| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Bortezomib perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Bortezomib_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.358715 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.172583 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.136186 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 0.0978734 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0839247 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0761027 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0752938 |
| FTL | ferritin, light polypeptide | 0.0662738 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0567273 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.0563744 |
| DNAJB1 | DnaJ (Hsp40) homolog, subfamily B, member 1 | 0.0511983 |
| UBC | ubiquitin C | 0.0470263 |
| CANX | calnexin | 0.0436213 |
| EFNA5 | ephrin-A5 | 0.0413562 |
| TMSB4X | thymosin beta 4, X-linked | 0.0373017 |
| APP | amyloid beta (A4) precursor protein | 0.0368031 |
| CADM2 | cell adhesion molecule 2 | 0.0342747 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | 0.0336529 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.0322342 |
| EPHA4 | EPH receptor A4 | 0.0319246 |
| ZDHHC14 | zinc finger, DHHC-type containing 14 | 0.0312012 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0308138 |
| DPYD | dihydropyrimidine dehydrogenase | 0.0290002 |
| BAG3 | BCL2-associated athanogene 3 | 0.0281628 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0277247 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0266922 |
| PTPRF | protein tyrosine phosphatase, receptor type, F | 0.0263964 |
| TFDP2 | transcription factor Dp-2 (E2F dimerization partner 2) | 0.0255976 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0255582 |
| CSMD3 | CUB and Sushi multiple domains 3 | 0.0254658 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0253308 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.025037 |
| RACK1 | receptor for activated C kinase 1 | 0.0245379 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.0244433 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | 0.0233012 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.0231973 |
| UBR3 | ubiquitin protein ligase E3 component n-recognin 3 (putative) | 0.0230176 |
| CFAP299 | cilia and flagella associated protein 299 | 0.0229728 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | 0.0223816 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0222145 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.021192 |
| FMNL2 | formin-like 2 | 0.0210586 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0206177 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0205977 |
| HDLBP | high density lipoprotein binding protein | 0.0196919 |
| ACACA | acetyl-CoA carboxylase alpha | 0.0195533 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.019392 |
| HSPA1A | heat shock 70kDa protein 1A | 0.0193805 |
| GNGT1 | guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 | 0.0192782 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0192461 |
| MYOF | myoferlin | 0.0187502 |
| CLIP1 | CAP-GLY domain containing linker protein 1 | 0.0182805 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | 0.0179115 |
| PLK2 | polo-like kinase 2 | 0.0178037 |
| IARS1 | isoleucyl-tRNA synthetase 1 | 0.0176854 |
| HDAC9 | histone deacetylase 9 | 0.0175247 |
| EPB41 | erythrocyte membrane protein band 4.1 | 0.0174327 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | 0.0174308 |
| UBE3C | ubiquitin protein ligase E3C | 0.0174235 |
| ACAP2 | ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 | 0.0174125 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0172604 |
| ABHD3 | abhydrolase domain containing 3 | 0.0172346 |
| MAP4 | microtubule-associated protein 4 | 0.0171364 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | 0.0169967 |
| HSPB1 | heat shock 27kDa protein 1 | 0.0168995 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0167629 |
| ATP2C1 | ATPase, Ca++ transporting, type 2C, member 1 | 0.0165495 |
| TMEM123 | transmembrane protein 123 | 0.0164384 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0163484 |
| CALR | calreticulin | 0.0162785 |
| OSBPL1A | oxysterol binding protein-like 1A | 0.0162564 |
| TNS3 | tensin 3 | 0.0158593 |
| GYS1 | glycogen synthase 1 (muscle) | 0.0157641 |
| PUS7 | pseudouridylate synthase 7 (putative) | 0.0156817 |
| STIP1 | stress-induced phosphoprotein 1 | 0.0152817 |
| EGFR | epidermal growth factor receptor | 0.0148767 |
| SET | SET nuclear proto-oncogene | 0.0146739 |
| SOD1 | superoxide dismutase 1, soluble | 0.0146174 |
| LRRC49 | leucine rich repeat containing 49 | 0.0144783 |
| SPIRE1 | spire-type actin nucleation factor 1 | 0.0144122 |
| IFRD1 | interferon-related developmental regulator 1 | 0.0143755 |
| DST | dystonin | 0.0143555 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | 0.0141774 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0141656 |
| HSPE1 | heat shock 10kDa protein 1 | 0.0139019 |
| ZKSCAN1 | zinc finger with KRAB and SCAN domains 1 | 0.0137935 |
| TBCA | tubulin folding cofactor A | 0.0137376 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | 0.0137187 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | 0.0136512 |
| CUX1 | cut-like homeobox 1 | 0.0136156 |
| ECPAS | Ecm29 proteasome adaptor and scaffold | 0.0135361 |
| KRT18 | keratin 18, type I | 0.0135177 |
| HIBCH | 3-hydroxyisobutyryl-CoA hydrolase | 0.0134113 |
| LOXL2 | lysyl oxidase-like 2 | 0.0133947 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | 0.0133829 |
| ATXN2 | ataxin 2 | 0.0133062 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0132057 |
| DFFA | DNA fragmentation factor, 45kDa, alpha polypeptide | 0.0132012 |
| UBR2 | ubiquitin protein ligase E3 component n-recognin 2 | 0.0132004 |
| NR2F1 | nuclear receptor subfamily 2, group F, member 1 | 0.0131753 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.255842 |
| MT2A | metallothionein 2A | -0.17564 |
| VIM | vimentin | -0.0942167 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | -0.0860739 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.061418 |
| POTEF | POTE ankyrin domain family, member F | -0.0611731 |
| WWTR1 | WW domain containing transcription regulator 1 | -0.059688 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0586609 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0578164 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | -0.0551943 |
| EGR1 | early growth response 1 | -0.0527277 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0525202 |
| TMSB10 | thymosin beta 10 | -0.0516231 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0515098 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0488135 |
| RTN4 | reticulon 4 | -0.047332 |
| CAPRIN2 | caprin family member 2 | -0.0442313 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0422614 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | -0.040139 |
| MT1E | metallothionein 1E | -0.0387757 |
| TNFRSF6B | tumor necrosis factor receptor superfamily, member 6b, decoy | -0.0387178 |
| EZR | ezrin | -0.0368388 |
| TMEM41B | transmembrane protein 41B | -0.0359076 |
| TXNRD1 | thioredoxin reductase 1 | -0.0358765 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | -0.0342704 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.0326512 |
| MT1X | metallothionein 1X | -0.0326139 |
| LOC112694756 | uncharaterized LOC112694756 | -0.032327 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0312789 |
| BIRC3 | baculoviral IAP repeat containing 3 | -0.030352 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0303242 |
| EMP1 | epithelial membrane protein 1 | -0.0301426 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0298732 |
| SLC20A1 | solute carrier family 20 (phosphate transporter), member 1 | -0.0298538 |
| ERBIN | erbb2 interacting protein | -0.0298184 |
| SPRY4 | sprouty homolog 4 (Drosophila) | -0.0296238 |
| ACTG1 | actin gamma 1 | -0.0292464 |
| HMGA1 | high mobility group AT-hook 1 | -0.0285327 |
| RIGI | RNA sensor RIG-I | -0.0280822 |
| YBX3 | Y box binding protein 3 | -0.0274677 |
| USP12 | ubiquitin specific peptidase 12 | -0.026992 |
| GPAT3 | glycerol-3-phosphate acyltransferase 3 | -0.0269064 |
| FOSL1 | FOS-like antigen 1 | -0.0267767 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0260419 |
| VCL | vinculin | -0.0259584 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | -0.025831 |
| ZBTB38 | zinc finger and BTB domain containing 38 | -0.0256529 |
| ANGPTL4 | angiopoietin-like 4 | -0.0256195 |
| RPS6KA3 | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | -0.0255929 |
| PTP4A2 | protein tyrosine phosphatase type IVA, member 2 | -0.025477 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.025125 |
| SRGN | serglycin | -0.024876 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0247832 |
| SMAD3 | SMAD family member 3 | -0.0245918 |
| FBXO11 | F-box protein 11 | -0.0245036 |
| NT5E | 5'-nucleotidase, ecto (CD73) | -0.0244871 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0243724 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | -0.024162 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | -0.0236549 |
| S100A6 | S100 calcium binding protein A6 | -0.0226438 |
| TOP1 | topoisomerase (DNA) I | -0.0220334 |
| PLSCR1 | phospholipid scramblase 1 | -0.0217996 |
| MKI67 | marker of proliferation Ki-67 | -0.0216164 |
| SHC1 | SHC (Src homology 2 domain containing) transforming protein 1 | -0.0214489 |
| CENPF | centromere protein F, 350/400kDa | -0.0214481 |
| CMIP | c-Maf inducing protein | -0.0213488 |
| ZEB1 | zinc finger E-box binding homeobox 1 | -0.0210794 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | -0.0209297 |
| PLEKHA4 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 | -0.0207803 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | -0.0205987 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0200699 |
| ADAM17 | ADAM metallopeptidase domain 17 | -0.0199203 |
| DNTTIP1 | deoxynucleotidyltransferase, terminal, interacting protein 1 | -0.0197599 |
| TRIP12 | thyroid hormone receptor interactor 12 | -0.0197174 |
| HPCAL1 | hippocalcin-like 1 | -0.0192342 |
| VMP1 | vacuole membrane protein 1 | -0.0191624 |
| CAPN2 | calpain 2, (m/II) large subunit | -0.0189922 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.01879 |
| SERPINB9 | serpin peptidase inhibitor, clade B (ovalbumin), member 9 | -0.0187439 |
| CDCP1 | CUB domain containing protein 1 | -0.0184858 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | -0.0184391 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0182559 |
| BRAF | B-Raf proto-oncogene, serine/threonine kinase | -0.0181365 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | -0.0180587 |
| RPL5 | ribosomal protein L5 | -0.0178726 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0178389 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | -0.0177751 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | -0.017727 |
| ERCC1 | excision repair cross-complementation group 1 | -0.0176663 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | -0.0176548 |
| DSCAM | Down syndrome cell adhesion molecule | -0.0175476 |
| ETNK1 | ethanolamine kinase 1 | -0.0173462 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0172199 |
| YAP1 | Yes-associated protein 1 | -0.0172009 |
| RAB27B | RAB27B, member RAS oncogene family | -0.0171929 |
| RRM2 | ribonucleotide reductase M2 | -0.0171125 |
| PYGB | phosphorylase, glycogen; brain | -0.017096 |
| JMJD1C | jumonji domain containing 1C | -0.016989 |
| HELZ2 | helicase with zinc finger 2, transcriptional coactivator | -0.0169669 |
| MIS18BP1 | MIS18 binding protein 1 | -0.0169611 |
