Bosentan (hydrate)_A498 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Bosentan (hydrate) perturbation in A498 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Bosentan (hydrate)_A498 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CCL2 chemokine (C-C motif) ligand 2 0.0648747
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0619148
CXCL8 chemokine (C-X-C motif) ligand 8 0.0522811
GPC6 glypican 6 0.0491743
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.04159
CSF1 colony stimulating factor 1 (macrophage) 0.0413768
MSN moesin 0.0397062
CADM1 cell adhesion molecule 1 0.0358138
ZFP36L1 ZFP36 ring finger protein-like 1 0.0357653
GLS2 glutaminase 2 (liver, mitochondrial) 0.0355231
TPM3 tropomyosin 3 0.0343934
PTBP3 polypyrimidine tract binding protein 3 0.0299887
ATP13A3 ATPase type 13A3 0.0274196
UBA6 ubiquitin-like modifier activating enzyme 6 0.0270191
PDIA3 protein disulfide isomerase family A, member 3 0.0260848
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0255236
ZCCHC7 zinc finger, CCHC domain containing 7 0.0254258
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0237993
DSTN destrin (actin depolymerizing factor) 0.0230237
PLK2 polo-like kinase 2 0.0228731
PAX8 paired box 8 0.0223042
VCAM1 vascular cell adhesion molecule 1 0.0221253
KTN1 kinectin 1 (kinesin receptor) 0.0221199
KDM6A lysine (K)-specific demethylase 6A 0.0220479
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0214283
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0212956
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0211165
SPAG9 sperm associated antigen 9 0.0209417
RPL21 ribosomal protein L21 0.020901
NRIP1 nuclear receptor interacting protein 1 0.0203917
ADAM17 ADAM metallopeptidase domain 17 0.0197766
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0191871
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase 0.0191851
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.01918
SET SET nuclear proto-oncogene 0.0186356
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0186
ADAM9 ADAM metallopeptidase domain 9 0.0185022
ARHGAP26 Rho GTPase activating protein 26 0.018304
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) 0.018201
TRIO trio Rho guanine nucleotide exchange factor 0.0175672
SRRM2 serine/arginine repetitive matrix 2 0.0170638
SBF2 SET binding factor 2 0.0170186
BIRC3 baculoviral IAP repeat containing 3 0.0168232
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0167688
ACBD3 acyl-CoA binding domain containing 3 0.0167391
FAT1 FAT atypical cadherin 1 0.015678
KMT2E lysine (K)-specific methyltransferase 2E 0.015542
ADAM10 ADAM metallopeptidase domain 10 0.0153704
WDR43 WD repeat domain 43 0.015
MYO1B myosin IB 0.0149138
HDGF hepatoma-derived growth factor 0.0148496
GOLGA4 golgin A4 0.0146884
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0146197
FNIP1 folliculin interacting protein 1 0.0144437
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0142274
VCAN versican 0.0141298
FMNL2 formin-like 2 0.0141237
P3H2 prolyl 3-hydroxylase 2 0.0141058
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0139173
ECPAS Ecm29 proteasome adaptor and scaffold 0.0138525
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.0134591
LCOR ligand dependent nuclear receptor corepressor 0.0133827
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa 0.0133105
PCBP2 poly(rC) binding protein 2 0.0132144
RAI14 retinoic acid induced 14 0.0131531
IFI44L interferon-induced protein 44-like 0.0131202
DGKI diacylglycerol kinase, iota 0.013024
RTN4 reticulon 4 0.013002
USP34 ubiquitin specific peptidase 34 0.0129913
FNDC3B fibronectin type III domain containing 3B 0.0129783
STOM stomatin 0.0129624
MAML2 mastermind-like 2 (Drosophila) 0.0129138
SLMAP sarcolemma associated protein 0.0128314
RALB v-ral simian leukemia viral oncogene homolog B 0.0127839
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0127102
TNS1 tensin 1 0.0126942
PNN pinin, desmosome associated protein 0.0126516
SLTM SAFB-like, transcription modulator 0.0126444
CYLD cylindromatosis (turban tumor syndrome) 0.0125014
MIER1 mesoderm induction early response 1, transcriptional regulator 0.0124678
CDK6 cyclin-dependent kinase 6 0.0123599
PPP1R15B protein phosphatase 1, regulatory subunit 15B 0.0123571
TMEM65 transmembrane protein 65 0.0122631
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.012186
RNPS1 RNA binding protein S1, serine-rich domain 0.0120218
SPTY2D1 SPT2, Suppressor of Ty, domain containing 1 (S. cerevisiae) 0.0119883
BIRC6 baculoviral IAP repeat containing 6 0.0119688
RB1CC1 RB1-inducible coiled-coil 1 0.0117582
CD47 CD47 molecule 0.0117559
CXCL3 chemokine (C-X-C motif) ligand 3 0.0116736
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0116196
HIPK2 homeodomain interacting protein kinase 2 0.011572
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.011492
USP9X ubiquitin specific peptidase 9, X-linked 0.0114263
TPST1 tyrosylprotein sulfotransferase 1 0.0113673
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0113601
PALS2 protein associated with LIN7 2, MAGUK p55 family member 0.0112844
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1 0.011284
APLP2 amyloid beta (A4) precursor-like protein 2 0.0112314
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 0.0111388

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.19194
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.182317
FTL ferritin, light polypeptide -0.149919
TMSB10 thymosin beta 10 -0.125487
HLA-B major histocompatibility complex, class I, B -0.0991839
VIM vimentin -0.0843167
TPT1 tumor protein, translationally-controlled 1 -0.0739831
TXNRD1 thioredoxin reductase 1 -0.0727109
RPLP1 ribosomal protein, large, P1 -0.0672531
EIF1 eukaryotic translation initiation factor 1 -0.0593666
HSPB1 heat shock 27kDa protein 1 -0.0577035
RPS6 ribosomal protein S6 -0.0562139
RRBP1 ribosome binding protein 1 -0.0559571
UBC ubiquitin C -0.0556131
ICAM1 intercellular adhesion molecule 1 -0.0526763
PTMA prothymosin, alpha -0.0503941
NAMPT nicotinamide phosphoribosyltransferase -0.0498982
ACTG1 actin gamma 1 -0.0498748
RPL35A ribosomal protein L35a -0.0494912
MT2A metallothionein 2A -0.0491895
RPL28 ribosomal protein L28 -0.0491471
RPL34 ribosomal protein L34 -0.0489978
RPL8 ribosomal protein L8 -0.0483711
RPL19 ribosomal protein L19 -0.0467222
LMNA lamin A/C -0.0464703
RPS24 ribosomal protein S24 -0.0427362
RPS4X ribosomal protein S4, X-linked -0.0424823
RPL12 ribosomal protein L12 -0.042095
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0419079
RPLP2 ribosomal protein, large, P2 -0.0405509
RPS5 ribosomal protein S5 -0.0401942
CALR calreticulin -0.0399895
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0396048
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0393687
RPS19 ribosomal protein S19 -0.0387549
EXT1 exostosin glycosyltransferase 1 -0.0385859
S100A10 S100 calcium binding protein A10 -0.0384748
RPS8 ribosomal protein S8 -0.038473
FUS FUS RNA binding protein -0.0373802
HLA-C major histocompatibility complex, class I, C -0.0362761
NDRG1 N-myc downstream regulated 1 -0.0359038
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0348742
LOXL2 lysyl oxidase-like 2 -0.0344931
RPS20 ribosomal protein S20 -0.0344153
LOC112694756 uncharaterized LOC112694756 -0.0343737
ANXA2 annexin A2 -0.0338972
FTH1 ferritin, heavy polypeptide 1 -0.0336265
RPL31 ribosomal protein L31 -0.0334919
RPS21 ribosomal protein S21 -0.0318742
RPS23 ribosomal protein S23 -0.0316756
B2M beta-2-microglobulin -0.0305301
CAVIN1 caveolae associated protein 1 -0.0303999
RPL26 ribosomal protein L26 -0.0302791
RPS27A ribosomal protein S27a -0.0301706
KPNB1 karyopherin (importin) beta 1 -0.0299241
HMGB1 high mobility group box 1 -0.029704
RPL38 ribosomal protein L38 -0.0294985
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0292158
RPS16 ribosomal protein S16 -0.0290622
COTL1 coactosin-like F-actin binding protein 1 -0.0290585
RPL7A ribosomal protein L7a -0.0288418
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.0284568
RPS13 ribosomal protein S13 -0.0283589
HDLBP high density lipoprotein binding protein -0.0283446
RPS15 ribosomal protein S15 -0.0283094
RPS11 ribosomal protein S11 -0.0282903
RPL30 ribosomal protein L30 -0.0272587
TMEM263 transmembrane protein 263 -0.0265251
G0S2 G0/G1 switch 2 -0.0262011
IRS2 insulin receptor substrate 2 -0.0259053
ANKRD11 ankyrin repeat domain 11 -0.025898
FRMD4A FERM domain containing 4A -0.0258699
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0256474
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0255441
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0255354
RPL32 ribosomal protein L32 -0.0252579
CA12 carbonic anhydrase XII -0.0249733
ARF1 ADP-ribosylation factor 1 -0.0247186
GNAS GNAS complex locus -0.0246371
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0246161
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0244274
ACTN4 actinin, alpha 4 -0.0239822
CD44 CD44 molecule (Indian blood group) -0.0237708
CTSD cathepsin D -0.0235562
H3-3B H3.3 histone B -0.0235323
GARS1 glycyl-tRNA synthetase 1 -0.0234154
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0232902
RPL37 ribosomal protein L37 -0.0230684
RPL35 ribosomal protein L35 -0.0230589
SDC4 syndecan 4 -0.0229932
PKM pyruvate kinase, muscle -0.0227148
PXDN peroxidasin -0.022524
PPIB peptidylprolyl isomerase B (cyclophilin B) -0.0224838
TLE4 transducin-like enhancer of split 4 -0.0221439
RACK1 receptor for activated C kinase 1 -0.022008
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase) -0.0220078
MKNK2 MAP kinase interacting serine/threonine kinase 2 -0.0219912
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0219707
RPLP0 ribosomal protein, large, P0 -0.0218565
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0217012