| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Bosentan (hydrate) perturbation in BT-474 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Bosentan (hydrate)_BT-474 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0879961 |
| IGFBP5 | insulin-like growth factor binding protein 5 | 0.054856 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0308013 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0279048 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.027264 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0260216 |
| TOP6BL | TOP6B like initiator of meiotic double strand breaks | 0.0253968 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0251593 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0229745 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0226165 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0210461 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.020905 |
| TENM2 | teneurin transmembrane protein 2 | 0.0205464 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | 0.0204032 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0203423 |
| KIF16B | kinesin family member 16B | 0.019012 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.01832 |
| PRELID2 | PRELI domain containing 2 | 0.0181269 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0179795 |
| DHX15 | DEAH (Asp-Glu-Ala-His) box helicase 15 | 0.017585 |
| MATR3 | matrin 3 | 0.0172212 |
| PBX1 | pre-B-cell leukemia homeobox 1 | 0.016856 |
| SAMD12 | sterile alpha motif domain containing 12 | 0.0162252 |
| ELOVL5 | ELOVL fatty acid elongase 5 | 0.0161484 |
| DSPP | dentin sialophosphoprotein | 0.0159498 |
| TPM3 | tropomyosin 3 | 0.0156252 |
| SLC22A23 | solute carrier family 22, member 23 | 0.0155698 |
| PDCD4 | programmed cell death 4 (neoplastic transformation inhibitor) | 0.0154761 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0154307 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.0153198 |
| PLSCR2 | phospholipid scramblase 2 | 0.0146472 |
| FAM168A | family with sequence similarity 168, member A | 0.0145239 |
| USP3 | ubiquitin specific peptidase 3 | 0.0145061 |
| DGKD | diacylglycerol kinase, delta 130kDa | 0.0144237 |
| FHIT | fragile histidine triad | 0.0141986 |
| LRP1B | low density lipoprotein receptor-related protein 1B | 0.0141246 |
| VEGFA | vascular endothelial growth factor A | 0.0140025 |
| SCFD1 | sec1 family domain containing 1 | 0.0139161 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0138722 |
| ZNF292 | zinc finger protein 292 | 0.0138406 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0138304 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0138292 |
| GOLGA4 | golgin A4 | 0.0136322 |
| YWHAQ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta | 0.0135805 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0134153 |
| TOP2B | topoisomerase (DNA) II beta 180kDa | 0.0133834 |
| ATAD2 | ATPase family, AAA domain containing 2 | 0.0133329 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | 0.0131364 |
| CD24 | CD24 molecule | 0.0131058 |
| GPC6 | glypican 6 | 0.0129156 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0127725 |
| KAZN | kazrin, periplakin interacting protein | 0.0127687 |
| CEP250 | centrosomal protein 250kDa | 0.0127374 |
| AFF3 | AF4/FMR2 family, member 3 | 0.0125727 |
| POLD3 | polymerase (DNA-directed), delta 3, accessory subunit | 0.012483 |
| ST8SIA6 | ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6 | 0.0123195 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0122448 |
| TOM1L1 | target of myb1 (chicken)-like 1 | 0.011981 |
| PGR | progesterone receptor | 0.0119674 |
| CENPF | centromere protein F, 350/400kDa | 0.0119666 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0118884 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0118664 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0118005 |
| CCNY | cyclin Y | 0.0117798 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0117765 |
| HELZ | helicase with zinc finger | 0.0117365 |
| NCAM2 | neural cell adhesion molecule 2 | 0.0117153 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0116562 |
| MSMO1 | methylsterol monooxygenase 1 | 0.0116298 |
| DIP2C | DIP2 disco-interacting protein 2 homolog C (Drosophila) | 0.0115258 |
| GIGYF2 | GRB10 interacting GYF protein 2 | 0.0114645 |
| AUH | AU RNA binding protein/enoyl-CoA hydratase | 0.0114388 |
| EXOC4 | exocyst complex component 4 | 0.0114103 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0113947 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0113873 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0113468 |
| RPS6KA5 | ribosomal protein S6 kinase, 90kDa, polypeptide 5 | 0.0113195 |
| SEC24A | SEC24 family member A | 0.0112835 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.0112639 |
| WEE1 | WEE1 G2 checkpoint kinase | 0.0110938 |
| ATP13A3 | ATPase type 13A3 | 0.0110493 |
| INTS6 | integrator complex subunit 6 | 0.0109936 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0109567 |
| WWOX | WW domain containing oxidoreductase | 0.0108885 |
| PRLR | prolactin receptor | 0.0108684 |
| CTNND2 | catenin (cadherin-associated protein), delta 2 | 0.0108618 |
| ACTR3 | ARP3 actin-related protein 3 homolog (yeast) | 0.010855 |
| IGF1R | insulin-like growth factor 1 receptor | 0.0107428 |
| CKAP5 | cytoskeleton associated protein 5 | 0.0107216 |
| TMEM178B | transmembrane protein 178B | 0.0105347 |
| DHRSX | dehydrogenase/reductase (SDR family) X-linked | 0.0104586 |
| BBX | bobby sox homolog (Drosophila) | 0.0103943 |
| HMGB2 | high mobility group box 2 | 0.0103024 |
| UNC13B | unc-13 homolog B (C. elegans) | 0.0102727 |
| RAD51B | RAD51 paralog B | 0.0102557 |
| INSIG2 | insulin induced gene 2 | 0.0102041 |
| TMEM123 | transmembrane protein 123 | 0.0101968 |
| NCKAP1 | NCK-associated protein 1 | 0.0101552 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.0101146 |
| ANKIB1 | ankyrin repeat and IBR domain containing 1 | 0.0100955 |
| Symbol | Name | Standardized Value |
|---|---|---|
| RPL19 | ribosomal protein L19 | -0.188045 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.156887 |
| RPL23 | ribosomal protein L23 | -0.147048 |
| MT2A | metallothionein 2A | -0.107508 |
| ACACA | acetyl-CoA carboxylase alpha | -0.0990387 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0921935 |
| TMSB10 | thymosin beta 10 | -0.0868417 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0838798 |
| CATSPERB | catsper channel auxiliary subunit beta | -0.0829987 |
| CDK12 | cyclin-dependent kinase 12 | -0.0726053 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0706338 |
| ASPH | aspartate beta-hydroxylase | -0.0697251 |
| SRCIN1 | SRC kinase signaling inhibitor 1 | -0.0622584 |
| S100A9 | S100 calcium binding protein A9 | -0.0603991 |
| ACTG1 | actin gamma 1 | -0.0586583 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | -0.0585742 |
| S100A8 | S100 calcium binding protein A8 | -0.0583657 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0581744 |
| RPL35A | ribosomal protein L35a | -0.0567604 |
| CCND1 | cyclin D1 | -0.0549348 |
| ABCC3 | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 | -0.0548534 |
| LASP1 | LIM and SH3 protein 1 | -0.0533267 |
| OSMR | oncostatin M receptor | -0.0527226 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0504917 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0497667 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | -0.0444944 |
| NCOA6 | nuclear receptor coactivator 6 | -0.0440241 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0418174 |
| PIK3R3 | phosphoinositide-3-kinase, regulatory subunit 3 (gamma) | -0.041586 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0412099 |
| RAB22A | RAB22A, member RAS oncogene family | -0.040655 |
| RPS6KA3 | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | -0.0386372 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0383211 |
| FTL | ferritin, light polypeptide | -0.0381182 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0380017 |
| S100A14 | S100 calcium binding protein A14 | -0.037145 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0368633 |
| VMP1 | vacuole membrane protein 1 | -0.036075 |
| GRB7 | growth factor receptor-bound protein 7 | -0.0359753 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | -0.0357608 |
| NTN4 | netrin 4 | -0.0352685 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -0.0352682 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0352085 |
| DYNLRB1 | dynein, light chain, roadblock-type 1 | -0.0342361 |
| EGR1 | early growth response 1 | -0.0340704 |
| ZNFX1 | zinc finger, NFX1-type containing 1 | -0.0340184 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0339109 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0338074 |
| CCNI | cyclin I | -0.0337982 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0334588 |
| CDH15 | cadherin 15, type 1, M-cadherin (myotubule) | -0.0333745 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0332252 |
| ST3GAL1 | ST3 beta-galactoside alpha-2,3-sialyltransferase 1 | -0.0328524 |
| CLTC | clathrin, heavy chain (Hc) | -0.0325166 |
| RPL8 | ribosomal protein L8 | -0.0321733 |
| RPL32 | ribosomal protein L32 | -0.0318947 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | -0.0315328 |
| GLCCI1 | glucocorticoid induced 1 | -0.0313031 |
| MUC6 | mucin 6, oligomeric mucus/gel-forming | -0.0311929 |
| RPS19 | ribosomal protein S19 | -0.0308954 |
| KRT7 | keratin 7, type II | -0.0306399 |
| MLLT6 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6 | -0.0297338 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | -0.0296742 |
| PGK1 | phosphoglycerate kinase 1 | -0.0291007 |
| S100A6 | S100 calcium binding protein A6 | -0.0290373 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0290329 |
| ARID5B | AT rich interactive domain 5B (MRF1-like) | -0.0285807 |
| ANXA2 | annexin A2 | -0.0285577 |
| EGFR | epidermal growth factor receptor | -0.0285519 |
| RPS29 | ribosomal protein S29 | -0.0284774 |
| PRRC2B | proline-rich coiled-coil 2B | -0.028474 |
| TRPS1 | trichorhinophalangeal syndrome I | -0.0283415 |
| LMNA | lamin A/C | -0.027979 |
| S100A11 | S100 calcium binding protein A11 | -0.0277505 |
| RPL12 | ribosomal protein L12 | -0.0276898 |
| ZNF217 | zinc finger protein 217 | -0.0275714 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0275273 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0272708 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0267294 |
| RARRES1 | retinoic acid receptor responder (tazarotene induced) 1 | -0.0262624 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.0261366 |
| NDRG1 | N-myc downstream regulated 1 | -0.0261203 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0258528 |
| HLA-C | major histocompatibility complex, class I, C | -0.0256271 |
| ERBB2 | erb-b2 receptor tyrosine kinase 2 | -0.0253577 |
| UBE2H | ubiquitin-conjugating enzyme E2H | -0.0253067 |
| DUSP4 | dual specificity phosphatase 4 | -0.0252413 |
| MDK | midkine (neurite growth-promoting factor 2) | -0.024971 |
| SEPTIN9 | septin 9 | -0.0247801 |
| TXNRD1 | thioredoxin reductase 1 | -0.024444 |
| RPS3 | ribosomal protein S3 | -0.0242939 |
| PSMB3 | proteasome (prosome, macropain) subunit, beta type, 3 | -0.0242258 |
| ACTN4 | actinin, alpha 4 | -0.0242174 |
| GNAS | GNAS complex locus | -0.0241938 |
| RPL9 | ribosomal protein L9 | -0.0241918 |
| ACSS2 | acyl-CoA synthetase short-chain family member 2 | -0.0241393 |
| FBXL20 | F-box and leucine-rich repeat protein 20 | -0.024007 |
| MIEN1 | migration and invasion enhancer 1 | -0.023636 |
| SMYD3 | SET and MYND domain containing 3 | -0.0235742 |
| EPAS1 | endothelial PAS domain protein 1 | -0.0234663 |
