Bortezomib_SNU-423 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Bortezomib perturbation in SNU-423 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Bortezomib_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.203049
FN1 fibronectin 1 0.0940588
SOD2 superoxide dismutase 2, mitochondrial 0.0847498
MYH9 myosin, heavy chain 9, non-muscle 0.0519644
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0504056
TXNRD1 thioredoxin reductase 1 0.0470291
EEF2 eukaryotic translation elongation factor 2 0.0456735
DST dystonin 0.0440924
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0349118
USP9X ubiquitin specific peptidase 9, X-linked 0.0344584
ATXN1 ataxin 1 0.0343663
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0338434
EXT1 exostosin glycosyltransferase 1 0.032769
ZFAND3 zinc finger, AN1-type domain 3 0.0318277
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0317216
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 0.0306523
TRIO trio Rho guanine nucleotide exchange factor 0.0274862
BIRC6 baculoviral IAP repeat containing 6 0.0267833
SPAG9 sperm associated antigen 9 0.0261334
FNDC3B fibronectin type III domain containing 3B 0.0258482
SBF2 SET binding factor 2 0.0258012
KIF1B kinesin family member 1B 0.0249999
MKI67 marker of proliferation Ki-67 0.0235323
HSPH1 heat shock 105kDa/110kDa protein 1 0.0230446
FRMD5 FERM domain containing 5 0.0229242
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0228657
UBR2 ubiquitin protein ligase E3 component n-recognin 2 0.0220511
TNIP1 TNFAIP3 interacting protein 1 0.0220268
MAP1B microtubule-associated protein 1B 0.0219421
VMP1 vacuole membrane protein 1 0.0215962
OGA O-GlcNAcase 0.0213897
ECPAS Ecm29 proteasome adaptor and scaffold 0.0213136
TUSC3 tumor suppressor candidate 3 0.0210742
ANLN anillin, actin binding protein 0.0208572
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0207545
HSPA1B heat shock 70kDa protein 1B 0.0205924
PSMD1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 0.0204637
PTGES3 prostaglandin E synthase 3 (cytosolic) 0.0201017
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0199413
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.019907
BICC1 BicC family RNA binding protein 1 0.0196541
FLNA filamin A, alpha 0.0193683
UBQLN1 ubiquilin 1 0.0193593
PTPRK protein tyrosine phosphatase, receptor type, K 0.0191893
MSN moesin 0.0190696
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0190529
UBR3 ubiquitin protein ligase E3 component n-recognin 3 (putative) 0.0188249
TGFB2 transforming growth factor, beta 2 0.018625
BAG3 BCL2-associated athanogene 3 0.0185596
HSPA8 heat shock 70kDa protein 8 0.0183277
GLS2 glutaminase 2 (liver, mitochondrial) 0.0181601
DIAPH3 diaphanous-related formin 3 0.0179903
TRIP12 thyroid hormone receptor interactor 12 0.0178567
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0177088
FXR1 fragile X mental retardation, autosomal homolog 1 0.0176858
CKAP5 cytoskeleton associated protein 5 0.0176857
CENPF centromere protein F, 350/400kDa 0.0174674
AGTPBP1 ATP/GTP binding protein 1 0.0174394
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.0174358
LPP LIM domain containing preferred translocation partner in lipoma 0.0170624
SQSTM1 sequestosome 1 0.0166143
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0162065
TPM3 tropomyosin 3 0.0162001
EDIL3 EGF-like repeats and discoidin I-like domains 3 0.0161387
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.0160937
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0159607
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0156424
SH3RF2 SH3 domain containing ring finger 2 0.0155397
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0154895
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.015408
VCL vinculin 0.0153973
XPO1 exportin 1 0.0153022
TSC22D2 TSC22 domain family, member 2 0.0152696
KDM6A lysine (K)-specific demethylase 6A 0.0152676
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0150257
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.014964
VCP valosin containing protein 0.0148788
SLMAP sarcolemma associated protein 0.014818
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0148126
PDE1C phosphodiesterase 1C, calmodulin-dependent 70kDa 0.0147997
NCKAP1 NCK-associated protein 1 0.0147415
SMAD3 SMAD family member 3 0.0147403
HSPA1A heat shock 70kDa protein 1A 0.014458
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0142498
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0140844
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.014039
EXOC6B exocyst complex component 6B 0.0139025
AHR aryl hydrocarbon receptor 0.0138864
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 0.0138853
KIAA1217 KIAA1217 0.0138561
THOC2 THO complex 2 0.0137421
NUP153 nucleoporin 153kDa 0.0137152
FAM219A family with sequence similarity 219, member A 0.0136698
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 0.0136168
MAP4 microtubule-associated protein 4 0.0134016
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0133901
ENAH enabled homolog (Drosophila) 0.0132232
ZSWIM6 zinc finger, SWIM-type containing 6 0.0130734
NT5C2 5'-nucleotidase, cytosolic II 0.0130538
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2) 0.0130537

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.309589
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.137877
AKAP12 A kinase (PRKA) anchor protein 12 -0.127211
HLA-B major histocompatibility complex, class I, B -0.124393
IER3 immediate early response 3 -0.100335
IGFBP3 insulin-like growth factor binding protein 3 -0.0984075
FTL ferritin, light polypeptide -0.0872799
TPT1 tumor protein, translationally-controlled 1 -0.0839808
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0831191
CD44 CD44 molecule (Indian blood group) -0.0817164
TMSB10 thymosin beta 10 -0.0759627
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0680592
HLA-A major histocompatibility complex, class I, A -0.0671923
NDRG1 N-myc downstream regulated 1 -0.0648201
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A -0.0628053
FTH1 ferritin, heavy polypeptide 1 -0.0588951
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0577813
STC1 stanniocalcin 1 -0.0562635
MT2A metallothionein 2A -0.0556695
ADM adrenomedullin -0.0541575
RPS6 ribosomal protein S6 -0.0540409
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.0536021
BTG1 B-cell translocation gene 1, anti-proliferative -0.0515093
COL6A3 collagen, type VI, alpha 3 -0.0486104
PLIN2 perilipin 2 -0.0485433
CDH13 cadherin 13 -0.0464378
LDHA lactate dehydrogenase A -0.0461001
TMSB4X thymosin beta 4, X-linked -0.0447714
ZMYND8 zinc finger, MYND-type containing 8 -0.0436642
VEGFA vascular endothelial growth factor A -0.0428942
RPS8 ribosomal protein S8 -0.0413363
RPS12 ribosomal protein S12 -0.0408374
UBB ubiquitin B -0.0405104
SFRP1 secreted frizzled-related protein 1 -0.0405022
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.039328
NAMPT nicotinamide phosphoribosyltransferase -0.0387443
ARL4C ADP-ribosylation factor-like 4C -0.0386672
BASP1 brain abundant, membrane attached signal protein 1 -0.0381665
RPL35A ribosomal protein L35a -0.0376722
ENO1 enolase 1, (alpha) -0.0374796
PGK1 phosphoglycerate kinase 1 -0.0374567
SLC38A1 solute carrier family 38, member 1 -0.0360656
AFF3 AF4/FMR2 family, member 3 -0.0356406
RPL23 ribosomal protein L23 -0.0348498
GNAS GNAS complex locus -0.0344868
RPS3 ribosomal protein S3 -0.0343749
RPL37A ribosomal protein L37a -0.0340477
HMGA2 high mobility group AT-hook 2 -0.0339017
PDE10A phosphodiesterase 10A -0.0338209
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0334335
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0333664
MMP12 matrix metallopeptidase 12 -0.0326984
RPS23 ribosomal protein S23 -0.0319774
TMEM132D transmembrane protein 132D -0.0312146
EGFR epidermal growth factor receptor -0.0309225
C3 complement component 3 -0.030782
RPS13 ribosomal protein S13 -0.0307625
IFITM3 interferon induced transmembrane protein 3 -0.030183
RPL9 ribosomal protein L9 -0.0300291
CTSD cathepsin D -0.029677
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 -0.0294708
UGCG UDP-glucose ceramide glucosyltransferase -0.0290366
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) -0.0288904
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0287373
ACTG1 actin gamma 1 -0.0286949
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0286292
RPLP1 ribosomal protein, large, P1 -0.0283201
B2M beta-2-microglobulin -0.0277966
HMGA1 high mobility group AT-hook 1 -0.0274227
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0273782
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0269434
RPL11 ribosomal protein L11 -0.0267658
SDK1 sidekick cell adhesion molecule 1 -0.0267483
RPS27A ribosomal protein S27a -0.0267165
HLA-E major histocompatibility complex, class I, E -0.026515
GDF15 growth differentiation factor 15 -0.026458
RND3 Rho family GTPase 3 -0.0264288
EGR1 early growth response 1 -0.0263841
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0254537
CLMP CXADR-like membrane protein -0.0253075
RPS24 ribosomal protein S24 -0.0248952
ENO2 enolase 2 (gamma, neuronal) -0.0246813
ARFGAP3 ADP-ribosylation factor GTPase activating protein 3 -0.0246692
RPL38 ribosomal protein L38 -0.0245179
TPM4 tropomyosin 4 -0.0241353
EIF1 eukaryotic translation initiation factor 1 -0.0237909
FRMPD4 FERM and PDZ domain containing 4 -0.0231261
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0231186
PKM pyruvate kinase, muscle -0.0230887
RPLP2 ribosomal protein, large, P2 -0.0225334
HILPDA hypoxia inducible lipid droplet-associated -0.0224977
RPL36A ribosomal protein L36a -0.0224915
RPS19 ribosomal protein S19 -0.0223528
COL5A1 collagen, type V, alpha 1 -0.0221577
PTMA prothymosin, alpha -0.0220745
RPL37 ribosomal protein L37 -0.0220166
SAMD3 sterile alpha motif domain containing 3 -0.0220141
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0219251
RAI14 retinoic acid induced 14 -0.0218862
RPS29 ribosomal protein S29 -0.0217849