| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Bortezomib perturbation in NCI-H1573 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Bortezomib_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.415355 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.110583 |
| EGFR | epidermal growth factor receptor | 0.106931 |
| UBC | ubiquitin C | 0.104688 |
| HSPA1A | heat shock 70kDa protein 1A | 0.103332 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0852497 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0816747 |
| ASPH | aspartate beta-hydroxylase | 0.0471063 |
| UBR3 | ubiquitin protein ligase E3 component n-recognin 3 (putative) | 0.0466996 |
| PSMD1 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 | 0.0426515 |
| TBCA | tubulin folding cofactor A | 0.0425217 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0399443 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0373149 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0369672 |
| DST | dystonin | 0.0368868 |
| ABHD3 | abhydrolase domain containing 3 | 0.0355916 |
| TXNRD1 | thioredoxin reductase 1 | 0.0344958 |
| AJAP1 | adherens junctions associated protein 1 | 0.0337577 |
| PSMD14 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | 0.0331041 |
| HSPA1B | heat shock 70kDa protein 1B | 0.0326079 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0318181 |
| PSMD2 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 | 0.0306715 |
| CMIP | c-Maf inducing protein | 0.0302479 |
| STC2 | stanniocalcin 2 | 0.030061 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0295384 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0286211 |
| PCDHB16 | protocadherin beta 16 | 0.0276294 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 0.0269422 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.0267446 |
| SOD1 | superoxide dismutase 1, soluble | 0.0252791 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | 0.0250411 |
| DNAJB1 | DnaJ (Hsp40) homolog, subfamily B, member 1 | 0.024729 |
| ABCC2 | ATP-binding cassette, sub-family C (CFTR/MRP), member 2 | 0.0242627 |
| SQSTM1 | sequestosome 1 | 0.0236625 |
| FLNB | filamin B, beta | 0.0221935 |
| PSMD11 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 | 0.0219436 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0217192 |
| TPM3 | tropomyosin 3 | 0.0217096 |
| RPTOR | regulatory associated protein of MTOR, complex 1 | 0.0213885 |
| HIBCH | 3-hydroxyisobutyryl-CoA hydrolase | 0.0210447 |
| LANCL2 | LanC lantibiotic synthetase component C-like 2 (bacterial) | 0.0208649 |
| EXOC6B | exocyst complex component 6B | 0.0205533 |
| ST13 | suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) | 0.0203767 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | 0.0201464 |
| NAA25 | N(alpha)-acetyltransferase 25, NatB auxiliary subunit | 0.0198064 |
| FTL | ferritin, light polypeptide | 0.0196947 |
| FAM219A | family with sequence similarity 219, member A | 0.0195083 |
| MGST1 | microsomal glutathione S-transferase 1 | 0.0193444 |
| PTK2 | protein tyrosine kinase 2 | 0.0193433 |
| GPATCH2L | G patch domain containing 2-like | 0.0191774 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0187572 |
| VCP | valosin containing protein | 0.0186891 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | 0.0186732 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0186304 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0182993 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0181269 |
| SEM1 | SEM1 26S proteasome subunit | 0.0175793 |
| DLGAP3 | discs, large (Drosophila) homolog-associated protein 3 | 0.0175649 |
| INTS6 | integrator complex subunit 6 | 0.0174816 |
| STIP1 | stress-induced phosphoprotein 1 | 0.0168871 |
| RACK1 | receptor for activated C kinase 1 | 0.0168565 |
| RTN4 | reticulon 4 | 0.0167425 |
| UFD1 | ubiquitin recognition factor in ER associated degradation 1 | 0.0167404 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0167087 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0167038 |
| FOSL1 | FOS-like antigen 1 | 0.0166806 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | 0.0166173 |
| TNKS | tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase | 0.0165625 |
| NPLOC4 | nuclear protein localization 4 homolog (S. cerevisiae) | 0.0165084 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0163818 |
| REXO2 | RNA exonuclease 2 | 0.0163311 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.016309 |
| HSPA4 | heat shock 70kDa protein 4 | 0.0162234 |
| USP14 | ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) | 0.0161427 |
| CREB5 | cAMP responsive element binding protein 5 | 0.0160773 |
| PSMD12 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 | 0.0159092 |
| TAS2R14 | taste receptor, type 2, member 14 | 0.0156896 |
| MAP7 | microtubule-associated protein 7 | 0.0156743 |
| ATP2C1 | ATPase, Ca++ transporting, type 2C, member 1 | 0.0155046 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0154581 |
| DNTTIP2 | deoxynucleotidyltransferase, terminal, interacting protein 2 | 0.0152083 |
| CAMK2G | calcium/calmodulin-dependent protein kinase II gamma | 0.0151982 |
| KIF1B | kinesin family member 1B | 0.0150146 |
| PRDX1 | peroxiredoxin 1 | 0.0149797 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0148597 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.014842 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0148393 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.0147288 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0147252 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0147085 |
| CORO1C | coronin, actin binding protein, 1C | 0.014554 |
| FLNA | filamin A, alpha | 0.014512 |
| PPP2R2C | protein phosphatase 2, regulatory subunit B, gamma | 0.0144952 |
| MSN | moesin | 0.0143128 |
| EGF | epidermal growth factor | 0.0142797 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | 0.0142041 |
| SEPTIN9 | septin 9 | 0.0141318 |
| PHKB | phosphorylase kinase, beta | 0.0140678 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0139475 |
| PSMB7 | proteasome (prosome, macropain) subunit, beta type, 7 | 0.0139346 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.216872 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0959269 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0777213 |
| LMO7 | LIM domain 7 | -0.0585751 |
| NDRG1 | N-myc downstream regulated 1 | -0.0573756 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0540167 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0497538 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0450964 |
| FNDC3B | fibronectin type III domain containing 3B | -0.044486 |
| LRP1B | low density lipoprotein receptor-related protein 1B | -0.0431835 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.0417813 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0383696 |
| DSCAM | Down syndrome cell adhesion molecule | -0.0381301 |
| MCTP1 | multiple C2 domains, transmembrane 1 | -0.0375628 |
| FAM13A | family with sequence similarity 13, member A | -0.0374067 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | -0.0363324 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0357773 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0354821 |
| H1-0 | H1.0 linker histone | -0.0354753 |
| BIRC3 | baculoviral IAP repeat containing 3 | -0.0351942 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0328478 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0326963 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0326589 |
| EFNA5 | ephrin-A5 | -0.0323864 |
| TOP1 | topoisomerase (DNA) I | -0.031475 |
| CPE | carboxypeptidase E | -0.0313972 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -0.0313768 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.030997 |
| MKI67 | marker of proliferation Ki-67 | -0.0309506 |
| LAMC2 | laminin, gamma 2 | -0.0308113 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0304833 |
| TMEM165 | transmembrane protein 165 | -0.0300804 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0300431 |
| SPAG9 | sperm associated antigen 9 | -0.0294546 |
| STC1 | stanniocalcin 1 | -0.0285924 |
| MT2A | metallothionein 2A | -0.0277329 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0275219 |
| OSMR | oncostatin M receptor | -0.0272963 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0271494 |
| CES1 | carboxylesterase 1 | -0.0271037 |
| AGO2 | argonaute RISC catalytic component 2 | -0.0264776 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0263297 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | -0.0261832 |
| TMSB10 | thymosin beta 10 | -0.0261147 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0257987 |
| PTMA | prothymosin, alpha | -0.0255456 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0253647 |
| ARRDC3 | arrestin domain containing 3 | -0.0253386 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | -0.0245755 |
| FRY | furry homolog (Drosophila) | -0.0243257 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0235299 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | -0.0229945 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0224376 |
| LDHA | lactate dehydrogenase A | -0.022124 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0219701 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0216341 |
| OGA | O-GlcNAcase | -0.0214643 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | -0.0213597 |
| CCNL1 | cyclin L1 | -0.0203806 |
| BLZF1 | basic leucine zipper nuclear factor 1 | -0.0203711 |
| WDR45B | WD repeat domain 45B | -0.020339 |
| RNF145 | ring finger protein 145 | -0.0201182 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | -0.0197723 |
| SUCO | SUN domain containing ossification factor | -0.0195106 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0192797 |
| ZNF292 | zinc finger protein 292 | -0.019017 |
| VCL | vinculin | -0.0189724 |
| EGLN3 | egl-9 family hypoxia-inducible factor 3 | -0.0189471 |
| NGLY1 | N-glycanase 1 | -0.018852 |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 | -0.018794 |
| USP34 | ubiquitin specific peptidase 34 | -0.0186341 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0182804 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0181891 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0181811 |
| CAMTA1 | calmodulin binding transcription activator 1 | -0.0180345 |
| UVRAG | UV radiation resistance associated | -0.0179494 |
| PGK1 | phosphoglycerate kinase 1 | -0.0178573 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | -0.0178224 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | -0.0176836 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.0173912 |
| EYA2 | EYA transcriptional coactivator and phosphatase 2 | -0.0173568 |
| MCL1 | myeloid cell leukemia 1 | -0.0172376 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | -0.0172359 |
| JAK1 | Janus kinase 1 | -0.0171394 |
| GOLGA4 | golgin A4 | -0.0171025 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0169033 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | -0.0169021 |
| ARL5B | ADP-ribosylation factor-like 5B | -0.0167788 |
| RUNX1 | runt-related transcription factor 1 | -0.0167472 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0166788 |
| ELF2 | E74-like factor 2 (ets domain transcription factor) | -0.0165572 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | -0.016466 |
| NDE1 | nudE neurodevelopment protein 1 | -0.016275 |
| RBM39 | RNA binding motif protein 39 | -0.0162688 |
| ANXA2 | annexin A2 | -0.0162602 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | -0.0162046 |
| TES | testin LIM domain protein | -0.0161233 |
| KDM2A | lysine (K)-specific demethylase 2A | -0.0160567 |
| REL | v-rel avian reticuloendotheliosis viral oncogene homolog | -0.0160525 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | -0.0159854 |
