Bortezomib_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Bortezomib perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Bortezomib_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.291241
UBC ubiquitin C 0.0593671
NDRG1 N-myc downstream regulated 1 0.0581487
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0527238
ZSWIM6 zinc finger, SWIM-type containing 6 0.0452423
HSPA1A heat shock 70kDa protein 1A 0.0379317
PRRC2C proline-rich coiled-coil 2C 0.0373878
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0358752
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0328247
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.029173
PTK2 protein tyrosine kinase 2 0.0291032
GRB10 growth factor receptor-bound protein 10 0.0283094
RASAL2 RAS protein activator like 2 0.0274546
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0267691
UBR3 ubiquitin protein ligase E3 component n-recognin 3 (putative) 0.026545
RB1CC1 RB1-inducible coiled-coil 1 0.0260319
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.025389
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0248314
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0247174
TRIO trio Rho guanine nucleotide exchange factor 0.0246945
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0246442
RICTOR RPTOR independent companion of MTOR, complex 2 0.0244831
GOLGA4 golgin A4 0.0239188
FAT1 FAT atypical cadherin 1 0.0236346
HSPA1B heat shock 70kDa protein 1B 0.0235231
DST dystonin 0.0231589
FAM219A family with sequence similarity 219, member A 0.0214614
SLMAP sarcolemma associated protein 0.021383
CD109 CD109 molecule 0.0212373
TPM3 tropomyosin 3 0.0205792
HELZ helicase with zinc finger 0.0200545
DENND5B DENN/MADD domain containing 5B 0.0199248
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0199119
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0195831
CSNK1A1 casein kinase 1, alpha 1 0.019536
VEGFA vascular endothelial growth factor A 0.0194294
AKAP12 A kinase (PRKA) anchor protein 12 0.0193624
KIF1B kinesin family member 1B 0.0192777
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0188134
RBM25 RNA binding motif protein 25 0.0187527
KTN1 kinectin 1 (kinesin receptor) 0.0183707
NPTN neuroplastin 0.0179632
NOP58 NOP58 ribonucleoprotein 0.0176697
ELOVL5 ELOVL fatty acid elongase 5 0.0176575
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) 0.0176428
FMNL2 formin-like 2 0.0173702
KIF21A kinesin family member 21A 0.0173495
EZR ezrin 0.0171504
UBE2H ubiquitin-conjugating enzyme E2H 0.017029
TENT2 terminal nucleotidyltransferase 2 0.0166894
RACK1 receptor for activated C kinase 1 0.0166814
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0163947
KMT2C lysine (K)-specific methyltransferase 2C 0.0161323
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0158175
WDR43 WD repeat domain 43 0.0157219
UBA6 ubiquitin-like modifier activating enzyme 6 0.0156842
KIAA1217 KIAA1217 0.015618
AKAP13 A kinase (PRKA) anchor protein 13 0.0156116
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0154556
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0154423
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0153603
ANKRD28 ankyrin repeat domain 28 0.0150781
SIK3 SIK family kinase 3 0.0150373
KCMF1 potassium channel modulatory factor 1 0.0150307
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 0.0148979
BIRC6 baculoviral IAP repeat containing 6 0.0148644
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0146872
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0146669
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 0.014632
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 0.0146192
SAMD4B sterile alpha motif domain containing 4B 0.0143559
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0142541
RANBP2 RAN binding protein 2 0.0142179
EPS8 epidermal growth factor receptor pathway substrate 8 0.0141482
CTBP2 C-terminal binding protein 2 0.0141238
HILPDA hypoxia inducible lipid droplet-associated 0.014046
TBC1D15 TBC1 domain family, member 15 0.0139703
AFF1 AF4/FMR2 family, member 1 0.0139614
EMP1 epithelial membrane protein 1 0.0138983
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0138475
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0136957
JMJD1C jumonji domain containing 1C 0.0136804
DTNA dystrobrevin, alpha 0.0136005
MSN moesin 0.0135993
NCKAP1 NCK-associated protein 1 0.0135501
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0134016
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0133664
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0132758
GLS2 glutaminase 2 (liver, mitochondrial) 0.0132704
VPS53 vacuolar protein sorting 53 homolog (S. cerevisiae) 0.0132584
ATF6 activating transcription factor 6 0.0128838
CHD1 chromodomain helicase DNA binding protein 1 0.0127745
BOD1L1 biorientation of chromosomes in cell division 1-like 1 0.0126326
PSMD1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 0.0125443
MIDEAS mitotic deacetylase associated SANT domain protein 0.0123988
ZEB1 zinc finger E-box binding homeobox 1 0.0123559
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 0.0123311
CSPP1 centrosome and spindle pole associated protein 1 0.0121896
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0121357
SLTM SAFB-like, transcription modulator 0.0120874

decreased expression

Symbol Name Standardized Value
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.24259
NRG1 neuregulin 1 -0.208148
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.196418
FN1 fibronectin 1 -0.1748
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.111632
HMGA2 high mobility group AT-hook 2 -0.0944841
ITGA1 integrin, alpha 1 -0.0918041
PTMA prothymosin, alpha -0.0805273
FTL ferritin, light polypeptide -0.0721827
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0691297
SQSTM1 sequestosome 1 -0.0690446
HLA-B major histocompatibility complex, class I, B -0.0633149
VCL vinculin -0.0579182
TMSB10 thymosin beta 10 -0.0552759
S100A6 S100 calcium binding protein A6 -0.0495367
NAMPT nicotinamide phosphoribosyltransferase -0.0482113
IFI27 interferon, alpha-inducible protein 27 -0.0467049
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0449764
CANX calnexin -0.0439824
SYT1 synaptotagmin I -0.0435852
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0435511
TMSB4X thymosin beta 4, X-linked -0.0435193
RAI14 retinoic acid induced 14 -0.0420312
TMEM156 transmembrane protein 156 -0.0407603
GLIS3 GLIS family zinc finger 3 -0.0354205
EXT1 exostosin glycosyltransferase 1 -0.033581
TAS2R14 taste receptor, type 2, member 14 -0.0314279
AHR aryl hydrocarbon receptor -0.03125
NCOA7 nuclear receptor coactivator 7 -0.0306972
ACTG1 actin gamma 1 -0.0300875
ETV1 ets variant 1 -0.0298276
EFNA5 ephrin-A5 -0.0287502
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0285967
KLHL5 kelch-like family member 5 -0.0273461
PLIN2 perilipin 2 -0.0271227
IER3 immediate early response 3 -0.0264939
LRMDA leucine rich melanocyte differentiation associated -0.0259232
ZBTB20 zinc finger and BTB domain containing 20 -0.0255744
OSMR oncostatin M receptor -0.0250264
SOX4 SRY (sex determining region Y)-box 4 -0.0239124
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0235678
MAML2 mastermind-like 2 (Drosophila) -0.0234316
AEBP2 AE binding protein 2 -0.0232648
TFPI2 tissue factor pathway inhibitor 2 -0.0231
ASPH aspartate beta-hydroxylase -0.0225825
TXNRD1 thioredoxin reductase 1 -0.0224158
HLA-A major histocompatibility complex, class I, A -0.0223616
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0223201
TPT1 tumor protein, translationally-controlled 1 -0.0222172
RPS24 ribosomal protein S24 -0.022123
RNF213 ring finger protein 213 -0.0217759
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0217234
SFTPA2 surfactant protein A2 -0.0215709
NTN4 netrin 4 -0.0214701
ETV6 ets variant 6 -0.0214277
FTH1 ferritin, heavy polypeptide 1 -0.0213872
FAM20C family with sequence similarity 20, member C -0.020978
RPL31 ribosomal protein L31 -0.0209419
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0208677
TM4SF1 transmembrane 4 L six family member 1 -0.0207239
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0206697
VIM vimentin -0.0205898
PDE4D phosphodiesterase 4D, cAMP-specific -0.0203223
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0201938
TENM4 teneurin transmembrane protein 4 -0.0200454
DNAH5 dynein, axonemal, heavy chain 5 -0.0200037
HSPA6 heat shock 70kDa protein 6 (HSP70B') -0.0199359
PALLD palladin, cytoskeletal associated protein -0.0199287
IFI6 interferon, alpha-inducible protein 6 -0.019604
RUNX2 runt-related transcription factor 2 -0.0193755
TNS3 tensin 3 -0.0192748
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.019025
RPS21 ribosomal protein S21 -0.018823
IRAK3 interleukin-1 receptor-associated kinase 3 -0.018512
UGDH UDP-glucose 6-dehydrogenase -0.0182764
CALU calumenin -0.0180471
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0176338
AHRR aryl-hydrocarbon receptor repressor -0.0175738
ARHGAP35 Rho GTPase activating protein 35 -0.0175424
FAM114A1 family with sequence similarity 114, member A1 -0.0174294
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0173861
CENPF centromere protein F, 350/400kDa -0.0172634
NRP1 neuropilin 1 -0.0170268
EXOC4 exocyst complex component 4 -0.0170193
DDIT4 DNA-damage-inducible transcript 4 -0.0169884
EREG epiregulin -0.0169722
GNAS GNAS complex locus -0.0168701
RPL38 ribosomal protein L38 -0.0167763
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0166843
ARF1 ADP-ribosylation factor 1 -0.0166689
SLC38A1 solute carrier family 38, member 1 -0.0165716
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0165406
RPS23 ribosomal protein S23 -0.0164561
HMGA1 high mobility group AT-hook 1 -0.0163953
FNDC3B fibronectin type III domain containing 3B -0.0162467
NRIP1 nuclear receptor interacting protein 1 -0.0161943
CADM1 cell adhesion molecule 1 -0.0161567
SMIM14 small integral membrane protein 14 -0.0160005
GLUL glutamate-ammonia ligase -0.0159749
SFRP1 secreted frizzled-related protein 1 -0.0158395