Bortezomib_SW 1088 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Bortezomib perturbation in SW 1088 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Bortezomib_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.445166
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.142649
NDRG1 N-myc downstream regulated 1 0.0949561
HSPA8 heat shock 70kDa protein 8 0.0846387
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.070961
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0635065
UBC ubiquitin C 0.0618621
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0607654
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 0.0504093
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.048732
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0482439
TGFBI transforming growth factor, beta-induced, 68kDa 0.0478261
KIF1B kinesin family member 1B 0.0450654
COL6A3 collagen, type VI, alpha 3 0.0450546
FTH1 ferritin, heavy polypeptide 1 0.0439233
HSPB1 heat shock 27kDa protein 1 0.0426087
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 0.0415571
HSPA1B heat shock 70kDa protein 1B 0.0402163
AFF4 AF4/FMR2 family, member 4 0.038371
TIMP3 TIMP metallopeptidase inhibitor 3 0.0372927
HIP1 huntingtin interacting protein 1 0.0366924
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.034905
TENT5A terminal nucleotidyltransferase 5A 0.033243
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0331097
UBR3 ubiquitin protein ligase E3 component n-recognin 3 (putative) 0.0326589
ANXA5 annexin A5 0.0319965
DSCAM Down syndrome cell adhesion molecule 0.0314063
JUN jun proto-oncogene 0.0306919
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) 0.0304039
ESYT2 extended synaptotagmin-like protein 2 0.0294068
SPAG9 sperm associated antigen 9 0.0291853
STC2 stanniocalcin 2 0.0284842
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0280198
VEGFA vascular endothelial growth factor A 0.0277058
SEPTIN9 septin 9 0.0275357
UBA6 ubiquitin-like modifier activating enzyme 6 0.0274393
SMAD3 SMAD family member 3 0.0273351
USP9Y ubiquitin specific peptidase 9, Y-linked 0.0270842
BAG3 BCL2-associated athanogene 3 0.027069
ZSWIM6 zinc finger, SWIM-type containing 6 0.0269779
KMT2C lysine (K)-specific methyltransferase 2C 0.0259946
CLTC clathrin, heavy chain (Hc) 0.0258876
SNX29 sorting nexin 29 0.0256762
MAP2K1 mitogen-activated protein kinase kinase 1 0.0253899
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.025137
COPA coatomer protein complex, subunit alpha 0.0250552
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.025038
NAV1 neuron navigator 1 0.0245398
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.0240086
HSPH1 heat shock 105kDa/110kDa protein 1 0.0236303
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0236205
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0234534
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit 0.0232792
SFPQ splicing factor proline/glutamine-rich 0.0232742
CAPN2 calpain 2, (m/II) large subunit 0.0230506
AFTPH aftiphilin 0.0230475
MARCHF7 membrane associated ring-CH-type finger 7 0.0224969
NRXN3 neurexin 3 0.0224321
TENT2 terminal nucleotidyltransferase 2 0.0222661
FLNA filamin A, alpha 0.0222416
CORO1C coronin, actin binding protein, 1C 0.0222242
HAPSTR1 HUWE1 associated protein modifying stress responses 0.0221442
WDR59 WD repeat domain 59 0.0220822
RNF145 ring finger protein 145 0.0218705
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0218468
HOOK2 hook microtubule-tethering protein 2 0.0217532
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0217377
IPO7 importin 7 0.0217006
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.0216997
ADM adrenomedullin 0.0216331
JARID2 jumonji, AT rich interactive domain 2 0.0214959
SEC24A SEC24 family member A 0.0212673
C1D C1D nuclear receptor corepressor 0.0212267
ELL2 elongation factor, RNA polymerase II, 2 0.0209331
AFF1 AF4/FMR2 family, member 1 0.0207568
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0204994
ZNF292 zinc finger protein 292 0.0204663
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) 0.0204498
CTBP2 C-terminal binding protein 2 0.0204141
UBQLN1 ubiquilin 1 0.0203778
ELF2 E74-like factor 2 (ets domain transcription factor) 0.0203741
SETD5 SET domain containing 5 0.0203042
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0203022
BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB 0.0202959
BRWD3 bromodomain and WD repeat domain containing 3 0.0200601
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3 0.0200211
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) 0.0199636
ICE1 interactor of little elongation complex ELL subunit 1 0.0199077
ESCO1 establishment of sister chromatid cohesion N-acetyltransferase 1 0.0198112
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0193604
SUPT6H suppressor of Ty 6 homolog (S. cerevisiae) 0.019278
SPART spartin 0.0190062
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0189728
CNOT4 CCR4-NOT transcription complex, subunit 4 0.018961
SRP54 signal recognition particle 54kDa 0.0188858
PSMD12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 0.0188821
ECPAS Ecm29 proteasome adaptor and scaffold 0.0186706
VCP valosin containing protein 0.0186706
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0186478
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0186074

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.1856
TMSB10 thymosin beta 10 -0.14451
MT2A metallothionein 2A -0.12099
FTL ferritin, light polypeptide -0.119846
PTMA prothymosin, alpha -0.0804899
FN1 fibronectin 1 -0.0757391
VIM vimentin -0.0748113
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0729289
SLC38A1 solute carrier family 38, member 1 -0.0635995
MT1X metallothionein 1X -0.0624146
CALU calumenin -0.0610724
LOX lysyl oxidase -0.0563677
RPL37A ribosomal protein L37a -0.0535665
VCL vinculin -0.0516508
CALD1 caldesmon 1 -0.0508435
F3 coagulation factor III (thromboplastin, tissue factor) -0.0487105
ZMYND8 zinc finger, MYND-type containing 8 -0.0485712
RPS24 ribosomal protein S24 -0.0465449
STC1 stanniocalcin 1 -0.0464437
FBXL7 F-box and leucine-rich repeat protein 7 -0.0431478
CCNI cyclin I -0.0422975
HLA-B major histocompatibility complex, class I, B -0.0394874
RPS19 ribosomal protein S19 -0.0392617
ZFAND3 zinc finger, AN1-type domain 3 -0.0387999
PRKCA protein kinase C, alpha -0.038691
RPL12 ribosomal protein L12 -0.0386786
GLIS3 GLIS family zinc finger 3 -0.0382649
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0378014
RPLP2 ribosomal protein, large, P2 -0.0377279
RPL26 ribosomal protein L26 -0.0373272
H3-3B H3.3 histone B -0.0370107
EXT1 exostosin glycosyltransferase 1 -0.0361455
S100A9 S100 calcium binding protein A9 -0.0353363
PRSS23 protease, serine, 23 -0.0353329
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.035067
COL1A1 collagen, type I, alpha 1 -0.0341903
S100A6 S100 calcium binding protein A6 -0.0338868
B2M beta-2-microglobulin -0.0338749
TM4SF1 transmembrane 4 L six family member 1 -0.0331194
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0328275
COL1A2 collagen, type I, alpha 2 -0.0325894
PLAUR plasminogen activator, urokinase receptor -0.032399
TAS2R14 taste receptor, type 2, member 14 -0.0323597
HMGA2 high mobility group AT-hook 2 -0.0318658
TRIO trio Rho guanine nucleotide exchange factor -0.0318448
MED13L mediator complex subunit 13-like -0.0314383
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0313545
QKI QKI, KH domain containing, RNA binding -0.0311664
MORF4L2 mortality factor 4 like 2 -0.0310172
FLOT1 flotillin 1 -0.0309326
EFNA5 ephrin-A5 -0.0308347
AUTS2 autism susceptibility candidate 2 -0.0305121
PRKCE protein kinase C, epsilon -0.0300165
RPL35A ribosomal protein L35a -0.0299556
PGK1 phosphoglycerate kinase 1 -0.0299338
POTEF POTE ankyrin domain family, member F -0.0295991
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0292489
CAV1 caveolin 1, caveolae protein, 22kDa -0.029087
TNS3 tensin 3 -0.0290431
GSE1 Gse1 coiled-coil protein -0.0288119
MBD5 methyl-CpG binding domain protein 5 -0.0287426
PSD3 pleckstrin and Sec7 domain containing 3 -0.0287099
SLC38A2 solute carrier family 38, member 2 -0.0285635
LAMB3 laminin, beta 3 -0.0284564
WSB1 WD repeat and SOCS box containing 1 -0.028407
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0278202
TRPS1 trichorhinophalangeal syndrome I -0.0277735
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0277504
RPS8 ribosomal protein S8 -0.0276577
RPS14 ribosomal protein S14 -0.0274951
CALR calreticulin -0.0274642
ACTG1 actin gamma 1 -0.0273405
HNRNPK heterogeneous nuclear ribonucleoprotein K -0.0270412
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0266316
RRBP1 ribosome binding protein 1 -0.0266133
TPM4 tropomyosin 4 -0.0265641
NAV2 neuron navigator 2 -0.0264304
RPS5 ribosomal protein S5 -0.0263157
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0259994
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0257303
UBB ubiquitin B -0.0255203
CD44 CD44 molecule (Indian blood group) -0.0254915
TPT1 tumor protein, translationally-controlled 1 -0.0254272
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0251958
TUBB tubulin, beta class I -0.0250826
RPL28 ribosomal protein L28 -0.0249095
RAD51B RAD51 paralog B -0.0247491
HLA-C major histocompatibility complex, class I, C -0.024236
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.0241396
FAF1 Fas (TNFRSF6) associated factor 1 -0.0241179
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0236559
ATP5F1E ATP synthase F1 subunit epsilon -0.0236463
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0233885
RBM6 RNA binding motif protein 6 -0.0233811
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0232825
RFC3 replication factor C (activator 1) 3, 38kDa -0.0232769
HMGB2 high mobility group box 2 -0.0231635
PARP4 poly (ADP-ribose) polymerase family, member 4 -0.0231262
PFN1 profilin 1 -0.0230995
PTPN14 protein tyrosine phosphatase, non-receptor type 14 -0.0229155