| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Bortezomib perturbation in HS-578T cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Bortezomib_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.313778 |
| NDRG1 | N-myc downstream regulated 1 | 0.263928 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.171671 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.127589 |
| HSPA1A | heat shock 70kDa protein 1A | 0.102239 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.094989 |
| MT2A | metallothionein 2A | 0.0851958 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0849054 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0692625 |
| SQSTM1 | sequestosome 1 | 0.0635608 |
| VEGFA | vascular endothelial growth factor A | 0.0633306 |
| CADM1 | cell adhesion molecule 1 | 0.0622988 |
| FTL | ferritin, light polypeptide | 0.0621749 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.05896 |
| B2M | beta-2-microglobulin | 0.0573364 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.0565226 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.05432 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0529803 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0528825 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.051179 |
| HSPA1B | heat shock 70kDa protein 1B | 0.0511176 |
| SLC39A14 | solute carrier family 39 (zinc transporter), member 14 | 0.0483022 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0466964 |
| BAG3 | BCL2-associated athanogene 3 | 0.0445585 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0429749 |
| LDHA | lactate dehydrogenase A | 0.0427285 |
| UBC | ubiquitin C | 0.0382568 |
| CALR | calreticulin | 0.0370575 |
| HLA-A | major histocompatibility complex, class I, A | 0.0359107 |
| KIF1B | kinesin family member 1B | 0.0352595 |
| CYB5R3 | cytochrome b5 reductase 3 | 0.0350908 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0348182 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0343862 |
| ENO1 | enolase 1, (alpha) | 0.0334619 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0329375 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0321897 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0314065 |
| ELOVL5 | ELOVL fatty acid elongase 5 | 0.0313157 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0312868 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0311822 |
| HYOU1 | hypoxia up-regulated 1 | 0.0311108 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 0.0310393 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.0282431 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0281086 |
| PKM | pyruvate kinase, muscle | 0.0279785 |
| MTDH | metadherin | 0.0279611 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0275424 |
| PTK2 | protein tyrosine kinase 2 | 0.0262436 |
| STC2 | stanniocalcin 2 | 0.026221 |
| BRD2 | bromodomain containing 2 | 0.0259769 |
| RACK1 | receptor for activated C kinase 1 | 0.0255764 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0254124 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0253995 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.0251331 |
| EGFR | epidermal growth factor receptor | 0.0247734 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0245232 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0240692 |
| ATF4 | activating transcription factor 4 | 0.0236532 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.02362 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0234276 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0233133 |
| MRTFA | myocardin related transcription factor A | 0.0229434 |
| MSN | moesin | 0.022707 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.022659 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0225706 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0224669 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0221819 |
| AZIN1 | antizyme inhibitor 1 | 0.0218368 |
| DNAJB1 | DnaJ (Hsp40) homolog, subfamily B, member 1 | 0.02162 |
| ARRDC3 | arrestin domain containing 3 | 0.0215707 |
| CCNL1 | cyclin L1 | 0.0215216 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0214742 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | 0.0214291 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0213297 |
| PCBP2 | poly(rC) binding protein 2 | 0.0212879 |
| FOSL1 | FOS-like antigen 1 | 0.0212629 |
| JUN | jun proto-oncogene | 0.0211727 |
| MYO1B | myosin IB | 0.0211222 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0210614 |
| CD44 | CD44 molecule (Indian blood group) | 0.0210022 |
| TRAM1 | translocation associated membrane protein 1 | 0.0209031 |
| ATP2C1 | ATPase, Ca++ transporting, type 2C, member 1 | 0.0208079 |
| SOD1 | superoxide dismutase 1, soluble | 0.0205269 |
| TAPBP | TAP binding protein (tapasin) | 0.0204471 |
| TNKS | tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase | 0.0203912 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0202961 |
| RPS6 | ribosomal protein S6 | 0.0201501 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0200696 |
| VMP1 | vacuole membrane protein 1 | 0.0199237 |
| NLRP1 | NLR family, pyrin domain containing 1 | 0.0199201 |
| DNAJB6 | DnaJ (Hsp40) homolog, subfamily B, member 6 | 0.0197352 |
| CSF1 | colony stimulating factor 1 (macrophage) | 0.019343 |
| MYO10 | myosin X | 0.0188836 |
| RPL23 | ribosomal protein L23 | 0.0188749 |
| PFN1 | profilin 1 | 0.0188474 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0187829 |
| PSMD14 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | 0.0186832 |
| ALKBH5 | AlkB family member 5, RNA demethylase | 0.0184391 |
| FAM219A | family with sequence similarity 219, member A | 0.0183207 |
| BRD4 | bromodomain containing 4 | 0.0178801 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.220861 |
| COL1A1 | collagen, type I, alpha 1 | -0.148941 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.111093 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0792554 |
| HMGA2 | high mobility group AT-hook 2 | -0.0740184 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0705006 |
| VIM | vimentin | -0.0650194 |
| UBB | ubiquitin B | -0.0636505 |
| IER3 | immediate early response 3 | -0.0624603 |
| COL6A3 | collagen, type VI, alpha 3 | -0.056576 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0528032 |
| ATP13A3 | ATPase type 13A3 | -0.0517702 |
| NKAIN3 | Na+/K+ transporting ATPase interacting 3 | -0.0511125 |
| WWTR1 | WW domain containing transcription regulator 1 | -0.0475358 |
| FBN1 | fibrillin 1 | -0.047192 |
| STC1 | stanniocalcin 1 | -0.0467304 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.0406529 |
| HSPA6 | heat shock 70kDa protein 6 (HSP70B') | -0.0405938 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0393602 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0387288 |
| GLIS3 | GLIS family zinc finger 3 | -0.0369671 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0368462 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.036415 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0361439 |
| COL1A2 | collagen, type I, alpha 2 | -0.0349893 |
| CAVIN1 | caveolae associated protein 1 | -0.0344768 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.0343325 |
| TRPS1 | trichorhinophalangeal syndrome I | -0.0338015 |
| CDH13 | cadherin 13 | -0.0331824 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.032956 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0327572 |
| AHNAK | AHNAK nucleoprotein | -0.0322408 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0315639 |
| TPM4 | tropomyosin 4 | -0.0311273 |
| TMSB4X | thymosin beta 4, X-linked | -0.029972 |
| DPYD | dihydropyrimidine dehydrogenase | -0.029368 |
| RRBP1 | ribosome binding protein 1 | -0.0263431 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0259469 |
| VCAN | versican | -0.0259269 |
| ZBTB38 | zinc finger and BTB domain containing 38 | -0.0256225 |
| UGDH | UDP-glucose 6-dehydrogenase | -0.025597 |
| COL3A1 | collagen, type III, alpha 1 | -0.0242198 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0237532 |
| INHBA | inhibin, beta A | -0.0233217 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0231116 |
| TMSB10 | thymosin beta 10 | -0.022521 |
| OSMR | oncostatin M receptor | -0.0221242 |
| LTBP1 | latent transforming growth factor beta binding protein 1 | -0.022065 |
| ASPH | aspartate beta-hydroxylase | -0.0219416 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0217619 |
| PRELID2 | PRELI domain containing 2 | -0.0212954 |
| RASA2 | RAS p21 protein activator 2 | -0.0210598 |
| CLIC4 | chloride intracellular channel 4 | -0.0206434 |
| COPB2 | coatomer protein complex, subunit beta 2 (beta prime) | -0.0199968 |
| ICAM1 | intercellular adhesion molecule 1 | -0.0199296 |
| CRYAB | crystallin, alpha B | -0.0193231 |
| PTMA | prothymosin, alpha | -0.0191957 |
| VCL | vinculin | -0.0191796 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0187447 |
| DUSP6 | dual specificity phosphatase 6 | -0.0186455 |
| ACTG1 | actin gamma 1 | -0.0183257 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0181454 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0180364 |
| BHLHE40 | basic helix-loop-helix family, member e40 | -0.017979 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0179502 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.0178868 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0178412 |
| PXDN | peroxidasin | -0.0174178 |
| DPYSL3 | dihydropyrimidinase-like 3 | -0.0172092 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | -0.0172009 |
| KLF6 | Kruppel-like factor 6 | -0.0168344 |
| IL6ST | interleukin 6 signal transducer | -0.0166663 |
| LOX | lysyl oxidase | -0.016542 |
| MICAL2 | microtubule associated monooxygenase, calponin and LIM domain containing 2 | -0.0165038 |
| NAV1 | neuron navigator 1 | -0.0163071 |
| RPS24 | ribosomal protein S24 | -0.016277 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | -0.016203 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0161582 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | -0.0159317 |
| TUBB6 | tubulin, beta 6 class V | -0.0158697 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0158386 |
| ANKH | ANKH inorganic pyrophosphate transport regulator | -0.0158377 |
| RSU1 | Ras suppressor protein 1 | -0.0155821 |
| THY1 | Thy-1 cell surface antigen | -0.0153134 |
| HYCC1 | hyccin PI4KA lipid kinase complex subunit 1 | -0.0152764 |
| VEGFC | vascular endothelial growth factor C | -0.0152691 |
| ZFPM2 | zinc finger protein, FOG family member 2 | -0.0152685 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.015201 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0151303 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0151285 |
| CALD1 | caldesmon 1 | -0.0150889 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.0150679 |
| RFX8 | RFX family member 8, lacking RFX DNA binding domain | -0.0150352 |
| S100A6 | S100 calcium binding protein A6 | -0.0148177 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0147522 |
| EFNA5 | ephrin-A5 | -0.0146465 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0143949 |
| FBXL7 | F-box and leucine-rich repeat protein 7 | -0.0143936 |
| PIEZO2 | piezo-type mechanosensitive ion channel component 2 | -0.0143012 |
| CLMP | CXADR-like membrane protein | -0.0141109 |
