Bortezomib_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Bortezomib perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Bortezomib_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.162729
HSPH1 heat shock 105kDa/110kDa protein 1 0.0690181
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0611842
HSPA1A heat shock 70kDa protein 1A 0.0596426
KRT6A keratin 6A, type II 0.056071
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0557936
HSPA8 heat shock 70kDa protein 8 0.0549706
UBC ubiquitin C 0.0515796
SQSTM1 sequestosome 1 0.0340522
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 0.0289448
GRB10 growth factor receptor-bound protein 10 0.0271981
FTH1 ferritin, heavy polypeptide 1 0.0223874
HSPA1B heat shock 70kDa protein 1B 0.0197521
BAG3 BCL2-associated athanogene 3 0.018649
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0170439
STIP1 stress-induced phosphoprotein 1 0.0167305
KIF1B kinesin family member 1B 0.0166539
ECPAS Ecm29 proteasome adaptor and scaffold 0.0165895
EEF2 eukaryotic translation elongation factor 2 0.0162297
TXNRD1 thioredoxin reductase 1 0.0162022
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) 0.0157571
FAM219A family with sequence similarity 219, member A 0.0155094
TRIO trio Rho guanine nucleotide exchange factor 0.015399
EXT1 exostosin glycosyltransferase 1 0.0148079
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.0145532
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0142856
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0138989
UBR3 ubiquitin protein ligase E3 component n-recognin 3 (putative) 0.0138291
PTGES3 prostaglandin E synthase 3 (cytosolic) 0.0137524
LRP1B low density lipoprotein receptor-related protein 1B 0.0134225
UBQLN1 ubiquilin 1 0.0133729
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) 0.0133127
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.013252
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0131173
FXR1 fragile X mental retardation, autosomal homolog 1 0.0128434
PSMD1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 0.0127932
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.0125253
IARS1 isoleucyl-tRNA synthetase 1 0.0121359
SNX29 sorting nexin 29 0.0121024
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0112774
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0112324
RPL3 ribosomal protein L3 0.0107825
SUGT1 SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae) 0.0104317
VCP valosin containing protein 0.0103719
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0103018
ABHD3 abhydrolase domain containing 3 0.0102657
TKT transketolase 0.0102452
CHCHD3 coiled-coil-helix-coiled-coil-helix domain containing 3 0.0100753
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0100752
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.00981565
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.00981106
HSPA4 heat shock 70kDa protein 4 0.00978055
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 0.00965547
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.00954327
RAD23B RAD23 homolog B (S. cerevisiae) 0.00933121
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.00932533
APLP2 amyloid beta (A4) precursor-like protein 2 0.00924963
CAMK2G calcium/calmodulin-dependent protein kinase II gamma 0.00919599
WNK1 WNK lysine deficient protein kinase 1 0.00903658
SKP1 S-phase kinase-associated protein 1 0.00901984
HIBCH 3-hydroxyisobutyryl-CoA hydrolase 0.00896338
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.00889382
TCP1 t-complex 1 0.0088709
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.00883125
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.00882869
KRT17 keratin 17, type I 0.00879751
ELOVL5 ELOVL fatty acid elongase 5 0.00876436
WAPL WAPL cohesin release factor 0.00872932
ANXA1 annexin A1 0.00848167
ATP2C1 ATPase, Ca++ transporting, type 2C, member 1 0.0084746
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 0.0084128
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1) 0.00838364
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.00825334
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2) 0.0082415
SOD1 superoxide dismutase 1, soluble 0.00823224
YBX1 Y box binding protein 1 0.00821798
TXNL1 thioredoxin-like 1 0.00815469
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 0.00813068
LARP4 La ribonucleoprotein domain family, member 4 0.00811552
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.00808816
PAPOLA poly(A) polymerase alpha 0.00801102
ASPH aspartate beta-hydroxylase 0.00798967
AKAP12 A kinase (PRKA) anchor protein 12 0.00797527
RPL37 ribosomal protein L37 0.00796149
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.00791882
GOLGB1 golgin B1 0.00780302
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.00774998
IFRD1 interferon-related developmental regulator 1 0.00774957
SFTPA2 surfactant protein A2 0.00774829
MACF1 microtubule-actin crosslinking factor 1 0.00769779
CCT5 chaperonin containing TCP1, subunit 5 (epsilon) 0.00761807
RPS25 ribosomal protein S25 0.00760858
CCT3 chaperonin containing TCP1, subunit 3 (gamma) 0.00755421
ATP9A ATPase, class II, type 9A 0.00748055
PTGR1 prostaglandin reductase 1 0.00746338
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.00744252
CSPP1 centrosome and spindle pole associated protein 1 0.00738926
RTN3 reticulon 3 0.00737852
GSR glutathione reductase 0.0073214
ICE1 interactor of little elongation complex ELL subunit 1 0.0072638

decreased expression

Symbol Name Standardized Value
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.173789
TIMP3 TIMP metallopeptidase inhibitor 3 -0.14752
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.110284
DPYD dihydropyrimidine dehydrogenase -0.0764533
ITGA6 integrin, alpha 6 -0.0542623
FLNB filamin B, beta -0.0541932
NDRG1 N-myc downstream regulated 1 -0.041896
LMO7 LIM domain 7 -0.0415815
SULF1 sulfatase 1 -0.0397769
CAV1 caveolin 1, caveolae protein, 22kDa -0.037978
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0372565
MEF2A myocyte enhancer factor 2A -0.0367351
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0366763
PSD3 pleckstrin and Sec7 domain containing 3 -0.0363979
PDE4D phosphodiesterase 4D, cAMP-specific -0.0352995
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0343681
AHNAK AHNAK nucleoprotein -0.0328403
CD44 CD44 molecule (Indian blood group) -0.0325048
PDLIM5 PDZ and LIM domain 5 -0.0316071
MECOM MDS1 and EVI1 complex locus -0.0315275
POTEF POTE ankyrin domain family, member F -0.0312229
ANXA2 annexin A2 -0.0295235
TMSB4X thymosin beta 4, X-linked -0.0286934
BCL2L1 BCL2-like 1 -0.0281086
BCAR3 breast cancer anti-estrogen resistance 3 -0.0272332
DOCK5 dedicator of cytokinesis 5 -0.026303
NEK7 NIMA-related kinase 7 -0.0257828
BLCAP bladder cancer associated protein -0.0254395
HSPG2 heparan sulfate proteoglycan 2 -0.0248567
STC1 stanniocalcin 1 -0.0247752
TMSB10 thymosin beta 10 -0.0246382
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0245268
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) -0.0240495
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0240423
PGK1 phosphoglycerate kinase 1 -0.0235925
PLS3 plastin 3 -0.023525
RIN2 Ras and Rab interactor 2 -0.0233114
H1-0 H1.0 linker histone -0.0228606
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0228028
PODXL podocalyxin-like -0.0225609
PTMA prothymosin, alpha -0.022297
MTSS1 metastasis suppressor 1 -0.0218104
LMNA lamin A/C -0.0214273
PRSS23 protease, serine, 23 -0.0214122
EPB41L1 erythrocyte membrane protein band 4.1-like 1 -0.0212772
FOXO1 forkhead box O1 -0.0211719
MYOF myoferlin -0.0207927
MBNL1 muscleblind-like splicing regulator 1 -0.0207714
RBM39 RNA binding motif protein 39 -0.0207485
COL17A1 collagen, type XVII, alpha 1 -0.0205877
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0203696
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) -0.0203484
LAMC2 laminin, gamma 2 -0.020247
RAD51B RAD51 paralog B -0.0200021
ZEB1 zinc finger E-box binding homeobox 1 -0.0199458
PRELID2 PRELI domain containing 2 -0.0198938
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0198181
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 -0.0195296
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0192772
SLCO1B3 solute carrier organic anion transporter family, member 1B3 -0.0188808
TXNIP thioredoxin interacting protein -0.0188398
VCL vinculin -0.0184328
PICALM phosphatidylinositol binding clathrin assembly protein -0.0182095
ZMYND8 zinc finger, MYND-type containing 8 -0.0182042
ABI3BP ABI family, member 3 (NESH) binding protein -0.018094
SMYD3 SET and MYND domain containing 3 -0.0179992
HMGA2 high mobility group AT-hook 2 -0.0175542
ARHGAP29 Rho GTPase activating protein 29 -0.0175015
ENO1 enolase 1, (alpha) -0.0173741
DDAH1 dimethylarginine dimethylaminohydrolase 1 -0.0173501
CD9 CD9 molecule -0.0171385
RABGAP1L RAB GTPase activating protein 1-like -0.0170545
SLC35F3 solute carrier family 35, member F3 -0.0170153
ANO1 anoctamin 1, calcium activated chloride channel -0.0169443
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0167756
ITCH itchy E3 ubiquitin protein ligase -0.0166802
WASF2 WAS protein family, member 2 -0.0165241
IFI16 interferon, gamma-inducible protein 16 -0.0164974
UTRN utrophin -0.0164102
TSC22D1 TSC22 domain family, member 1 -0.016409
GNAS GNAS complex locus -0.0162333
RPS21 ribosomal protein S21 -0.0161178
DPYSL2 dihydropyrimidinase-like 2 -0.0160216
PALLD palladin, cytoskeletal associated protein -0.015919
IGF2 insulin-like growth factor 2 -0.0159069
OXR1 oxidation resistance 1 -0.0158356
SAMD9 sterile alpha motif domain containing 9 -0.0158211
IFI6 interferon, alpha-inducible protein 6 -0.0157086
KMT2E lysine (K)-specific methyltransferase 2E -0.0156179
LUZP1 leucine zipper protein 1 -0.015507
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2 -0.0154752
C4BPB complement component 4 binding protein, beta -0.0149523
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0148928
ACTN4 actinin, alpha 4 -0.0145249
OSMR oncostatin M receptor -0.0144906
ITSN1 intersectin 1 (SH3 domain protein) -0.014382
CALU calumenin -0.0143658
THSD4 thrombospondin, type I, domain containing 4 -0.0143271
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0142671
SLC38A2 solute carrier family 38, member 2 -0.0141397