Bortezomib_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Bortezomib perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Bortezomib_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.430557
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.164244
HSPA1A heat shock 70kDa protein 1A 0.0720469
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0715024
IGFBP3 insulin-like growth factor binding protein 3 0.0709223
RAB7A RAB7A, member RAS oncogene family 0.0635527
ZSWIM6 zinc finger, SWIM-type containing 6 0.0627373
HSPA1B heat shock 70kDa protein 1B 0.0621742
MYO6 myosin VI 0.0608025
CALR calreticulin 0.0560929
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0546964
CSNK1A1 casein kinase 1, alpha 1 0.0542478
RBM25 RNA binding motif protein 25 0.0537035
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0536568
DTNA dystrobrevin, alpha 0.0531875
VEGFA vascular endothelial growth factor A 0.0500406
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.049427
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0492222
GPBP1 GC-rich promoter binding protein 1 0.0490074
GRB10 growth factor receptor-bound protein 10 0.0482119
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0481313
CANX calnexin 0.0462814
MAP1B microtubule-associated protein 1B 0.0460461
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0457421
MCL1 myeloid cell leukemia 1 0.044414
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0430227
UBE2H ubiquitin-conjugating enzyme E2H 0.0425484
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.042521
APLP2 amyloid beta (A4) precursor-like protein 2 0.0420455
FBXO32 F-box protein 32 0.0412851
EEF2 eukaryotic translation elongation factor 2 0.0409575
TPM3 tropomyosin 3 0.040673
NDRG1 N-myc downstream regulated 1 0.0402136
MYH9 myosin, heavy chain 9, non-muscle 0.0401339
MSN moesin 0.0398273
PCBP2 poly(rC) binding protein 2 0.0397984
RAB11FIP1 RAB11 family interacting protein 1 (class I) 0.0397195
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0394339
GOLGB1 golgin B1 0.0365008
JUN jun proto-oncogene 0.0362119
SAMD4A sterile alpha motif domain containing 4A 0.0358869
SLMAP sarcolemma associated protein 0.0357807
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0356078
PLEC plectin 0.0353951
FXR1 fragile X mental retardation, autosomal homolog 1 0.0351661
COPA coatomer protein complex, subunit alpha 0.0349048
DSPP dentin sialophosphoprotein 0.0347158
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0343056
KDM2A lysine (K)-specific demethylase 2A 0.0342361
IFI16 interferon, gamma-inducible protein 16 0.0331434
MX1 MX dynamin-like GTPase 1 0.0324522
BAZ1A bromodomain adjacent to zinc finger domain, 1A 0.0323783
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.030908
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 0.03008
ERBIN erbb2 interacting protein 0.0298348
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0296532
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0293814
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0293028
MCU mitochondrial calcium uniporter 0.0292328
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0290751
SRP54 signal recognition particle 54kDa 0.0288533
PRRC2C proline-rich coiled-coil 2C 0.0288435
BBX bobby sox homolog (Drosophila) 0.0288408
SH3KBP1 SH3-domain kinase binding protein 1 0.0287678
MED13 mediator complex subunit 13 0.0285103
ABHD3 abhydrolase domain containing 3 0.028391
RB1CC1 RB1-inducible coiled-coil 1 0.0281512
TMF1 TATA element modulatory factor 1 0.0281025
RNF213 ring finger protein 213 0.0279362
MACC1 metastasis associated in colon cancer 1 0.0279009
AKAP13 A kinase (PRKA) anchor protein 13 0.0278208
FNBP4 formin binding protein 4 0.0276007
CWF19L2 CWF19-like 2, cell cycle control (S. pombe) 0.0275453
USP53 ubiquitin specific peptidase 53 0.0275029
VEZT vezatin, adherens junctions transmembrane protein 0.0274651
PPARD peroxisome proliferator-activated receptor delta 0.0274346
BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB 0.0269986
HDGF hepatoma-derived growth factor 0.0269688
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0269178
DST dystonin 0.026871
MACF1 microtubule-actin crosslinking factor 1 0.0268119
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.026749
CD109 CD109 molecule 0.0266305
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0265842
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 0.0263441
ZNF207 zinc finger protein 207 0.0263438
HDAC9 histone deacetylase 9 0.0261424
KIF1B kinesin family member 1B 0.0261307
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 0.0261109
FBXL20 F-box and leucine-rich repeat protein 20 0.0259146
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0258456
TBC1D15 TBC1 domain family, member 15 0.0258161
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3 0.0257289
PTGES3 prostaglandin E synthase 3 (cytosolic) 0.0255616
ANKHD1 ankyrin repeat and KH domain containing 1 0.025399
KTN1 kinectin 1 (kinesin receptor) 0.0252324
POTEF POTE ankyrin domain family, member F 0.0250532
PSMD1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 0.0249515
EZR ezrin 0.0249002
SUPT6H suppressor of Ty 6 homolog (S. cerevisiae) 0.0245003

decreased expression

Symbol Name Standardized Value
FTL ferritin, light polypeptide -0.221332
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.203541
FN1 fibronectin 1 -0.168998
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.157286
ASPH aspartate beta-hydroxylase -0.115003
HSPB1 heat shock 27kDa protein 1 -0.105366
RPL35A ribosomal protein L35a -0.088445
TPT1 tumor protein, translationally-controlled 1 -0.0769807
SLC38A1 solute carrier family 38, member 1 -0.0756352
HSPA8 heat shock 70kDa protein 8 -0.0737818
NAMPT nicotinamide phosphoribosyltransferase -0.0689279
RPS23 ribosomal protein S23 -0.0662748
RPL11 ribosomal protein L11 -0.064262
RACK1 receptor for activated C kinase 1 -0.0638124
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0631456
HSPA6 heat shock 70kDa protein 6 (HSP70B') -0.0624636
KRT18 keratin 18, type I -0.0582921
RPS8 ribosomal protein S8 -0.0579779
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0558857
RPS13 ribosomal protein S13 -0.0538512
RPLP0 ribosomal protein, large, P0 -0.0525095
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0512824
RPL12 ribosomal protein L12 -0.0501812
RPL9 ribosomal protein L9 -0.0497072
RPS17 ribosomal protein S17 -0.049686
TM4SF1 transmembrane 4 L six family member 1 -0.0493637
FNDC3B fibronectin type III domain containing 3B -0.0488264
TMSB10 thymosin beta 10 -0.0485394
SACK1A scaffolding CK1 anchoring protein A -0.0480336
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0471702
KRT8 keratin 8, type II -0.0468136
RPL31 ribosomal protein L31 -0.0460666
RPS5 ribosomal protein S5 -0.0458483
RPS3 ribosomal protein S3 -0.045385
PTMA prothymosin, alpha -0.0444598
RPS19 ribosomal protein S19 -0.044271
RPS6 ribosomal protein S6 -0.0439585
RPL34 ribosomal protein L34 -0.0437137
RPS29 ribosomal protein S29 -0.0436187
RPL30 ribosomal protein L30 -0.0430262
UBC ubiquitin C -0.0430007
RPS27A ribosomal protein S27a -0.0425832
LAMC2 laminin, gamma 2 -0.0424579
RPL37A ribosomal protein L37a -0.04233
DDIT4 DNA-damage-inducible transcript 4 -0.0422971
MSMO1 methylsterol monooxygenase 1 -0.0407529
HMGA1 high mobility group AT-hook 1 -0.0375584
HSPH1 heat shock 105kDa/110kDa protein 1 -0.0373468
RPL37 ribosomal protein L37 -0.0370885
ACTG1 actin gamma 1 -0.0369028
RPL32 ribosomal protein L32 -0.0367414
S100A6 S100 calcium binding protein A6 -0.0363346
RPL19 ribosomal protein L19 -0.0352519
CAPN2 calpain 2, (m/II) large subunit -0.0349988
RPS24 ribosomal protein S24 -0.0347187
UBB ubiquitin B -0.0344964
PEG10 paternally expressed 10 -0.0341279
RPS27 ribosomal protein S27 -0.0340407
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0339486
RAD21 RAD21 homolog (S. pombe) -0.0326846
RPL7 ribosomal protein L7 -0.0322984
ANXA2 annexin A2 -0.0321967
RPL4 ribosomal protein L4 -0.0321781
SDC4 syndecan 4 -0.0318953
TXNRD1 thioredoxin reductase 1 -0.0316408
KRT7 keratin 7, type II -0.0299092
FAM3C family with sequence similarity 3, member C -0.0293856
RPS12 ribosomal protein S12 -0.0292294
RPL27 ribosomal protein L27 -0.0291969
RPL38 ribosomal protein L38 -0.0288959
RPL13A ribosomal protein L13a -0.0287663
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 -0.0286825
RPS14 ribosomal protein S14 -0.0285011
RPLP1 ribosomal protein, large, P1 -0.0284062
NPC2 Niemann-Pick disease, type C2 -0.0280226
NRIP1 nuclear receptor interacting protein 1 -0.0277234
AREG amphiregulin -0.0275611
MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene) -0.0274766
CD46 CD46 molecule, complement regulatory protein -0.027123
EREG epiregulin -0.0270284
RPL5 ribosomal protein L5 -0.0264117
RPS16 ribosomal protein S16 -0.0263704
EIF1 eukaryotic translation initiation factor 1 -0.0260666
RPS25 ribosomal protein S25 -0.0255738
RPLP2 ribosomal protein, large, P2 -0.0253943
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0251396
RPL23 ribosomal protein L23 -0.0251392
RPS10 ribosomal protein S10 -0.0248652
RPL28 ribosomal protein L28 -0.0247436
ALCAM activated leukocyte cell adhesion molecule -0.0246885
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.024668
LMO7 LIM domain 7 -0.0245794
KRT6A keratin 6A, type II -0.0237756
CRABP2 cellular retinoic acid binding protein 2 -0.023707
TMEM263 transmembrane protein 263 -0.023292
S100A10 S100 calcium binding protein A10 -0.0232425
RPS15 ribosomal protein S15 -0.0232081
RPS11 ribosomal protein S11 -0.0231855
ARHGAP29 Rho GTPase activating protein 29 -0.0229426
RPS21 ribosomal protein S21 -0.0220633