| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Bortezomib perturbation in NCI-H661 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Bortezomib_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA1A | heat shock 70kDa protein 1A | 0.0756449 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 0.0348046 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0340797 |
| COL3A1 | collagen, type III, alpha 1 | 0.0309215 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0301466 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0279293 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | 0.0263819 |
| UBR3 | ubiquitin protein ligase E3 component n-recognin 3 (putative) | 0.0261713 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0259244 |
| UBQLN1 | ubiquilin 1 | 0.0258345 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0246101 |
| STIP1 | stress-induced phosphoprotein 1 | 0.023855 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.0235155 |
| PSMA6 | proteasome (prosome, macropain) subunit, alpha type, 6 | 0.0224125 |
| HIBCH | 3-hydroxyisobutyryl-CoA hydrolase | 0.0223877 |
| RPS2 | ribosomal protein S2 | 0.0222197 |
| MKI67 | marker of proliferation Ki-67 | 0.0221774 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0218274 |
| KIF21A | kinesin family member 21A | 0.0216296 |
| AFF4 | AF4/FMR2 family, member 4 | 0.0214714 |
| DST | dystonin | 0.0202375 |
| ISG15 | ISG15 ubiquitin-like modifier | 0.0190624 |
| RAB6A | RAB6A, member RAS oncogene family | 0.0187875 |
| TJP1 | tight junction protein 1 | 0.0187643 |
| JMJD1C | jumonji domain containing 1C | 0.0187535 |
| SQSTM1 | sequestosome 1 | 0.018678 |
| ENO1 | enolase 1, (alpha) | 0.0182408 |
| ACIN1 | apoptotic chromatin condensation inducer 1 | 0.0180813 |
| RPS6KC1 | ribosomal protein S6 kinase, 52kDa, polypeptide 1 | 0.0179836 |
| KIF1B | kinesin family member 1B | 0.0179036 |
| GOLGB1 | golgin B1 | 0.0177695 |
| PSMD14 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | 0.0177689 |
| HERC5 | HECT and RLD domain containing E3 ubiquitin protein ligase 5 | 0.017761 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0177482 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.0176928 |
| PSMD1 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 | 0.0173357 |
| CUL4B | cullin 4B | 0.0171807 |
| BRD2 | bromodomain containing 2 | 0.0171477 |
| VCP | valosin containing protein | 0.0169091 |
| INO80D | INO80 complex subunit D | 0.0167179 |
| VPS72 | vacuolar protein sorting 72 homolog (S. cerevisiae) | 0.0165529 |
| NSUN6 | NOP2/Sun domain family, member 6 | 0.0165207 |
| FAM219A | family with sequence similarity 219, member A | 0.0164883 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.016353 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0161313 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | 0.0160266 |
| STK38L | serine/threonine kinase 38 like | 0.0159232 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0156177 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | 0.0155002 |
| ALS2 | amyotrophic lateral sclerosis 2 (juvenile) | 0.0151906 |
| VMP1 | vacuole membrane protein 1 | 0.0149807 |
| GCLM | glutamate-cysteine ligase, modifier subunit | 0.0149723 |
| TARS1 | threonyl-tRNA synthetase 1 | 0.0146534 |
| FLNA | filamin A, alpha | 0.0144409 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0143775 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0142082 |
| ZNF721 | zinc finger protein 721 | 0.0142076 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | 0.0141455 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0141248 |
| ICE1 | interactor of little elongation complex ELL subunit 1 | 0.0138534 |
| TBK1 | TANK-binding kinase 1 | 0.0137297 |
| XRCC5 | X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) | 0.0137186 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | 0.0136721 |
| ANKRD17 | ankyrin repeat domain 17 | 0.01367 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.013471 |
| FAM177A1 | family with sequence similarity 177, member A1 | 0.013455 |
| EP300 | E1A binding protein p300 | 0.0134126 |
| NIBAN1 | niban apoptosis regulator 1 | 0.0133568 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0130314 |
| CCT6A | chaperonin containing TCP1, subunit 6A (zeta 1) | 0.0130046 |
| SERPINH1 | serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) | 0.0129664 |
| SOD1 | superoxide dismutase 1, soluble | 0.012959 |
| RPS14 | ribosomal protein S14 | 0.012924 |
| PSMD11 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 | 0.0129164 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0128524 |
| SPAG9 | sperm associated antigen 9 | 0.0128257 |
| UTY | ubiquitously transcribed tetratricopeptide repeat containing, Y-linked | 0.0128172 |
| PSMC6 | proteasome (prosome, macropain) 26S subunit, ATPase, 6 | 0.0126391 |
| INTS6 | integrator complex subunit 6 | 0.0125482 |
| EGLN3 | egl-9 family hypoxia-inducible factor 3 | 0.0124667 |
| YBX1 | Y box binding protein 1 | 0.0124591 |
| ZNFX1 | zinc finger, NFX1-type containing 1 | 0.0124127 |
| TTBK2 | tau tubulin kinase 2 | 0.0123856 |
| SPART | spartin | 0.0122562 |
| ELOVL5 | ELOVL fatty acid elongase 5 | 0.0122476 |
| TSEN15 | TSEN15 tRNA splicing endonuclease subunit | 0.0122416 |
| ASPH | aspartate beta-hydroxylase | 0.0121775 |
| DLGAP3 | discs, large (Drosophila) homolog-associated protein 3 | 0.0121646 |
| PSMD8 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 8 | 0.0121407 |
| HELB | helicase (DNA) B | 0.0121266 |
| PSMD3 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 | 0.0120771 |
| CPED1 | cadherin-like and PC-esterase domain containing 1 | 0.0120706 |
| PSMB7 | proteasome (prosome, macropain) subunit, beta type, 7 | 0.0120612 |
| WWOX | WW domain containing oxidoreductase | 0.012009 |
| FOXP2 | forkhead box P2 | 0.0119412 |
| EGFR | epidermal growth factor receptor | 0.0118485 |
| EP400 | E1A binding protein p400 | 0.011807 |
| MYH14 | myosin, heavy chain 14, non-muscle | 0.0118005 |
| JAZF1 | JAZF zinc finger 1 | 0.0116725 |
| SLC20A2 | solute carrier family 20 (phosphate transporter), member 2 | 0.0116112 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | -0.11657 |
| COL11A1 | collagen, type XI, alpha 1 | -0.0818422 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | -0.0814671 |
| PHIP | pleckstrin homology domain interacting protein | -0.0730047 |
| CDH10 | cadherin 10, type 2 (T2-cadherin) | -0.0691843 |
| CDH6 | cadherin 6, type 2, K-cadherin (fetal kidney) | -0.0691767 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0662103 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0627455 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.062478 |
| PEG10 | paternally expressed 10 | -0.0624131 |
| BACH2 | BTB and CNC homology 1, basic leucine zipper transcription factor 2 | -0.0535697 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0501237 |
| GPC3 | glypican 3 | -0.0498634 |
| PPP1R12A | protein phosphatase 1, regulatory subunit 12A | -0.0467473 |
| NOP58 | NOP58 ribonucleoprotein | -0.0464744 |
| ADGRL3 | adhesion G protein-coupled receptor L3 | -0.0457946 |
| PCLO | piccolo presynaptic cytomatrix protein | -0.0436425 |
| PLPP1 | phospholipid phosphatase 1 | -0.0435736 |
| CTNNA3 | catenin (cadherin-associated protein), alpha 3 | -0.0433143 |
| RAD51B | RAD51 paralog B | -0.0409174 |
| STRN3 | striatin, calmodulin binding protein 3 | -0.039947 |
| CTNNA2 | catenin (cadherin-associated protein), alpha 2 | -0.0380735 |
| CHD1 | chromodomain helicase DNA binding protein 1 | -0.0378482 |
| ZNF292 | zinc finger protein 292 | -0.0376404 |
| ANKRD33B | ankyrin repeat domain 33B | -0.0376002 |
| HS3ST5 | heparan sulfate (glucosamine) 3-O-sulfotransferase 5 | -0.0373943 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0373204 |
| MRPS30 | mitochondrial ribosomal protein S30 | -0.0367752 |
| PRR16 | proline rich 16 | -0.0356432 |
| FTL | ferritin, light polypeptide | -0.035638 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | -0.0337717 |
| NCOR1 | nuclear receptor corepressor 1 | -0.0333154 |
| RFPL4B | ret finger protein-like 4B | -0.032185 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | -0.0319672 |
| PGAP1 | post-GPI attachment to proteins 1 | -0.0317498 |
| HMGA2 | high mobility group AT-hook 2 | -0.0314577 |
| GALNTL6 | polypeptide N-acetylgalactosaminyltransferase-like 6 | -0.0314305 |
| NRG1 | neuregulin 1 | -0.0314176 |
| RBM39 | RNA binding motif protein 39 | -0.0311153 |
| HCN1 | hyperpolarization activated cyclic nucleotide gated potassium channel 1 | -0.0307791 |
| MAP4 | microtubule-associated protein 4 | -0.0298653 |
| RPL37A | ribosomal protein L37a | -0.0298239 |
| MEIS2 | Meis homeobox 2 | -0.0295081 |
| SHROOM3 | shroom family member 3 | -0.0289949 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0287048 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0283735 |
| PFN1 | profilin 1 | -0.0283506 |
| EMP1 | epithelial membrane protein 1 | -0.0274764 |
| RPL12 | ribosomal protein L12 | -0.0272275 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0271107 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0267908 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0265419 |
| RPS16 | ribosomal protein S16 | -0.0265328 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0264439 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.0264421 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0263688 |
| RAPGEF2 | Rap guanine nucleotide exchange factor (GEF) 2 | -0.0261444 |
| USP3 | ubiquitin specific peptidase 3 | -0.0251199 |
| PPP4R1 | protein phosphatase 4, regulatory subunit 1 | -0.0248781 |
| ADGRL2 | adhesion G protein-coupled receptor L2 | -0.0247213 |
| ADGRV1 | adhesion G protein-coupled receptor V1 | -0.0246863 |
| DNAJC1 | DnaJ (Hsp40) homolog, subfamily C, member 1 | -0.0246325 |
| URI1 | URI1, prefoldin-like chaperone | -0.0245245 |
| ZEB2 | zinc finger E-box binding homeobox 2 | -0.024125 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0239217 |
| MTDH | metadherin | -0.0238708 |
| SCAF11 | SR-related CTD-associated factor 11 | -0.0238375 |
| PRAG1 | PEAK1 related, kinase-activating pseudokinase 1 | -0.0237389 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0235572 |
| HS6ST2 | heparan sulfate 6-O-sulfotransferase 2 | -0.0231707 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0229285 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0225411 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0220987 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | -0.0218905 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0218872 |
| ZNF385D | zinc finger protein 385D | -0.0218502 |
| PRELID2 | PRELI domain containing 2 | -0.0216882 |
| FAT1 | FAT atypical cadherin 1 | -0.0216315 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0215186 |
| LRRC4C | leucine rich repeat containing 4C | -0.0213729 |
| METAP2 | methionyl aminopeptidase 2 | -0.0210763 |
| RASAL2 | RAS protein activator like 2 | -0.0208718 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | -0.0206735 |
| UBC | ubiquitin C | -0.0204315 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | -0.0204113 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | -0.0204044 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0200969 |
| ACBD3 | acyl-CoA binding domain containing 3 | -0.0199508 |
| FBL | fibrillarin | -0.0199283 |
| TBC1D12 | TBC1 domain family, member 12 | -0.0199056 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0197306 |
| NPAS3 | neuronal PAS domain protein 3 | -0.0196534 |
| CDC50A | cell division cycle 50 P4-ATPase accessory subunit A | -0.0196521 |
| CBFA2T2 | core-binding factor, runt domain, alpha subunit 2; translocated to, 2 | -0.0196148 |
| CACYBP | calcyclin binding protein | -0.0196078 |
| PTMA | prothymosin, alpha | -0.0195775 |
| MYO10 | myosin X | -0.0195695 |
| CBL | Cbl proto-oncogene, E3 ubiquitin protein ligase | -0.0194218 |
| USP34 | ubiquitin specific peptidase 34 | -0.0193395 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0191421 |
