Bosentan (hydrate)_COLO 205 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Bosentan (hydrate) perturbation in COLO 205 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Bosentan (hydrate)_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MBNL2 muscleblind-like splicing regulator 2 0.064719
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0643505
ERRFI1 ERBB receptor feedback inhibitor 1 0.0476736
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0440977
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0393787
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0326717
COG6 component of oligomeric golgi complex 6 0.0324994
FNIP1 folliculin interacting protein 1 0.0313622
SUCO SUN domain containing ossification factor 0.0291854
BTBD9 BTB (POZ) domain containing 9 0.0265806
PRELID2 PRELI domain containing 2 0.0249875
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0236763
CALU calumenin 0.0233965
GRK3 G protein-coupled receptor kinase 3 0.023013
MCTP2 multiple C2 domains, transmembrane 2 0.022006
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0219026
HELZ helicase with zinc finger 0.0216535
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0216286
SEC31A SEC31 homolog A (S. cerevisiae) 0.0211946
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 0.0209808
RBM39 RNA binding motif protein 39 0.0203416
SEC24D SEC24 family member D 0.020289
BCLAF1 BCL2-associated transcription factor 1 0.0201326
ZNF451 zinc finger protein 451 0.0195852
KDM6A lysine (K)-specific demethylase 6A 0.0191955
TAS2R14 taste receptor, type 2, member 14 0.0190348
SAMD4A sterile alpha motif domain containing 4A 0.0186792
FEM1C fem-1 homolog c (C. elegans) 0.0185616
ZBTB20 zinc finger and BTB domain containing 20 0.0184192
GOLGA4 golgin A4 0.0183794
USP9X ubiquitin specific peptidase 9, X-linked 0.0180916
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme 0.0177428
GORASP2 golgi reassembly stacking protein 2, 55kDa 0.0177065
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0175704
ARRDC3 arrestin domain containing 3 0.0173578
RAB1A RAB1A, member RAS oncogene family 0.0173576
USP3 ubiquitin specific peptidase 3 0.0171773
BIRC6 baculoviral IAP repeat containing 6 0.0168632
TMEM39A transmembrane protein 39A 0.016798
METTL15 methyltransferase like 15 0.0167783
NAMPT nicotinamide phosphoribosyltransferase 0.0167204
PDIA6 protein disulfide isomerase family A, member 6 0.0163531
UBL3 ubiquitin-like 3 0.0162529
LCORL ligand dependent nuclear receptor corepressor-like 0.0161523
UBR3 ubiquitin protein ligase E3 component n-recognin 3 (putative) 0.015813
ZC3H11A zinc finger CCCH-type containing 11A 0.015659
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0156152
MBD5 methyl-CpG binding domain protein 5 0.0155479
FNDC3A fibronectin type III domain containing 3A 0.015449
CANX calnexin 0.0148759
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0148365
ARHGAP32 Rho GTPase activating protein 32 0.0146281
FNDC3B fibronectin type III domain containing 3B 0.0145676
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.01448
NBAS neuroblastoma amplified sequence 0.0144206
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0143705
DIAPH3 diaphanous-related formin 3 0.0142186
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0140309
BRWD3 bromodomain and WD repeat domain containing 3 0.0139309
TFG TRK-fused gene 0.0138756
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.0137784
NSD3 nuclear receptor binding SET domain protein 3 0.0135421
PCCA propionyl CoA carboxylase, alpha polypeptide 0.0134873
CEP152 centrosomal protein 152kDa 0.0134098
UBE2O ubiquitin-conjugating enzyme E2O 0.0133766
KIZ kizuna centrosomal protein 0.0133456
SBF2 SET binding factor 2 0.0132969
ZNF841 zinc finger protein 841 0.013274
COPA coatomer protein complex, subunit alpha 0.0132573
TUBGCP3 tubulin, gamma complex associated protein 3 0.0132435
AP3B1 adaptor-related protein complex 3, beta 1 subunit 0.0130739
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0130649
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0129229
TMED2 transmembrane emp24 domain trafficking protein 2 0.0128202
USPL1 ubiquitin specific peptidase like 1 0.0127062
EHF ets homologous factor 0.0126812
BHLHE40 basic helix-loop-helix family, member e40 0.0126715
ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7 0.0126598
NDEL1 nudE neurodevelopment protein 1-like 1 0.0125008
TAOK1 TAO kinase 1 0.012475
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0124384
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) 0.0123916
SLC10A7 solute carrier family 10, member 7 0.0122632
TES testin LIM domain protein 0.0122103
MYH9 myosin, heavy chain 9, non-muscle 0.0121452
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 0.0121003
CCNL1 cyclin L1 0.0119438
OGA O-GlcNAcase 0.0118922
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0118503
USP49 ubiquitin specific peptidase 49 0.0118344
KANSL1 KAT8 regulatory NSL complex subunit 1 0.0117431
ANKIB1 ankyrin repeat and IBR domain containing 1 0.011725
ADAM17 ADAM metallopeptidase domain 17 0.0117109
TRAM1 translocation associated membrane protein 1 0.0117089
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0116833
PTEN phosphatase and tensin homolog 0.0116324
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0115987
GPBP1L1 GC-rich promoter binding protein 1-like 1 0.0115849
RAB8B RAB8B, member RAS oncogene family 0.0115821
ARF4 ADP-ribosylation factor 4 0.0115223

decreased expression

Symbol Name Standardized Value
B2M beta-2-microglobulin -0.248847
TPT1 tumor protein, translationally-controlled 1 -0.179609
EPSTI1 epithelial stromal interaction 1 (breast) -0.151928
LCN2 lipocalin 2 -0.124285
PTMA prothymosin, alpha -0.115173
IFI6 interferon, alpha-inducible protein 6 -0.104832
RNF213 ring finger protein 213 -0.103754
C6ORF132 chromosome 6 open reading frame 132 -0.101431
HLA-B major histocompatibility complex, class I, B -0.0977211
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0843752
IFI27 interferon, alpha-inducible protein 27 -0.0813732
SP100 SP100 nuclear antigen -0.0813005
MX2 MX dynamin-like GTPase 2 -0.0811992
RPL35A ribosomal protein L35a -0.0775627
FTL ferritin, light polypeptide -0.0753713
TMSB10 thymosin beta 10 -0.0702866
EGR1 early growth response 1 -0.0682624
ERBIN erbb2 interacting protein -0.0670627
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0666397
PKM pyruvate kinase, muscle -0.0639988
MX1 MX dynamin-like GTPase 1 -0.063297
RIGI RNA sensor RIG-I -0.0607324
RPS6 ribosomal protein S6 -0.0593764
LYZ lysozyme -0.0571146
ZMYND8 zinc finger, MYND-type containing 8 -0.0565944
RPL23 ribosomal protein L23 -0.0561874
RABGAP1L RAB GTPase activating protein 1-like -0.0559299
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0558068
TMC5 transmembrane channel-like 5 -0.0551642
STS steroid sulfatase (microsomal), isozyme S -0.0543544
MT2A metallothionein 2A -0.0525868
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0518021
EIF1 eukaryotic translation initiation factor 1 -0.0504111
PERP PERP, TP53 apoptosis effector -0.0500689
RPL19 ribosomal protein L19 -0.0499124
RPS3 ribosomal protein S3 -0.0495116
RPS8 ribosomal protein S8 -0.0488534
RPS19 ribosomal protein S19 -0.0481687
ACTG1 actin gamma 1 -0.0474318
RAB7A RAB7A, member RAS oncogene family -0.0472161
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 -0.0469885
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.0467453
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0466845
RPL7L1 ribosomal protein L7-like 1 -0.0461868
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0461335
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0424458
MAP7 microtubule-associated protein 7 -0.0401788
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0401557
AREG amphiregulin -0.0396661
PRRC2C proline-rich coiled-coil 2C -0.0390541
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0386592
GCLC glutamate-cysteine ligase, catalytic subunit -0.0384814
RPS27 ribosomal protein S27 -0.0379765
ETV6 ets variant 6 -0.0378049
S100A6 S100 calcium binding protein A6 -0.0377215
RPL34 ribosomal protein L34 -0.0375777
GMDS GDP-mannose 4,6-dehydratase -0.0369743
KRT19 keratin 19, type I -0.0366156
HLA-A major histocompatibility complex, class I, A -0.0364817
RPL37A ribosomal protein L37a -0.0364394
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0361234
RPL11 ribosomal protein L11 -0.0360057
SLC38A1 solute carrier family 38, member 1 -0.0352413
HLA-C major histocompatibility complex, class I, C -0.0350396
RPL9 ribosomal protein L9 -0.0348985
IFITM3 interferon induced transmembrane protein 3 -0.0348958
RPL12 ribosomal protein L12 -0.0348922
PMP22 peripheral myelin protein 22 -0.0346573
EPHB2 EPH receptor B2 -0.0345862
XAF1 XIAP associated factor 1 -0.0345154
RPLP1 ribosomal protein, large, P1 -0.0342786
RPS12 ribosomal protein S12 -0.0341886
NPSR1 neuropeptide S receptor 1 -0.0339825
RPLP2 ribosomal protein, large, P2 -0.0335736
LIMA1 LIM domain and actin binding 1 -0.0333234
JUN jun proto-oncogene -0.0332034
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0331123
TSHZ2 teashirt zinc finger homeobox 2 -0.0328284
RPL26 ribosomal protein L26 -0.0325885
TSC22D1 TSC22 domain family, member 1 -0.0325744
SPATA13 spermatogenesis associated 13 -0.0323536
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 -0.0319289
PGK1 phosphoglycerate kinase 1 -0.0317681
ITGA6 integrin, alpha 6 -0.0316023
PLSCR1 phospholipid scramblase 1 -0.0312973
INTS6 integrator complex subunit 6 -0.0312901
RPL37 ribosomal protein L37 -0.0312159
S100A9 S100 calcium binding protein A9 -0.0311934
SERF2 small EDRK-rich factor 2 -0.0310985
RPS24 ribosomal protein S24 -0.0310297
S100P S100 calcium binding protein P -0.0310157
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) -0.0309598
RPL31 ribosomal protein L31 -0.0306815
ANXA2 annexin A2 -0.0306419
IFIH1 interferon induced with helicase C domain 1 -0.0304931
EPB41L1 erythrocyte membrane protein band 4.1-like 1 -0.0304204
CSTB cystatin B (stefin B) -0.0302908
PRKCA protein kinase C, alpha -0.0299662
TXNIP thioredoxin interacting protein -0.0297264
NDRG1 N-myc downstream regulated 1 -0.0294331