| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Bosentan (hydrate) perturbation in C-33 A cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Bosentan (hydrate)_C-33 A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| CTNNA2 | catenin (cadherin-associated protein), alpha 2 | 0.139901 |
| TENM3 | teneurin transmembrane protein 3 | 0.0734473 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.068576 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0666175 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | 0.0637964 |
| DST | dystonin | 0.0608117 |
| NPAS3 | neuronal PAS domain protein 3 | 0.0547468 |
| RAD51B | RAD51 paralog B | 0.052721 |
| TTC28 | tetratricopeptide repeat domain 28 | 0.0452412 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0436953 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0412364 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0403108 |
| RPL23 | ribosomal protein L23 | 0.0402394 |
| CTNNA3 | catenin (cadherin-associated protein), alpha 3 | 0.0395769 |
| RABGAP1L | RAB GTPase activating protein 1-like | 0.0367955 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0357009 |
| RPL4 | ribosomal protein L4 | 0.032997 |
| DHX15 | DEAH (Asp-Glu-Ala-His) box helicase 15 | 0.0329294 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0323152 |
| ARB2A | ARB2 cotranscriptional regulator A | 0.0314178 |
| RCC1 | regulator of chromosome condensation 1 | 0.0311316 |
| PARD3 | par-3 family cell polarity regulator | 0.0311028 |
| EXOC6B | exocyst complex component 6B | 0.0307566 |
| NFIA | nuclear factor I/A | 0.0304538 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0301411 |
| ZC3H12B | zinc finger CCCH-type containing 12B | 0.0292839 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0292035 |
| PHF3 | PHD finger protein 3 | 0.0283938 |
| SMYD3 | SET and MYND domain containing 3 | 0.028375 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0279054 |
| HNRNPK | heterogeneous nuclear ribonucleoprotein K | 0.0277517 |
| EXOC4 | exocyst complex component 4 | 0.0272152 |
| PTK2 | protein tyrosine kinase 2 | 0.0269855 |
| ATG10 | autophagy related 10 | 0.026751 |
| PRELID2 | PRELI domain containing 2 | 0.0263492 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0252921 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0242805 |
| CADM2 | cell adhesion molecule 2 | 0.02405 |
| ETNK1 | ethanolamine kinase 1 | 0.0240046 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0235808 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | 0.0233181 |
| GRID2 | glutamate receptor, ionotropic, delta 2 | 0.0232608 |
| ENO1 | enolase 1, (alpha) | 0.0232384 |
| KIAA1958 | KIAA1958 | 0.0232184 |
| SMAD2 | SMAD family member 2 | 0.0231683 |
| QKI | QKI, KH domain containing, RNA binding | 0.0228973 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0227751 |
| NR6A1 | nuclear receptor subfamily 6, group A, member 1 | 0.022742 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0226062 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0221794 |
| MIMS1 | mitochondrial inner membrane scaffold 1 | 0.0219676 |
| CASK | calcium/calmodulin-dependent serine protein kinase (MAGUK family) | 0.0217743 |
| STT3B | STT3B, subunit of the oligosaccharyltransferase complex (catalytic) | 0.0216702 |
| CCNY | cyclin Y | 0.021656 |
| MED13L | mediator complex subunit 13-like | 0.0214465 |
| HNRNPR | heterogeneous nuclear ribonucleoprotein R | 0.0214395 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0212431 |
| KIAA1328 | KIAA1328 | 0.0210923 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.0205529 |
| RPL3 | ribosomal protein L3 | 0.0205442 |
| BTAF1 | BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa | 0.0204629 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | 0.0204388 |
| DIAPH3 | diaphanous-related formin 3 | 0.0203855 |
| RPL14 | ribosomal protein L14 | 0.0199466 |
| ANKRD36 | ankyrin repeat domain 36 | 0.0198282 |
| BCKDHB | branched chain keto acid dehydrogenase E1, beta polypeptide | 0.0196042 |
| KAT6A | K(lysine) acetyltransferase 6A | 0.0195231 |
| FER | fer (fps/fes related) tyrosine kinase | 0.0194536 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0193803 |
| LCOR | ligand dependent nuclear receptor corepressor | 0.0193461 |
| RPL26 | ribosomal protein L26 | 0.0193259 |
| RACK1 | receptor for activated C kinase 1 | 0.0192721 |
| CAND1 | cullin-associated and neddylation-dissociated 1 | 0.0189717 |
| ASPH | aspartate beta-hydroxylase | 0.0188398 |
| RPL18 | ribosomal protein L18 | 0.0187452 |
| CAPRIN1 | cell cycle associated protein 1 | 0.0184167 |
| ZNF407 | zinc finger protein 407 | 0.0183526 |
| RPL21 | ribosomal protein L21 | 0.0182631 |
| CD164 | CD164 molecule, sialomucin | 0.0181251 |
| SMARCA5 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 | 0.0180613 |
| TAS2R14 | taste receptor, type 2, member 14 | 0.0180507 |
| ARID1B | AT rich interactive domain 1B (SWI1-like) | 0.0180451 |
| TOP2B | topoisomerase (DNA) II beta 180kDa | 0.0180224 |
| MEF2A | myocyte enhancer factor 2A | 0.0179496 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0177754 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0176811 |
| PPP2R5E | protein phosphatase 2, regulatory subunit B', epsilon isoform | 0.0176331 |
| CAPZA2 | capping protein (actin filament) muscle Z-line, alpha 2 | 0.0175435 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0175147 |
| LGALS12 | lectin, galactoside-binding, soluble, 12 | 0.0173999 |
| ELAPOR2 | endosome-lysosome associated apoptosis and autophagy regulator family member 2 | 0.0173822 |
| LBR | lamin B receptor | 0.0173784 |
| LRRC8D | leucine rich repeat containing 8 family, member D | 0.0173716 |
| UBE2V1 | ubiquitin-conjugating enzyme E2 variant 1 | 0.0172614 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0172479 |
| PANK3 | pantothenate kinase 3 | 0.0171681 |
| ACTR3 | ARP3 actin-related protein 3 homolog (yeast) | 0.0171351 |
| PEAK1 | pseudopodium-enriched atypical kinase 1 | 0.0170823 |
| CCDC146 | coiled-coil domain containing 146 | 0.0167266 |
| WAC | WW domain containing adaptor with coiled-coil | 0.016703 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.268343 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.123629 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.12022 |
| COL5A2 | collagen, type V, alpha 2 | -0.0976993 |
| ACTG1 | actin gamma 1 | -0.0942493 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0913272 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0852168 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0833457 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0771654 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0736941 |
| NR4A3 | nuclear receptor subfamily 4, group A, member 3 | -0.070112 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0676614 |
| GNAS | GNAS complex locus | -0.0672339 |
| ZNF638 | zinc finger protein 638 | -0.0655764 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0653716 |
| SEMA3D | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D | -0.0648348 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0642867 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0623673 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0556372 |
| CABIN1 | calcineurin binding protein 1 | -0.0542375 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.0522741 |
| HMGA1 | high mobility group AT-hook 1 | -0.0507345 |
| PRICKLE1 | prickle homolog 1 (Drosophila) | -0.0503374 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0490934 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0488966 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0488189 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.04688 |
| ALDH7A1 | aldehyde dehydrogenase 7 family, member A1 | -0.0456866 |
| PCBP2 | poly(rC) binding protein 2 | -0.0454498 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | -0.0451782 |
| BRD4 | bromodomain containing 4 | -0.0451697 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | -0.0446349 |
| SMARCC1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 | -0.0442505 |
| CCDC88A | coiled-coil domain containing 88A | -0.0435672 |
| PFN1 | profilin 1 | -0.0434939 |
| SYAP1 | synapse associated protein 1 | -0.0432289 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | -0.0429399 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0426628 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | -0.042546 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | -0.0417522 |
| CDH18 | cadherin 18, type 2 | -0.0415085 |
| NOP58 | NOP58 ribonucleoprotein | -0.0407689 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.040754 |
| EGR1 | early growth response 1 | -0.0403559 |
| BACH2 | BTB and CNC homology 1, basic leucine zipper transcription factor 2 | -0.040103 |
| RPLP1 | ribosomal protein, large, P1 | -0.0400596 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | -0.0389509 |
| RBM25 | RNA binding motif protein 25 | -0.0380614 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0377425 |
| BRD2 | bromodomain containing 2 | -0.0377256 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0371923 |
| KDM2A | lysine (K)-specific demethylase 2A | -0.0371719 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | -0.0368659 |
| CELF2 | CUGBP, Elav-like family member 2 | -0.0365952 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.036404 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0361219 |
| RPL11 | ribosomal protein L11 | -0.0357268 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0356568 |
| HMGB1 | high mobility group box 1 | -0.035321 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | -0.0352067 |
| GYS1 | glycogen synthase 1 (muscle) | -0.0344616 |
| RPS6 | ribosomal protein S6 | -0.0339641 |
| UBE3C | ubiquitin protein ligase E3C | -0.0335246 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0329687 |
| LATS2 | large tumor suppressor kinase 2 | -0.0327517 |
| PRKRIP1 | PRKR interacting protein 1 (IL11 inducible) | -0.0326642 |
| RFX7 | regulatory factor X, 7 | -0.0323251 |
| NCOR1 | nuclear receptor corepressor 1 | -0.0321791 |
| FUS | FUS RNA binding protein | -0.0320726 |
| SETD5 | SET domain containing 5 | -0.0318568 |
| WDR45B | WD repeat domain 45B | -0.0318114 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.0316994 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | -0.0316258 |
| PCNX4 | pecanex 4 | -0.0314217 |
| FBL | fibrillarin | -0.0313748 |
| RNMT | RNA (guanine-7-) methyltransferase | -0.0309421 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | -0.0306987 |
| PHACTR4 | phosphatase and actin regulator 4 | -0.030631 |
| FAM162A | family with sequence similarity 162, member A | -0.0305097 |
| HIP1 | huntingtin interacting protein 1 | -0.0299841 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | -0.0289952 |
| RPL8 | ribosomal protein L8 | -0.0289395 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0288608 |
| HELZ | helicase with zinc finger | -0.0286443 |
| ATRN | attractin | -0.0282905 |
| DDX46 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 | -0.028289 |
| PDE7A | phosphodiesterase 7A | -0.0280922 |
| PHIP | pleckstrin homology domain interacting protein | -0.0278937 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.0276383 |
| MAPT | microtubule-associated protein tau | -0.0275726 |
| RSRC2 | arginine/serine-rich coiled-coil 2 | -0.0274474 |
| RPL28 | ribosomal protein L28 | -0.0274471 |
| ALKBH5 | AlkB family member 5, RNA demethylase | -0.0273331 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.027224 |
| SOX5 | SRY (sex determining region Y)-box 5 | -0.027213 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0271698 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0269337 |
| DEK | DEK proto-oncogene | -0.026906 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | -0.0263843 |
| FOXO3 | forkhead box O3 | -0.0261647 |
