| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Bosentan (hydrate) perturbation in C32 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Bosentan (hydrate)_C32 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NAMPT | nicotinamide phosphoribosyltransferase | 0.194703 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.167669 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0906786 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.088552 |
| CDC73 | cell division cycle 73 | 0.0806778 |
| PGK1 | phosphoglycerate kinase 1 | 0.0792447 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | 0.0737082 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.062693 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0596081 |
| RNF145 | ring finger protein 145 | 0.0578114 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.055971 |
| FBXO7 | F-box protein 7 | 0.0553566 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0548858 |
| VMP1 | vacuole membrane protein 1 | 0.0516683 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0499991 |
| UBE2H | ubiquitin-conjugating enzyme E2H | 0.0493771 |
| LEF1 | lymphoid enhancer-binding factor 1 | 0.0475633 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0470141 |
| NUP58 | nucleoporin 58 | 0.0469406 |
| ZNF292 | zinc finger protein 292 | 0.0461932 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0451466 |
| ENO1 | enolase 1, (alpha) | 0.045096 |
| LDHA | lactate dehydrogenase A | 0.0440088 |
| DHX15 | DEAH (Asp-Glu-Ala-His) box helicase 15 | 0.0431603 |
| FN1 | fibronectin 1 | 0.0428649 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0424467 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0416213 |
| NEK7 | NIMA-related kinase 7 | 0.0404811 |
| RLF | rearranged L-myc fusion | 0.040441 |
| RBM39 | RNA binding motif protein 39 | 0.0391151 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0382568 |
| ARRDC3 | arrestin domain containing 3 | 0.0364879 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0361828 |
| APP | amyloid beta (A4) precursor protein | 0.0361118 |
| CCNL1 | cyclin L1 | 0.0357967 |
| UBC | ubiquitin C | 0.0357412 |
| HELZ | helicase with zinc finger | 0.03499 |
| TM9SF3 | transmembrane 9 superfamily member 3 | 0.0349787 |
| RBM33 | RNA binding motif protein 33 | 0.0346263 |
| SPRED1 | sprouty-related, EVH1 domain containing 1 | 0.0342407 |
| ANXA2 | annexin A2 | 0.0339661 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0337464 |
| RTN4 | reticulon 4 | 0.0337352 |
| WDR43 | WD repeat domain 43 | 0.0332266 |
| NT5C3A | 5'-nucleotidase, cytosolic IIIA | 0.0330101 |
| MRTFA | myocardin related transcription factor A | 0.0328541 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0324982 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0324393 |
| RAD21 | RAD21 homolog (S. pombe) | 0.0323753 |
| MATR3 | matrin 3 | 0.0319976 |
| SPAG9 | sperm associated antigen 9 | 0.031718 |
| FOXJ3 | forkhead box J3 | 0.0315834 |
| SLMAP | sarcolemma associated protein | 0.0313544 |
| IL6ST | interleukin 6 signal transducer | 0.0306246 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0306155 |
| UHMK1 | U2AF homology motif (UHM) kinase 1 | 0.0297779 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | 0.0288859 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0284569 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.0282541 |
| TMEM123 | transmembrane protein 123 | 0.0279471 |
| ANXA5 | annexin A5 | 0.0276254 |
| INSIG2 | insulin induced gene 2 | 0.027066 |
| HBP1 | HMG-box transcription factor 1 | 0.026819 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | 0.0260608 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.026031 |
| USP3 | ubiquitin specific peptidase 3 | 0.0259265 |
| COG5 | component of oligomeric golgi complex 5 | 0.025499 |
| BIRC2 | baculoviral IAP repeat containing 2 | 0.0254778 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.025356 |
| CPEB2 | cytoplasmic polyadenylation element binding protein 2 | 0.0246333 |
| CAPZA2 | capping protein (actin filament) muscle Z-line, alpha 2 | 0.0245457 |
| BTAF1 | BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa | 0.0244355 |
| PUM1 | pumilio RNA-binding family member 1 | 0.0239389 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0235732 |
| CDK19 | cyclin-dependent kinase 19 | 0.0233128 |
| SSBP2 | single-stranded DNA binding protein 2 | 0.0230836 |
| RAD23B | RAD23 homolog B (S. cerevisiae) | 0.0226237 |
| PPP2CA | protein phosphatase 2, catalytic subunit, alpha isozyme | 0.0219076 |
| TOP1 | topoisomerase (DNA) I | 0.0217816 |
| ARL8B | ADP-ribosylation factor-like 8B | 0.0214872 |
| TPR | translocated promoter region, nuclear basket protein | 0.0213872 |
| CD109 | CD109 molecule | 0.0208788 |
| TMEM178B | transmembrane protein 178B | 0.0208151 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0206836 |
| MARK3 | MAP/microtubule affinity-regulating kinase 3 | 0.020283 |
| RNMT | RNA (guanine-7-) methyltransferase | 0.0200606 |
| PIAS1 | protein inhibitor of activated STAT, 1 | 0.0200384 |
| GALNT2 | polypeptide N-acetylgalactosaminyltransferase 2 | 0.0200109 |
| NAV2 | neuron navigator 2 | 0.020007 |
| PLA2G4A | phospholipase A2, group IVA (cytosolic, calcium-dependent) | 0.0199145 |
| MTPN | myotrophin | 0.0198693 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | 0.0195274 |
| SUCO | SUN domain containing ossification factor | 0.0193391 |
| AHR | aryl hydrocarbon receptor | 0.0192808 |
| BCLAF1 | BCL2-associated transcription factor 1 | 0.0192741 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0191445 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0190659 |
| PPP2R5E | protein phosphatase 2, regulatory subunit B', epsilon isoform | 0.019041 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.0189991 |
| VAPA | VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa | 0.0188329 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.222008 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.196465 |
| NLGN1 | neuroligin 1 | -0.167512 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.121156 |
| MT2A | metallothionein 2A | -0.113811 |
| VGF | VGF nerve growth factor inducible | -0.103829 |
| CTTNBP2 | cortactin binding protein 2 | -0.0951727 |
| GPC6 | glypican 6 | -0.0884084 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | -0.0853952 |
| RUNX1 | runt-related transcription factor 1 | -0.0844972 |
| MDGA2 | MAM domain containing glycosylphosphatidylinositol anchor 2 | -0.079736 |
| FRMD4A | FERM domain containing 4A | -0.0734207 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0700753 |
| EHBP1 | EH domain binding protein 1 | -0.0685383 |
| COL19A1 | collagen, type XIX, alpha 1 | -0.0581454 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | -0.0573923 |
| CPED1 | cadherin-like and PC-esterase domain containing 1 | -0.0565098 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0551767 |
| PCDH7 | protocadherin 7 | -0.0544202 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0538651 |
| FMN1 | formin 1 | -0.0530905 |
| SCFD2 | sec1 family domain containing 2 | -0.052653 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.0520421 |
| TBC1D22A | TBC1 domain family, member 22A | -0.0513834 |
| KIRREL1 | kirre like nephrin family adhesion molecule 1 | -0.0512676 |
| MACROD2 | MACRO domain containing 2 | -0.0507804 |
| NAV1 | neuron navigator 1 | -0.050652 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0504051 |
| LINGO2 | leucine rich repeat and Ig domain containing 2 | -0.0496282 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0495222 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0476548 |
| NAV3 | neuron navigator 3 | -0.0475447 |
| PTK2 | protein tyrosine kinase 2 | -0.0470705 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | -0.0467551 |
| PPFIA4 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4 | -0.0462483 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0459992 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0443329 |
| SETBP1 | SET binding protein 1 | -0.0432701 |
| BACE2 | beta-site APP-cleaving enzyme 2 | -0.0430333 |
| CABIN1 | calcineurin binding protein 1 | -0.0424718 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0423936 |
| PAX3 | paired box 3 | -0.0414656 |
| NDRG1 | N-myc downstream regulated 1 | -0.0409716 |
| CALD1 | caldesmon 1 | -0.0397796 |
| SOX5 | SRY (sex determining region Y)-box 5 | -0.039621 |
| FBXL7 | F-box and leucine-rich repeat protein 7 | -0.0394358 |
| EGR1 | early growth response 1 | -0.0381912 |
| PDE10A | phosphodiesterase 10A | -0.0367695 |
| TRIM2 | tripartite motif containing 2 | -0.0366376 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0365902 |
| ST6GALNAC3 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 | -0.0350018 |
| C10ORF90 | chromosome 10 open reading frame 90 | -0.0346827 |
| CDK14 | cyclin-dependent kinase 14 | -0.0346417 |
| RNF213 | ring finger protein 213 | -0.0344257 |
| NEGR1 | neuronal growth regulator 1 | -0.0340372 |
| GALNT18 | polypeptide N-acetylgalactosaminyltransferase 18 | -0.0340324 |
| CEMIP2 | cell migration inducing hyaluronidase 2 | -0.0338975 |
| EXOC4 | exocyst complex component 4 | -0.033889 |
| ADAM19 | ADAM metallopeptidase domain 19 | -0.0337972 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.0337553 |
| PTCHD4 | patched domain containing 4 | -0.0334723 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0332332 |
| CUX1 | cut-like homeobox 1 | -0.0328735 |
| LRMDA | leucine rich melanocyte differentiation associated | -0.0325271 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0323791 |
| RPL37A | ribosomal protein L37a | -0.0315534 |
| PARVB | parvin, beta | -0.0312044 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | -0.0311504 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0306777 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | -0.0305976 |
| PHC2 | polyhomeotic homolog 2 (Drosophila) | -0.0299579 |
| TMSB10 | thymosin beta 10 | -0.0296938 |
| CTBP2 | C-terminal binding protein 2 | -0.029356 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0291337 |
| ASPH | aspartate beta-hydroxylase | -0.0286799 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0279839 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0276178 |
| MEIS2 | Meis homeobox 2 | -0.0276102 |
| HMGA2 | high mobility group AT-hook 2 | -0.0270306 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | -0.0268474 |
| WNK1 | WNK lysine deficient protein kinase 1 | -0.026437 |
| RPL36 | ribosomal protein L36 | -0.0264097 |
| MEF2C | myocyte enhancer factor 2C | -0.0263174 |
| ATXN1 | ataxin 1 | -0.0261604 |
| RPS3 | ribosomal protein S3 | -0.0260177 |
| CFAP20DC | CFAP20 domain containing | -0.0254615 |
| ARNT2 | aryl-hydrocarbon receptor nuclear translocator 2 | -0.0254488 |
| TLE4 | transducin-like enhancer of split 4 | -0.0254462 |
| EBF1 | early B-cell factor 1 | -0.0254023 |
| CPQ | carboxypeptidase Q | -0.0252401 |
| FGF13 | fibroblast growth factor 13 | -0.0249987 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | -0.0248417 |
| HIPK2 | homeodomain interacting protein kinase 2 | -0.0246375 |
| ZNF704 | zinc finger protein 704 | -0.0243564 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0242873 |
| RPS19 | ribosomal protein S19 | -0.0242752 |
| LARGE1 | LARGE xylosyl- and glucuronyltransferase 1 | -0.0241876 |
| NAALADL2 | N-acetylated alpha-linked acidic dipeptidase-like 2 | -0.024009 |
| UTRN | utrophin | -0.0239808 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0239407 |
