| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Bosentan (hydrate) perturbation in AsPC-1 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Bosentan (hydrate)_AsPC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.111386 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.10738 |
| SLC20A1 | solute carrier family 20 (phosphate transporter), member 1 | 0.0734994 |
| ITGA6 | integrin, alpha 6 | 0.0704707 |
| PTMA | prothymosin, alpha | 0.05099 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0498209 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0489467 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0463099 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0462952 |
| NEK7 | NIMA-related kinase 7 | 0.0453489 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0446662 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0436705 |
| VCAN | versican | 0.042032 |
| ZNF292 | zinc finger protein 292 | 0.039838 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0393681 |
| CDH17 | cadherin 17, LI cadherin (liver-intestine) | 0.0392676 |
| MED13L | mediator complex subunit 13-like | 0.0387034 |
| TOP1 | topoisomerase (DNA) I | 0.0384971 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0372002 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.036879 |
| FGD4 | FYVE, RhoGEF and PH domain containing 4 | 0.0364656 |
| MYOF | myoferlin | 0.0363973 |
| ASPH | aspartate beta-hydroxylase | 0.0356045 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0347941 |
| PPARG | peroxisome proliferator-activated receptor gamma | 0.034208 |
| OGA | O-GlcNAcase | 0.034179 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0334513 |
| AFDN | afadin, adherens junction formation factor | 0.0326915 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0326444 |
| ANLN | anillin, actin binding protein | 0.0320282 |
| ITPRID2 | ITPR interacting domain containing 2 | 0.0316249 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0315328 |
| RNF145 | ring finger protein 145 | 0.0306376 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0301954 |
| SQSTM1 | sequestosome 1 | 0.0301751 |
| PTK2 | protein tyrosine kinase 2 | 0.030039 |
| EPCAM | epithelial cell adhesion molecule | 0.029747 |
| NCKAP1 | NCK-associated protein 1 | 0.0292309 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0289445 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0288151 |
| NOS1AP | nitric oxide synthase 1 (neuronal) adaptor protein | 0.028788 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.028488 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.0280952 |
| ARHGAP26 | Rho GTPase activating protein 26 | 0.0276267 |
| CDC42SE2 | CDC42 small effector 2 | 0.0272482 |
| XPO1 | exportin 1 | 0.0269169 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0267944 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.0261796 |
| NPTN | neuroplastin | 0.0261246 |
| SLTM | SAFB-like, transcription modulator | 0.0261065 |
| ATP13A3 | ATPase type 13A3 | 0.0259677 |
| CD46 | CD46 molecule, complement regulatory protein | 0.025964 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0255211 |
| PON2 | paraoxonase 2 | 0.0255209 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | 0.0253528 |
| PRAG1 | PEAK1 related, kinase-activating pseudokinase 1 | 0.0252323 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.02499 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0249887 |
| RSRC2 | arginine/serine-rich coiled-coil 2 | 0.0248584 |
| SSBP2 | single-stranded DNA binding protein 2 | 0.0245528 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0244226 |
| HIBADH | 3-hydroxyisobutyrate dehydrogenase | 0.0240818 |
| DST | dystonin | 0.0237007 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0236446 |
| SERINC1 | serine incorporator 1 | 0.0236279 |
| MEF2A | myocyte enhancer factor 2A | 0.023613 |
| OSBPL3 | oxysterol binding protein-like 3 | 0.0235286 |
| ZMYM2 | zinc finger, MYM-type 2 | 0.0234127 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0231921 |
| RALB | v-ral simian leukemia viral oncogene homolog B | 0.0229923 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.0227029 |
| RTN4 | reticulon 4 | 0.0226541 |
| QKI | QKI, KH domain containing, RNA binding | 0.0225853 |
| AGFG1 | ArfGAP with FG repeats 1 | 0.0225391 |
| HMGB2 | high mobility group box 2 | 0.0223679 |
| DSTN | destrin (actin depolymerizing factor) | 0.0223194 |
| SLMAP | sarcolemma associated protein | 0.0222855 |
| MYO6 | myosin VI | 0.0220903 |
| PLEKHA1 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 | 0.0220489 |
| JMJD1C | jumonji domain containing 1C | 0.0220418 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0218406 |
| ANKRD10 | ankyrin repeat domain 10 | 0.0217223 |
| CYP3A5 | cytochrome P450, family 3, subfamily A, polypeptide 5 | 0.0216687 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.021651 |
| CPNE8 | copine VIII | 0.0211505 |
| MBOAT2 | membrane bound O-acyltransferase domain containing 2 | 0.0211101 |
| CUL3 | cullin 3 | 0.0210881 |
| ACTR3 | ARP3 actin-related protein 3 homolog (yeast) | 0.0209699 |
| ARHGAP21 | Rho GTPase activating protein 21 | 0.020867 |
| TES | testin LIM domain protein | 0.0207385 |
| LRRFIP2 | leucine rich repeat (in FLII) interacting protein 2 | 0.0207319 |
| ITGAV | integrin, alpha V | 0.020696 |
| MATR3 | matrin 3 | 0.0206639 |
| SBF2 | SET binding factor 2 | 0.0205713 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0204503 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0204501 |
| PTPRR | protein tyrosine phosphatase, receptor type, R | 0.0203644 |
| WDFY3 | WD repeat and FYVE domain containing 3 | 0.0203571 |
| SERTAD2 | SERTA domain containing 2 | 0.0203404 |
| TMEM41B | transmembrane protein 41B | 0.0202815 |
| Symbol | Name | Standardized Value |
|---|---|---|
| LAMB3 | laminin, beta 3 | -0.215585 |
| DHRS9 | dehydrogenase/reductase (SDR family) member 9 | -0.192921 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | -0.16991 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.166591 |
| NDRG1 | N-myc downstream regulated 1 | -0.13277 |
| SACK1A | scaffolding CK1 anchoring protein A | -0.119904 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.118909 |
| UBC | ubiquitin C | -0.118485 |
| TMSB10 | thymosin beta 10 | -0.105446 |
| KLK10 | kallikrein-related peptidase 10 | -0.103036 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.101097 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.100881 |
| ARPC1B | actin related protein 2/3 complex, subunit 1B, 41kDa | -0.10041 |
| TXNRD1 | thioredoxin reductase 1 | -0.0975572 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0910596 |
| TXNIP | thioredoxin interacting protein | -0.0816265 |
| ARPC1A | actin related protein 2/3 complex, subunit 1A, 41kDa | -0.0797271 |
| EGR1 | early growth response 1 | -0.0773657 |
| MXD1 | MAX dimerization protein 1 | -0.0693289 |
| MCL1 | myeloid cell leukemia 1 | -0.0681661 |
| TRRAP | transformation/transcription domain-associated protein | -0.0676535 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | -0.0669172 |
| MUC17 | mucin 17, cell surface associated | -0.0664831 |
| HMGA1 | high mobility group AT-hook 1 | -0.0654054 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0648278 |
| CLMP | CXADR-like membrane protein | -0.063717 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0609724 |
| FLNB | filamin B, beta | -0.0607575 |
| CALU | calumenin | -0.0595377 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0591311 |
| FTL | ferritin, light polypeptide | -0.0562347 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0549115 |
| BLZF1 | basic leucine zipper nuclear factor 1 | -0.0545531 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.05021 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0501811 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0497275 |
| DIAPH1 | diaphanous-related formin 1 | -0.0496291 |
| UBE2H | ubiquitin-conjugating enzyme E2H | -0.0476624 |
| PPARD | peroxisome proliferator-activated receptor delta | -0.0474601 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0469689 |
| B2M | beta-2-microglobulin | -0.045875 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0456734 |
| TPM4 | tropomyosin 4 | -0.0456194 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.044399 |
| POTEF | POTE ankyrin domain family, member F | -0.0443339 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0439096 |
| PMM2 | phosphomannomutase 2 | -0.0438187 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0427493 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0419994 |
| CAP1 | CAP, adenylate cyclase-associated protein 1 (yeast) | -0.0399673 |
| PARD3 | par-3 family cell polarity regulator | -0.0398723 |
| PDXDC1 | pyridoxal-dependent decarboxylase domain containing 1 | -0.0398231 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0398052 |
| LAMC2 | laminin, gamma 2 | -0.0397594 |
| ARF4 | ADP-ribosylation factor 4 | -0.0392211 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0388953 |
| VIM | vimentin | -0.0386021 |
| HM13 | histocompatibility (minor) 13 | -0.0374111 |
| EGFR | epidermal growth factor receptor | -0.0366753 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0365138 |
| UPP1 | uridine phosphorylase 1 | -0.0358713 |
| ACTN4 | actinin, alpha 4 | -0.0357268 |
| MSN | moesin | -0.035537 |
| AHNAK | AHNAK nucleoprotein | -0.0353318 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0347818 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0347536 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.034665 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.034587 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | -0.0340253 |
| GREB1L | growth regulation by estrogen in breast cancer-like | -0.0339793 |
| TPM3 | tropomyosin 3 | -0.0334851 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.0334682 |
| TMBIM1 | transmembrane BAX inhibitor motif containing 1 | -0.033138 |
| RRBP1 | ribosome binding protein 1 | -0.0331254 |
| MORF4L2 | mortality factor 4 like 2 | -0.0330491 |
| FBXO11 | F-box protein 11 | -0.0327767 |
| RIOK3 | RIO kinase 3 | -0.0324648 |
| PKM | pyruvate kinase, muscle | -0.0324292 |
| HDAC9 | histone deacetylase 9 | -0.0324116 |
| S100A11 | S100 calcium binding protein A11 | -0.0320964 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0320314 |
| GOLGB1 | golgin B1 | -0.0318268 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0316251 |
| SMC3 | structural maintenance of chromosomes 3 | -0.0315263 |
| SEC24A | SEC24 family member A | -0.0315002 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | -0.0309223 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.03086 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0303734 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0297819 |
| SP100 | SP100 nuclear antigen | -0.0296485 |
| OSMR | oncostatin M receptor | -0.0291102 |
| AK1 | adenylate kinase 1 | -0.0290057 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | -0.0285425 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0284708 |
| ACBD3 | acyl-CoA binding domain containing 3 | -0.027791 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0275619 |
| FUT8 | fucosyltransferase 8 (alpha (1,6) fucosyltransferase) | -0.0274076 |
| SKAP2 | src kinase associated phosphoprotein 2 | -0.0273737 |
| CEACAM1 | carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) | -0.0272701 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0266505 |
