Bortezomib_NCI-H1792 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Bortezomib perturbation in NCI-H1792 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Bortezomib_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.196563
CXCL8 chemokine (C-X-C motif) ligand 8 0.190528
GNGT1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 0.0785818
UBC ubiquitin C 0.0717943
DST dystonin 0.0610038
SNX29 sorting nexin 29 0.0537795
HSPA1A heat shock 70kDa protein 1A 0.0535676
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.052878
TUSC3 tumor suppressor candidate 3 0.0526942
MAP1B microtubule-associated protein 1B 0.0519716
UBR3 ubiquitin protein ligase E3 component n-recognin 3 (putative) 0.0509282
EXOC6B exocyst complex component 6B 0.0492133
TXNRD1 thioredoxin reductase 1 0.0470763
CXCL5 chemokine (C-X-C motif) ligand 5 0.0465254
HSPA8 heat shock 70kDa protein 8 0.0456037
SQSTM1 sequestosome 1 0.0448142
KIF1B kinesin family member 1B 0.0439376
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.043694
TRIO trio Rho guanine nucleotide exchange factor 0.0424495
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.038617
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0373093
MACF1 microtubule-actin crosslinking factor 1 0.0358314
KIAA1217 KIAA1217 0.0354051
BICD1 bicaudal D homolog 1 (Drosophila) 0.0344056
AKAP12 A kinase (PRKA) anchor protein 12 0.033331
ABHD3 abhydrolase domain containing 3 0.0323412
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0314593
ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12 0.0298764
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0296657
ZSWIM6 zinc finger, SWIM-type containing 6 0.0295945
MGST1 microsomal glutathione S-transferase 1 0.0292695
PSMD1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 0.0289783
DYNC1I1 dynein, cytoplasmic 1, intermediate chain 1 0.0288756
NIBAN1 niban apoptosis regulator 1 0.0286531
EXOC4 exocyst complex component 4 0.0282485
PCDHB16 protocadherin beta 16 0.028103
KIF21A kinesin family member 21A 0.0280796
MED13 mediator complex subunit 13 0.0277775
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0273126
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0272262
HSPA1B heat shock 70kDa protein 1B 0.0269397
DLGAP3 discs, large (Drosophila) homolog-associated protein 3 0.0263673
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.0263033
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0262206
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 0.0261685
ANXA1 annexin A1 0.0251519
ASPH aspartate beta-hydroxylase 0.025001
RPTOR regulatory associated protein of MTOR, complex 1 0.0248761
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.0248143
NRCAM neuronal cell adhesion molecule 0.0237322
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) 0.0236201
VCP valosin containing protein 0.0233536
KLC1 kinesin light chain 1 0.0231928
RABGAP1L RAB GTPase activating protein 1-like 0.0231606
GPATCH2L G patch domain containing 2-like 0.0227475
FAM219A family with sequence similarity 219, member A 0.0221621
CLIP1 CAP-GLY domain containing linker protein 1 0.0221587
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0217621
PIR pirin (iron-binding nuclear protein) 0.0217619
ZNF804A zinc finger protein 804A 0.0217421
ZEB1 zinc finger E-box binding homeobox 1 0.0214254
UMAD1 UBAP1-MVB12-associated (UMA) domain containing 1 0.0214031
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0210168
AADAC arylacetamide deacetylase 0.0208025
THBD thrombomodulin 0.0204369
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 0.0203548
NPLOC4 nuclear protein localization 4 homolog (S. cerevisiae) 0.0200992
GLIS3 GLIS family zinc finger 3 0.0192081
SLMAP sarcolemma associated protein 0.0191695
LRP1B low density lipoprotein receptor-related protein 1B 0.019082
CDH13 cadherin 13 0.0190211
SLC39A11 solute carrier family 39, member 11 0.0187964
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0185245
NAA25 N(alpha)-acetyltransferase 25, NatB auxiliary subunit 0.018429
SUPT6H suppressor of Ty 6 homolog (S. cerevisiae) 0.018046
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 0.0178753
PAPPA pregnancy-associated plasma protein A, pappalysin 1 0.0178737
USP14 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) 0.017848
BIRC6 baculoviral IAP repeat containing 6 0.017822
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 0.0177483
HECW1 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1 0.0177423
SEPTIN9 septin 9 0.0177402
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0175638
PSMB7 proteasome (prosome, macropain) subunit, beta type, 7 0.0175432
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 0.0172897
NRG1 neuregulin 1 0.0172682
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 0.0172318
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 0.0169481
KCMF1 potassium channel modulatory factor 1 0.0168887
SDK1 sidekick cell adhesion molecule 1 0.0166908
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 0.0166823
SLC44A5 solute carrier family 44, member 5 0.0165297
L3MBTL4 l(3)mbt-like 4 (Drosophila) 0.0163979
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 0.0163018
LARP4B La ribonucleoprotein domain family, member 4B 0.0162286
SOD2 superoxide dismutase 2, mitochondrial 0.0162273
HSPH1 heat shock 105kDa/110kDa protein 1 0.0161784
GCLC glutamate-cysteine ligase, catalytic subunit 0.0160897
TPST1 tyrosylprotein sulfotransferase 1 0.0159555
EHBP1 EH domain binding protein 1 0.015894

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.164009
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.157818
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.126852
TMSB10 thymosin beta 10 -0.123179
NAMPT nicotinamide phosphoribosyltransferase -0.106213
PTMA prothymosin, alpha -0.0750426
MT2A metallothionein 2A -0.0702978
PDE4D phosphodiesterase 4D, cAMP-specific -0.0680469
FTL ferritin, light polypeptide -0.0614176
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0611899
RPLP1 ribosomal protein, large, P1 -0.0577859
GOLGA4 golgin A4 -0.05631
STC1 stanniocalcin 1 -0.0527062
BASP1 brain abundant, membrane attached signal protein 1 -0.0491579
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0483784
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0469545
ELL2 elongation factor, RNA polymerase II, 2 -0.0466824
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0460953
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0460416
FNDC3B fibronectin type III domain containing 3B -0.0454456
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0451847
RPL35A ribosomal protein L35a -0.0445597
RBM39 RNA binding motif protein 39 -0.044404
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.044047
EIF1 eukaryotic translation initiation factor 1 -0.0398733
RPS6 ribosomal protein S6 -0.0395215
RPS19 ribosomal protein S19 -0.0371791
RPS8 ribosomal protein S8 -0.0365217
NDRG1 N-myc downstream regulated 1 -0.0353693
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0351787
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0335884
ZNF292 zinc finger protein 292 -0.0331706
RPL32 ribosomal protein L32 -0.0329106
IER3 immediate early response 3 -0.0327213
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0326245
RPS29 ribosomal protein S29 -0.032221
LMAN1 lectin, mannose-binding, 1 -0.0318344
NCOA7 nuclear receptor coactivator 7 -0.0313438
KDM3A lysine (K)-specific demethylase 3A -0.0306114
RPLP2 ribosomal protein, large, P2 -0.0305709
C15ORF48 chromosome 15 open reading frame 48 -0.0295436
RPL31 ribosomal protein L31 -0.029516
PDIA3 protein disulfide isomerase family A, member 3 -0.0294164
RPL12 ribosomal protein L12 -0.0293066
RPS21 ribosomal protein S21 -0.0292933
RPL23 ribosomal protein L23 -0.0289567
LOX lysyl oxidase -0.0286837
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0285024
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0283816
RPLP0 ribosomal protein, large, P0 -0.0281387
OGA O-GlcNAcase -0.0278907
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0277499
RPL36 ribosomal protein L36 -0.0276179
RPL37A ribosomal protein L37a -0.0275743
S100A6 S100 calcium binding protein A6 -0.027357
RPL34 ribosomal protein L34 -0.027158
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0266866
RPS12 ribosomal protein S12 -0.026632
CD44 CD44 molecule (Indian blood group) -0.0266315
RPS3 ribosomal protein S3 -0.0264604
RPS24 ribosomal protein S24 -0.0261621
UGCG UDP-glucose ceramide glucosyltransferase -0.0251108
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0250604
RPL11 ribosomal protein L11 -0.0248881
RPS13 ribosomal protein S13 -0.0248375
RPL28 ribosomal protein L28 -0.0241866
PARP8 poly (ADP-ribose) polymerase family, member 8 -0.0241214
FAM13A family with sequence similarity 13, member A -0.0239536
YBX3 Y box binding protein 3 -0.0236808
GNAS GNAS complex locus -0.023636
EGR1 early growth response 1 -0.0236326
RPL9 ribosomal protein L9 -0.0230791
SLC38A1 solute carrier family 38, member 1 -0.0230761
RPL5 ribosomal protein L5 -0.0229978
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0227763
HAS2 hyaluronan synthase 2 -0.022759
RAB1A RAB1A, member RAS oncogene family -0.0226712
WDR45B WD repeat domain 45B -0.0224823
RAB27B RAB27B, member RAS oncogene family -0.0222248
EFNA5 ephrin-A5 -0.0222209
TMEM263 transmembrane protein 263 -0.0219941
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0218755
RPS23 ribosomal protein S23 -0.0216995
RPS25 ribosomal protein S25 -0.0215216
WSB1 WD repeat and SOCS box containing 1 -0.0213888
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.021336
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0211067
CLEC1B C-type lectin domain family 1, member B -0.0210472
KDM2A lysine (K)-specific demethylase 2A -0.0210266
LDHA lactate dehydrogenase A -0.0208909
RPL19 ribosomal protein L19 -0.0208584
EDIL3 EGF-like repeats and discoidin I-like domains 3 -0.0208241
FHIP1A FHF complex subunit HOOK interacting protein 1A -0.0207528
IFI16 interferon, gamma-inducible protein 16 -0.0207355
RPS16 ribosomal protein S16 -0.020639
RPS5 ribosomal protein S5 -0.0204504
PTPN14 protein tyrosine phosphatase, non-receptor type 14 -0.0204462
KMT2E lysine (K)-specific methyltransferase 2E -0.020156
CALR calreticulin -0.0199535
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0199237