| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Bortezomib perturbation in NCI-H2122 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Bortezomib_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NDRG1 | N-myc downstream regulated 1 | 0.166475 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.144506 |
| UBC | ubiquitin C | 0.127019 |
| LAMB3 | laminin, beta 3 | 0.111908 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.109245 |
| JMJD1C | jumonji domain containing 1C | 0.0990163 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0950408 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0747749 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0729739 |
| MT2A | metallothionein 2A | 0.0725033 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0706497 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0704718 |
| MYOF | myoferlin | 0.0639904 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | 0.063841 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0627871 |
| NPEPPS | aminopeptidase puromycin sensitive | 0.0614104 |
| OGA | O-GlcNAcase | 0.0583248 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0580525 |
| UBE2H | ubiquitin-conjugating enzyme E2H | 0.0556635 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0550876 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | 0.0545418 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0520221 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0499909 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0498401 |
| AK1 | adenylate kinase 1 | 0.0496801 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0490268 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0484736 |
| ASPH | aspartate beta-hydroxylase | 0.0483711 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0474385 |
| PRKCA | protein kinase C, alpha | 0.0468081 |
| KYNU | kynureninase | 0.0467924 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0455287 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0450381 |
| TBC1D22A | TBC1 domain family, member 22A | 0.0444939 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0442736 |
| DNAJB1 | DnaJ (Hsp40) homolog, subfamily B, member 1 | 0.0428536 |
| CANX | calnexin | 0.0417722 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0411582 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0407274 |
| ENO1 | enolase 1, (alpha) | 0.0403637 |
| ANXA2 | annexin A2 | 0.040174 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0398322 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | 0.0395607 |
| USP34 | ubiquitin specific peptidase 34 | 0.039518 |
| FN1 | fibronectin 1 | 0.0391556 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0390157 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | 0.0389225 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0387659 |
| ATP2C2 | ATPase, Ca++ transporting, type 2C, member 2 | 0.0385853 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0385333 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0378799 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0378528 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0377697 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0371645 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0368712 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0359089 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0352014 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0349787 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0332456 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0326047 |
| CALU | calumenin | 0.0321019 |
| ZMYND8 | zinc finger, MYND-type containing 8 | 0.0316152 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0315231 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0312673 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | 0.0308943 |
| TMSB10 | thymosin beta 10 | 0.0308885 |
| LAMA4 | laminin, alpha 4 | 0.0308167 |
| EFNA5 | ephrin-A5 | 0.0306111 |
| SQSTM1 | sequestosome 1 | 0.0305038 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0302048 |
| KRT17 | keratin 17, type I | 0.0298744 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | 0.0297133 |
| STAU1 | staufen double-stranded RNA binding protein 1 | 0.0295621 |
| GPATCH2L | G patch domain containing 2-like | 0.02945 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0293771 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.028667 |
| MYO1E | myosin IE | 0.0264076 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0262574 |
| EZR | ezrin | 0.0253573 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | 0.0239172 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.023856 |
| PAN3 | PAN3 poly(A) specific ribonuclease subunit | 0.0233803 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0226942 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0225741 |
| STC1 | stanniocalcin 1 | 0.0225098 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0224889 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0224337 |
| TXNRD1 | thioredoxin reductase 1 | 0.022158 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0211937 |
| SFTPA2 | surfactant protein A2 | 0.0207281 |
| VIM | vimentin | 0.0206666 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0187771 |
| ZNF638 | zinc finger protein 638 | 0.018445 |
| CD44 | CD44 molecule (Indian blood group) | 0.0183324 |
| ANKRD17 | ankyrin repeat domain 17 | 0.0177627 |
| ABI1 | abl-interactor 1 | 0.0176026 |
| PDE10A | phosphodiesterase 10A | 0.0171757 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0169723 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | 0.0169666 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | 0.0167846 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IFIH1 | interferon induced with helicase C domain 1 | -0.121079 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.110721 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | -0.105116 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | -0.0917205 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | -0.0751986 |
| SPAG9 | sperm associated antigen 9 | -0.0705582 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0689113 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.067024 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0627251 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | -0.0616308 |
| IGF2 | insulin-like growth factor 2 | -0.0603553 |
| PGK1 | phosphoglycerate kinase 1 | -0.0599715 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0575501 |
| PAPOLA | poly(A) polymerase alpha | -0.0564373 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0559136 |
| FAT1 | FAT atypical cadherin 1 | -0.055141 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0532107 |
| XPR1 | xenotropic and polytropic retrovirus receptor 1 | -0.0529459 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0528351 |
| RPS6 | ribosomal protein S6 | -0.0528145 |
| MED13L | mediator complex subunit 13-like | -0.0518951 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | -0.0515003 |
| CHORDC1 | cysteine and histidine-rich domain (CHORD) containing 1 | -0.0509143 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0498425 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0498356 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | -0.0475931 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0467924 |
| VCL | vinculin | -0.0454525 |
| BPTF | bromodomain PHD finger transcription factor | -0.0449793 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.044741 |
| CREBBP | CREB binding protein | -0.0446166 |
| CHST11 | carbohydrate (chondroitin 4) sulfotransferase 11 | -0.0445367 |
| TANC1 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 | -0.0442035 |
| RPS8 | ribosomal protein S8 | -0.0437611 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | -0.0429495 |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | -0.0421611 |
| FRMD5 | FERM domain containing 5 | -0.0403677 |
| OASL | 2'-5'-oligoadenylate synthetase-like | -0.0398744 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | -0.0391011 |
| DSPP | dentin sialophosphoprotein | -0.038545 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0383305 |
| RPS21 | ribosomal protein S21 | -0.0380352 |
| C6ORF132 | chromosome 6 open reading frame 132 | -0.0378773 |
| SLC2A13 | solute carrier family 2 (facilitated glucose transporter), member 13 | -0.0377893 |
| RPL7A | ribosomal protein L7a | -0.037564 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0373854 |
| MSI2 | musashi RNA-binding protein 2 | -0.0372955 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0372571 |
| PRELID2 | PRELI domain containing 2 | -0.037233 |
| EGFR | epidermal growth factor receptor | -0.0360593 |
| STK17A | serine/threonine kinase 17a | -0.03582 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0355658 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | -0.0349505 |
| PTMA | prothymosin, alpha | -0.0348536 |
| RPS6KA3 | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | -0.0340624 |
| COPA | coatomer protein complex, subunit alpha | -0.0339349 |
| VMP1 | vacuole membrane protein 1 | -0.033687 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0335634 |
| DIP2B | DIP2 disco-interacting protein 2 homolog B (Drosophila) | -0.0331072 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0322933 |
| NRG1 | neuregulin 1 | -0.0322225 |
| RBM25 | RNA binding motif protein 25 | -0.0320677 |
| RPL9 | ribosomal protein L9 | -0.0306654 |
| EFNB2 | ephrin-B2 | -0.0305222 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0304761 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | -0.0295563 |
| NOS1AP | nitric oxide synthase 1 (neuronal) adaptor protein | -0.0291024 |
| SMYD3 | SET and MYND domain containing 3 | -0.0290102 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | -0.0287489 |
| TJP1 | tight junction protein 1 | -0.028418 |
| RPL37 | ribosomal protein L37 | -0.0283706 |
| UBB | ubiquitin B | -0.0278708 |
| RPS12 | ribosomal protein S12 | -0.0276706 |
| HSPE1 | heat shock 10kDa protein 1 | -0.026444 |
| HSPA6 | heat shock 70kDa protein 6 (HSP70B') | -0.0257579 |
| CSNK1A1 | casein kinase 1, alpha 1 | -0.0252231 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0249359 |
| BRD4 | bromodomain containing 4 | -0.0249357 |
| DIAPH1 | diaphanous-related formin 1 | -0.0249254 |
| LDHA | lactate dehydrogenase A | -0.0247275 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0242647 |
| ACTN4 | actinin, alpha 4 | -0.0238655 |
| SMCHD1 | structural maintenance of chromosomes flexible hinge domain containing 1 | -0.0236524 |
| RIGI | RNA sensor RIG-I | -0.0235474 |
| GPHN | gephyrin | -0.0234603 |
| ILF3 | interleukin enhancer binding factor 3, 90kDa | -0.0226079 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0219893 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.021722 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0208089 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0205692 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0201852 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.020169 |
| NF1 | neurofibromin 1 | -0.0200716 |
| AFF4 | AF4/FMR2 family, member 4 | -0.0193321 |
| DST | dystonin | -0.0190057 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0189042 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.018809 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.0187303 |
| HSPA4 | heat shock 70kDa protein 4 | -0.0181958 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0181544 |
