| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Bortezomib perturbation in LS 180 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Bortezomib_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.271412 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | 0.086867 |
| MUC6 | mucin 6, oligomeric mucus/gel-forming | 0.0564216 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.056136 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0525774 |
| PTMA | prothymosin, alpha | 0.0519776 |
| VEGFA | vascular endothelial growth factor A | 0.0508436 |
| ITGA6 | integrin, alpha 6 | 0.0477007 |
| LMO7 | LIM domain 7 | 0.0427048 |
| LDHA | lactate dehydrogenase A | 0.0378886 |
| LGR4 | leucine-rich repeat containing G protein-coupled receptor 4 | 0.0376848 |
| TMSB10 | thymosin beta 10 | 0.0365042 |
| GOLGA4 | golgin A4 | 0.034101 |
| EZR | ezrin | 0.0329299 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | 0.0326362 |
| AFF1 | AF4/FMR2 family, member 1 | 0.0312721 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.030943 |
| MT2A | metallothionein 2A | 0.0303966 |
| POTEF | POTE ankyrin domain family, member F | 0.030362 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0288812 |
| NDRG1 | N-myc downstream regulated 1 | 0.0282427 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0277132 |
| ABHD3 | abhydrolase domain containing 3 | 0.0274235 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0269881 |
| RPS8 | ribosomal protein S8 | 0.0267092 |
| MED13 | mediator complex subunit 13 | 0.0251936 |
| FAT1 | FAT atypical cadherin 1 | 0.0250413 |
| LGALS3 | lectin, galactoside-binding, soluble, 3 | 0.0248236 |
| YBX1 | Y box binding protein 1 | 0.0245542 |
| TXNIP | thioredoxin interacting protein | 0.0245287 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0241906 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0241027 |
| TPM3 | tropomyosin 3 | 0.0233221 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0232875 |
| CALR | calreticulin | 0.0229824 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | 0.0229779 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0228116 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0225565 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0223537 |
| GPBP1 | GC-rich promoter binding protein 1 | 0.0222676 |
| PNN | pinin, desmosome associated protein | 0.0219821 |
| ENO1 | enolase 1, (alpha) | 0.0218784 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 0.0214221 |
| SIK3 | SIK family kinase 3 | 0.0214169 |
| SLMAP | sarcolemma associated protein | 0.0212421 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0211123 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0207944 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0204045 |
| PSMD14 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | 0.0203111 |
| BRD2 | bromodomain containing 2 | 0.0200882 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0199412 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0198524 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0198187 |
| TPI1 | triosephosphate isomerase 1 | 0.0197639 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0193985 |
| CENPF | centromere protein F, 350/400kDa | 0.0193934 |
| CHORDC1 | cysteine and histidine-rich domain (CHORD) containing 1 | 0.0192481 |
| UBE2H | ubiquitin-conjugating enzyme E2H | 0.0189607 |
| MYO5B | myosin VB | 0.0187392 |
| PDZD8 | PDZ domain containing 8 | 0.018727 |
| PELI1 | pellino E3 ubiquitin protein ligase 1 | 0.0186981 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0186587 |
| GAREM1 | GRB2 associated regulator of MAPK1 subtype 1 | 0.0185054 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0183875 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0182297 |
| SOX9 | SRY (sex determining region Y)-box 9 | 0.0179504 |
| LMNA | lamin A/C | 0.0177744 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.0177618 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0177408 |
| PKM | pyruvate kinase, muscle | 0.0175863 |
| TMF1 | TATA element modulatory factor 1 | 0.0175703 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0175361 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0174767 |
| MT1E | metallothionein 1E | 0.0171915 |
| KRT18 | keratin 18, type I | 0.0171425 |
| SREK1IP1 | SREK1-interacting protein 1 | 0.0171214 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.0170006 |
| RPS26 | ribosomal protein S26 | 0.0168551 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | 0.0168374 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0168142 |
| UNC13B | unc-13 homolog B (C. elegans) | 0.0167587 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0166299 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.016571 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0165353 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0164758 |
| EHF | ets homologous factor | 0.0164575 |
| WHRN | whirlin | 0.0164572 |
| ZNF292 | zinc finger protein 292 | 0.0164353 |
| SRRM1 | serine/arginine repetitive matrix 1 | 0.0163785 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0162313 |
| ZFC3H1 | zinc finger, C3H1-type containing | 0.0160687 |
| RBM25 | RNA binding motif protein 25 | 0.0160199 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0158834 |
| PSMA7 | proteasome (prosome, macropain) subunit, alpha type, 7 | 0.0158066 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | 0.0156179 |
| TGFBR3 | transforming growth factor, beta receptor III | 0.0156175 |
| RPL36 | ribosomal protein L36 | 0.0155582 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0153357 |
| PFN1 | profilin 1 | 0.0152558 |
| CLCN3 | chloride channel, voltage-sensitive 3 | 0.0151037 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.134369 |
| VCL | vinculin | -0.128804 |
| NPSR1 | neuropeptide S receptor 1 | -0.107545 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0666168 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.062393 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0621869 |
| GPHN | gephyrin | -0.0537428 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0506304 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0479113 |
| MYO1E | myosin IE | -0.0475217 |
| S100P | S100 calcium binding protein P | -0.0429952 |
| RPL12 | ribosomal protein L12 | -0.0414703 |
| CCSER1 | coiled-coil serine-rich protein 1 | -0.0403416 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0398152 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0392653 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0392589 |
| PALLD | palladin, cytoskeletal associated protein | -0.0391445 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0390476 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0388248 |
| AHNAK | AHNAK nucleoprotein | -0.0383322 |
| ASPH | aspartate beta-hydroxylase | -0.0382502 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0353799 |
| LAMA4 | laminin, alpha 4 | -0.0347722 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | -0.0340422 |
| PIGR | polymeric immunoglobulin receptor | -0.0331506 |
| ONECUT3 | one cut homeobox 3 | -0.0327847 |
| TPM4 | tropomyosin 4 | -0.0312246 |
| SLC35F3 | solute carrier family 35, member F3 | -0.0310464 |
| FHIT | fragile histidine triad | -0.0302899 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.0301982 |
| SMYD3 | SET and MYND domain containing 3 | -0.0301118 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0296511 |
| IER3 | immediate early response 3 | -0.0296403 |
| TNS4 | tensin 4 | -0.0295335 |
| RPS24 | ribosomal protein S24 | -0.0291951 |
| PRSS3 | protease, serine, 3 | -0.0287547 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0280335 |
| GRIN2B | glutamate receptor, ionotropic, N-methyl D-aspartate 2B | -0.0279109 |
| KRT6A | keratin 6A, type II | -0.0277974 |
| ANXA2 | annexin A2 | -0.0262762 |
| FTL | ferritin, light polypeptide | -0.0260483 |
| FLNB | filamin B, beta | -0.026014 |
| UBC | ubiquitin C | -0.0258469 |
| FHL2 | four and a half LIM domains 2 | -0.0256971 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0251541 |
| RPL4 | ribosomal protein L4 | -0.0250945 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0246477 |
| SLC20A2 | solute carrier family 20 (phosphate transporter), member 2 | -0.0243983 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.024142 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.0236756 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0235904 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | -0.0233606 |
| POF1B | premature ovarian failure, 1B | -0.0232625 |
| AHCYL2 | adenosylhomocysteinase-like 2 | -0.0231417 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0220427 |
| CD46 | CD46 molecule, complement regulatory protein | -0.0219064 |
| HSD17B12 | hydroxysteroid (17-beta) dehydrogenase 12 | -0.0217387 |
| SAMD5 | sterile alpha motif domain containing 5 | -0.0216717 |
| NFIA | nuclear factor I/A | -0.0215029 |
| NR4A1 | nuclear receptor subfamily 4, group A, member 1 | -0.0212485 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0211809 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0211785 |
| UBB | ubiquitin B | -0.0209952 |
| FERMT1 | fermitin family member 1 | -0.0209808 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0209238 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | -0.0209082 |
| ARL15 | ADP-ribosylation factor-like 15 | -0.0202371 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0200678 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.020056 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0199208 |
| TUFT1 | tuftelin 1 | -0.0197506 |
| MECOM | MDS1 and EVI1 complex locus | -0.0196707 |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | -0.0195668 |
| TXNRD1 | thioredoxin reductase 1 | -0.0194835 |
| KRT16 | keratin 16, type I | -0.0194777 |
| TBC1D22A | TBC1 domain family, member 22A | -0.0194648 |
| NRXN3 | neurexin 3 | -0.0194378 |
| LARGE1 | LARGE xylosyl- and glucuronyltransferase 1 | -0.0193224 |
| DIAPH2 | diaphanous-related formin 2 | -0.0188603 |
| ANKRD10 | ankyrin repeat domain 10 | -0.018752 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0186237 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.018475 |
| RPL26 | ribosomal protein L26 | -0.0184547 |
| MTAP | methylthioadenosine phosphorylase | -0.0184309 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0183437 |
| OSBPL10 | oxysterol binding protein-like 10 | -0.0183421 |
| SETX | senataxin | -0.0182985 |
| DENND1A | DENN/MADD domain containing 1A | -0.0182545 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.018187 |
| EXOC4 | exocyst complex component 4 | -0.0180652 |
| PKP2 | plakophilin 2 | -0.0180075 |
| LDLR | low density lipoprotein receptor | -0.0179136 |
| RPLP0 | ribosomal protein, large, P0 | -0.0177964 |
| ABR | active BCR-related | -0.0177579 |
| RABGAP1L | RAB GTPase activating protein 1-like | -0.0177378 |
| RNF43 | ring finger protein 43 | -0.0176961 |
| LAMC2 | laminin, gamma 2 | -0.0176429 |
| ACTN4 | actinin, alpha 4 | -0.0175678 |
| EGR1 | early growth response 1 | -0.0175288 |
| RPL13A | ribosomal protein L13a | -0.017413 |
