Bortezomib_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Bortezomib perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Bortezomib_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSPA1A heat shock 70kDa protein 1A 0.231166
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.161794
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.152367
HSPA1B heat shock 70kDa protein 1B 0.0895889
AKAP12 A kinase (PRKA) anchor protein 12 0.0824374
UBC ubiquitin C 0.0774922
LRPPRC leucine-rich pentatricopeptide repeat containing 0.065612
BIRC6 baculoviral IAP repeat containing 6 0.0652638
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.061953
DST dystonin 0.0614477
ERRFI1 ERBB receptor feedback inhibitor 1 0.0603673
GRAMD1B GRAM domain containing 1B 0.0587576
TPM3 tropomyosin 3 0.0584662
YBX3 Y box binding protein 3 0.0578084
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.057745
CSDE1 cold shock domain containing E1, RNA-binding 0.0574058
HSPA8 heat shock 70kDa protein 8 0.0567731
TXNRD1 thioredoxin reductase 1 0.0565215
HSPH1 heat shock 105kDa/110kDa protein 1 0.0552218
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0521422
MACF1 microtubule-actin crosslinking factor 1 0.0486334
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0479267
PDE4D phosphodiesterase 4D, cAMP-specific 0.0420199
UBR3 ubiquitin protein ligase E3 component n-recognin 3 (putative) 0.0417555
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0409938
EEF2 eukaryotic translation elongation factor 2 0.0389685
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.037483
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0373844
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0364631
KTN1 kinectin 1 (kinesin receptor) 0.0362225
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0361569
MAP1B microtubule-associated protein 1B 0.0359801
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 0.0358975
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0357527
VCP valosin containing protein 0.0352221
TRIP12 thyroid hormone receptor interactor 12 0.0349828
OSMR oncostatin M receptor 0.0347039
EXOC4 exocyst complex component 4 0.0345618
JMJD1C jumonji domain containing 1C 0.0337157
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0331411
ZFAND3 zinc finger, AN1-type domain 3 0.0318172
AAK1 AP2 associated kinase 1 0.0314868
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0314452
CANX calnexin 0.0310082
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 0.0309633
LARP4 La ribonucleoprotein domain family, member 4 0.0301344
VMP1 vacuole membrane protein 1 0.0298466
PTK2 protein tyrosine kinase 2 0.0295337
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0284738
SPATS2 spermatogenesis associated, serine-rich 2 0.0283989
KIF1B kinesin family member 1B 0.0281938
SLMAP sarcolemma associated protein 0.0281074
ATF6 activating transcription factor 6 0.0279619
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0272895
KDM2A lysine (K)-specific demethylase 2A 0.027201
KIF1A kinesin family member 1A 0.0271138
MAP4 microtubule-associated protein 4 0.0270066
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0269389
CHCHD3 coiled-coil-helix-coiled-coil-helix domain containing 3 0.0266258
FKBP4 FK506 binding protein 4, 59kDa 0.026554
RPTOR regulatory associated protein of MTOR, complex 1 0.0263483
PSMD12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 0.026325
NBAS neuroblastoma amplified sequence 0.0263069
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0262896
CLTC clathrin, heavy chain (Hc) 0.0262119
PSMD1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 0.0257276
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0257228
NIPBL Nipped-B homolog (Drosophila) 0.025491
CSNK1A1 casein kinase 1, alpha 1 0.0253985
CLIP1 CAP-GLY domain containing linker protein 1 0.0253099
IGF1R insulin-like growth factor 1 receptor 0.0252706
ATP2C1 ATPase, Ca++ transporting, type 2C, member 1 0.0249391
XPO1 exportin 1 0.0247904
FXR1 fragile X mental retardation, autosomal homolog 1 0.0244109
EXOC6B exocyst complex component 6B 0.0243588
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0239784
MYH9 myosin, heavy chain 9, non-muscle 0.0238937
TPI1 triosephosphate isomerase 1 0.0237197
USP14 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) 0.0236776
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 0.0236329
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0235558
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0235464
NCKAP1 NCK-associated protein 1 0.0233593
ZFC3H1 zinc finger, C3H1-type containing 0.0229687
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0228194
PTPN11 protein tyrosine phosphatase, non-receptor type 11 0.0227459
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0222739
PPME1 protein phosphatase methylesterase 1 0.0222621
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0221902
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0221582
NCOR1 nuclear receptor corepressor 1 0.022114
AFF4 AF4/FMR2 family, member 4 0.0220972
VPS53 vacuolar protein sorting 53 homolog (S. cerevisiae) 0.0220451
FAF1 Fas (TNFRSF6) associated factor 1 0.0219276
HSPA4 heat shock 70kDa protein 4 0.0218619
KCMF1 potassium channel modulatory factor 1 0.0218555
STARD7 StAR-related lipid transfer (START) domain containing 7 0.0215293
CAMTA1 calmodulin binding transcription activator 1 0.0213902
TAS2R14 taste receptor, type 2, member 14 0.0213473
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0213005

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.174641
PTMA prothymosin, alpha -0.105461
TMSB10 thymosin beta 10 -0.0748173
RPL35A ribosomal protein L35a -0.0641724
VIM vimentin -0.0619008
EGR1 early growth response 1 -0.0573323
RPL37A ribosomal protein L37a -0.0562185
MCL1 myeloid cell leukemia 1 -0.0555399
RPS8 ribosomal protein S8 -0.0548375
MT2A metallothionein 2A -0.0518504
HSPA6 heat shock 70kDa protein 6 (HSP70B') -0.0499503
RPS3 ribosomal protein S3 -0.0470348
TPT1 tumor protein, translationally-controlled 1 -0.0458489
RPL31 ribosomal protein L31 -0.0399922
RPS29 ribosomal protein S29 -0.0365116
RPLP1 ribosomal protein, large, P1 -0.0342158
HLA-B major histocompatibility complex, class I, B -0.0333906
FTL ferritin, light polypeptide -0.030785
RPS24 ribosomal protein S24 -0.0305707
RPL38 ribosomal protein L38 -0.0301875
RPS15 ribosomal protein S15 -0.0294276
RPS6 ribosomal protein S6 -0.0286851
RPS19 ribosomal protein S19 -0.0282786
RPL34 ribosomal protein L34 -0.0278013
RPS27A ribosomal protein S27a -0.0277331
MYL12B myosin, light chain 12B, regulatory -0.0276976
WSB1 WD repeat and SOCS box containing 1 -0.0263496
RPS27 ribosomal protein S27 -0.0262673
RPS13 ribosomal protein S13 -0.0262196
RPL9 ribosomal protein L9 -0.0260532
IFI6 interferon, alpha-inducible protein 6 -0.0257256
RPS21 ribosomal protein S21 -0.0256978
RPL26 ribosomal protein L26 -0.0252012
RPS10 ribosomal protein S10 -0.0249697
RPLP2 ribosomal protein, large, P2 -0.0237534
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0229206
RPL5 ribosomal protein L5 -0.022717
RPL11 ribosomal protein L11 -0.0226968
RPS14 ribosomal protein S14 -0.0224271
RPL19 ribosomal protein L19 -0.0222961
RPL36 ribosomal protein L36 -0.0220414
S100A6 S100 calcium binding protein A6 -0.0194216
RPS25 ribosomal protein S25 -0.0191936
ZBTB20 zinc finger and BTB domain containing 20 -0.018641
WNT2B wingless-type MMTV integration site family, member 2B -0.0182501
RPL28 ribosomal protein L28 -0.0179475
RPS16 ribosomal protein S16 -0.0175701
RPS12 ribosomal protein S12 -0.0170902
ACTG1 actin gamma 1 -0.0170102
RPLP0 ribosomal protein, large, P0 -0.0170099
MORF4L2 mortality factor 4 like 2 -0.0169203
RPL23 ribosomal protein L23 -0.0168582
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0165594
RPL7A ribosomal protein L7a -0.0163953
RPS23 ribosomal protein S23 -0.0163614
IER3 immediate early response 3 -0.0163447
HELZ2 helicase with zinc finger 2, transcriptional coactivator -0.0161364
NABP1 nucleic acid binding protein 1 -0.0161037
RPL13A ribosomal protein L13a -0.0160402
RPL12 ribosomal protein L12 -0.0160232
PNISR PNN-interacting serine/arginine-rich protein -0.0159581
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0158805
LOC102724023 ES1 protein homolog, mitochondrial -0.0152788
RPL36A ribosomal protein L36a -0.0151879
PFN1 profilin 1 -0.0148538
RPL37 ribosomal protein L37 -0.0147556
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0144614
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.014042
RPL27 ribosomal protein L27 -0.0139836
POTEF POTE ankyrin domain family, member F -0.0137799
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0137023
SMC4 structural maintenance of chromosomes 4 -0.0136548
HMGA1 high mobility group AT-hook 1 -0.013631
PTPRF protein tyrosine phosphatase, receptor type, F -0.0134663
RPL15 ribosomal protein L15 -0.0132647
EIF1 eukaryotic translation initiation factor 1 -0.013081
WASF2 WAS protein family, member 2 -0.0130232
SLC38A2 solute carrier family 38, member 2 -0.0129539
DEK DEK proto-oncogene -0.0126304
PTP4A2 protein tyrosine phosphatase type IVA, member 2 -0.0124184
RPL8 ribosomal protein L8 -0.0122786
MT1E metallothionein 1E -0.0122525
GNAS GNAS complex locus -0.0121966
SLC25A3 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3 -0.0121115
H3-3B H3.3 histone B -0.0117763
RPS17 ribosomal protein S17 -0.0117622
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0117585
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.011754
S100A11 S100 calcium binding protein A11 -0.0113821
NTSR1 neurotensin receptor 1 (high affinity) -0.0113607
TOMM7 translocase of outer mitochondrial membrane 7 homolog (yeast) -0.0113271
RCC1 regulator of chromosome condensation 1 -0.0111928
VDAC1 voltage-dependent anion channel 1 -0.0111514
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0111123
ATP5F1E ATP synthase F1 subunit epsilon -0.0111098
COX7A2 cytochrome c oxidase subunit VIIa polypeptide 2 (liver) -0.0108903
EIF5B eukaryotic translation initiation factor 5B -0.0108464
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0108036
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0108019
FBXO11 F-box protein 11 -0.0107435