| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Bortezomib perturbation in HepG2/C3A cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Bortezomib_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| IGF2 | insulin-like growth factor 2 | 0.350409 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.151808 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0949463 |
| ASPH | aspartate beta-hydroxylase | 0.0921174 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0895688 |
| UBC | ubiquitin C | 0.0798644 |
| GCNT2 | glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) | 0.0706527 |
| HSPA1A | heat shock 70kDa protein 1A | 0.0682198 |
| KIF1B | kinesin family member 1B | 0.0611225 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0591247 |
| ABCC2 | ATP-binding cassette, sub-family C (CFTR/MRP), member 2 | 0.0547805 |
| PSMD14 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | 0.0539437 |
| SQSTM1 | sequestosome 1 | 0.0534908 |
| HSPA1B | heat shock 70kDa protein 1B | 0.0522277 |
| ENO1 | enolase 1, (alpha) | 0.0451832 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0449821 |
| CLIP1 | CAP-GLY domain containing linker protein 1 | 0.0448971 |
| UBR3 | ubiquitin protein ligase E3 component n-recognin 3 (putative) | 0.0428536 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0426677 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0425217 |
| SNX29 | sorting nexin 29 | 0.0419366 |
| FAM107B | family with sequence similarity 107, member B | 0.041504 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.0406533 |
| FAM219A | family with sequence similarity 219, member A | 0.0405576 |
| MAP1B | microtubule-associated protein 1B | 0.039832 |
| TUSC3 | tumor suppressor candidate 3 | 0.0391476 |
| ATXN1 | ataxin 1 | 0.0389452 |
| PSMD1 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 | 0.0378114 |
| USP47 | ubiquitin specific peptidase 47 | 0.0358173 |
| NDRG1 | N-myc downstream regulated 1 | 0.0353018 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0339103 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0338887 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0337144 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0334492 |
| DST | dystonin | 0.0327346 |
| KIF21A | kinesin family member 21A | 0.032255 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0322101 |
| ABAT | 4-aminobutyrate aminotransferase | 0.0310206 |
| SPSB1 | splA/ryanodine receptor domain and SOCS box containing 1 | 0.0306461 |
| KIAA1217 | KIAA1217 | 0.0306339 |
| TXNRD1 | thioredoxin reductase 1 | 0.0296154 |
| JUN | jun proto-oncogene | 0.0290625 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0283818 |
| GK | glycerol kinase | 0.0282742 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0280968 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0277169 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0274561 |
| VCP | valosin containing protein | 0.0272719 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0270216 |
| SLMAP | sarcolemma associated protein | 0.0268813 |
| RPTOR | regulatory associated protein of MTOR, complex 1 | 0.0266011 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0264599 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | 0.025944 |
| GLIS3 | GLIS family zinc finger 3 | 0.0255431 |
| SUPT6H | suppressor of Ty 6 homolog (S. cerevisiae) | 0.0244755 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0244577 |
| GPATCH2L | G patch domain containing 2-like | 0.0244159 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0242799 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.0241556 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | 0.0239566 |
| RUNX1 | runt-related transcription factor 1 | 0.023898 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0234552 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0232474 |
| HMGA1 | high mobility group AT-hook 1 | 0.022817 |
| UBE4B | ubiquitination factor E4B | 0.022636 |
| STC2 | stanniocalcin 2 | 0.0226284 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0224129 |
| ABCB1 | ATP-binding cassette, sub-family B (MDR/TAP), member 1 | 0.022345 |
| TNKS | tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase | 0.0221136 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0219879 |
| BMERB1 | bMERB domain containing 1 | 0.0218986 |
| UBQLN1 | ubiquilin 1 | 0.0218961 |
| PSMD12 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 | 0.0217574 |
| KYNU | kynureninase | 0.0217074 |
| TBCA | tubulin folding cofactor A | 0.0214138 |
| ABHD3 | abhydrolase domain containing 3 | 0.021368 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0212603 |
| ALS2 | amyotrophic lateral sclerosis 2 (juvenile) | 0.0212422 |
| KLC1 | kinesin light chain 1 | 0.0211139 |
| CMIP | c-Maf inducing protein | 0.0210378 |
| STK17A | serine/threonine kinase 17a | 0.0209961 |
| AP1G1 | adaptor-related protein complex 1, gamma 1 subunit | 0.0208776 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | 0.0207673 |
| TNS1 | tensin 1 | 0.0206348 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | 0.0205958 |
| ARID5B | AT rich interactive domain 5B (MRF1-like) | 0.0205002 |
| SON | SON DNA binding protein | 0.0204946 |
| WNK1 | WNK lysine deficient protein kinase 1 | 0.0203757 |
| PHTF1 | putative homeodomain transcription factor 1 | 0.0202104 |
| TPM4 | tropomyosin 4 | 0.0202053 |
| IARS1 | isoleucyl-tRNA synthetase 1 | 0.0201932 |
| ECPAS | Ecm29 proteasome adaptor and scaffold | 0.0201847 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | 0.0199065 |
| PPP4R3B | protein phosphatase 4 regulatory subunit 3B | 0.0198101 |
| CLTC | clathrin, heavy chain (Hc) | 0.019626 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0194573 |
| CANX | calnexin | 0.0194546 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0193494 |
| ZNF638 | zinc finger protein 638 | 0.0193364 |
| DNAJB1 | DnaJ (Hsp40) homolog, subfamily B, member 1 | 0.0192347 |
| Symbol | Name | Standardized Value |
|---|---|---|
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | -0.263793 |
| APOB | apolipoprotein B | -0.202072 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.137277 |
| C3 | complement component 3 | -0.0931536 |
| FTL | ferritin, light polypeptide | -0.0882447 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0813318 |
| UBB | ubiquitin B | -0.0711181 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.069454 |
| RPL37A | ribosomal protein L37a | -0.0611306 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0589426 |
| GPC6 | glypican 6 | -0.054648 |
| CRYAB | crystallin, alpha B | -0.053104 |
| RPL11 | ribosomal protein L11 | -0.048424 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | -0.0481492 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0469496 |
| CCL20 | chemokine (C-C motif) ligand 20 | -0.0467491 |
| RPS8 | ribosomal protein S8 | -0.0458219 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | -0.0448164 |
| TRIM26 | tripartite motif containing 26 | -0.043134 |
| GPC3 | glypican 3 | -0.0427868 |
| RPS6 | ribosomal protein S6 | -0.0410958 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0383847 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | -0.0381762 |
| RPL5 | ribosomal protein L5 | -0.0375727 |
| RPLP0 | ribosomal protein, large, P0 | -0.0368814 |
| HSPA8 | heat shock 70kDa protein 8 | -0.0339174 |
| RPS27A | ribosomal protein S27a | -0.0337326 |
| RPS12 | ribosomal protein S12 | -0.033166 |
| VPS54 | vacuolar protein sorting 54 homolog (S. cerevisiae) | -0.0325978 |
| RPS3 | ribosomal protein S3 | -0.032357 |
| JMJD1C | jumonji domain containing 1C | -0.0320939 |
| A2M | alpha-2-macroglobulin | -0.0312487 |
| LRMDA | leucine rich melanocyte differentiation associated | -0.030447 |
| SDC4 | syndecan 4 | -0.0303498 |
| ABTB3 | ankyrin repeat and BTB domain containing 3 | -0.0302981 |
| RPS17 | ribosomal protein S17 | -0.0296734 |
| DHRS2 | dehydrogenase/reductase (SDR family) member 2 | -0.0292506 |
| ITIH2 | inter-alpha-trypsin inhibitor heavy chain 2 | -0.0291125 |
| HSPA6 | heat shock 70kDa protein 6 (HSP70B') | -0.0290302 |
| MBNL3 | muscleblind-like splicing regulator 3 | -0.028956 |
| MT2A | metallothionein 2A | -0.0289502 |
| RPL13A | ribosomal protein L13a | -0.0286218 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0285313 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | -0.0285154 |
| RPS19 | ribosomal protein S19 | -0.0280963 |
| EML4 | echinoderm microtubule associated protein like 4 | -0.0278885 |
| GOLGA4 | golgin A4 | -0.0270759 |
| RRBP1 | ribosome binding protein 1 | -0.0263238 |
| RPL9 | ribosomal protein L9 | -0.0262377 |
| RPL31 | ribosomal protein L31 | -0.026233 |
| LCN2 | lipocalin 2 | -0.0256794 |
| RPL38 | ribosomal protein L38 | -0.0253382 |
| RPL19 | ribosomal protein L19 | -0.0251196 |
| RPS25 | ribosomal protein S25 | -0.0246499 |
| FBF1 | Fas (TNFRSF6) binding factor 1 | -0.0244007 |
| PEG10 | paternally expressed 10 | -0.0232428 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | -0.0230619 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | -0.0229223 |
| PTBP3 | polypyrimidine tract binding protein 3 | -0.0226432 |
| RPL26 | ribosomal protein L26 | -0.0222907 |
| GPAM | glycerol-3-phosphate acyltransferase, mitochondrial | -0.0222867 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0222573 |
| EPB41L2 | erythrocyte membrane protein band 4.1-like 2 | -0.0221029 |
| RPL12 | ribosomal protein L12 | -0.0220564 |
| RPS13 | ribosomal protein S13 | -0.0220018 |
| SESTD1 | SEC14 and spectrin domains 1 | -0.0219895 |
| MALT1 | MALT1 paracaspase | -0.021878 |
| SLC6A14 | solute carrier family 6 (amino acid transporter), member 14 | -0.0213159 |
| WWC2 | WW and C2 domain containing 2 | -0.0208325 |
| HLF | hepatic leukemia factor | -0.0207224 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0206592 |
| MEF2A | myocyte enhancer factor 2A | -0.0206284 |
| MTUS1 | microtubule associated tumor suppressor 1 | -0.020588 |
| ANKRD10 | ankyrin repeat domain 10 | -0.0205587 |
| NRIP1 | nuclear receptor interacting protein 1 | -0.0205188 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0203326 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -0.0202755 |
| QKI | QKI, KH domain containing, RNA binding | -0.0199352 |
| CEMIP2 | cell migration inducing hyaluronidase 2 | -0.0192057 |
| ITGA1 | integrin, alpha 1 | -0.0190622 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.0190501 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0189291 |
| XPR1 | xenotropic and polytropic retrovirus receptor 1 | -0.018903 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0188932 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | -0.0186864 |
| RPS16 | ribosomal protein S16 | -0.0185037 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0184318 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0184314 |
| CFB | complement factor B | -0.0175932 |
| RPL7 | ribosomal protein L7 | -0.0173715 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0172577 |
| ACYP2 | acylphosphatase 2, muscle type | -0.0171985 |
| PTP4A1 | protein tyrosine phosphatase type IVA, member 1 | -0.0171644 |
| MRTFA | myocardin related transcription factor A | -0.0170911 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | -0.0170899 |
| ARID1B | AT rich interactive domain 1B (SWI1-like) | -0.0170311 |
| IGFBP1 | insulin-like growth factor binding protein 1 | -0.016983 |
| RBM25 | RNA binding motif protein 25 | -0.016898 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0168188 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0166726 |
