Bortezomib_NCI-H2030 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Bortezomib perturbation in NCI-H2030 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Bortezomib_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.106621
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0515109
FMNL2 formin-like 2 0.0480707
UBC ubiquitin C 0.0479509
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0468043
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0452877
ZFAND3 zinc finger, AN1-type domain 3 0.0452133
KTN1 kinectin 1 (kinesin receptor) 0.0428097
BIRC6 baculoviral IAP repeat containing 6 0.0424433
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0385378
EEF2 eukaryotic translation elongation factor 2 0.0382218
TRIO trio Rho guanine nucleotide exchange factor 0.0372967
WAC WW domain containing adaptor with coiled-coil 0.0359541
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0351079
SPAG9 sperm associated antigen 9 0.0339788
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0337276
MACF1 microtubule-actin crosslinking factor 1 0.0329813
TPM3 tropomyosin 3 0.031686
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0313581
HSPA1B heat shock 70kDa protein 1B 0.0313436
UBR3 ubiquitin protein ligase E3 component n-recognin 3 (putative) 0.0312913
PTK2 protein tyrosine kinase 2 0.031177
NCKAP1 NCK-associated protein 1 0.0303618
ANKRD11 ankyrin repeat domain 11 0.0301618
SLMAP sarcolemma associated protein 0.0295138
APP amyloid beta (A4) precursor protein 0.0294414
RBM39 RNA binding motif protein 39 0.0291519
TPD52 tumor protein D52 0.0279158
RPS4Y1 ribosomal protein S4, Y-linked 1 0.0275628
ZSWIM6 zinc finger, SWIM-type containing 6 0.0271187
KIF1B kinesin family member 1B 0.0266337
RAB7A RAB7A, member RAS oncogene family 0.0266265
CHD1 chromodomain helicase DNA binding protein 1 0.0260985
CSNK1A1 casein kinase 1, alpha 1 0.0256609
PCBP2 poly(rC) binding protein 2 0.0253227
ELL2 elongation factor, RNA polymerase II, 2 0.0247109
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0245746
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0243914
HSPA1A heat shock 70kDa protein 1A 0.0241801
RBM25 RNA binding motif protein 25 0.0237158
MYH9 myosin, heavy chain 9, non-muscle 0.0235323
KCMF1 potassium channel modulatory factor 1 0.0232367
FOXO3 forkhead box O3 0.0232175
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0231815
PSMC6 proteasome (prosome, macropain) 26S subunit, ATPase, 6 0.0227149
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0226129
RICTOR RPTOR independent companion of MTOR, complex 2 0.0221498
KMT2C lysine (K)-specific methyltransferase 2C 0.0219961
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0219354
NPLOC4 nuclear protein localization 4 homolog (S. cerevisiae) 0.0218036
MARCHF6 membrane associated ring-CH-type finger 6 0.0217007
OLA1 Obg-like ATPase 1 0.0213966
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0213323
USP36 ubiquitin specific peptidase 36 0.0213278
UBASH3B ubiquitin associated and SH3 domain containing B 0.0208371
PUM2 pumilio RNA-binding family member 2 0.0205833
HELZ helicase with zinc finger 0.0201439
RANBP10 RAN binding protein 10 0.020061
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0198374
CCNL1 cyclin L1 0.0195464
CUL3 cullin 3 0.0194677
LPP LIM domain containing preferred translocation partner in lipoma 0.0193391
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 0.0193201
ZNF207 zinc finger protein 207 0.0192914
TRA2A transformer 2 alpha homolog (Drosophila) 0.019166
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.019064
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0187834
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0187115
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 0.0186733
ADAM17 ADAM metallopeptidase domain 17 0.0184695
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0184233
PUM1 pumilio RNA-binding family member 1 0.0184156
FLNA filamin A, alpha 0.0183096
ELOVL5 ELOVL fatty acid elongase 5 0.0182839
FNDC3B fibronectin type III domain containing 3B 0.0181823
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.018155
PSMD1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 0.0178926
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.017854
ZNF292 zinc finger protein 292 0.0177325
PNN pinin, desmosome associated protein 0.0175738
WDR43 WD repeat domain 43 0.0175602
AFF4 AF4/FMR2 family, member 4 0.0175019
UBAP2L ubiquitin associated protein 2-like 0.017489
COPA coatomer protein complex, subunit alpha 0.0173729
STRN3 striatin, calmodulin binding protein 3 0.0172039
CABIN1 calcineurin binding protein 1 0.0170831
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0169591
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0168296
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 0.0168275
CTNNBL1 catenin, beta like 1 0.0166887
KLC1 kinesin light chain 1 0.0166696
SIK3 SIK family kinase 3 0.0166053
RPL3 ribosomal protein L3 0.0163717
PAPOLA poly(A) polymerase alpha 0.016331
GLG1 golgi glycoprotein 1 0.0160469
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.016038
RSRC2 arginine/serine-rich coiled-coil 2 0.0160069
NOP58 NOP58 ribonucleoprotein 0.0159018
SAMD4A sterile alpha motif domain containing 4A 0.0158256
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0155214

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.196057
MT2A metallothionein 2A -0.113645
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.100814
VIM vimentin -0.0986061
TMSB10 thymosin beta 10 -0.0933538
FTL ferritin, light polypeptide -0.0757772
GRAMD1B GRAM domain containing 1B -0.0721512
IER3 immediate early response 3 -0.0553962
TM4SF1 transmembrane 4 L six family member 1 -0.0535124
THSD4 thrombospondin, type I, domain containing 4 -0.0500579
ACTG1 actin gamma 1 -0.0496276
HSPA6 heat shock 70kDa protein 6 (HSP70B') -0.0486308
RPL19 ribosomal protein L19 -0.0462387
TFPI2 tissue factor pathway inhibitor 2 -0.0441194
IGF2 insulin-like growth factor 2 -0.0429156
S100A6 S100 calcium binding protein A6 -0.0391222
RPL35A ribosomal protein L35a -0.0379796
STC1 stanniocalcin 1 -0.0358332
TXNRD1 thioredoxin reductase 1 -0.0341843
BICC1 BicC family RNA binding protein 1 -0.0334306
CCL2 chemokine (C-C motif) ligand 2 -0.0314184
RPS21 ribosomal protein S21 -0.0309087
RPL11 ribosomal protein L11 -0.0291819
RPL37A ribosomal protein L37a -0.0287947
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0280849
RPS27A ribosomal protein S27a -0.028022
PYGL phosphorylase, glycogen, liver -0.0280187
BASP1 brain abundant, membrane attached signal protein 1 -0.0280012
TPM4 tropomyosin 4 -0.027972
EGR1 early growth response 1 -0.0271121
LDHA lactate dehydrogenase A -0.0267155
TPT1 tumor protein, translationally-controlled 1 -0.0263032
SLC38A1 solute carrier family 38, member 1 -0.026144
NQO1 NAD(P)H dehydrogenase, quinone 1 -0.0259454
RPS29 ribosomal protein S29 -0.0259264
PTMA prothymosin, alpha -0.0252764
FGB fibrinogen beta chain -0.0252669
RPL31 ribosomal protein L31 -0.0251599
HSPA8 heat shock 70kDa protein 8 -0.0243312
PFN1 profilin 1 -0.024126
IGFBP4 insulin-like growth factor binding protein 4 -0.0240007
RPLP1 ribosomal protein, large, P1 -0.0234084
RPS23 ribosomal protein S23 -0.0227892
SLC38A2 solute carrier family 38, member 2 -0.0224234
RPS8 ribosomal protein S8 -0.0223855
S100A10 S100 calcium binding protein A10 -0.0222959
RPS19 ribosomal protein S19 -0.0217639
C15ORF48 chromosome 15 open reading frame 48 -0.0216826
RPLP0 ribosomal protein, large, P0 -0.0216198
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0208225
S100A11 S100 calcium binding protein A11 -0.0207623
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0206436
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0204073
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.020405
CLU clusterin -0.0202402
RPS24 ribosomal protein S24 -0.0200858
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0199371
PM20D1 peptidase M20 domain containing 1 -0.0198494
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0197943
RPS6 ribosomal protein S6 -0.0197893
RPL9 ribosomal protein L9 -0.0196399
RPS5 ribosomal protein S5 -0.0196064
NEGR1 neuronal growth regulator 1 -0.019593
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.019238
NNMT nicotinamide N-methyltransferase -0.019217
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.019039
ENO1 enolase 1, (alpha) -0.0187879
PRDX1 peroxiredoxin 1 -0.0182995
SLC35F3 solute carrier family 35, member F3 -0.0180784
POTEF POTE ankyrin domain family, member F -0.0180777
MYL12B myosin, light chain 12B, regulatory -0.0178865
RPS15 ribosomal protein S15 -0.0174638
OSMR oncostatin M receptor -0.0165733
ZBTB20 zinc finger and BTB domain containing 20 -0.0165695
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0163874
RPS14 ribosomal protein S14 -0.0161009
RPS16 ribosomal protein S16 -0.0160708
EHBP1 EH domain binding protein 1 -0.0159983
RPL36AL ribosomal protein L36a-like -0.015964
PKM pyruvate kinase, muscle -0.0158978
EDIL3 EGF-like repeats and discoidin I-like domains 3 -0.0158749
RPL30 ribosomal protein L30 -0.0158746
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.015784
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0157663
TAGLN2 transgelin 2 -0.0157011
RPL36 ribosomal protein L36 -0.0156541
ASPH aspartate beta-hydroxylase -0.0156211
UBB ubiquitin B -0.0154588
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0152951
HDAC9 histone deacetylase 9 -0.0152108
RPL23 ribosomal protein L23 -0.0148411
RPL26 ribosomal protein L26 -0.014742
EFNA5 ephrin-A5 -0.0145642
RPS11 ribosomal protein S11 -0.0143758
HMGA1 high mobility group AT-hook 1 -0.014345
INHBA inhibin, beta A -0.0143036
TTC28 tetratricopeptide repeat domain 28 -0.0141005
RPL28 ribosomal protein L28 -0.0140893
PTPRG protein tyrosine phosphatase, receptor type, G -0.0139718
ZMYND8 zinc finger, MYND-type containing 8 -0.0139164