| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Bortezomib perturbation in NCI-H460 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Bortezomib_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.194186 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.123451 |
| UBC | ubiquitin C | 0.0760081 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0650901 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0578714 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.0573908 |
| TUSC3 | tumor suppressor candidate 3 | 0.0482103 |
| GNGT1 | guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 | 0.0469256 |
| KIF21A | kinesin family member 21A | 0.0434853 |
| SQSTM1 | sequestosome 1 | 0.0433936 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0399152 |
| NIBAN1 | niban apoptosis regulator 1 | 0.0386875 |
| UBR3 | ubiquitin protein ligase E3 component n-recognin 3 (putative) | 0.0351559 |
| HSPA1A | heat shock 70kDa protein 1A | 0.0336055 |
| MAP1B | microtubule-associated protein 1B | 0.0314218 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0312819 |
| EXOC6B | exocyst complex component 6B | 0.0290463 |
| TBCA | tubulin folding cofactor A | 0.0283738 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0281327 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | 0.0264704 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0261569 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0255952 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0255302 |
| RPS6KC1 | ribosomal protein S6 kinase, 52kDa, polypeptide 1 | 0.0249882 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0248947 |
| PDE10A | phosphodiesterase 10A | 0.0243247 |
| CTIF | CBP80/20-dependent translation initiation factor | 0.024114 |
| CREB5 | cAMP responsive element binding protein 5 | 0.023416 |
| PSMD1 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 | 0.0232321 |
| MAP7 | microtubule-associated protein 7 | 0.0228887 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0228547 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0228462 |
| PCDHB16 | protocadherin beta 16 | 0.0228089 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | 0.022746 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | 0.0226528 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | 0.0226037 |
| SNX29 | sorting nexin 29 | 0.0225775 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0223014 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.022143 |
| DLGAP3 | discs, large (Drosophila) homolog-associated protein 3 | 0.0220168 |
| SMYD3 | SET and MYND domain containing 3 | 0.021682 |
| CD44 | CD44 molecule (Indian blood group) | 0.0211669 |
| FAM219A | family with sequence similarity 219, member A | 0.0207855 |
| VTI1A | vesicle transport through interaction with t-SNAREs 1A | 0.0203647 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0202609 |
| PSMD14 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | 0.0201329 |
| HSPA1B | heat shock 70kDa protein 1B | 0.0198079 |
| ATP9B | ATPase, class II, type 9B | 0.0197885 |
| CHCHD3 | coiled-coil-helix-coiled-coil-helix domain containing 3 | 0.0196383 |
| CDH13 | cadherin 13 | 0.0193155 |
| DHRSX | dehydrogenase/reductase (SDR family) X-linked | 0.0192717 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0192541 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.0192299 |
| LRP1B | low density lipoprotein receptor-related protein 1B | 0.0191427 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0186451 |
| CLIP1 | CAP-GLY domain containing linker protein 1 | 0.0182938 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0181978 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0179996 |
| GPATCH2L | G patch domain containing 2-like | 0.0176598 |
| RPTOR | regulatory associated protein of MTOR, complex 1 | 0.0175443 |
| UBQLN1 | ubiquilin 1 | 0.0174971 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0173542 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | 0.0172531 |
| DENND1A | DENN/MADD domain containing 1A | 0.0172274 |
| HSD17B12 | hydroxysteroid (17-beta) dehydrogenase 12 | 0.0172157 |
| GPATCH2 | G patch domain containing 2 | 0.0169637 |
| FMNL2 | formin-like 2 | 0.0169263 |
| ABCC2 | ATP-binding cassette, sub-family C (CFTR/MRP), member 2 | 0.0167603 |
| AGTPBP1 | ATP/GTP binding protein 1 | 0.0165655 |
| EXOC4 | exocyst complex component 4 | 0.0164814 |
| ECPAS | Ecm29 proteasome adaptor and scaffold | 0.0163899 |
| NPLOC4 | nuclear protein localization 4 homolog (S. cerevisiae) | 0.0160408 |
| SMAD2 | SMAD family member 2 | 0.0158765 |
| TFDP2 | transcription factor Dp-2 (E2F dimerization partner 2) | 0.0158296 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.0156121 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | 0.0154133 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0153473 |
| INTS6 | integrator complex subunit 6 | 0.0149989 |
| MYO10 | myosin X | 0.0149323 |
| ADGRD1 | adhesion G protein-coupled receptor D1 | 0.0148556 |
| DNAJB1 | DnaJ (Hsp40) homolog, subfamily B, member 1 | 0.0144031 |
| DST | dystonin | 0.0143965 |
| YWHAQ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta | 0.0142472 |
| PRKN | parkin RBR E3 ubiquitin protein ligase | 0.0141323 |
| MTAP | methylthioadenosine phosphorylase | 0.0141212 |
| VCP | valosin containing protein | 0.0140357 |
| KIF1B | kinesin family member 1B | 0.0139723 |
| NCAM1 | neural cell adhesion molecule 1 | 0.0138761 |
| DPP10 | dipeptidyl-peptidase 10 (non-functional) | 0.0138097 |
| FLNA | filamin A, alpha | 0.0137716 |
| TPM3 | tropomyosin 3 | 0.0137468 |
| LARP4 | La ribonucleoprotein domain family, member 4 | 0.0137233 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0136239 |
| UCHL1 | ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) | 0.0135783 |
| NAA25 | N(alpha)-acetyltransferase 25, NatB auxiliary subunit | 0.0134805 |
| AEBP2 | AE binding protein 2 | 0.0132683 |
| SPATS2 | spermatogenesis associated, serine-rich 2 | 0.0131841 |
| PAPPA2 | pappalysin 2 | 0.0131725 |
| KIAA1217 | KIAA1217 | 0.013109 |
| CXCL5 | chemokine (C-X-C motif) ligand 5 | 0.0130595 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.132723 |
| EFNA5 | ephrin-A5 | -0.0729628 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0695201 |
| FTL | ferritin, light polypeptide | -0.0640718 |
| PTMA | prothymosin, alpha | -0.0561503 |
| TMSB10 | thymosin beta 10 | -0.0525684 |
| VIM | vimentin | -0.0488418 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | -0.0478281 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0469657 |
| FN1 | fibronectin 1 | -0.045081 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0417853 |
| GDA | guanine deaminase | -0.0384939 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0381062 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0374922 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0372246 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0359902 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0335247 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0315041 |
| EPB41L3 | erythrocyte membrane protein band 4.1-like 3 | -0.0312875 |
| NEK7 | NIMA-related kinase 7 | -0.0307026 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0305178 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0299315 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0296475 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.029512 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0283358 |
| MYOF | myoferlin | -0.0272855 |
| GOLGA4 | golgin A4 | -0.0258615 |
| PGK1 | phosphoglycerate kinase 1 | -0.0255 |
| GNAS | GNAS complex locus | -0.0254929 |
| RGS2 | regulator of G-protein signaling 2 | -0.0253704 |
| OGA | O-GlcNAcase | -0.0252297 |
| RPS6 | ribosomal protein S6 | -0.0252068 |
| PDGFA | platelet-derived growth factor alpha polypeptide | -0.0248378 |
| MFF | mitochondrial fission factor | -0.0247964 |
| MCL1 | myeloid cell leukemia 1 | -0.0241749 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0240477 |
| S100A6 | S100 calcium binding protein A6 | -0.0237209 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.023506 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0231853 |
| STC1 | stanniocalcin 1 | -0.0231244 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | -0.0230704 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0227682 |
| PDIA6 | protein disulfide isomerase family A, member 6 | -0.0227189 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0226729 |
| RPL12 | ribosomal protein L12 | -0.022406 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0219587 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0212886 |
| RTN4 | reticulon 4 | -0.0208 |
| WDR45B | WD repeat domain 45B | -0.0206496 |
| SLC39A8 | solute carrier family 39 (zinc transporter), member 8 | -0.0202726 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0202281 |
| HILPDA | hypoxia inducible lipid droplet-associated | -0.0200053 |
| MT2A | metallothionein 2A | -0.0199113 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0198093 |
| RPLP0 | ribosomal protein, large, P0 | -0.0194795 |
| AGFG1 | ArfGAP with FG repeats 1 | -0.0191071 |
| B2M | beta-2-microglobulin | -0.0190414 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.0188244 |
| SLC25A5 | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 | -0.0187921 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0186812 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0186702 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | -0.018662 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0183689 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0182913 |
| RPL35A | ribosomal protein L35a | -0.018012 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0177792 |
| NRCAM | neuronal cell adhesion molecule | -0.0176897 |
| ZNF292 | zinc finger protein 292 | -0.0176202 |
| FAM13A | family with sequence similarity 13, member A | -0.0176191 |
| NDRG1 | N-myc downstream regulated 1 | -0.0175827 |
| CENPF | centromere protein F, 350/400kDa | -0.0175186 |
| RPLP1 | ribosomal protein, large, P1 | -0.01749 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0171849 |
| RNF145 | ring finger protein 145 | -0.0171251 |
| COL5A2 | collagen, type V, alpha 2 | -0.0170682 |
| RPL37A | ribosomal protein L37a | -0.0170172 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | -0.0169636 |
| NUP58 | nucleoporin 58 | -0.0168828 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0166477 |
| RPL19 | ribosomal protein L19 | -0.0166225 |
| S100A10 | S100 calcium binding protein A10 | -0.0165321 |
| NPAS2 | neuronal PAS domain protein 2 | -0.016397 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0163718 |
| PM20D1 | peptidase M20 domain containing 1 | -0.0163618 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0161668 |
| DDIT4 | DNA-damage-inducible transcript 4 | -0.0161155 |
| CRYAB | crystallin, alpha B | -0.0159609 |
| PRKD3 | protein kinase D3 | -0.0158887 |
| TENT5A | terminal nucleotidyltransferase 5A | -0.0158168 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0156228 |
| RBM39 | RNA binding motif protein 39 | -0.0156182 |
| DGKD | diacylglycerol kinase, delta 130kDa | -0.0155408 |
| COPA | coatomer protein complex, subunit alpha | -0.0155354 |
| MXI1 | MAX interactor 1, dimerization protein | -0.015411 |
| LDHA | lactate dehydrogenase A | -0.0153595 |
| ESYT2 | extended synaptotagmin-like protein 2 | -0.015327 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0153015 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | -0.0152988 |
| LAMB1 | laminin, beta 1 | -0.0152313 |
| SEPTIN7 | septin 7 | -0.0152026 |
