| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Bosentan (hydrate) perturbation in A549 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Bosentan (hydrate)_A549 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0534861 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0510626 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0509938 |
| GOLGA4 | golgin A4 | 0.0497118 |
| SPAG9 | sperm associated antigen 9 | 0.0429302 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0408071 |
| USP3 | ubiquitin specific peptidase 3 | 0.0399687 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0364214 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0361237 |
| FMNL2 | formin-like 2 | 0.0352392 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0351801 |
| NDRG1 | N-myc downstream regulated 1 | 0.0350193 |
| NUP58 | nucleoporin 58 | 0.033298 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0321077 |
| FAM13A | family with sequence similarity 13, member A | 0.030279 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.0288555 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0287186 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0286963 |
| SUCO | SUN domain containing ossification factor | 0.0280749 |
| NBAS | neuroblastoma amplified sequence | 0.0278733 |
| RAB1A | RAB1A, member RAS oncogene family | 0.0277398 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0276243 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0273812 |
| HELZ | helicase with zinc finger | 0.0273438 |
| SRP54 | signal recognition particle 54kDa | 0.0272839 |
| ATP13A3 | ATPase type 13A3 | 0.0262382 |
| USP47 | ubiquitin specific peptidase 47 | 0.0255675 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0250118 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | 0.0250104 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0248485 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0237994 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0233992 |
| DENND4A | DENN/MADD domain containing 4A | 0.0226306 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | 0.0224808 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.022171 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.021869 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0218312 |
| PSMD14 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | 0.0209345 |
| SEC24A | SEC24 family member A | 0.0208589 |
| RND3 | Rho family GTPase 3 | 0.0204581 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.020382 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0201064 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0200121 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | 0.020003 |
| ENO1 | enolase 1, (alpha) | 0.0195627 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.0195272 |
| TFG | TRK-fused gene | 0.0193344 |
| EFNA5 | ephrin-A5 | 0.0192233 |
| ACBD3 | acyl-CoA binding domain containing 3 | 0.0191901 |
| DAPK1 | death-associated protein kinase 1 | 0.0191771 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0188781 |
| PGK1 | phosphoglycerate kinase 1 | 0.0188036 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0185468 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0184625 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0184235 |
| FNBP1L | formin binding protein 1-like | 0.0181045 |
| NGLY1 | N-glycanase 1 | 0.0177788 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0177418 |
| USP34 | ubiquitin specific peptidase 34 | 0.0176871 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0175743 |
| TMF1 | TATA element modulatory factor 1 | 0.0175301 |
| GOLGB1 | golgin B1 | 0.0174745 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0173821 |
| BTAF1 | BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa | 0.0172653 |
| ZNF654 | zinc finger protein 654 | 0.0170724 |
| COPA | coatomer protein complex, subunit alpha | 0.0170415 |
| ZFC3H1 | zinc finger, C3H1-type containing | 0.0170278 |
| INSIG2 | insulin induced gene 2 | 0.0170088 |
| PRAG1 | PEAK1 related, kinase-activating pseudokinase 1 | 0.0169741 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0167345 |
| YWHAQ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta | 0.0167312 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.0166221 |
| NAV2 | neuron navigator 2 | 0.0164582 |
| PCBP2 | poly(rC) binding protein 2 | 0.0163837 |
| ACVR1 | activin A receptor, type I | 0.0163789 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0163136 |
| QKI | QKI, KH domain containing, RNA binding | 0.0161863 |
| FGFR1 | fibroblast growth factor receptor 1 | 0.0160605 |
| PRKCA | protein kinase C, alpha | 0.0159806 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0159684 |
| WDR45B | WD repeat domain 45B | 0.0158487 |
| TRPM7 | transient receptor potential cation channel, subfamily M, member 7 | 0.0158009 |
| TOP2B | topoisomerase (DNA) II beta 180kDa | 0.0157539 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.0157388 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0156639 |
| USP37 | ubiquitin specific peptidase 37 | 0.0155372 |
| ATP2C1 | ATPase, Ca++ transporting, type 2C, member 1 | 0.0154623 |
| TMEM65 | transmembrane protein 65 | 0.0153931 |
| EIF2AK3 | eukaryotic translation initiation factor 2-alpha kinase 3 | 0.0153477 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0151478 |
| CANX | calnexin | 0.0151237 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0149545 |
| IARS1 | isoleucyl-tRNA synthetase 1 | 0.0149493 |
| GNL3 | guanine nucleotide binding protein-like 3 (nucleolar) | 0.0149481 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | 0.0149466 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0149366 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0148713 |
| UBA2 | ubiquitin-like modifier activating enzyme 2 | 0.0148351 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | 0.0147763 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0146295 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.306862 |
| PDE10A | phosphodiesterase 10A | -0.170475 |
| MT2A | metallothionein 2A | -0.14941 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | -0.139182 |
| TMSB10 | thymosin beta 10 | -0.138871 |
| KYNU | kynureninase | -0.131125 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.103563 |
| OSMR | oncostatin M receptor | -0.0959958 |
| IGFBP4 | insulin-like growth factor binding protein 4 | -0.090833 |
| RPS19 | ribosomal protein S19 | -0.0868464 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0841506 |
| PAPPA | pregnancy-associated plasma protein A, pappalysin 1 | -0.082424 |
| ARHGAP26 | Rho GTPase activating protein 26 | -0.0792338 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.07742 |
| CMIP | c-Maf inducing protein | -0.0736747 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0695475 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0690948 |
| VCL | vinculin | -0.0671495 |
| ANXA2 | annexin A2 | -0.0635748 |
| SMAD3 | SMAD family member 3 | -0.0629815 |
| RNF213 | ring finger protein 213 | -0.0590127 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0585749 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0580602 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0580264 |
| FTL | ferritin, light polypeptide | -0.0564798 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0560107 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | -0.0544498 |
| ACTN4 | actinin, alpha 4 | -0.0533274 |
| MT1X | metallothionein 1X | -0.0488745 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.047801 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.047562 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0473259 |
| RPL23 | ribosomal protein L23 | -0.0469747 |
| GLIS3 | GLIS family zinc finger 3 | -0.0447194 |
| C15ORF48 | chromosome 15 open reading frame 48 | -0.0434262 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | -0.0431299 |
| TXNRD1 | thioredoxin reductase 1 | -0.0430905 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0423184 |
| RIGI | RNA sensor RIG-I | -0.04205 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0417553 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | -0.0411777 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.040763 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0399582 |
| ASPH | aspartate beta-hydroxylase | -0.0394794 |
| RPL19 | ribosomal protein L19 | -0.0385561 |
| RPL26 | ribosomal protein L26 | -0.0358474 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0357287 |
| RPL12 | ribosomal protein L12 | -0.0355907 |
| RRBP1 | ribosome binding protein 1 | -0.0349002 |
| ITGB5 | integrin, beta 5 | -0.0341218 |
| GRAMD1B | GRAM domain containing 1B | -0.0340122 |
| RTN4 | reticulon 4 | -0.0335334 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0334912 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0333581 |
| BICC1 | BicC family RNA binding protein 1 | -0.0330428 |
| RPL13A | ribosomal protein L13a | -0.0329212 |
| NRP1 | neuropilin 1 | -0.0328324 |
| GPRIN3 | GPRIN family member 3 | -0.0327353 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0326963 |
| WWC1 | WW and C2 domain containing 1 | -0.0326124 |
| BMAL2 | basic helix-loop-helix ARNT like 2 | -0.0325785 |
| BMERB1 | bMERB domain containing 1 | -0.0324505 |
| KRT81 | keratin 81, type II | -0.0324347 |
| RPS24 | ribosomal protein S24 | -0.0320257 |
| DSCAM | Down syndrome cell adhesion molecule | -0.0312504 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | -0.0311142 |
| RACK1 | receptor for activated C kinase 1 | -0.0302726 |
| TNS3 | tensin 3 | -0.0301949 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.030156 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0300955 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0300454 |
| AOPEP | aminopeptidase O (putative) | -0.0299512 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0298246 |
| AXL | AXL receptor tyrosine kinase | -0.0296865 |
| RPS3 | ribosomal protein S3 | -0.0290856 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.0290559 |
| TGM2 | transglutaminase 2 | -0.0285224 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0283855 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0283743 |
| ETV6 | ets variant 6 | -0.0281777 |
| NPC1 | Niemann-Pick disease, type C1 | -0.0277829 |
| WWOX | WW domain containing oxidoreductase | -0.0274995 |
| BHLHE40 | basic helix-loop-helix family, member e40 | -0.0274182 |
| RPLP1 | ribosomal protein, large, P1 | -0.0273979 |
| RPL18 | ribosomal protein L18 | -0.0271384 |
| NRG1 | neuregulin 1 | -0.0268882 |
| ZFAND6 | zinc finger, AN1-type domain 6 | -0.0268207 |
| DOCK5 | dedicator of cytokinesis 5 | -0.026704 |
| RPS16 | ribosomal protein S16 | -0.0265757 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | -0.0265124 |
| RPL37A | ribosomal protein L37a | -0.0264627 |
| SSH1 | slingshot protein phosphatase 1 | -0.0260942 |
| RPL35A | ribosomal protein L35a | -0.0256028 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0255146 |
| PDE8A | phosphodiesterase 8A | -0.0254124 |
| PFN1 | profilin 1 | -0.0253971 |
| DGKD | diacylglycerol kinase, delta 130kDa | -0.0253404 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0248061 |
| RBBP6 | retinoblastoma binding protein 6 | -0.0247725 |
| NRIP1 | nuclear receptor interacting protein 1 | -0.0246349 |
