| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Bosentan (hydrate) perturbation in A-172 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Bosentan (hydrate)_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GOLGA4 | golgin A4 | 0.059596 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0577233 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0572471 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0527802 |
| CSTB | cystatin B (stefin B) | 0.0465731 |
| ATP13A3 | ATPase type 13A3 | 0.0385702 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0350634 |
| PTMA | prothymosin, alpha | 0.0346945 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0343334 |
| CYLD | cylindromatosis (turban tumor syndrome) | 0.0310443 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0308411 |
| MXI1 | MAX interactor 1, dimerization protein | 0.0303418 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0300964 |
| HELZ | helicase with zinc finger | 0.0295667 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0287428 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0281453 |
| RNMT | RNA (guanine-7-) methyltransferase | 0.0280796 |
| SQSTM1 | sequestosome 1 | 0.028062 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0273777 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0273355 |
| MIMS1 | mitochondrial inner membrane scaffold 1 | 0.0267439 |
| YWHAQ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta | 0.0264082 |
| SBF2 | SET binding factor 2 | 0.0259931 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0259179 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0256839 |
| OGA | O-GlcNAcase | 0.0253682 |
| ZNF292 | zinc finger protein 292 | 0.024946 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0244534 |
| CD109 | CD109 molecule | 0.0242984 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0242914 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.0240786 |
| RPS6 | ribosomal protein S6 | 0.0234701 |
| MT2A | metallothionein 2A | 0.0226417 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0224045 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.0218326 |
| DTNA | dystrobrevin, alpha | 0.0217555 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0217045 |
| ADM | adrenomedullin | 0.0210313 |
| AGPAT5 | 1-acylglycerol-3-phosphate O-acyltransferase 5 | 0.0209313 |
| RNF145 | ring finger protein 145 | 0.0208913 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0204411 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0202937 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0202369 |
| BBX | bobby sox homolog (Drosophila) | 0.0201997 |
| ANKIB1 | ankyrin repeat and IBR domain containing 1 | 0.0201145 |
| FAM107B | family with sequence similarity 107, member B | 0.0201089 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.020101 |
| SKIC3 | SKI3 subunit of superkiller complex | 0.0200386 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | 0.0199784 |
| RIOK3 | RIO kinase 3 | 0.0196482 |
| INSIG1 | insulin induced gene 1 | 0.0195542 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0195256 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | 0.019424 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.0191209 |
| TRPM7 | transient receptor potential cation channel, subfamily M, member 7 | 0.0190958 |
| NPEPPS | aminopeptidase puromycin sensitive | 0.0190954 |
| GPC6 | glypican 6 | 0.0186001 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0185643 |
| FTL | ferritin, light polypeptide | 0.0185482 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0185019 |
| INSIG2 | insulin induced gene 2 | 0.0183387 |
| TNFAIP2 | tumor necrosis factor, alpha-induced protein 2 | 0.0183381 |
| OPTN | optineurin | 0.0181671 |
| LPCAT2 | lysophosphatidylcholine acyltransferase 2 | 0.017988 |
| DENND4C | DENN/MADD domain containing 4C | 0.0176587 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | 0.0176558 |
| WDFY1 | WD repeat and FYVE domain containing 1 | 0.0175092 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0174612 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0174066 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0173101 |
| GPHN | gephyrin | 0.0172551 |
| ANK2 | ankyrin 2, neuronal | 0.0172233 |
| SLC41A2 | solute carrier family 41 (magnesium transporter), member 2 | 0.0171809 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0171501 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0171063 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0169779 |
| CLU | clusterin | 0.0168552 |
| SSBP2 | single-stranded DNA binding protein 2 | 0.0167829 |
| PSMA7 | proteasome (prosome, macropain) subunit, alpha type, 7 | 0.0167582 |
| RYBP | RING1 and YY1 binding protein | 0.0167431 |
| SNX9 | sorting nexin 9 | 0.0166373 |
| MEF2A | myocyte enhancer factor 2A | 0.016548 |
| PRKD3 | protein kinase D3 | 0.0165268 |
| RNF24 | ring finger protein 24 | 0.0163245 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | 0.0162001 |
| FNBP1L | formin binding protein 1-like | 0.0161844 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0160977 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0160696 |
| C1GALT1 | core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 | 0.0160063 |
| PDK3 | pyruvate dehydrogenase kinase, isozyme 3 | 0.0159616 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0158321 |
| FAM162A | family with sequence similarity 162, member A | 0.0157846 |
| MATR3 | matrin 3 | 0.0155334 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | 0.0155221 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0154794 |
| AMPD3 | adenosine monophosphate deaminase 3 | 0.0153927 |
| NGLY1 | N-glycanase 1 | 0.0152938 |
| RPS8 | ribosomal protein S8 | 0.0152622 |
| KIF13A | kinesin family member 13A | 0.0150756 |
| USP3 | ubiquitin specific peptidase 3 | 0.0150715 |
| Symbol | Name | Standardized Value |
|---|---|---|
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.219836 |
| PODXL | podocalyxin-like | -0.202306 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.200326 |
| COL5A1 | collagen, type V, alpha 1 | -0.166407 |
| NAV1 | neuron navigator 1 | -0.151604 |
| CDH13 | cadherin 13 | -0.142667 |
| AHNAK | AHNAK nucleoprotein | -0.137556 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.137371 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.125503 |
| LOX | lysyl oxidase | -0.113888 |
| PLAT | plasminogen activator, tissue | -0.113758 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0922545 |
| CACNA2D3 | calcium channel, voltage-dependent, alpha 2/delta subunit 3 | -0.0909054 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0892157 |
| SLC39A11 | solute carrier family 39, member 11 | -0.0819178 |
| MAP1B | microtubule-associated protein 1B | -0.0815049 |
| VIM | vimentin | -0.0804592 |
| UBC | ubiquitin C | -0.077672 |
| CD44 | CD44 molecule (Indian blood group) | -0.0754192 |
| COL3A1 | collagen, type III, alpha 1 | -0.0718123 |
| RIGI | RNA sensor RIG-I | -0.0660156 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.062564 |
| TMSB10 | thymosin beta 10 | -0.0609744 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0583569 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.058351 |
| THBS2 | thrombospondin 2 | -0.0570534 |
| EGFR | epidermal growth factor receptor | -0.0560962 |
| FLNA | filamin A, alpha | -0.0533451 |
| EFNA5 | ephrin-A5 | -0.0518758 |
| FN1 | fibronectin 1 | -0.0492303 |
| GLIS3 | GLIS family zinc finger 3 | -0.047834 |
| APP | amyloid beta (A4) precursor protein | -0.0477062 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | -0.0464707 |
| CUX1 | cut-like homeobox 1 | -0.0463978 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0459317 |
| COL5A2 | collagen, type V, alpha 2 | -0.0457772 |
| FRMD4A | FERM domain containing 4A | -0.0454714 |
| ASPH | aspartate beta-hydroxylase | -0.0449257 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0447211 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0444394 |
| VCL | vinculin | -0.0442772 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.044177 |
| PRSS23 | protease, serine, 23 | -0.0436816 |
| FSTL1 | follistatin-like 1 | -0.0434619 |
| PKM | pyruvate kinase, muscle | -0.0430295 |
| PBX3 | pre-B-cell leukemia homeobox 3 | -0.0425934 |
| ANXA2 | annexin A2 | -0.0421004 |
| SAMD9 | sterile alpha motif domain containing 9 | -0.0420855 |
| RNF213 | ring finger protein 213 | -0.0415334 |
| CYTH3 | cytohesin 3 | -0.0411914 |
| COL8A1 | collagen, type VIII, alpha 1 | -0.0410342 |
| DGKG | diacylglycerol kinase, gamma 90kDa | -0.0403368 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | -0.0402667 |
| SUCNR1 | succinate receptor 1 | -0.0397898 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0376626 |
| RASAL2 | RAS protein activator like 2 | -0.0373619 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0371589 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | -0.0371082 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | -0.0370578 |
| MX2 | MX dynamin-like GTPase 2 | -0.0370153 |
| INTS6 | integrator complex subunit 6 | -0.0369322 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | -0.0366127 |
| HLA-B | major histocompatibility complex, class I, B | -0.0355272 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0354494 |
| CD99 | CD99 molecule | -0.0349321 |
| CD59 | CD59 molecule, complement regulatory protein | -0.0344922 |
| RPS6KA2 | ribosomal protein S6 kinase, 90kDa, polypeptide 2 | -0.0339938 |
| SDCCAG8 | serologically defined colon cancer antigen 8 | -0.0337398 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0330791 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0330366 |
| FLT1 | fms-related tyrosine kinase 1 | -0.0328505 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0328266 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0326467 |
| SP100 | SP100 nuclear antigen | -0.0322742 |
| AHNAK2 | AHNAK nucleoprotein 2 | -0.0322687 |
| DKK3 | dickkopf WNT signaling pathway inhibitor 3 | -0.0319196 |
| PLXNA2 | plexin A2 | -0.0317063 |
| SEPTIN9 | septin 9 | -0.0305881 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0301261 |
| EHBP1 | EH domain binding protein 1 | -0.0300619 |
| TNS3 | tensin 3 | -0.0300119 |
| LMNA | lamin A/C | -0.0293377 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0292939 |
| RUNX1 | runt-related transcription factor 1 | -0.0287458 |
| MCL1 | myeloid cell leukemia 1 | -0.0285574 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0284856 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0283162 |
| DOCK5 | dedicator of cytokinesis 5 | -0.028105 |
| HLA-C | major histocompatibility complex, class I, C | -0.0278459 |
| DHRSX | dehydrogenase/reductase (SDR family) X-linked | -0.0276339 |
| AUTS2 | autism susceptibility candidate 2 | -0.027571 |
| ZNF217 | zinc finger protein 217 | -0.0272912 |
| IPO9 | importin 9 | -0.0268291 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0266902 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | -0.0266073 |
| SMYD3 | SET and MYND domain containing 3 | -0.0265839 |
| COL4A2 | collagen, type IV, alpha 2 | -0.0262949 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0260565 |
| XKR6 | XK, Kell blood group complex subunit-related family, member 6 | -0.0259441 |
| S100A10 | S100 calcium binding protein A10 | -0.0257234 |
