Bosentan (hydrate)_A-427 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Bosentan (hydrate) perturbation in A-427 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Bosentan (hydrate)_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.14589
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0569126
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0566463
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0498115
FXR1 fragile X mental retardation, autosomal homolog 1 0.0427152
USP53 ubiquitin specific peptidase 53 0.0379512
RLF rearranged L-myc fusion 0.0369715
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0341086
BIRC6 baculoviral IAP repeat containing 6 0.0340002
OSBPL8 oxysterol binding protein-like 8 0.0333841
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0327411
TAOK1 TAO kinase 1 0.0314384
SF3B2 splicing factor 3b, subunit 2, 145kDa 0.0306088
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0294818
ZCCHC7 zinc finger, CCHC domain containing 7 0.0288347
PTGES3 prostaglandin E synthase 3 (cytosolic) 0.0285692
CDK19 cyclin-dependent kinase 19 0.0283285
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0268613
PDK4 pyruvate dehydrogenase kinase, isozyme 4 0.0267705
GPBP1 GC-rich promoter binding protein 1 0.0261753
SYT1 synaptotagmin I 0.0261642
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.025674
HSPB1 heat shock 27kDa protein 1 0.0251957
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0247653
SPAG9 sperm associated antigen 9 0.0246932
CSNK1A1 casein kinase 1, alpha 1 0.0240773
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0240523
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0235554
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0233613
MBD5 methyl-CpG binding domain protein 5 0.0233266
POTEF POTE ankyrin domain family, member F 0.0232074
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0231837
RBM26 RNA binding motif protein 26 0.0230781
AKAP12 A kinase (PRKA) anchor protein 12 0.0230012
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0224275
EPRS1 glutamyl-prolyl-tRNA synthetase 1 0.0219529
KMT2E lysine (K)-specific methyltransferase 2E 0.0219366
HDGF hepatoma-derived growth factor 0.0219139
LARS1 leucyl-tRNA synthetase 1 0.0203984
ARID4B AT rich interactive domain 4B (RBP1-like) 0.020385
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0201243
ZSWIM6 zinc finger, SWIM-type containing 6 0.0200817
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0200813
TTC3 tetratricopeptide repeat domain 3 0.0200313
TFG TRK-fused gene 0.0199874
PICALM phosphatidylinositol binding clathrin assembly protein 0.0198043
PCBP2 poly(rC) binding protein 2 0.019786
KMT2C lysine (K)-specific methyltransferase 2C 0.0193048
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0191473
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) 0.0190085
TCEA1 transcription elongation factor A (SII), 1 0.0189718
LCORL ligand dependent nuclear receptor corepressor-like 0.018658
WAC WW domain containing adaptor with coiled-coil 0.0186373
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa 0.0186106
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0184516
SLC38A1 solute carrier family 38, member 1 0.0184238
ERRFI1 ERBB receptor feedback inhibitor 1 0.0182559
PPP1R21 protein phosphatase 1, regulatory subunit 21 0.018156
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0180318
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0179033
HELZ helicase with zinc finger 0.0178678
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.0178081
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0178039
CAMKMT calmodulin-lysine N-methyltransferase 0.0177642
SETD5 SET domain containing 5 0.01755
INTS6 integrator complex subunit 6 0.0174057
PRKCI protein kinase C, iota 0.0170194
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0170173
HSPA8 heat shock 70kDa protein 8 0.0169246
KDM2A lysine (K)-specific demethylase 2A 0.0169241
LNPEP leucyl/cystinyl aminopeptidase 0.0167538
KIF5B kinesin family member 5B 0.0166291
ANXA1 annexin A1 0.0165184
HSPH1 heat shock 105kDa/110kDa protein 1 0.0163311
KDM6A lysine (K)-specific demethylase 6A 0.0162204
AKAP9 A kinase (PRKA) anchor protein 9 0.0160883
NOLC1 nucleolar and coiled-body phosphoprotein 1 0.0160428
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0158985
CCNY cyclin Y 0.0158819
ADAM9 ADAM metallopeptidase domain 9 0.0158801
PAPOLA poly(A) polymerase alpha 0.0158719
TMEM135 transmembrane protein 135 0.0158693
BCL6 B-cell CLL/lymphoma 6 0.0158343
LOC102724023 ES1 protein homolog, mitochondrial 0.0156617
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.015584
CHD7 chromodomain helicase DNA binding protein 7 0.0154876
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0154711
KDM3A lysine (K)-specific demethylase 3A 0.0154705
CCT5 chaperonin containing TCP1, subunit 5 (epsilon) 0.0154213
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0153914
UBE2K ubiquitin-conjugating enzyme E2K 0.0152114
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.015121
CHCHD3 coiled-coil-helix-coiled-coil-helix domain containing 3 0.0150568
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0149062
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0148854
NIPBL Nipped-B homolog (Drosophila) 0.0148227
PDE7A phosphodiesterase 7A 0.0147589
FGFR1OP2 FGFR1 oncogene partner 2 0.0146858
MLF1 myeloid leukemia factor 1 0.0146661
S100A10 S100 calcium binding protein A10 0.014666

decreased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific -0.268593
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.204138
TMSB10 thymosin beta 10 -0.182697
VIM vimentin -0.153218
NLGN1 neuroligin 1 -0.13361
MMP12 matrix metallopeptidase 12 -0.103196
CELF2 CUGBP, Elav-like family member 2 -0.0955439
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0933975
MTAP methylthioadenosine phosphorylase -0.0861345
ANKRD12 ankyrin repeat domain 12 -0.076604
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0754042
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0744916
RPL35A ribosomal protein L35a -0.0683257
PCDH7 protocadherin 7 -0.0652795
MYL12B myosin, light chain 12B, regulatory -0.0643972
BCHE butyrylcholinesterase -0.0639853
ADGRG6 adhesion G protein-coupled receptor G6 -0.0614996
PDGFC platelet derived growth factor C -0.0606814
EDARADD EDAR-associated death domain -0.0606368
TENM3 teneurin transmembrane protein 3 -0.0602669
MGAT4C MGAT4 family, member C -0.0583516
RPL26 ribosomal protein L26 -0.0576588
RPS12 ribosomal protein S12 -0.0561674
TMEM41B transmembrane protein 41B -0.0559177
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0549056
VCL vinculin -0.0548902
AREG amphiregulin -0.0521854
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.05184
RPS8 ribosomal protein S8 -0.0513268
RPS19 ribosomal protein S19 -0.0487496
RPLP2 ribosomal protein, large, P2 -0.048481
RTN4 reticulon 4 -0.0483577
NHSL1 NHS-like 1 -0.0480889
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0471422
ZNF217 zinc finger protein 217 -0.0469376
RPL37A ribosomal protein L37a -0.0465827
TXNRD1 thioredoxin reductase 1 -0.0458221
RPS27A ribosomal protein S27a -0.0457983
RAB7A RAB7A, member RAS oncogene family -0.0450749
RPS21 ribosomal protein S21 -0.0446383
RPL23 ribosomal protein L23 -0.0441567
ERBB4 erb-b2 receptor tyrosine kinase 4 -0.0440839
CNRIP1 cannabinoid receptor interacting protein 1 -0.044071
RPL12 ribosomal protein L12 -0.0435932
LMO7 LIM domain 7 -0.0434437
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0431097
SLC38A2 solute carrier family 38, member 2 -0.0430808
LRRTM4 leucine rich repeat transmembrane neuronal 4 -0.0425627
NPC1 Niemann-Pick disease, type C1 -0.0424411
DLC1 DLC1 Rho GTPase activating protein -0.0418145
NCEH1 neutral cholesterol ester hydrolase 1 -0.0417796
RPL9 ribosomal protein L9 -0.0415331
NR5A2 nuclear receptor subfamily 5, group A, member 2 -0.0412609
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0401514
RPL34 ribosomal protein L34 -0.0399815
ANKUB1 ankyrin repeat and ubiquitin domain containing 1 -0.0398345
YAP1 Yes-associated protein 1 -0.0396403
JMJD1C jumonji domain containing 1C -0.0393421
SMC4 structural maintenance of chromosomes 4 -0.0380477
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0376784
ANKRD28 ankyrin repeat domain 28 -0.036881
RIMS2 regulating synaptic membrane exocytosis 2 -0.0360642
RPL5 ribosomal protein L5 -0.035892
TAS2R14 taste receptor, type 2, member 14 -0.0358055
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) -0.035526
RAP1B RAP1B, member of RAS oncogene family -0.0348358
AXIN2 axin 2 -0.0341633
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1 -0.0340932
RPL19 ribosomal protein L19 -0.0339362
CMIP c-Maf inducing protein -0.0326576
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.032656
TUBB6 tubulin, beta 6 class V -0.0323934
IPO7 importin 7 -0.0321296
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0320321
KIF18B kinesin family member 18B -0.0316713
RBM25 RNA binding motif protein 25 -0.0316418
HMGA1 high mobility group AT-hook 1 -0.0314797
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0314007
RPLP1 ribosomal protein, large, P1 -0.0310852
TNPO1 transportin 1 -0.0308523
RACK1 receptor for activated C kinase 1 -0.0306697
RPL37 ribosomal protein L37 -0.0303563
AFG3L2 AFG3-like AAA ATPase 2 -0.0303554
YBX3 Y box binding protein 3 -0.0298522
NABP1 nucleic acid binding protein 1 -0.0297788
ATP5F1B ATP synthase F1 subunit beta -0.0297219
TIGAR TP53 induced glycolysis regulatory phosphatase -0.0296287
TPI1 triosephosphate isomerase 1 -0.0295702
NCAPD2 non-SMC condensin I complex, subunit D2 -0.0294221
CUBN cubilin (intrinsic factor-cobalamin receptor) -0.0294033
DPYD dihydropyrimidine dehydrogenase -0.0291697
TGIF1 TGFB-induced factor homeobox 1 -0.0285345
KLF6 Kruppel-like factor 6 -0.0282996
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0282335
AHNAK AHNAK nucleoprotein -0.0282138
MYPN myopalladin -0.0281192
FEZ2 fasciculation and elongation protein zeta 2 (zygin II) -0.027912
DLGAP1 discs, large (Drosophila) homolog-associated protein 1 -0.0274801
GNB4 guanine nucleotide binding protein (G protein), beta polypeptide 4 -0.0273093
TEAD4 TEA domain family member 4 -0.027219