing 2 -0.0186564
RNF43 ring finger protein 43 -0.0183776
IFNGR1 interferon gamma receptor 1 -0.0183132
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0180654
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) -0.0177567
RPS19 ribosomal protein S19 -0.0177258
ITGA6 integrin, alpha 6 -0.0175894
BPTF bromodomain PHD finger transcription factor -0.0174534
LIMA1 LIM domain and actin binding 1 -0.0173818
RPL31 ribosomal protein L31 -0.0172875
IRF1 interferon regulatory factor 1 -0.0172448
RPS27 ribosomal protein S27 -0.0172034
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 -0.0171852
CSTB cystatin B (stefin B) -0.0171733
IFITM3 interferon induced transmembrane protein 3 -0.017129
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) -0.017103
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0170058
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 -0.0168659
KMT2E lysine (K)-specific methyltransferase 2E -0.0167048
PRRC2C proline-rich coiled-coil 2C -0.0165579
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0164986
AHI1 Abelson helper integration site 1 -0.0164891
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0164652
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0164004
RRBP1 ribosome binding protein 1 -0.016388
TPI1 triosephosphate isomerase 1 -0.0163679
HLA-A major histocompatibility complex, class I, A -0.0162623
PRKCA protein kinase C, alpha -0.0162011
RPLP2 ribosomal protein, large, P2 -0.0161677
EPS8 epidermal growth factor receptor pathway substrate 8 -0.016164
EGLN3 egl-9 family hypoxia-inducible factor 3 -0.0161273
CD46 CD46 molecule, complement regulatory protein -0.0161187
LDHA lactate dehydrogenase A -0.0160778
RPS3 ribosomal protein S3 -0.0159708
FOXP1 forkhead box P1 -0.0159403
FNDC3B fibronectin type III domain containing 3B -0.0158602
RPL19 ribosomal protein L19 -0.0156884
CLDN4 claudin 4 -0.0156747
STS steroid sulfatase (microsomal), isozyme S -0.0156667
SLC38A1 solute carrier family 38, member 1 -0.0156267
RNF149 ring finger protein 149 -0.0155526
GNAS GNAS complex locus -0.0155242
EZR ezrin -0.0155215