Bortezomib_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Bortezomib perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Bortezomib_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.208977
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.145168
EEF2 eukaryotic translation elongation factor 2 0.0832704
UBC ubiquitin C 0.0614085
SQSTM1 sequestosome 1 0.0493143
PSMD1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 0.0490156
UBR3 ubiquitin protein ligase E3 component n-recognin 3 (putative) 0.0399873
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0399511
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0373624
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0340428
SNX29 sorting nexin 29 0.0323381
DLGAP3 discs, large (Drosophila) homolog-associated protein 3 0.0316601
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.0304799
FAM219A family with sequence similarity 219, member A 0.0301351
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0297845
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0256819
WARS1 tryptophanyl-tRNA synthetase 1 0.0254545
TBCA tubulin folding cofactor A 0.0248676
CLIP1 CAP-GLY domain containing linker protein 1 0.0244061
SLC38A6 solute carrier family 38, member 6 0.0232522
BICD1 bicaudal D homolog 1 (Drosophila) 0.0231316
ANKFN1 ankyrin-repeat and fibronectin type III domain containing 1 0.0230708
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 0.0228288
PSMB7 proteasome (prosome, macropain) subunit, beta type, 7 0.0220076
CAMK2G calcium/calmodulin-dependent protein kinase II gamma 0.0213662
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0209427
PLAA phospholipase A2-activating protein 0.0208749
NAA25 N(alpha)-acetyltransferase 25, NatB auxiliary subunit 0.0208289
FLNA filamin A, alpha 0.0199518
FHAD1 forkhead-associated (FHA) phosphopeptide binding domain 1 0.0197437
DST dystonin 0.0195875
KCMF1 potassium channel modulatory factor 1 0.0192418
EPB41 erythrocyte membrane protein band 4.1 0.0192206
KIF21A kinesin family member 21A 0.0187952
VMP1 vacuole membrane protein 1 0.0186151
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 0.0185523
VCP valosin containing protein 0.0183648
ZFAND5 zinc finger, AN1-type domain 5 0.0181669
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0181335
ALS2 amyotrophic lateral sclerosis 2 (juvenile) 0.0180834
EPS15L1 epidermal growth factor receptor pathway substrate 15-like 1 0.017865
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0176922
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.01761
RAD23B RAD23 homolog B (S. cerevisiae) 0.0174282
IARS1 isoleucyl-tRNA synthetase 1 0.0173993
MYH14 myosin, heavy chain 14, non-muscle 0.0168317
BSDC1 BSD domain containing 1 0.0168049
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.0165169
MACF1 microtubule-actin crosslinking factor 1 0.0164096
PHKB phosphorylase kinase, beta 0.0162916
NSFL1C NSFL1 (p97) cofactor (p47) 0.0162727
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0161721
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0158434
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2 0.0158131
UFD1 ubiquitin recognition factor in ER associated degradation 1 0.0157798
CEP290 centrosomal protein 290kDa 0.0157788
NSMAF neutral sphingomyelinase (N-SMase) activation associated factor 0.0157352
RPTOR regulatory associated protein of MTOR, complex 1 0.0154702
PTGES3 prostaglandin E synthase 3 (cytosolic) 0.0154593
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 0.0153487
LPIN1 lipin 1 0.0152767
GPATCH2L G patch domain containing 2-like 0.0152477
LARGE1 LARGE xylosyl- and glucuronyltransferase 1 0.0152225
HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2 0.0152082
TXNL1 thioredoxin-like 1 0.0150759
ERI3 ERI1 exoribonuclease family member 3 0.0150275
PRDM16 PR domain containing 16 0.0149336
SLC39A11 solute carrier family 39, member 11 0.0148304
TRAPPC8 trafficking protein particle complex 8 0.0146249
LPP LIM domain containing preferred translocation partner in lipoma 0.014582
INVS inversin 0.0145338
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0144678
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0143813
SLC10A7 solute carrier family 10, member 7 0.0141487
LARP1 La ribonucleoprotein domain family, member 1 0.0140887
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 0.0140436
CSNK1A1 casein kinase 1, alpha 1 0.0140047
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0139464
ACO2 aconitase 2, mitochondrial 0.0139045
MPP2 membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2) 0.0136409
PSMA5 proteasome (prosome, macropain) subunit, alpha type, 5 0.0135423
PSMC3 proteasome (prosome, macropain) 26S subunit, ATPase, 3 0.0134864
VWA8 von Willebrand factor A domain containing 8 0.0133817
HYOU1 hypoxia up-regulated 1 0.0132904
STK40 serine/threonine kinase 40 0.0131032
PSMC6 proteasome (prosome, macropain) 26S subunit, ATPase, 6 0.0130366
FN1 fibronectin 1 0.0130328
CORO1C coronin, actin binding protein, 1C 0.0129095
DDIT3 DNA-damage-inducible transcript 3 0.0127029
TACC2 transforming, acidic coiled-coil containing protein 2 0.0126679
NPLOC4 nuclear protein localization 4 homolog (S. cerevisiae) 0.0126005
DCTN4 dynactin 4 (p62) 0.0125602
SEM1 SEM1 26S proteasome subunit 0.0123357
USP14 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) 0.0123198
NDRG1 N-myc downstream regulated 1 0.0123134
RPL3 ribosomal protein L3 0.0123087
FTH1 ferritin, heavy polypeptide 1 0.0122632
RB1CC1 RB1-inducible coiled-coil 1 0.0122055
CFAP47 cilia and flagella associated protein 47 0.0121933
PSMD12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 0.0120673

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.294285
ADAM10 ADAM metallopeptidase domain 10 -0.159483
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.117703
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.104539
AHNAK AHNAK nucleoprotein -0.0953212
HSPH1 heat shock 105kDa/110kDa protein 1 -0.091317
RPS6 ribosomal protein S6 -0.0880247
HSPB1 heat shock 27kDa protein 1 -0.0840698
SOX6 SRY (sex determining region Y)-box 6 -0.0840163
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0768239
MKI67 marker of proliferation Ki-67 -0.0759397
TMSB4X thymosin beta 4, X-linked -0.0746455
EVI5 ecotropic viral integration site 5 -0.0696371
CCND1 cyclin D1 -0.0665677
EML4 echinoderm microtubule associated protein like 4 -0.0659886
VCL vinculin -0.0656258
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0632028
PKM pyruvate kinase, muscle -0.0610427
GOLGA4 golgin A4 -0.0609786
RPS8 ribosomal protein S8 -0.0603193
NBEA neurobeachin -0.0602826
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -0.0602342
CENPF centromere protein F, 350/400kDa -0.059455
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0594237
PGK1 phosphoglycerate kinase 1 -0.0588385
CAMTA1 calmodulin binding transcription activator 1 -0.057956
RPS2 ribosomal protein S2 -0.0574253
BMP10 bone morphogenetic protein 10 -0.0556733
ZNF292 zinc finger protein 292 -0.0554407
RPL26 ribosomal protein L26 -0.0550214
PYGB phosphorylase, glycogen; brain -0.0549242
FLNB filamin B, beta -0.0543253
TJP1 tight junction protein 1 -0.0540332
RBM39 RNA binding motif protein 39 -0.053892
EZR ezrin -0.0527584
RPL11 ribosomal protein L11 -0.0526088
RPL37A ribosomal protein L37a -0.0525519
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0524276
RPS3 ribosomal protein S3 -0.0513643
ECT2 epithelial cell transforming 2 -0.0502261
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0492616
RPL12 ribosomal protein L12 -0.0486606
S100A6 S100 calcium binding protein A6 -0.0477036
RPL19 ribosomal protein L19 -0.0475209
PRELID2 PRELI domain containing 2 -0.0466724
DPYD dihydropyrimidine dehydrogenase -0.0463874
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0451457
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.045057
CACNB4 calcium channel, voltage-dependent, beta 4 subunit -0.0448657
QKI QKI, KH domain containing, RNA binding -0.0443583
TPT1 tumor protein, translationally-controlled 1 -0.0442816
SMC4 structural maintenance of chromosomes 4 -0.0428811
DIAPH3 diaphanous-related formin 3 -0.0417996
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0415246
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme -0.0411435
NAV2 neuron navigator 2 -0.0402651
NFIA nuclear factor I/A -0.0400512
SMNDC1 survival motor neuron domain containing 1 -0.0399776
EIF4A2 eukaryotic translation initiation factor 4A2 -0.0398905
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 -0.039775
CD47 CD47 molecule -0.0395538
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0394424
B2M beta-2-microglobulin -0.0390245
RPL35A ribosomal protein L35a -0.0390134
PNISR PNN-interacting serine/arginine-rich protein -0.0388804
MYO5C myosin VC -0.0384175
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0381624
RPL36 ribosomal protein L36 -0.0379768
DSCAM Down syndrome cell adhesion molecule -0.0379635
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0377477
ZMYM2 zinc finger, MYM-type 2 -0.0377252
MATR3 matrin 3 -0.037699
SMYD3 SET and MYND domain containing 3 -0.0374282
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila) -0.03722
BMP2K BMP2 inducible kinase -0.0371933
TMEM65 transmembrane protein 65 -0.0371043
XPO1 exportin 1 -0.0370298
UBB ubiquitin B -0.0369009
DLG1 discs, large homolog 1 (Drosophila) -0.036671
MBNL1 muscleblind-like splicing regulator 1 -0.0365497
CALU calumenin -0.0363664
RBM25 RNA binding motif protein 25 -0.0359054
SLC38A2 solute carrier family 38, member 2 -0.0357672
EGFR epidermal growth factor receptor -0.0357325
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0355251
POTEF POTE ankyrin domain family, member F -0.0351811
FOXP1 forkhead box P1 -0.0349685
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0346782
ACTG1 actin gamma 1 -0.0346321
RPLP1 ribosomal protein, large, P1 -0.0346183
TPX2 TPX2, microtubule-associated -0.0345935
GLI3 GLI family zinc finger 3 -0.0341277
NUP58 nucleoporin 58 -0.0340969
RPS23 ribosomal protein S23 -0.0338472
WSB1 WD repeat and SOCS box containing 1 -0.0337103
RPL7 ribosomal protein L7 -0.033469
KIF5B kinesin family member 5B -0.0334137
NOP58 NOP58 ribonucleoprotein -0.0329796
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0329466
SDK1 sidekick cell adhesion molecule 1 -0.0326695